Classical Paradigm Research Articles

Classical computation over quantum architectures

Abstract The lack of purely Quantum Programming Languages constitutes a hurdle in the general description of quantum computational processes; the implementation is heavily dependent on the considered quantum computational model. To bypass the obstacle, this paper pursues a new direction, investigating the compilation of classical programming paradigms over different quantum computational models: Gate-Based, Measurement-Based and Adiabatic Quantum Computation. Since graphs can be exploited to describe both classical and quantum computations, the problem of graph encoding on quantum hardware is tightly connected to our purposes. As such, it holds a major relevance in our quest for quantum compilation. While studying these topics through the lenses of Graph Theory, declarative programming emerges as the ideal candidate for such endeavour. In this paper we consider some existing quantum computational models and for each of them we identify the main subtleties in the compilation of classical languages. In turn, we break these complexities down into easier problems to stimulate further developments in this area of research. As it turns out, the observations for each model differ widely. Nevertheless, as for the tasks here considered, no model seems to claim supremacy over the others. In contrast, declarative programming maintains the spot as the ideal candidate for quantum compilation, independently of the model.

Trioxidized cysteine and aging: a molecular binomial that extends far beyond classical proteinopathic paradigms.

Increased oxidative stress (OS) and the disruption of the equilibrium between the production of reactive oxygen species and antioxidants are key molecular features of unhealthy aging. OS results in the formation of oxidative posttranslational modifications (PTMs), some of which involve cysteine (Cys) residues in aging proteomes, and specifically, the formation of trioxidized Cys (t-Cys), which leads to permanent protein damage. Recent findings in rodents have uncovered that irregular regulation of t-Cys residues in the aging proteome disrupts homeostatic phosphorylation signaling, resulting in alterations to proteins that are analogous to those caused by phosphorylated serine (p-Ser) residues. This work contextualizes these significant findings and discusses the implications and molecular role(s) of t-Cys in the aging proteome. Furthermore, we present novel data, validating the increase of specific t-Cys sites associated with aging in a blood-related circulating human proteome. The scope and findings included here support the hypothesis that t-Cys residues may serve as important mechanistic and biological markers, warranting further exploration in the context of unhealthy aging and age-related major diseases.

A grazing crab drives saltmarsh carbon storage and recovery.

Consumers can directly (e.g., consumption) and indirectly (e.g., trophic cascades) influence carbon cycling in blue carbon ecosystems. Previous work found that large grazers have nuanced effects on carbon stocks, yet, small, bioturbating-grazers, which remove plant biomass and alter sediment properties, remain an understudied driver of carbon cycling. We used field-derived and remote sensing data to quantify how the purple marsh crab, Sesarma reticulatum, influenced carbon stocks, flux, and recovery in salt marshes. Sesarma caused a 40%-70% loss in carbon stocks as fronts propagated inland (i.e., ungrazed to recovered transition), with front migration rates accelerating over time. Despite latitudinal differences, front migration rate had no effect on carbon stocks, flux, or time to replacement. When we included Sesarma disturbance in carbon flux calculations, we found it may take 5-100 years for marshes to replace lost carbon, if at all. Combined, we show that small grazers cause a net loss in carbon stocks as they move through the landscape, and irrespective of migration rate, these grazer-driven impacts persist for decades. This work showcases the significant role of consumers in carbon storage and flux, challenging the classic paradigm of plant-sediment feedbacks as the primary ecogeomorphic driver of carbon cycling in blue carbon ecosystems.

Abscopal Effects, Clastogenic Effects and Bystander Effects: 70 Years of Non-Targeted Effects of Radiation.

