Class Action Research Articles

A 2024 Update on Menin Inhibitors. A New Class of Target Agents against KMT2A-Rearranged and NPM1-Mutated Acute Myeloid Leukemia.

Menin inhibitors are new and promising agents currently in clinical development that target the HOX/MEIS1 transcriptional program which is critical for leukemogenesis in histone-lysine N-methyltransferase 2A-rearranged (KMT2Ar) and in NPM1-mutated (NPM1mut) acute leukemias. The mechanism of action of this new class of agents is based on the disruption of the menin-KMT2A complex (consisting of chromatin remodeling proteins), leading to the differentiation and apoptosis of AML cells expressing KMT2A or with mutated NPM1. To date, this new class of drugs has been tested in phase I and II clinical trials, both alone and in combination with synergistic drugs showing promising results in terms of response rates and safety in heavily pre-treated acute leukemia patients. In this brief review, we summarize the key findings on menin inhibitors, focusing on the mechanism of action and preliminary clinical data on the treatment of acute myeloid leukemia with this promising new class of agents, particularly revumenib and ziftomenib.

Peningkatan Hasil Belajar Siswa Dengan Menggunakan Media Kartu Truth Or Dare Pada Pembelajaran Matematika Kelas IV SD Pertiwi Makassar Kota Makassar

The study aims to enhance the learning outcomes of students using Truth or Dare card media on students of 4th grade SD Pertiwi Makassar City of Makassar.This type of research is a Class Action Reaserch that consists of two cycles in which each cycle is performed twice as many meetings. Research procedures include planning, implementation of action, observation and reflection. Subjects in this study are students of the 4th grade SD Pertiwi Makassar City of Makassar of 16 people.The results of the study show that in the first cycle of 16 individual students only 10 students or 63% that meet the criteria of minimum proficiency (KKM) or are in the category sufficient. Classicly already met because of the average score obtained of 75. Whereas in the second cycle where of 16 students there are 14 students or 88% have met the KKM and classically already fulfilled that is an average score gained of 80 or is in the good category. Based on the results of the above research, it can be concluded that the mathematics learning results of students of 4th grade SD Pertiwi Makassar city of Makssar through the media application of Truth or Dare cards have improved

Of fogs and bogs: Does litigation risk make financial reports less readable?

We predict that firms’ attempts to reduce litigation risk can inadvertently worsen financial report readability by increasing reports’ size, complexity, and altering their linguistic characteristics. We find that litigation risk reduces report readability. Readability worsens after firms experience a securities class action. This persists for several years after lawsuit resolution. To alleviate endogeneity concerns, we show that the litigation experience of a firm's managers and directors at other firms impacts readability. We also find that firms adjust readability around litigation flashpoints. Using an SEC rule change as an exogenous shock, we show that adjustments to readability can moderate firm litigation risk.

USING VIDEO ANIMATION IN CONTEXTUAL TEACHING AND LEARNING TO ENHANCE STUDENT ENGAGEMENT IN SCIENCE LEARNING

Science learning that only prioritizes conceptual learning and ignores relevance to the environmental context and society in which students live needs to be immediately abandoned and changed to contextual learning oriented towards student activity and engagement. The research aims to implement the contextual teaching and learning (CTL) model assisted by video animation to improve student learning processes and engagement in science learning about the Water Cycle. For this reason, a qualitative approach to this type of classroom action research is a research method that is considered relevant. Class actions were carried out in cycles (planning, implementation, observation and reflection) in class 5 of SDN 3 Watang Sidenreng, Sidrap Regency, South Sulawesi. Three instruments were used as data collection tools: teacher and student observation sheets and student learning engagement observation. Descriptive analysis was used for the analysis of data. The result is significant changes after implementing three class actions, especially in the student-centred orientation of learning science. With worksheets supported by animated video media, everything strengthens the contextualization of the Water Cycle material to be closer to students' daily phenomena. Various activities and learning experiences are realized when implementing the CTL model's seven learning steps (syntax). At the end of the cycle, student engagement could increase significantly. Thus, implementing CTL assisted by video animation could improve the learning process and engagement.

