Accuracy Of Classifier Research Articles

Evaluation of the ActiMotus Software to Accurately Classify Postures and Movements in Children Aged 3–14

Background: ActiMotus, a thigh-accelerometer-based software used for the classification of postures and movements (PaMs), has shown high accuracy among adults and school-aged children; however, its accuracy among younger children and potential differences between sexes are unknown. This study aimed to evaluate the accuracy of ActiMotus to measure PaMs among children between 3 and 14 years and to assess if this was influenced by the sex or age of children. Method: Forty-eight children attended a structured ~1-hour data collection session at a laboratory. Thigh acceleration was measured using a SENS accelerometer, which was classified into nine PaMs using the ActiMotus software. Human-coded video recordings of the session provided the ground truth. Results: Based on both F1 scores and balanced accuracy, the highest levels of accuracy were found for lying, sitting, and standing (63.2–88.2%). For walking and running, accuracy measures ranged from 48.0 to 85.8%. The lowest accuracy was observed for classifying stair climbing. We found a higher accuracy for stair climbing among girls compared to boys and for older compared to younger age groups for walking, running, and stair climbing. Conclusions: ActiMotus could accurately detect lying, sitting, and standing among children. The software could be improved for classifying walking, running, and stair climbing, particularly among younger children.

Enhancing Intent Classifier Training with Large Language Model-generated Data

ABSTRACT Intent classification is essential in Natural Language Processing, serving applications like virtual assistants and customer service by categorizing user inputs into predefined classes. Despite its importance, the effectiveness of intent classifiers is often constrained by the scarcity of labeled data, as acquiring substantial, annotated datasets is costly and impractical. Data augmentation addresses this by expanding datasets with modified or synthetic examples, a common practice in computer vision but more complex in NLP due to the discrete nature of language. Traditional NLP data augmentation methods have been explored but exhibit limitations. This paper investigates the use of Large Language Models for generating labeled data to enhance intent classification. We explore whether LLM-generated data can effectively augment training sets, comparing its impact on intent classifier performance against traditional augmentation methods. Our study reveals that LLMs can generate diverse and realistic data, potentially improving classifier accuracy in low-data scenarios, thereby providing valuable insights into leveraging generative AI for NLP tasks in real-world applications.

Prediction of brain metastasis development with DNA methylation signatures.

Brain metastases (BMs) are the most common and among the deadliest brain tumors. Currently, there are no reliable predictors of BM development from primary cancer, which limits early intervention. Lung adenocarcinoma (LUAD) is the most common BM source and here we obtained 402 tumor and plasma samples from a large cohort of patients with LUAD with or without BM (n = 346). LUAD DNA methylation signatures were evaluated to build and validate an accurate model predicting BM development from LUAD, which was integrated with clinical factors to provide comprehensive patient-specific BM risk probabilities in a nomogram. Additionally, immune and cell interaction gene sets were differentially methylated at promoters in BM versus paired primary LUAD and had aligning dysregulation in the proteome. Immune cells were differentially abundant in BM versus LUAD. Finally, liquid biomarkers identified from methylated cell-free DNA sequenced in plasma were used to generate and validate accurate classifiers for early BM detection. Overall, LUAD methylomes can be leveraged to predict and noninvasively identify BM, moving toward improved patient outcomes with personalized treatment.

A comparative performance assessment of artificial intelligence based classifiers and optimized feature reduction technique for breast cancer diagnosis

Breast cancer (BC) is a catastrophic global health concern that causes numerous fatalities worldwide. Early detection of breast cancer may mitigate death rates; however, the prevailing diagnostic procedure for the malignancy necessitates numerous multifaceted laboratory tests that must be performed by medical professionals. In this article machine learning, a branch of Artificial Intelligence (AI), has been employed to improve cancer diagnosis, prognoses and survival rates while reducing the vulnerability of humans. Support Vector Machine (SVM), K-nearest Neighbors (KNN), Decision Tree (DT), Random Forest (RF) and Grey Wolf Optimizer (GWO) are implemented to prognosticate breast cancer. Comprehensive insights into the efficacy of these approaches for breast cancer prognosis are provided by the performance assessment that is accomplished using the confusion matrix, Receiver Operating Characteristic (ROC) curves and parallel coordinate plots. Both UCI (University of California Irvine) and SEER (Surveillance, Epidemiology and End Results) datasets have been utilized to confirm the investigation's findings and ensure their generalizability across diverse data sources. The results conclusively demonstrate that SVM is the cohort's most accurate classifier. With a stupendous accuracy rate of 99.1 %, the GWO-SVM compares favorably to all other algorithms. Furthermore, feature reduction approaches such as Minimum Redundancy Maximum Relevance (mRMR), ReliefF and Principal Component Analysis (PCA) are utilized. ReliefF has demonstrated exceptional effectiveness with a maximum accuracy of 98.2 %.