In vitro and invivo observations accumulated over several decades have firmly shown that the biological effects of ionizing radiation can spread from irradiated cells/tissues to non-targeted cells/tissues. Redox-modulated intercellular communication mechanisms that include a role for secreted factors and gap junctions, can mediate these non-targeted effects. Clearly, the expression of such effects and their transmission to progeny cells has implications for issues related to radiation protection. Their elucidation is also relevant towards enhancing the efficacy of cancer radiotherapy and reducing its impact on the development of normal tissue toxicities. In addition, the study of non-targeted effects is pertinent to our basic understanding of intercellular communications under conditions of oxidative stress. This review will trace the history of non-targeted effects of radiation starting with early reports of abscopal effects which described radiation induced effects in tissues distant from the site of radiation exposure. A related effect involved the production of clastogenic factors in plasma following irradiation which can induce chromosome damage in unirradiated cells. Despite these early reports suggesting non-targeted effects of radiation, the classical paradigm that a direct deposition of energy in the nucleus was required still dominated. This paradigm was challenged by papers describing radiation induced bystander effects. This review will cover mechanisms of radiation-induced bystander effects and the potential impacts on radiation protection and radiation therapy.

A constraint programming framework for preliminary mission analysis: Applications for constellation-servicing active debris removal

Constraint Programming is a classical artificial intelligence paradigm characterised by its flexibility for the modelling of complex problems. In the field of space operations, this approach has been successfully used for mission planning and scheduling. This manuscript proposes a framework that leverages the strengths of Constraint Programming for the preliminary analysis of space missions, introducing some modifications to tailor it to the application at hand. Specifically, it uses constraint propagation and search techniques to thoroughly explore the configuration space of a mission in an efficient manner. Consequently, it is able to quantify the performance of precomputed mission choices with respect to the mission requirements, as well as generate new ones that optimise such performance. The proposed methodology has been particularised for two application cases involving active debris removal missions for large constellations in low Earth orbit, namely, a chaser case and a mothership case. The chaser case considers a servicing satellite that rendezvouses with the failed satellites of the constellation and directly transports them to a disposal orbit. The mothership case comprises a servicing satellite that installs deorbiting kits in each of the failed satellites, except for the one removed in the last place. This way, the servicing satellite will only transport this object, while the deorbiting kits will carry out the disposal of the rest of them. This methodology has been successfully used to evaluate a preliminary mission analysis of both application cases developed under ESA’s Sunrise project.

Generalizing electroosmotic-flow predictions over charge-modulated periodic topographies: tuneable far-field effects

The classical Helmholtz–Smoluchowski (HS) model of electroosmosis holds for homogeneously charged interfaces in contact with a fluid layer bearing an equal and opposite net charge. However, inhomogeneities in the surface charge and topography are inevitable, either as practical materials and fabrication artefacts, or at times as deliberately introduced modulations for flow control. In an effort to arrive at an analytically tractable theoretical framework for addressing the underlying electro-mechanical coupling, here, we generalize the traditional HS theory to an extent where both the surface charge and topographies may bear arbitrary and independent periodic forms. Using a spectral-asymptotic approach, we further arrive at closed-form expressions for describing the resulting electroosmotic pumping for topographic features with small characteristic amplitude to pattern period ratio, as relevant for most practical scenarios. We subsequently execute full-scale numerical simulations without any restrictions on the surface charge and topography variations to assess the efficacy of the theoretical framework. The corresponding test beds include distinctive signature patterns – for example, a square-wave surface charge distribution on trapezoidal pit topographies. Our results reveal that the charge–topography interplay induces an anisotropic flow drift, deviating from the classical HS paradigm. This, in turn, provides new quantitative insights into highly selective electroosmotic flow control via judicious design of the charge and topographical patterns, resulting in controllable accentuation, attenuation, nullification, deflection and even complete reversal of the flow. Our analysis further establishes a provision of estimating the zeta potentials of naturally ‘contaminated’ surfaces, as well as explaining the electrophoresis of large inhomogeneous particles; a paradigm that remained to be explored thus far.