UPAYA PENINGKATAN HASIL BELAJAR MATEMATIKA MELALUI PENERAPAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING (PBL) PADA SISWA KELAS X.E1 SMA NEGERI 6 DENPASAR TAHUN PELAJARAN 2023/2024

Teachers employ various methods for classroom instruction, but achieving optimal results remains challenging. Recognizing the need for innovation, this study focuses on implementing the Problem Based Learning (PBL) model to enhance mathematical learning outcomes, particularly in Trigonometry for class X.E1 at SMA Negeri 6 Denpasar during the 2023/2024 academic year. The two-cycle class action research reveals improved outcomes, demonstrating that the application of the PBL model leads to enhanced results and identifies sequential steps for implementation. The research, utilizing a class action methodology, involves students from class X.E1 during the academic year 2023/2024. The study emphasizes Trigonometry outcomes, employing the PBL model in two cycles, including initial reflection, action planning, implementation, observation/data collection, and reflection. Data, collected through observation and written tests using instruments such as observation sheets and descriptive questions, undergoes descriptive analysis. The findings underscore the efficacy of the PBL model in improving mathematics learning outcomes, offering insights into its application for Trigonometry in the specific context of class X.E1 at SMA Negeri 6 Denpasar during the first semester

Enhancing HR Technology Through Traceability and Auditing: Navigating Challenges and Legal Complexities for Operational Efficiency

This comprehensive study emphasizes the crucial need for holistic Human Resources (HR) management systems. These systems should ensure transparency, traceability, and alignment with strict regulatory standards, promoting organizational growth. The study highlights the essential role of time and attendance systems in managing hourly employees, ensuring compliance with wage laws and efficient payroll processes. By examining recent legal issues, including class-action lawsuits and key Supreme Court decisions, it illuminates the complex legal framework surrounding HR technology. The study promotes a solution-focused approach, advocating for improvements in data integrity, user interface design, and system interoperability. Additionally, it underlines the importance of including robust reporting and analytics features in time and attendance systems. These suggested strategic changes aim to reduce compliance liabilities, increase productivity, improve data retention practices, and promote a streamlined, legally compliant HR operational framework. This research plays a pivotal role in contributing to the ongoing discourse about enhancing technological infrastructures within Human Resources (HR). It provides insightful perspectives and robust data, serving as a valuable resource for HR professionals, leaders, and decision-makers. The ultimate objective of this study is to attain unparalleled operational excellence and rigorous legal compliance. This not only elevates the standard of HR management systems to new heights but also paves the way for future advancements in this critical field. By fostering a culture of continuous improvement and innovation, this research can inspire the development of more efficient, effective, and legally compliant HR management systems.

A Comparative Study of Traditional and Quiz Team-Type Cooperative Learning Approaches on Students' Academic Performance in Geography

This Classroom Action Research conducted at Madrasah Aliyah Negeri Asahan, Asahan Regency, in the academic year 2018/2019, investigates the efficacy of the Quiz Team Type Cooperative Learning Model (QTCLM) on enhancing student engagement and academic performance in Anthroposphere studies within class XI-IPS2. Specifically, it aims to assess: (1) the variation in student learning activities, and (2) the improvement in student learning outcomes following the QTCLM implementation. The research, adopting a Class Action Research (CAR) methodology, involved the entirety of the XI-IPS2 class, comprising 28 students. Data were amassed utilizing indirect communication techniques and systematic observation, subsequently analyzed through descriptive quantitative methods. Findings reveal a notable escalation in student learning activities from an initial 56.84% in Cycle I to 69.99% in Cycle II post-QTCLM application. Concurrently, student learning outcomes exhibited a significant rise from 71% in Cycle I to 87% in Cycle II. This improvement indicates that the objectives of classical completion have been satisfactorily achieved. The results corroborate the action hypothesis posited at the outset of the study: Implementing the QTCLM in teaching Anthroposphere material in class XI-IPS2 at MAN Asahan effectively enhances student participation and academic achievement, ensuring a minimum of 85% classical completeness. This research underscores the potential of interactive and cooperative learning strategies in fostering a more engaging and fruitful educational environment.

Проблемные аспекты выявления конфликта интересов в производстве по защите прав и законных интересов группы лиц

The article examines the problematic aspects of identifying and preventing conflicts of interest in proceedings for protection of the rights and legitimate interests of a group of persons. Considering the peculiarity of a class action, which consists in uniting of many various interests, the conclusion is argued, that determining the circumstances indicating the presence of a conflict of interest is a task of law enforcement in group proceedings, which must be resolved by judges individually every time, depending on the specific circumstances of the case.