Boosting Learning Algorithms for Chronic Diseases Prediction: A Review

Boosting algorithms are a set of machine learning techniques that are predicated on the notion that a weak learner's acquisition of multiple basic classifiers might yield results that are superior to those of any one simple classifier used alone. A comprehensive evaluation of regularly used boosting techniques against highly investigated diseases is lacking, despite the fact that boosting approaches have been used for disease prediction in many studies. Thus, the purpose of this work is to highlight the main algorithms and strategies in the boosting learning. The results of this work will help academics identify a more appropriate boosting approach to predict disease, as well as better understand current patterns and hotspots in diseases prediction models that use boosting learning. The results showed that adaboost algorithm outperformed other algorithms in terms of accuracy, achieving above 90%. This review also demonstrates how combining two boosting methods can increase the basic classifier's accuracy. By using AdaBoost and LightGBM, the accuracy reached 99.75%. XGBoost and Gradient Boosting techniques were employed more frequently in researches than other boosting algorithms.

Study on canopy extraction method for narrowband spectral images based on superpixel color gradation skewness distribution features

BackgroundCrop phenotype extraction devices based on multiband narrowband spectral images can effectively detect the physiological and biochemical parameters of crops, which plays a positive role in guiding the development of precision agriculture. Although the narrowband spectral image canopy extraction method is a fundamental algorithm for the development of crop phenotype extraction devices, developing a highly real-time and embedded integrated narrowband spectral image canopy extraction method remains challenging owing to the small difference between the narrowband spectral image canopy and background.MethodsThis study identified and validated the skewed distribution of leaf color gradation in narrowband spectral images. By introducing kurtosis and skewness feature parameters, a canopy extraction method based on a superpixel skewed color gradation distribution was proposed for narrowband spectral images. In addition, different types of parameter combinations were input to construct two classifier models, and the contribution of the skewed distribution feature parameters to the proposed canopy extraction method was evaluated to confirm the effectiveness of introducing skewed leaf color skewed distribution features.ResultsLeaf color gradient skewness verification was conducted on 4200 superpixels of different sizes, and 4190 superpixels conformed to the skewness distribution. The intersection over union (IoU) between the soil background and canopy of the expanded leaf color skewed distribution feature parameters was 90.41%, whereas that of the traditional Otsu segmentation algorithm was 77.95%. The canopy extraction method used in this study performed significantly better than the traditional threshold segmentation method, using the same training set, Y1 (without skewed parameters) and Y2 (with skewed parameters) Bayesian classifier models were constructed. After evaluating the segmentation effect of introducing skewed parameters, the average classification accuracies Acc_Y1 of the Y1 model and Acc_Y2 of the Y2 model were 72.02% and 91.76%, respectively, under the same test conditions. This indicates that introducing leaf color gradient skewed parameters can significantly improve the accuracy of Bayesian classifiers for narrowband spectral images of the canopy and soil background.ConclusionsThe introduction of kurtosis and skewness as leaf color skewness feature parameters can expand the expression of leaf color information in narrowband spectral images. The narrowband spectral image canopy extraction method based on superpixel color skewness distribution features can effectively segment the canopy and soil background in narrowband spectral images, thereby providing a new solution for crop canopy phenotype feature extraction.

Machine Learning Application to Classify Asteroids Based on Orbital Parameters

Abstract A machine learning application was developed to detect Potentially Hazardous Asteroid and mitigate asteroid collision risk with the Earth by applying three classifiers: the K-Nearest Neighbors, Naïve Bayes, and Random Forest. The study determined the most effective classifier for developing an asteroid classification program based on orbital motion. The machine learning classifier was then evaluated by its precision, accuracy, F1-score, and recall in determining Potentially Hazardous Asteroids and non-Potentially Hazardous Asteroids. The result presented Random Forest as the most appropriate classifier with the highest accuracy score of 99.53%, followed by the Naive Bayes classifier with an accuracy score of 92.00%, and the KNN classifier with an accuracy score of 84.45%. The study provided information on the most accurate machine learning classifier with the impact parameters for asteroid classification in an early warning system. By improving an embedded real-time detection system for Potentially Hazardous Asteroids, the study contributes to more effective strategies for mitigating the risk of asteroid impacts and enhancing planetary defence.

