This brief presents a filter-integrated high-efficiency class-F power amplifier (PA). The hybrid cavity–microstrip filtering circuit is employed not only to realize output impedance matching and the third-harmonic manipulation but also to provide high-selectivity bandpass responses. To fulfill the requirements of high-efficiency class-F PAs, cavity resonators and microstrip feeding structures are involved, and their benefits are fully exploited. The metal cavity resonator features a high $Q$ value and, thus, low loss in the passband, resulting in high efficiency. Moreover, metal walls of cavities act as heat sink for the transistor. The microstrip feeding structures are used to improve the skirt selectivity and manipulate the third harmonic. Moreover, it features easy integration with the transistor, and thus, the transition between cavity and microstrip lines is eliminated. The hybrid filter is characterized based on filter synthesis theory. Complex impedance conversion analysis is carried out to guide the impedance transformation from 50 $\Omega$ to a complex one desired by the transistor. For demonstration, a filtering PA operating at 2.4 GHz is designed and measured. It exhibits both high-selectivity bandpass responses and good PA performance with maximum power-added efficiency of 70.9% at 40.8-dBm output power.