City Of Tomsk Research Articles

Associations of rs4244285 in the CYP2C19 gene with multifactorial diseases

Xenobiotic metabolism system in the current populations is involved in the biotransformation of a wide range of endogenous substrates and various xenobiotics, which can contribute to developing the diseases of various organ systems, and, in some cases, comorbid conditions where increased biotransformation system activity is observed. In this regard, it is of great interest to study the involvement of polymorphism in xenobiotic metabolism genes in the development of both isolated pathology and various comorbid conditions.Aim. The goal of study was to investigate the involvement of rs4244285 in the CYP2C19 gene in the development of isolated pathology and comorbidities.Material and Methods. The frequencies of alleles and genotypes were studied in groups of patients with comorbid conditions including groups of coronary artery disease (CAD) with hypertension (HTN) (CAD_HTN, n = 133) and bronchial asthma (BA) with HTN (BA_HTN, n = 178), in group of isolated BA (n = 135), and in the population sample of the city of Tomsk (n = 377). Association analysis covered three initial groups of patients (CAD, BA, and BA_HTN) and subgroups assigned based on the presence of absence of HTN diagnosis taking into account comorbid conditions both in patient samples and in population control.Results and Discussion. The study demonstrated the predisposing eff ect of GA genotype on the development of comorbid BA and HTN (OR = 1.94, p = 0.038) and comorbid CAD and HTN (OR = 2.26, p = 0.009) compared to isolated BA. The AA genotype was observed 3.98 times less often in HTN patients than in normotensive individuals. However, the diff erences did not reach the level of statistical signifi cance due to the low occurrence of this genotype.Conclusion. The obtained results may be explained by the involvement of CYP2C19-metabolites of arachidonic acid in the regulation of vascular tone, which requires further study.

Структура песенных репертуаров томской популяции мухоловки-пеструшки (Ficedula hypoleuca) и их возрастная изменчивость

Структура песенных репертуаров томской популяции мухоловки-пеструшки (Ficedula hypoleuca) и их возрастная изменчивость

Расчет ослабления сигнала сетей сотовой связи 5G для частот диапазона FR1

The paper presents a model for the propagation of a radio signal of a fifth-generation cellular communication system, taking into account the unevenness of the terrain. The aim of the study is to assess the signal power level on the receiving side of the fourth and fifth generation cellular communication system when the signal propagates over uneven terrain in the frequency bands FR1 (2.6 GHz), FR1 (4.9 GHz). When estimating the power of the radio signal on the receiving side in the model, the values of the height map of the of Tomsk city, obtained in the course of the SRTM3 program, were used as uneven terrain. The presented radio signal propagation model is the Longley Rice ITM (Irregular Terrain Model). For this model, the main expressions are given that determine the resulting signal attenuation, as well as expressions that describe the geometry of the propagation path. The article reflects the main factors that determine the propagation of centimeter waves characteristic of the fifth generation cellular communication system, presents the results of modeling the propagation of the fifth 5G and fourth 4G generation cellular signal using the example of various scenarios for the location of a subscriber terminal and a base station in the Tomsk city. The simulation was carried out for two frequency bands FR1 (4.9 GHz) of the 5G network and FR1 (2.6 GHz) of the 4G network. As a result of the simulation, the values of the attenuation of the signal power level during propagation along the given paths were obtained, and also, taking into account the parameters of the transceiver equipment, the values of the signal power on the receiving side were calculated. Based on the data obtained, a comparative assessment of the communication range for 4G and 5G systems was made.

Методика определения времени вскрытия и замерзания реки по защищенным многоспектральным спутниковым данным и измерениям прибором MODIS

An observation of surface waters is of a great importance for environmental, hydrological research, as well as practical applications and for the Russian Ministry of Emergency Situations. This article deals with the issue of detection and monitoring of surface waters using optical remote sensing by the MODIS multispectral satellite instrument. The current status and problems in this area are briefly discussed. The water detection is based on an analysis of NDVI vegetation index values calculated from measurements throughout the year from a clear division by value of plant, snow or water index values. Based on this, a spatio-temporal mask of water objects or a mask is built, the pixels of which are only used to analyze the values of the vegetation index. Next, the graphs of spatiotemporal dynamics of water mask pixels and construct smoothed values are considered. The following step is related to the search in these dependencies for the moment of opening of the river from winter ice and freezing of the river. A description is given of the processing of real measurements for the territory of the Ob-Tom interfluve, in the region of the city of Tomsk.