Digital PCR threshold robustness analysis and optimization using dipcensR.

Digital polymerase chain reaction (dPCR) is a best-in-class molecular biology technique for the accurate and precise quantification of nucleic acids. The recent maturation of dPCR technology allows the quantification of up to thousands of targeted nucleic acids per instrument per day. A key step in the dPCR data analysis workflow is the classification of partitions into two classes based on their partition intensities: partitions either containing or lacking target nucleic acids of interest. Much effort has been invested in the design and tailoring of automated dPCR partition classification procedures, and such procedures will be increasingly important as the technology ventures into high-throughput applications. However, automated partition classification is not fail-safe, and evaluation of its accuracy ishighly advised. This accuracy evaluation is a manual endeavor and is becoming a bottleneck for high-throughput dPCR applications. Here, we introduce dipcensR, the first data-analysis procedure that automates the assessment of any linear partition classifier's partition classification accuracy, offering potentially substantial efficiency gains. dipcensR is based on a robustness evaluation of said partition classification and flags classifications with low robustness as needing review. Additionally, dipcensR's robustness analysis underpins (optional) automatic optimization of partition classification to achieve maximal robustness. A freely available R implementation supports dipcensR's use.

Using of high spatial resolution images to evaluate the thematic accuracy of land use and occupation maps with the Kappa index

The objective from this article evaluates the thematic quality of automatic mappings with supervised classification for land use and land cover, using high spatial resolution satellite images as "ground truth". This consider the advancement of remote sensing technologies has enabled the acquisition of satellite images with various spatial resolutions, which are essential for thematic mapping and automatic classifiers in the context of land use and land cover mapping. In fact, the wide availability of high, medium, and low spatial resolution satellite images has significantly optimized the time and resources required by using more accurate classifiers during data processing. The image used for verification of this paper was GeoEye, with a spatial resolution of 0.5m, dated October 2023. The images submitted to the automatic classifier were Sentinel-2A with a spatial resolution of 10m and Planet with a spatial resolution of 5m, both from the same satellite pass period (October 2023) over the study area, aiming to avoid seasonal and phenological variations in vegetation, as well as changes in the environment due to anthropogenic intervention. The classification method adopted was Maximum Likelihood (MAXVER). The classification accuracy was rigorously evaluated to ensure the reliability of the results using the Kappa index, assessing the agreement between the observed and expected classifications. Based on the methods presented, the set of mapped classes in this study showed good accuracy for the Planet image and very good accuracy for the Sentinel image.

Considerations on sentiment of social network posts as a feature of destructive impacts

Nowadays, people spend a lot of time in the information space, communicating within various social platforms. Content of those platforms can influence people’s feelings and personalities, which is especially relevant for young people. In this research, we made an attempt to prove this hypothesis. For the experiment, we selected the VKontakte social network and analysed users profiles together with the results of the psychological tests passed by them. The goal of the experiment was to find correlations between the information provided within the social network communities and the users’ personalities. Moreover, in this paper, we made an attempt to enhance the results of the classifier accuracy using the sentiment analysis. The experiments were conducted to test the sentiment analysis models, to analyse the proposed feature based on posts’ sentiment, and test the classifier for the detection of the potentially destructive impacts. The analysis of the correlation of the proposed feature with the communities that have potentially destructive impacts on anxiety is conducted. The analysis of the obtained results is provided. During the experiments, the authors found out that consideration of the posts’ sentiment allows increasing accuracy of the classifier for anxiety destructive impacts on 12.24 %. Additionally, we analysed the relationship between the user sentiments metric and destructiveness. We confirmed that the assessment of the user’s posts’ sentiment can be used to compile his psychological characteristics and determine possibility of destructiveness.

Computed tomography radiomics-based cross-sectional detection of mandibular osteoradionecrosis in head and neck cancer survivors.

