The effects of casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP) paste on the remineralization of white spot lesions, evaluated clinically (Nyvad Index) and by standard photography's. The aim of the study was analyses clinically, the effect of Tooth Mouse in orthodontic patients with active white scores. During orthodontic treatment, 12 patients with 134 white spot lesions, using Nyvad criteria and clinical photos were taken in order to confirm the diagnostic criteria. The patients were oriented to apply tooth mouse before going to sleep, after brushing the teeth, with a clean dry finger or cotton tip and leaved for 3 minutes and expectorate but not washed. The Patients were reexamined at three and six months after the mouse use of tooth mosse. Nyvad Scores 1:112 faces (83,6%); 2=14 faces (10,4%); 3=6 faces (4,5%); 5=2 faces (1,5%). The active white spots, were more frequent in score 1, when compared to scores 2, 3 and 5, significant at 1%. Score 2, had significative differences towards score 5. The active white spots, were more frequent in score 1, when compared to scores 2, 3 and 5, significant at 1%. Score 2, had significative differences towards score 5. After three month, from the 118 white spot lesions, the majority of them inactivated 114 (96, 61%), became inactive, while 4 remain active. The scores achieved after three month remain stable till one year evaluation. Tooth mouse, used topically in Brazilian patients, during orthodontic treatment, was effective in remineralizing white spots over one year period.
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