Опыт формирования территориального бренда и границы метода

The plurality of territorial brands is a problem of many large and small cities, regions, as well as historical, cultural, and natural territories; however, it continues to be under-researched. At the same time, understanding the reasons why we again and again have to observe this phenomenon in a particular territory is absolutely necessary for the successful solution of the tasks of their strategic development. The analysis of this phenomenon makes it possible to study the conceptual prerequisites that determine the emergence of a situation of a plurality of territorial brands and opens up the possibility of testing the validity of some theoretical concepts in practice. To achieve these objectives, using the example of the city of Tomsk and Tomsk Oblast, I analyze the history and logic of the formation of a territorial brand, the role of city and regional administrations at different stages of its formation and development. I also reveal the conceptual attitudes of the participants in the process of forming the territorial brand, which they voluntarily or involuntarily follow when making decisions in this area. The results of the study show that the principles of cognitive relativism have a significant impact on the decision-making of persons involved in the formation and management of a territorial brand, and also make it possible to establish the limits of applicability of the above methodological setting. The author declares no conflicts of interests.

The problems of assessing radon hazard of development sites in the Russian Federation and the Czech Republic

The problem associated with the risk assessment of radiation caused by the accumulation of radioactive radon gas in closed premises has not been solved to date. Additionally, there is no consensus regarding the set of parameters that should be used for radon hazard assessments of buildings. This paper presents the results of measurements related to radon assessments in the Russian Federation (radon flux density; RFD) and the Czech Republic (volumetric activity of radon in the soil air measured at a depth of 0.8 m and soil gas permeability). In the Russian Federation, RFD was measured in the city of Tomsk on the surface of loess loam using accumulation chambers and carbon adsorbers. In the Czech Republic, the volumetric activity of radon in the soil air and gas permeability were measured by the complexes RM-2 and RADON JOK, respectively, at a testing site located approximately 180 km southwest of Prague and characterised by brown forest and mountain sub-ash soils (cambisols) of the Bohemian Massif.The observed high variability of gas permeability in surface rocks and the radon flux density measured on the ground surface casts doubt on the reliability of assessments of radon hazard risks in the built-up areas. Based on the analysis of the results, other approaches are proposed for conducting radon hazard assessments of built-up areas.

Investigation of the Mixing Height in the Planetary Boundary Layer by Using Sodar and Microwave Radiometer Data

The height of the mixing layer is a significant parameter for describing the dynamics of the planetary boundary layer (PBL), especially for air quality control and for the parametrizations in numerical modeling. The problem is that the heights of the mixing layer cannot be measured directly. The values of this parameter are depending both on the applied algorithms for calculation and on the measuring instruments which have been used by the data source. To determine the height of a layer of intense turbulent heat exchange, data were used from acoustic meteorological locator (sodar) and from a passive single-channel scanning microwave radiometer MTP-5 (MWR) to measure the temperature profile in a layer of up to 1 km. Sodar can provide information on the structure of temperature turbulence in the PBL directly. These data have been compared with the mixing layer height calculated with the Parcel method by using the MTP-5 data. For the analysis, July and September 2020 were selected in the city of Tomsk in Siberia as characteristic periods of mid-summer and the transition period to autumn. The measurement results, calculations and inter-comparisons are shown and discussed in this work. During temperature inversions in the boundary layer, it was observed that turbulent heat transfer (increased dispersion of air temperature) is covering the inversion layers and the overlying ones. Moreover, this phenomenon is not only occurring during the morning destruction of inversions, but also in the process of their formation and development.