IMPROVING ENGLISH VOCABULARY PROFICIENCY THROUGH THE 'SAVE THE HANGMAN' GAME METHOD: A STUDY ON CLASS VIII B STUDENTS AT SMPN 11 PONTIANAK IN THE ACADEMIC YEAR 2022-2023

Improving English Vocabulary Proficiency by Using Save the Hangman Game Method to Students of Class VIII B in SMPN 11 Pontianak in Academic Year 2022-2023. This study aimed to enhance English vocabulary proficiency among eighth-grade students in Class VIII B at SMPN 11 Pontianak during the 2022-2023 academic year using the Hangman game method. It employed a Class Action Research approach, focusing on implementing the Save the Hangman game at SMPN 11 Pontianak. The research consisted of two cycles involving planning, action, observation, and reflection. Data collection instruments included observation sheets for student and teacher activities, vocabulary tests, and a questionnaire. The findings indicated a 7% increase in vocabulary skills from the first cycle (62%) to the second cycle (70%), reaching the passing criteria of a score above 61. The quality of teacher activity improved by 10%, from 64.52% in the first cycle to 74% in the second cycle. Additionally, student engagement in active learning increased by 14% for very active criteria (from 41% to 55%) and by 16% for active criteria (from 29% to 45%). However, the percentage of students considered active enough decreased by 5% (from 14% to 9%), and no students fell into the less active criteria in the second cycle.

PENERAPAN METODE PEMBELAJARAN DOUBLE LOOP PROBLEM SOLVING DALAM MENINGKATKAN HASIL BELAJAR PPKn KELAS VIII SMP NEGERI 2 TELUKDALAM

The problem in this research is that student learning outcomes tend to be low. The aim of the research is to determine the application of the double loop problem solving learning method to improve PPKn learning outcomes for class VIII SMP Negri 2 Teluk for the 2023/2024 academic year. This type of research is a class action lawsuit (PTK). This research targeted 30 class VIII students and the results showed that student learning outcomes increased. This is shown by an increase in student learning outcomes in Cycle I which has an average score of 1. Cycle II has a completeness level of 100% with a score of 64, a completeness level of 56.67%, and an average score of 78.17. By applying the double loop problem solving learning method, students are trained to design discoveries, solve problems, and build good working relationships between students. It can be concluded that the application of the "Double Loop Problem Solving" learning method will improve PPKn learning outcomes for class VIII SMP Negri 2 Teluk for the 2023/2024 academic year. The suggestions put forward by researchers are: 1) Students should play an active role in learning activities. Learning outcomes will definitely improve if you are actively involved in learning. 2) Teachers should use the "double loop problem-solving" learning method as an alternative to improve learning outcomes and involve students in the learning process. 3) Schools should encourage subject teachers to adopt learning methods.

Improving Students’ Writing Skills Using Grammarly Application Media

As technology advances, education becomes more sophisticated and the level becomes more advanced. The aim of this research is to determine the improvement in students' writing skills using the Grammarly application media. This research is classified as quantitative research using Class Action Research (CAR) design. The participants of this research were 32 students from SMP N 2 GODEAN. Data were collected through pre-test, progress-test and post-test. This study reveals how the media application, namely grammarly, can improve students' writing skills. Research data analysis is descriptive quantitative. The research results show students' writing skill improved by using Grammarly. This application is assumed very useful for use in class and helps students focus more on the material being studied. Keywords: Grammarly Application, Writing skills

Penggunaan Media Pembelajaran Amplop Ajaib untuk Meningkatkan Kemampuan Numerasi Siswa Kelas 2 di SDK Boba

This study aims to improve numeracy skills in mathematics for Grade 2 Elementary School students in Boba Village, South Golewa District, Ngada Regency. The type of research used is class action research involving 2nd grade students totaling 9 people. The research methods used were written and oral tests. This study was conducted with pre cycle, cycle 1, and Cycle 2. The use of magic envelopes Learning media in numeracy learning can improve students ' numeracy skills from pre-cycle to Cycle 1 by 6.67% and obtain an average pre-cycle score of 63.33 to Cycle 1 with an average of 70 or in the sufficient category. From Cycle 1 to cycle 2 experienced an average increase of 10%. While classically increased from Cycle 1 to cycle 2 by 95% of the minimum completeness of 70%. This shows that the use of magic envelopes Learning media can improve the numeracy ability of 2nd grade elementary school students.

Shaping leaves through TALE homeodomain transcription factors.