This study aims to identify radiomic features extracted from contrast-enhanced CT scans that differentiate osteoradionecrosis (ORN) from normal mandibular bone in patients with head and neck cancer (HNC) treated with radiotherapy (RT). Contrast-enhanced CT (CECT) images were collected for 150 patients (80% train, 20% test) with confirmed ORN diagnosis at The University of Texas MD Anderson Cancer Center between 2008 and 2018. Using PyRadiomics, radiomic features were extracted from manually segmented ORN regions and the corresponding automated control regions, the later defined as the contralateral healthy mandible region. A subset of pre-selected features was obtained based on correlation analysis (r > 0.95) and used to train a Random Forest (RF) classifier with Recursive Feature Elimination. Model explainability SHapley Additive exPlanations (SHAP) analysis was performed on the 20 most important features identified by the trained RF classifier. From a total of 1316 radiomic features extracted, 810 features were excluded due to high collinearity. From a set of 506 pre-selected radiomic features, the optimal subset resulting on the best discriminative accuracy of the RF classifier consisted of 67 features. The RF classifier was well calibrated (Log Loss 0.296, ECE 0.125) and achieved an accuracy of 88% and a ROC AUC of 0.96. The SHAP analysis revealed that higher values of Wavelet-LLH First-order Mean and Median were associated with ORN of the jaw (ORNJ). Conversely, higher Exponential GLDM Dependence Entropy and lower Square First-order Kurtosis were more characteristic of normal mandibular tissue. This study successfully developed a CECT-based radiomics model for differentiating ORNJ from healthy mandibular tissue in HNC patients after RT. Future work will focus on the detection of subclinical ORNJ regions to guide earlier interventions.

Performance of empirical and model-based classifiers for detecting sucrase-isomaltase inhibition using the 13C-sucrose breath test

The13C-sucrose breath test (13C-SBT) has been proposed to estimate sucrase-isomaltase (SIM) activity and is a promising test for SIM deficiency, which can cause gastrointestinal symptoms, and for intestinal mucosal damage caused by gut dysfunction or chemotherapy. We previously showed how various summary measures of the13C-SBT breath curve reflect SIM inhibition. However, it is uncertain how the performance of these classifiers is affected by test duration. We leveraged13C-SBT data from a cross-over study in 16 adults who received 0, 100, and 750 mg of Reducose, an SIM inhibitor. We evaluated the performance of a pharmacokinetic-model-based classifier,ρ, and three empirical classifiers (cumulative percent dose recovered at 90 min (cPDR90), time to 50% dose recovered, and time to peak dose recovery rate), as a function of test duration using receiver operating characteristic (ROC) curves. We also assessed the sensitivity, specificity, and accuracy of consensus classifiers. Test durations of less than 2 h generally failed to accurately predict later breath curve dynamics. The cPDR90 classifier had the highest ROC area-under-the-curve and, by design, was robust to shorter test durations. For detecting mild SIM inhibition,ρhad a higher sensitivity. We recommend13C-SBT tests run for at least a 2 h duration. Although cPDR90 was the classifier with highest accuracy and robustness to test duration in this application, concerns remain about its sensitivity to misspecification of the CO2production rate. More research is needed to assess these classifiers in target populations.

Machine-learning-based prediction by stacking ensemble strategy for surgical outcomes in patients with degenerative cervical myelopathy

BackgroundMachine learning (ML) is extensively employed for forecasting the outcome of various illnesses. The objective of the study was to develop ML based classifiers using a stacking ensemble strategy to predict the Japanese Orthopedic Association (JOA) recovery rate for patients with degenerative cervical myelopathy (DCM).MethodsA total of 672 patients with DCM were included in the study and labeled with JOA recovery rate by 1-year follow-up. All data were collected during 2012–2023 and were randomly divided into training and testing (8:2) sub-datasets. A total of 91 initial ML classifiers were developed, and the top 3 initial classifiers with the best performance were further stacked into an ensemble classifier with a supported vector machine (SVM) classifier. The area under the curve (AUC) was the main indicator to assess the prediction performance of all classifiers. The primary predicted outcome was the JOA recovery rate.ResultsBy applying an ensemble learning strategy (e.g., stacking), the accuracy of the ML classifier improved following combining three widely used ML models (e.g., RFE-SVM, EmbeddingLR-LR, and RFE-AdaBoost). Decision curve analysis showed the merits of the ensemble classifiers, as the curves of the top 3 initial classifiers varied a lot in predicting JOA recovery rate in DCM patients.ConclusionsThe ensemble classifiers successfully predict the JOA recovery rate in DCM patients, which showed a high potential for assisting physicians in managing DCM patients and making full use of medical resources.