Impact of Corporate Culture on the Universities’ Achievements in the “5-100” Project

The project called “5-100” has been established in Russia in 2013 for the period of time from 2013 up to 2020. It was supposed that this project would be resulted in entry of 5 Russian universities into 100 highest positions of the world university ratings. 21 Russian universities were chosen as the participants of the project. To achieve the purpose of the project, every chosen university received considerable financial support from the Russian federal government. Among others, two universities from the city of Tomsk – Tomsk State University (TSU) and Tomsk Polytechnic University (TPU) were the participants of this project. In spite of the identical starting points, the universities have demonstrated substantially different results by the end of the project implementation. In this article, we attempted to explain the difference of the results through difference of the corporate cultures of both universities. The corporate culture study has been done using OCAI method. The study showed that TGU’s corporate culture looks like more competitive than TPU’s one. It was proved by the comparison of the TPU and TGU cultures with cultures of the foreign universities.

Application of a Weather Research and Forecasting model to study the urban heat island in Tomsk

The results of application of a Weather Research and Forecasting model (version 4.2) to study the heat island phenomenon in the city of Tomsk are considered. The results of numerical calculations were compared with measurements obtained using the instruments of Joint Use Center (JUC) Atmosphere and Tomsk Bogashevo Airport. On some days, the temperature difference between the city and the suburbs was shown to reach 1-3 °C.

Preface

XVIII International Conference of Students and Young Scientists “Prospects of Fundamental Sciences Development” (PFSD 2021) April 27–30, 2021, Tomsk, Russia conf-prfn.org The XVIII International Conference of Students and Young Scientists “Prospects of Fundamental Sciences Development” (PFSD 2021), held on 27-30 April 2021 in Tomsk, Russia, is an annual multidisciplinary conference gathering together students, young researchers, post-docs, and experienced researchers working in the different research areas in order to share scientific results and ideas for a better collaboration.PFSD 2021 was dedicated to the 125th anniversary of Tomsk Polytechnic University and was held within the framework of the Year of Science and Technology in Russia. Five Tomsk universities hosted the conference. 467 young researchers applied for the participation in the conference from 67 universities and academic institutes of Russia and foreign countries. The conference presented 20 keynote speakers, 10 interactive masterclasses and competitions for participants.This year the conference was organized partially by personal attendance of participants (mainly from Tomsk city), and many foreign participants took part in conference virtually using Internet communication technologies (Zoom, Adobe Connect). The conference attendance was organized in compliance with all sanitary standards and safety requirements. The Organizing Committee was mainly located in Tomsk.List of PFSD 2021 PROGRAM COMMITTEE includes, ORGANIZING COMMITTEE are available in this pdf

ХАРАКТЕРИСТИКА ПРИРОДНЫХ ОЧАГОВ КЛЕЩЕВОГО ЭНЦЕФАЛИТА НА ТЕРРИТОРИИ ТОМСКОЙ ОБЛАСТИ

This paper characterizes the current epidemiological situation of tick-borne encephalitis in the Tomsk region. There has been a decrease in the incidence of TBE for 10 years. There was made an attempt to typify the epidemiological situation of tick-borne encephalitis nidus on the basis of analysis of epidemiological data of the recent years (2011-2020) in the context of administrative territories of Tomsk region. The typification of the foci of TBE was carried out in the context of the administrative territories of the region. Areas of high, medium, low risk of TBE infection are identified. The territories of the city of Tomsk and the Tomsk region, where the maximum infection rates are recorded (66-88 cases per year), are referred to the high-risk zone. Keywords: monitoring, morbidity, tick-borne encephalitis, natural focal infections, intensive indicator.

Experience of rehabilitation in children with chronic pyelonephritis living in industrial city

The consistently high frequency of pathology of urinary system in children dictates the need to find new methods for the treatment and prevention of pyelonephritis.Goal. To study clinical and laboratory indicators of health status in children with chronic pyelonephritis living in the industrial city of Tomsk and evaluate the effectiveness of various rehabilitation treatment regimens.Material and Methods. The kidney and urology examinations were performed in 58 children with a diagnosis of chronic pyelonephritis aged 7 to 12 years. Two treatment schemes including administration of mineral water and physiotherapy were used.Results and Discussion. The following symptoms were detected before treatment: oxaluria in 22.41% of children, microhematuria in 17.24% of children, significant increase in serum and morning urine nitrate/nitrite levels, and microalbuminuria suggesting the instability of cell membranes and inflammatory process in renal tissue.Conclusion. The administration of low-mineralized magnesium-sodium chloride-sulfate water in combination with physical therapy, manual massage, sapropel applications, interference therapy, and enteric oxygen therapy lead to normalization of clinical and laboratory health status indicators in the main group of patients.