A mathematical theory of relational generalization in transitive inference

Humans and animals routinely infer relations between different items or events and generalize these relations to novel combinations of items. This allows them to respond appropriately to radically novel circumstances and is fundamental to advanced cognition. However, how learning systems (including the brain) can implement the necessary inductive biases has been unclear. We investigated transitive inference (TI), a classic relational task paradigm in which subjects must learn a relation ([Formula: see text] and [Formula: see text]) and generalize it to new combinations of items ([Formula: see text]). Through mathematical analysis, we found that a broad range of biologically relevant learning models (e.g. gradient flow or ridge regression) perform TI successfully and recapitulate signature behavioral patterns long observed in living subjects. First, we found that models with item-wise additive representations automatically encode transitive relations. Second, for more general representations, a single scalar "conjunctivity factor" determines model behavior on TI and, further, the principle of norm minimization (a standard statistical inductive bias) enables models with fixed, partly conjunctive representations to generalize transitively. Finally, neural networks in the "rich regime," which enables representation learning and improves generalization on many tasks, unexpectedly show poor generalization and anomalous behavior on TI. We find that such networks implement a form of norm minimization (over hidden weights) that yields a local encoding mechanism lacking transitivity. Our findings show how minimal statistical learning principles give rise to a classical relational inductive bias (transitivity), explain empirically observed behaviors, and establish a formal approach to understanding the neural basis of relational abstraction.

Can Multisensory Olfactory Training Improve Olfactory Dysfunction Caused by COVID-19?

Approximately 30-60% of people suffer from olfactory dysfunction (OD) such as hyposmia or anosmia after being diagnosed with COVID-19; 15-20% of these cases last beyond resolution of the acute phase. Previous studies have shown that olfactory training can be beneficial for patients affected by OD caused by viral infections of the upper respiratory tract. The aim of the study is to evaluate whether a multisensory olfactory training involving simultaneously tasting and seeing congruent stimuli is more effective than the classical olfactory training. We recruited 68 participants with persistent OD for two months or more after COVID-19 infection; they were divided into three groups. One group received olfactory training which involved smelling four odorants (strawberry, cheese, coffee, lemon; classical olfactory training). The other group received the same olfactory stimuli but presented retronasally (i.e., as droplets on their tongue); while simultaneous and congruent gustatory (i.e., sweet, salty, bitter, sour) and visual (corresponding images) stimuli were presented (multisensory olfactory training). The third group received odorless propylene glycol in four bottles (control group). Training was carried out twice daily for 12 weeks. We assessed olfactory function and olfactory specific quality of life before and after the intervention. Both intervention groups showed a similar significant improvement of olfactory function, although there was no difference in the assessment of quality of life. Both multisensory and classical training can be beneficial for OD following a viral infection; however, only the classical olfactory training paradigm leads to an improvement that was significantly stronger than the control group.

Why the European Union Needs to Clarify and Codify its Engagement with Religion

Religion was outside the European Union’s original remit and the classic secular paradigm predicted it should remain there. However, the opposite happened: religion gradually seeped into the EU legal order. The 2009 Lisbon Treaty created a legal basis and political mandate for EU engagement with religion. This article shows the new treaty provisions represent a shift towards the post-secular paradigm, but implementation of this legal obligation lack coherence and has had mixed success. The case is made for a more systematic and orderly post-secular approach to EU policy and law making, which could help the EU reach certain key objectives.

Neural mechanism underlying preview effects and masked priming effects in visual word processing.

Two classic experimental paradigms - masked repetition priming and the boundary paradigm - have played a pivotal role in understanding the process of visual word recognition. Traditionally, these paradigms have been employed by different communities of researchers, with their own long-standing research traditions. Nevertheless, a review of the literature suggests that the brain-electric correlates of word processing established with both paradigms may show interesting similarities, in particular with regard to the location, timing, and direction of N1 and N250 effects. However, as of yet, no direct comparison has been undertaken between the two paradigms. In the current study, we used combined eye-tracking/EEG to perform such a within-subject comparison using the same materials (single Chinese characters) as stimuli. To facilitate direct comparisons, we used a simplified version of the boundary paradigm - the single word boundary paradigm. Our results show the typical early repetition effects of N1 and N250 for both paradigms. However, repetition effects in N250 (i.e., a reduced negativity following identical-word primes/previews as compared to different-word primes/previews) were larger with the single word boundary paradigm than with masked priming. For N1 effects, repetition effects were similar across the two paradigms, showing a larger N1 after repetitions as compared to alternations. Therefore, the results indicate that at the neural level, a briefly presented and masked foveal prime produces qualitatively similar facilitatory effects on visual word recognition as a parafoveal preview before a single saccade, although such effects appear to be stronger in the latter case.

Testing biased competition between attention shifts: The new multiple cue paradigm.