The first TALE homeodomain transcription factor to be described in plants was maize knotted1 (kn1). Dominant mutations in kn1 disrupt leaf development with abnormal knots of tissue forming in the leaf blade. kn1 was found to be expressed in the shoot meristem but not in a peripheral region that gives rise to leaves. Furthermore, KN1 and closely related proteins were excluded from initiating and developing leaves. These findings were a prelude to a large body of work wherein TALE homeodomain proteins have been identified as vital regulators of meristem homeostasis and organ development in plants. KN1 homologues are widely represented across land plant taxa. Thus, studying the regulation and mechanistic action of this gene class has allowed investigations into the evolution of diverse plant morphologies. This review will focus on the function of TALE homeodomain transcription factors in leaf development in eudicots. Here, we discuss how TALE homeodomain proteins contribute to a spectrum of leaf forms, from the simple leaves of Arabidopsis thaliana to the compound leaves of Cardamine hirsuta and species beyond the Brassicaceae.

Improving Science Learning Outcomes on Human Blood Circulatory System Material Through Experimentation Method for Fifth Grade Students

This research was motivated by the low science learning outcomes of class V students at SD Negeri 6 Palembang. The aim of this research is to improve the science learning outcomes of fifth grade students at SD Negeri 6 Palembang on the circulatory system material. The learning method that researchers used was the experimental method. This type of research is class action. (PTK) This is carried out in 2 cycles through 4 stages, namely: 1) planning, 2) implementation, 3) Observation, 4) Reflection. The methods used in collecting data are observation, documentation and tests. The research results showed that learning outcomes using the experimental method from cycle I to cycle II experienced a significant increase. The observation results show that the average value in the pre-cycle, that's not what it's about, was 61.67, increasing in cycle 1 to 76.32 in the active category, then in cycle 2 it increased to an average of 87.79, so that from cycle I and cycle II 2 there was an increase of 73. .53%. This shows that the use of experimental methods is able to improve student learning outcomes in science subjects on the subject of the circulatory system.

Increasing Student Activity Through The Implementation Of Limited-Time Practice Questions In Physics Learning

Physics is an exact subject that requires not only innovative learning methods but also practice problems. But in fact, in the application of the learning process, students are often seen who are less active in doing the practice questions given and contained in learning resources. For this reason, effective efforts are needed so that all students can play an active role during the learning process, one alternative is to implement a time limit in working on practice questions. This study aims to determine the effect of the implementation of time-limited questions in physics learning on increasing student activity. The research conducted was a class action research with the subject being class XI F 6 SMAN 2 Pariaman. Data analysis techniques use the formula of proportion techniques. Based on the study, it was found that there was an increase in student activity from 36.4% to 63.7%. So it can be concluded that the learning process with the implementation of limited-time practice questions can increase student activity in learning Physics.

APPLICATION OF CROSSWORD PUZZLE LEARNING MEDIA TO INCREASE STUDENTS' LEARNING INTEREST IN SOCIOLOGY LEARNING AT SMA MUHAMMADIYAH LAMAHALA

The purpose of this study was to determine whether there was an increase in students' interest in learning in the application of crossword learning media in sociology learning at SMA Muhammadiyah Lamahala. The type of research used is a class action research. The research subjects were taken from class XII IIS 3 as many as 20 students. This research was conducted at Muhammadiyah Lamahala High School for the 2022/2023 academic year, which is located in East Adonara District, Lamahala Jaya Village. The data in this study are data obtained from tests and scores of interest in learning questionnaires. This research is motivated by the problem, namely the low interest in learning students in learning sociology. To overcome this problem, apply crossword puzzle media to increase students' learning interest. Based on the results of observations, the average percentage of students' learning interest indicators in the pre-cycle had not reached the KKM score percentage, which was 40% before the crossword puzzle media was applied. in cycle 1 has not reached the success criteria. The average percentage of students' learning interest indicators in cycle 1 is 65%. The average percentage of indicators of interest in learning has not yet reached the criteria for success in action because it has only reached 65%, so it is continued with cycle 2. Based on observations, the average percentage of indicators of interest in learning students in cycle 2 has reached the criteria for success. The average percentage of students' learning interest indicators in cycle 2 is 92.7%.

