Civil engineering consistently encounters challenges related to the durability and safety of buildings, making the study of pathological manifestations a critical area of inquiry. These defects not only undermine the functionality, structural integrity, and aesthetic quality of constructions but also pose significant risks to occupant safety. It is imperative to understand the origins and progression of these pathologies to mitigate structural and functional damage. The application of technical standards, while essential, is often inadequate, thereby exacerbating the occurrence of these problems. This research seeks to identify the underlying causes and origins of building pathologies and to propose effective strategies for their prevention and remediation. Through an interdisciplinary methodology, incorporating diverse sources of information such as bibliographic surveys, technical site visits, and data analysis, the study identifies key pathological manifestations in buildings, including fissures, cracks, concrete deterioration, stains, and efflorescence. The research highlights critical contributing factors such as design errors, material defects, execution failures, and insufficient maintenance. The primary aim of this study is to investigate the principal causes of pathologies and pathological manifestations in a building located in the municipality of Nanuque, and to propose preventative and corrective measures. The research methodology is divided into two distinct phases: an extensive literature review to provide a theoretical foundation, enabling the analysis of prior studies on the subject, followed by a case study involving direct on-site assessments to document the identified pathologies. The findings reveal a range of issues, including reinforcement corrosion, concrete segregation, cracks, fissures, and efflorescence. Informed by the literature, the study proposes appropriate interventions to enhance the safety, stability, aesthetics, and comfort of the building's occupants.