While the classic Posner cuing paradigm has been used to study cuing of a single endogenous shift of attention, we present a new multiple cue paradigm to study the competition between multiple endogenous shifts of attention. The new paradigm enables us to manipulate the number of competing attention shifts and their relative importance. In three experiments, we demonstrate that the process of selecting one among other relevant attention shifts is governed by limited capacity and biased competition. We show that the probability of performing the most optimal attention shift is influenced by the total number of attention shifts competing for execution and that reward is a determining factor for the selection between attention shifts. We explain our results with a recent mathematical model of biased selection of response sets (the model of intention selection [MIS]). Our new paradigm offers a critical test of MIS and is an important new tool for investigating the mechanisms underlying the retrieval of response sets from long-term memory (LTM). The model (MIS) and the new multiple cue paradigm can provide a new perspective on LTM representations of response sets for instrumental action and on habitual and goal-directed processing in action control. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

#BlackLivesMatter: Where Do the Paradigms of Public Administration Fit?

This study provides an in-depth analysis of problems and policy proposals related to the Black Lives Matter (BLM) Movement in light of public administration (PA) theories. We examine the extant literature focusing on three PA paradigms: Classical, New Public Management (NPM), and Postmodernism (combined with New Public Administration—NPA). Based on a content analysis of BLM activists’ demands, Congressional bills, and resolutions, this study categorizes the problems and solutions according to the area of concern and PA paradigms. Results indicate that postmodern theories offer crucial lenses to understand BLM activists’ demands. However, Congressional bills and resolutions align more with Classical and NPM paradigms. We conclude that BLM policy proposals are more likely to be implemented if framed within NPM and “soft” postmodern perspectives. Similarly, policymakers and practitioners should know that the BLM movement reflects a postmodern approach. This study provides contributions that are relevant to both practitioners and academics.

Predictive evaluation of city sustainability based on benchmarking method - A case study of 34 cities in northeastern China

Sustainability is a recurring theme in city development, aiming to foster an environmentally friendly, livable, and prosperous future. Sustainable development, as a long-term vision for cities, requires an interdisciplinary method and a systems-orientated perspective on evaluating and solving city problems. The multi-criteria decision making (MCDM) method is highly applicable given the excellent multidimensional analytical and model building capabilities. As a widely used decision-making tool, the classical paradigm of MCDM is to make summary measurements of the system based on historical data to facilitate the best conclusions. Nevertheless, from the perspective of long-term sustainability evaluation, the currently available MCDM models are gradually failing to meet the predicting needs highlighted by policy makers in urban planning. Therefore, this paper proposes an innovative predictive evaluation method of city sustainability by integrating benchmarking and stochastic simulation under the framework of MCDM, which enables cities to develop visionary scenarios to accelerate the achievement of sustainability goals. This method was used to predict the future sustainability of 34 cities in northeastern China, which is a good demonstration of its utility and validity in sustainable cities and related fields.

Effect of additional tasks on the reaction time of braking responses in simulated car driving: beyond the PRP effect.

The presentation of one task increases the reaction time on a subsequent task, if stimulus onset asynchrony (SOA) between tasks is short. This psychological refractory period (PRP) effect is typically leveling off as SOA approaches 1 s, which has been documented both in classical laboratory paradigms and in simulated car driving. Here we report a more persistent effect on the subsequent task that goes well beyond the typical duration of the PRP effect. In a driving simulator, 120 healthy older participants followed a lead car that mostly drove at a constant speed. They had to maintain a regular distance from the lead car and had to brake when the lead car braked. Participants also engaged in several additional tasks during driving (two types of tasks: typing three-digit numbers, stating arguments on public issues). SOA between the braking task and the last preceding additional task was 11.49 s ± 1.99 (mean and standard deviation). In a control condition, the braking task was administered without additional tasks. Main performance outcome was Braking Reaction Time (RT, in s), as the interval between onset of brake lights of the lead car and the moment participants released the gas pedal. Additionally, foot movement time (MT, in s), i.e., the difference between gas pedal release and brake pedal onset, was considered for possible compensation behavior. Inter-vehicle distance to the lead car (in m) was taken into account as a moderator. We found that RT averaged 0.77 s without additional tasks, but averaged 1.45 s with additional tasks. This RT difference was less pronounced at smaller inter-vehicle distances, and was not compensated for by faster MT from the gas pedal to the brake pedal. We conclude that detrimental effects of additional tasks on subsequent braking responses can be more persistent than suggested by the PRP effect, possibly because of maintaining multiple task sets, requiring increased executive control. We further conclude that potential detrimental effects can be ameliorated at small inter-vehicle distances by mobilizing extra cognitive resources when response urgency is higher. As a practical implication of our study, distracting stimuli can have persisting detrimental effects on traffic safety.