LUWRAIN Books: DAISY for Schools

The report presents the experience obtained in the school for the blind in the city of Tomsk during the experiment which implies creation of a cloud service automatically producing the DAISY audiobooks and utilizing the commercial TTS. The advantages and the problems related to the work are described, as well as technical details of used software components.

ВЕЩЕСТВЕННЫЙ СОСТАВ ТОРФОВ ТИМИРЯЗЕВСКОГО БОЛОТА (ТОМСК, ЗАПАДНАЯ СИБИРЬ)

Актуальность. Болота одновременно являются индикатором состояния окружающей среды в целом и связанных с болотами речных и подземных вод в частности. Это определяет необходимость изучения состояния болот, особенно в районе размещения крупных водозаборов, например, Томского подземного водозабора. Цель: выявление изменений по глубине торфяной залежи Тимирязевского болота (западная окраина г. Томска, Западная Сибирь) химического состава торфов (кислотных вытяжек) и ассоциаций минеральных включений в торфяной залежи как индикаторов природно-антропогенных условий формирования болота. Методы: методы определения химического (включая масс-спектрометрический с индуктивно связанной плазмой) и минерального состава (сканирующая электронная микроскопия с локальным энергодисперсионным анализом), статистические методы. Результаты и выводы. Для переходного Тимирязевского болота в долине реки Томь у г. Томска выявлено неоднородное изменение зольности, Al, Ti, Cr и ряда других элементов с максимумами в верхней и нижней частях торфяной залежи пропорционально источнику минерального вещества (в верхней части залежи – пылевые выпадения, в нижней подстилающие грунты). С учетом данных, ранее полученных на Васюганском болоте, сделано предположение о наличии общего механизма формирования вещественного состава торфов и трансформации минерального вещества в болотах на основе фильтрационных свойств среды. Основные черты указанного выше механизма заключаются в биохимической трансформации минеральных веществ, поступающих из атмосферы, с поверхностным и подземным стоком с суходолов, в результате чего в деятельном горизонте вещество находится во взвешенном, коллоидном и растворенном состоянии, а в инертном горизонте с большей интенсивностью формируются минеральные фазы. На поверхности последних, а также на частицах гидроокислов происходит соосаждение ряда микроэлементов и формирование аутигенных минералов, в том числе фосфатов редкоземельных элементов. Скорость и направленность этих процессов зависит от геоморфологических и гидрологических условий, определяющих возникновение и функционирование геохимических барьеров.

Идеи сибирского областничества в художественной жизни дореволюционного Томска

The paper systematizes available information on regionalism influence on artistic life of Siberia and the city of Tomsk. The article considers the following issues: formation of a unified “Siberian” style, development and actualization of regional themes and images in visual and decorative and applied art. Scientific originality of the study lies in the fact that works of the regional painters of the beginning of the XX century and the regional press publications on art are for the first time analysed through the lens of the Siberian regionalism. The findings justify the thesis that regionalism had a considerable impact on the Siberian painters’ creativity in terms of forming the “Siberian” style and regional artistic school.

Combined Effect of Hypertension and Alcohol Consumption on the Risk of Death (27‑Year Cohort Prospective Study)

