Insomnia is a common problem across the world due to various reasons as increasing mental work and stress, less physical activities, social and personal life problems, lifestyle diseases and medication. Consensus proved its 30% incidence overall in the population but sleep-maintenance insomnia is considered up to 66.5%. The study aims to enlighten the Insomnia in Unani classical books in the mean of weighted causes, pathological condition and best treatment. Gathering tribute knowledge of insomnia from Unani books and framing up it on newly researched neurotransmitter consideration in the same meaning, as Unani System of medicine describes Su-i-mizaj Har yabis (hot and dry temperament) is a pivotal cause that is a pathological condition develops after hitting several causes as a collection of briny liquid, accumulation of waste material in the passages of the brain and meninges and Gastro-intestinal insufficiency, excessive flatus, headaches and cancer etc. these condition directly or by signalling motivates the nerves and brain cells and sometimes obstacle in the passage of psychic powering pathway causes more psychological disorders. In the right direction of reason, Unani physicians have presented lucid and articulated treatment to restore the brain’s temperament by administration of soothing and tranquil medicines, evacuate waste from brain channels and regularize the CSF flow and ion exchange. The study is concluded the result with hypothesis to set some clinical trials of mentioned drugs schedule and recommended modulation in a new scale to make practical generalize its result for future studies.