Denoising of partial discharges in switchgear insulation material using hybrid wavelet denoising-optimization-machine learning

Partial discharge (PD) diagnosis is essential for assessing the insulation status of power equipment, but onsite interferences often contaminate PD signals with noise, impacting diagnostic accuracy. This work proposes an adaptive wavelet threshold denoising technique, where the PD signal is first decomposed into wavelet coefficients using discrete wavelet transform (DWT). Traditional threshold selection methods rely on experience and statistical factors, challenging optimal threshold determination. To address this issue, Particle Swarm Optimization (PSO), Energy Valley Optimization (EVO) and Subtraction Average Based Optimization (SABO) are applied to achieve the best adaptive threshold. The proposed method is evaluated against traditional sqtwolog-based threshold methods using root mean square error (RMSE) and the recognition accuracy of classifiers, including Artificial Neural Networks (ANN), Support Vector Machines (SVM), Gradient Boosting Decision Trees (GBDT) and K-Nearest Neighbours (KNN). The results show that the proposed technique can find the best threshold and increase the recognition accuracy by 19% compared to the traditional method, demonstrating its superior performance.

Machine learning based stellar classification with highly sparse photometry data.

Identifying stars belonging to different classes is vital in order to build up statistical samples of different phases and pathways of stellar evolution. In the era of surveys covering billions of stars, an automated method of identifying these classes becomes necessary. Many classes of stars are identified based on their emitted spectra. In this paper, we use a combination of the multi-class multi-label Machine Learning (ML) method XGBoost and the PySSED spectral-energy-distribution fitting algorithm to classify stars into nine different classes, based on their photometric data. The classifier is trained on subsets of the SIMBAD database. Particular challenges are the very high sparsity (large fraction of missing values) of the underlying data as well as the high class imbalance. We discuss the different variables available, such as photometric measurements on the one hand, and indirect predictors such as Galactic position on the other hand. We show the difference in performance when excluding certain variables, and discuss in which contexts which of the variables should be used. Finally, we show that increasing the number of samples of a particular type of star significantly increases the performance of the model for that particular type, while having little to no impact on other types. The accuracy of the main classifier is ∼0.7 with a macro F1 score of 0.61. While the current accuracy of the classifier is not high enough to be reliably used in stellar classification, this work is an initial proof of feasibility for using ML to classify stars based on photometry.

Comparative analysis of features and classification techniques in breast cancer detection for Biglycan biomarker images.

Breast cancer (BC) is considered the world's most prevalent cancer. Early diagnosis of BC enables patients to receive better care and treatment, hence lowering patient mortality rates. Breast lesion identification and classification are challenging even for experienced radiologists due to the complexity of breast tissue and variations in lesion presentations. This work aims to investigate appropriate features and classification techniques for accurate breast cancer detection in 336 Biglycan biomarker images. The Biglycan biomarker images were retrieved from the Mendeley Data website (Repository name: Biglycan breast cancer dataset). Five features were extracted and compared based on shape characteristics (i.e., Harris Points and Minimum Eigenvalue (MinEigen) Points), frequency domain characteristics (i.e., The Two-dimensional Fourier Transform and the Wavelet Transform), and statistical characteristics (i.e., histogram). Six different commonly used classification algorithms were used; i.e., K-nearest neighbours (k-NN), Naïve Bayes (NB), Pseudo-Linear Discriminate Analysis (pl-DA), Support Vector Machine (SVM), Decision Tree (DT), and Random Forest (RF). The histogram of greyscale images showed the best performance for the k-NN (97.6%), SVM (95.8%), and RF (95.3%) classifiers. Additionally, among the five features, the greyscale histogram feature achieved the best accuracy in all classifiers with a maximum accuracy of 97.6%, while the wavelet feature provided a promising accuracy in most classifiers (up to 94.6%). Machine learning demonstrates high accuracy in estimating cancer and such technology can assist doctors in the analysis of routine medical images and biopsy samples to improve early diagnosis and risk stratification.

Toward an Explainable Large Language Model for the Automatic Identification of the Drug-Induced Liver Injury Literature.

Drug-induced liver injury (DILI) stands as a significant concern in drug safety, representing the primary cause of acute liver failure. Identifying the scientific literature related to DILI is crucial for monitoring, investigating, and conducting meta-analyses of drug safety issues. Given the intricate and often obscure nature of drug interactions, simple keyword searching can be insufficient for the exhaustive retrieval of the DILI-relevant literature. Manual curation of DILI-related publications demands pharmaceutical expertise and is susceptible to errors, severely limiting throughput. Despite numerous efforts utilizing cutting-edge natural language processing and deep learning techniques to automatically identify the DILI-related literature, their performance remains suboptimal for real-world applications in clinical research and regulatory contexts. In the past year, large language models (LLMs) such as ChatGPT and its open-source counterpart LLaMA have achieved groundbreaking progress in natural language understanding and question answering, paving the way for the automated, high-throughput identification of the DILI-related literature and subsequent analysis. Leveraging a large-scale public dataset comprising 14 203 training publications from the CAMDA 2022 literature AI challenge, we have developed what we believe to be the first LLM specialized in DILI analysis based on LLaMA-2. In comparison with other smaller language models such as BERT, GPT, and their variants, LLaMA-2 exhibits an enhanced out-of-fold accuracy of 97.19% and area under the ROC curve of 0.9947 using 3-fold cross-validation on the training set. Despite LLMs' initial design for dialogue systems, our study illustrates their successful adaptation into accurate classifiers for automated identification of the DILI-related literature from vast collections of documents. This work is a step toward unleashing the potential of LLMs in the context of regulatory science and facilitating the regulatory review process.