Revisiting representativeness heuristic classic paradigms: Replication and extensions of nine experiments in Kahneman and Tversky (1972).

Kahneman and Tversky showed that when people make probability judgements, they tend to ignore relevant statistical information (e.g., sample size) and instead rely on a representativeness heuristic, whereby subjective probabilities are influenced by the degree to which a target is perceived as similar to (representative of) a typical example of the relevant population, class or category. Their article has become a cornerstone in many lines of research and has been used to account for various biases in judgement and decision-making. Despite the impact this article has had on theory and practice, there have been no direct replications. In a pre-registered experiment (N = 623; Amazon MTurk on CloudResearch), we conducted a replication and extensions of nine problems from Kahneman and Tversky's 1972 article. We successfully replicated eight out of the nine problems. We extended the replication by examining the consistency of heuristic responses across problems and by examining decision style as a predictor of participants' use of the representativeness heuristic. Materials, data, and code are available on: https://osf.io/nhqc4/.

Hyperacusis questionnaire and event-related potential correlation in migraine patients

This study aims to investigate auditory hypersensitivity and cortical function in migraine patients using the Hyperacusis Questionnaire and the Event-Related Potential (ERP) technique. The study analyzes alterations in the latency and amplitude of the event-related potentials MMN and P300 components. The findings contribute to a better understanding of the physiological relationship between migraine and auditory hypersensitivity. Seventeen migraine patients were admitted to the outpatient clinic of the Department of Otorhinolaryngology-Head and Neck Surgery at Peking University People’s Hospital from June 2023 to September 2023. Nineteen matched healthy subjects were also selected. All participants underwent the pure tone audiometry and the auditory brainstem response test to determine hearing thresholds, the Hyperacusis Questionnaire, the Tinnitus Handicap Inventory, and an ERP examination. The Oddball classical paradigm was used as the stimulation task, and electroencephalography signals were recorded synchronously. The scores of the Hyperacusis Questionnaire, latency and amplitude of MMN and P300 component were compared between the migraine group and the control group, and their correlation was analyzed. The latency of MMN at the Fz and Cz sites in migraine patients was significantly shorter than that in the control group (P < 0.05), and the amplitudes were significantly higher than those in the control group (P < 0.05). The variances in latency and amplitude of P300 at Cz and Pz sites in migraine patients were not statistically significant when compared with the control group. (P > 0.05). The Hyperacusis Questionnaire was negatively correlated with MMN latency, with a correlation coefficient of − 0.374 (P = 0.025), and positively correlated with MMN amplitude, with a correlation coefficient of 0.378 (P = 0.023). There was no significant similarity between the Hyperacusis Questionnaire and P300 latency and amplitude (P > 0.05). Overall, auditory hypersensitivity was enhanced in individuals with migraines compared to healthy individuals, leading to faster information processing, while there may be less impairment in cognitive function.

Influence of expression and purification protocols on Gα biochemical activity: kinetics of plant and mammalian G protein cycles.

Heterotrimeric G proteins are a class of signal transduction complexes with broad roles in human health and agriculturally important plant traits. In the classic paradigm, guanine nucleotide binding to the Gα subunit regulates the activation status of the complex. Using the Arabidopsis thaliana Gα subunit, GPA1, we developed a rapid StrepII-tag mediated purification method that facilitates isolation of protein with increased enzymatic activities as compared to conventional methods, and is demonstrably also applicable to mammalian Gα subunits. We subsequently utilized domain swaps of GPA1 and human GNAO1 to demonstrate the instability of recombinant GPA1 is a function of the interaction between the Ras and helical domains, and can be partially uncoupled from the rapid nucleotide binding kinetics displayed by GPA1.