Aim To study the effect of arterial hypertension (AH) in combination with frequent alcohol consumption on the formation of risk for cardiovascular death and all-cause death according to results of a 27-year prospective cohort study.Material and methods This 27‑year prospective cohort study of an unorganized population of the Tomsk city (1546 people aged 20-59 years, including 630 men and 916 women) investigated AH prevalence and alcohol consumption (1988-1991) and analyzed the predictive significance of the effect of AH in combination with frequent alcohol consumption on the formation of risk for all-cause and cardiovascular death. AH was diagnosed at blood pressure ≥140 / 90 mm Hg. Frequent alcohol users were defined as those who consumed alcohol more than once a week.Results The combination of AH and frequent alcohol consumption increased the risk of all-cause death 4.1 times compared to that for persons without these risk factors (p<0.001). This was true for all age groups of the total cohort (higher relative risk, RR, was observed for persons aged 20-39 years) and for men (except for the group aged 40-59 years). RR of cardiovascular death was 5.3 (p<0.001) for frequent alcohol users with AH. It was established that frequent alcohol consumption additionally increased RR of all-cause death for persons with AH (RR 1.89; p<0.05) primarily at the expense of persons aged 20-39 years. Prediction of 27‑year survival for frequent alcohol users with AH was 35.3 %.Conclusion A combination of AH with frequent alcohol consumption considerably increases the risk of all-cause and cardiovascular death. Frequent alcohol consumption significantly impairs the prediction of 27-year survival for persons with AH by additionally (1.9 times) increasing the risk of all-cause death. Binary AH combinations with frequent alcohol consumption exert a more pronounced adverse effect on young men and women.

«Рейтарский» шлем первой половины - середины XVII в. с Воскресенской горы (г. Томск) из собрания МАЭС ТГУ

«Рейтарский» шлем первой половины - середины XVII в. с Воскресенской горы (г. Томск) из собрания МАЭС ТГУ

The assessment of the atmospheric air quality in Tomsk with the use of a mesoscale photochemical model

The paper presents the results of studying the influence of the development of meteorological situation in clear weather with a weak wind on the level of atmospheric surface air pollution in the city of Tomsk (Russia). Mesoscale meteorological and photochemical models with a new kinetic scheme were applied to the analysis. The main local weather conditions were identified, in which numerical calculations show increased values of the air pollution index. The numerical predictions have confirmed an increase in the ground-level concentration of pollutants in the presence of temperature inversion or isothermy.

Опыт проведения археологических наблюдений на участке культурного слоя города Томска в 2020 году

This article describes the results of rescue archaeological works at the site of archaeological heritage “Section of the cultural layer of the city of Tomsk on Altaiskaya St., 6, second half of the 19th - early 20th centuries,” in the area of constructing apartment building. The site is located in the central part of Tomsk (historical region) on the left bank of the Ushaika River (right tributary of the Tom River). In the course of archaeological observations, fundamentally new information on stratigraphic and planigraphic context of the site was obtained. A collection of archaeological objects (831 artifacts), including fragments of pottery, porcelain dishware, earthenware, meta dishware and glassware, leather and birch bark shoes, metal tools, jewelry and household items, coins, glazed and unglazed clay tiles, and cast-iron gravestone was collected in the destroyed cultural layer. The complex of things dates back to the period from 1830 to 1910, and enriches our understanding of various aspects of everyday life in Tomsk at that time. During archaeological observations, areas of undisturbed cultural layer at that site of archaeological heritage have not been found. As a special type of archaeological field works, archaeological observations make it possible to successfully employ the entire set of methodological tools available to archaeologists, focus on archaeologically promising sites, and accelerate works on unpromising or ruined areas.

ПРОБЛЕМЫ ИНФОРМАЦИОННОГО ОБЕСПЕЧЕНИЯ ИНЖЕНЕРНЫХ КОММУНИКАЦИЙ В УСЛОВИЯХ ЦИФРОВИЗАЦИИ СФЕРЫ ЗЕМЕЛЬНО-ИМУЩЕСТВЕННЫХ ОТНОШЕНИЙ

The article discusses the reasons for the lack of relevant spatial data, as well as other information about such linear structures as engineering communications. The analysis of problems in this area was carried out on the example of the city of Tomsk, which made it possible to establish the chronology of the duty mapping system development and identify the causes of the existing problems of inconsisten-cy. As examples of the identified problems, we have illustrated the frequent cases of data inconsisten-cy between resource supplying organizations and the cartographic support of the city, which negative-ly affects the management and rational use of urban areas. Conclusions are made about the possibility of solving this issue based on the analysis of the spatial situation with the involvement of new vol-umes of information from interested organizations and its integration into a single geospace.