Penerapan Asas Nebis In Idem Dalam Penyelesaian Sengketa Lingkungan Melalui Gugatan Perwakilan Kelompok Class Action

This study examines the theoretical basis of the Nebis In Idem principle in civil cases, especially in class actions and how the basis for the Judges' consideration in applying the Nebis In Idem principle in Class Action Decisions, where the method of approach used in this scientific work is normative juridical, namely research that analyzes laws and regulations with literature studies. Using primary source study materials in the form of regulations, while secondary legal materials include books, articles from accredited journals, besides that tertiary legal materials consist of legal dictionaries. This journal begins with a formulation of the meaning of the application of the Nebis In Idem principle. Then describes descriptively the relationship between Article 10 of PERMA No. 1 of 2002 concerning Class Action Procedures with Article 1917 of the Civil Code. It can be concluded that the theoretical basis of this principle is solely to provide legal protection for a person's human rights, so that a person is not tried for the same case and prioritizes legal certainty and does not let the government repeatedly talk about the same event.

Action-guided CycleGAN for Bi-directional Video Prediction

Most of the earlier proposed action prediction methods, such as PoseGAN, C2GAN, etc. are limited to unidirectional prediction and not intended to perform the desired class of action. In this paper, we propose an action-guided Cycle Generative Adversarial Network (AGCGAN), which is a bi-directional video prediction model to anticipate future frames from current visual frames and vice versa. The proposed CycleGAN architecture consists of two generators and two discriminators along with two additional keypoint detectors to make keypoint loss measurements. The adversarial and cycle losses perform the appearance modelling whereas the keypoint loss provides the necessary motion correction. We evaluated the effectiveness of our proposed method on the UT-Interaction dataset. Furthermore, we also tested our model on the standard Market-1501 dataset against the state-of-the-art schemes. Results show that our proposed method provides comparable visual quality with the state-of-the-art methods.

The Implementation of Differentiated Learning Strategies through Fun Cooking Activities of Kindergarden

This study aims to determine the description of the implementation of differentiated learning strategies through fun cooking activities. This type of research is a qualitative approach descriptive method of analysis. The instruments used are observation sheets to evaluate teacher actions and observation sheets, checklists and serial photos for student assessment. This research was conducted at Wahdah Islamiyah Integrated Islamic Kindergarten 01 Makassar with the research subject of group B children (5-6 years old). This research is a class action research, so the information reviewed in this article is concrete data that occurs in the research location. This research focuses on the differentiated learning process that focuses on four main components, namely differentiation of content, process, product and learning environment designed by the teacher in the teaching module based on the results of the initial assessment. The problem obtained in school learning is the role of teachers who are still lacking in understanding differentiated learning strategies so that learning is still confessional, not involving children in exploring the learning environment more deeply and meaningfully. Efforts to adjust learning based on children's learning needs specifically on children's learning readiness, interests and learning profiles are very important to be a concern because each child has unique characteristics that require different teacher stimulation for each child according to their learning needs. The results show that the implementation of differentiated learning strategies through fun cooking activities is very good for presenting more enjoyable, meaningful learning that not only improves the developmental aspects or competencies of students but children's interest and motivation to learn can develop more optimally.

Subsidiary liability of controlling persons for obligations of a company excluded from the Unified State Register of Legal Entities

The paper examines the issues of bringing controlling persons to subsidiary liability for the obligations of a company excluded from the Unified State Register of Legal Entities. The article determines the judicial procedure for holding controlling persons accountable for claims of creditors. It analyzes the provisions of Russian legislation and judicial practice regarding the grounds for prosecution under paragraph 3.1 Article 3 of the Law on Limited Liability Companies.The research reveals the effect of this rule of law over time and it essence, which excludes the use of the construction of limited liability of participants in a business company. An overview of the legal positions of the Constitutional Court of the Russian Federation on the issues under consideration including the circle of responsible persons, distribution of burden and circumstances of evidence is provided. The paper distinguishes characteristics of good faith and reasonable behavior of creditors and controlling persons as well as legal presumptions corresponding to the circumstance of the case. The conclusion is formulated on the recognition of subsidiary liability by inheritance of debts of a corporate organization. The paper investigates the competence of the court considering disputes on bringing to subsidiary liability of persons controlling a corporation and distinguishes between the corporate (under the general rules of litigation) and bankruptcy (under the rules of class action) proceedings. The characteristics of the powers of creditors acting in the interests of their civil law community are given. The research allows to ensure uniformity of judicial practice at interpreting the applicable rules of law.