Artificial neural networks with better analysis reliability in data mining

If there are relatively few cases, semi-supervised learning approaches make advantage of a large amount of unlabeled data to assist develop a better classifier. To expand the labeled training set and update the classifier, a fundamental method is to select and label the unlabeled instances for which the current classifier has higher classification confidence. This approach is primarily used in two distinct semi-supervised learning paradigms: co-training and self-training. However, compared to self-labeled examples that would be tagged by a classifier, the real labeled instances will be more trustworthy. Incorrect label assignment to unlabeled occurrences might potentially compromise the classifier's accuracy in classification. This research presents a novel instance selection method based on actual labeled data. This will take into account the classifier's current performance on unlabeled data in addition to its performance on actual labeled data alone. This uses the accuracy changes in the newly trained classifier over the original labeled data as a criterion in each iteration to determine whether or not the selected most confident unlabeled examples would be accepted by a subsequent iteration. Naïve Bayes (NB) will be used as the basic classifier in the co-training and self-training studies. The findings indicate that the accuracy and categorization of self-training and co-training will be greatly enhanced by SIS. As compared to semi-supervised classification methods, it will enhance accuracy, precision, recall, and F1 score, according to the findings.

Unraveling druggable cancer-driving proteins and targeted drugs using artificial intelligence and multi-omics analyses

The druggable proteome refers to proteins that can bind to small molecules with appropriate chemical affinity, inducing a favorable clinical response. Predicting druggable proteins through screening and in silico modeling is imperative for drug design. To contribute to this field, we developed an accurate predictive classifier for druggable cancer-driving proteins using amino acid composition descriptors of protein sequences and 13 machine learning linear and non-linear classifiers. The optimal classifier was achieved with the support vector machine method, utilizing 200 tri-amino acid composition descriptors. The high performance of the model is evident from an area under the receiver operating characteristics (AUROC) of 0.975 ± 0.003 and an accuracy of 0.929 ± 0.006 (threefold cross-validation). The machine learning prediction model was enhanced with multi-omics approaches, including the target-disease evidence score, the shortest pathways to cancer hallmarks, structure-based ligandability assessment, unfavorable prognostic protein analysis, and the oncogenic variome. Additionally, we performed a drug repurposing analysis to identify drugs with the highest affinity capable of targeting the best predicted proteins. As a result, we identified 79 key druggable cancer-driving proteins with the highest ligandability, and 23 of them demonstrated unfavorable prognostic significance across 16 TCGA PanCancer types: CDKN2A, BCL10, ACVR1, CASP8, JAG1, TSC1, NBN, PREX2, PPP2R1A, DNM2, VAV1, ASXL1, TPR, HRAS, BUB1B, ATG7, MARK3, SETD2, CCNE1, MUTYH, CDKN2C, RB1, and SMARCA4. Moreover, we prioritized 11 clinically relevant drugs targeting these proteins. This strategy effectively predicts and prioritizes biomarkers, therapeutic targets, and drugs for in-depth studies in clinical trials. Scripts are available at https://github.com/muntisa/machine-learning-for-druggable-proteins.

Smooth Ordered Weighted Averaging operators

The study demonstrates the application of OWA operators to binary and multiclass classification problems and seeks a way to improve classification accuracy using smoothing methods. OWA operators are used to aggregate class membership probabilities obtained from individual classifiers. Smoothing methods inspired by Newton-Cotes quadratures are applied before the aggregation step to improve the quality of the final results. Moreover, several sets of weights are used for OWA operators, including sets of weights based on the accuracy of individual classifiers. The experiments are conducted on 20 datasets, from which 7 are designed for binary classification and the rest are for multiclass classification. A comparison of the average accuracy for different sets of weights is shown. On the basis of experimental results, smoothing methods that significantly improve classification accuracy are identified.