Chip-encoded high-security classical optical key distribution

Abstract The information security plays a significant role in both our daily life and national security. As the traditional algorithm-based secure key distribution (SKD) is challenged by the quantum computers, the optical physical-layer SKD has attracted great attentions such as quantum SKD, chaos SKD, and reciprocity-based SKD. However, the cost of quantum SKD is still unaffordable and the latter two classical SKDs are only reliable with some preshared information or under simple eavesdrop. So far, there still lacks a high-security and low-cost optical SKD scheme. In this paper, we propose and demonstrate a high-security chip-encoded classical optical SKD paradigm based on the reciprocity of incoherent matrix. The security of SKD is facilitated by the incoherence of input light, and it is the first time that the classical optical SKD is achieved with silicon photonic chips and commercial optical fiber link. Experimentally, we set up a chip-to-chip communication link and achieve key generation rate of 100 bit/s over a 40 km single mode fiber, with key error rate of only 1.89 %. Moreover, we demonstrate the key capacity expansion of the proposed scheme with four-channel wavelength division multiplexing. Our proposal paves the way for the low-cost, high-security, and miniaturized optical SKD.

The role of individual differences in second language pragmatics: A systematic review

AbstractThe current systematic review aims to understand the role of individual differences (IDs) in second language (L2) pragmatics and offer recommendations for further research in this domain. To achieve this, 86 empirical studies in L2 pragmatics published in SSCI (Social Science Citation Index) journals from 2000 to 2023 were systematically selected and coded for IDs, pragmatic features and modalities investigated, methodological orientation, and research findings. The significance of this review paper is the inclusion of both qualitative and quantitative findings and the identification of research trends in the last two decades. This inclusive approach allowed us to reveal the extent to which ID factors were studied within the classic research paradigm (i.e., the influence of IDs in isolation) and the socio‐dynamic research paradigm (i.e., the combined influence of IDs and context over time). Findings revealed that the IDs identified (L2 proficiency, identity, intercultural competence, language mindsets, willingness to communicate, motivation, and cognitive factors) exerted considerable influence on L2 pragmatic competence. Accounting for research gaps, trends in methodology, and findings in the area, we provide specific recommendations for future research to bring the study of L2 pragmatics in line with the ‘affective turn’ in second language acquisition.

Inequivalent and uncorrelated response priming in motor imagery and execution.

Theoretical considerations on motor imagery and motor execution have long been dominated by the functional equivalence view. Previous empirical works comparing these two modes of actions, however, have largely relied on subjective judgments on the imagery process, which may be exposed to various biases. The current study aims to re-examine the commonality and distinguishable aspects of motor imagery and execution via a response repetition paradigm. This framework aims to offer an alternative approach devoid of self-reporting, opening the opportunity for less subjective evaluation of the disparities and correlations between motor imagery and motor execution. Participants performed manual speeded-choice on prime-probe pairs in each trial under three conditions distinguished by the modes of response on the prime: mere observation (Perceptual), imagining response (Imagery), and actual responses (Execution). Responses to the following probe were all actual execution of button press. While Experiment 1 compared the basic repetition effects in the three prime conditions, Experiment 2 extended the prime duration to enhance the quality of MI and monitored electromyography (EMG) for excluding prime imagery with muscle activities to enhance specificity of the underlying mechanism. In Experiment 1, there was no significant repetition effect after mere observation. However, significant repetition effects were observed in both imagery and execution conditions, respectively, which were also significantly correlated. In Experiment 2, trials with excessive EMG activities were excluded before further statistical analysis. A consistent repetition effect pattern in both Imagery and Execution but not the Perception condition. Now the correlation between Imagery and Execution conditions were not significant. Findings from the current study provide a novel application of a classical paradigm, aiming to minimize the subjectivity inherent in imagery assessments while examining the relationship between motor imagery and motor execution. By highlighting differences and the absence of correlation in repetition effects, the study challenges the functional equivalence hypothesis of imagery and execution. Motor representations of imagery and execution, when measured without subjective judgments, appear to be more distinguishable than traditionally thought. Future studies may examine the neural underpinnings of the response repetition paradigm to further elucidating the common and separable aspects of these two modes of action.