Abstract
Aim To study the effect of arterial hypertension (AH) in combination with frequent alcohol consumption on the formation of risk for cardiovascular death and all-cause death according to results of a 27-year prospective cohort study.Material and methods This 27‑year prospective cohort study of an unorganized population of the Tomsk city (1546 people aged 20-59 years, including 630 men and 916 women) investigated AH prevalence and alcohol consumption (1988-1991) and analyzed the predictive significance of the effect of AH in combination with frequent alcohol consumption on the formation of risk for all-cause and cardiovascular death. AH was diagnosed at blood pressure ≥140 / 90 mm Hg. Frequent alcohol users were defined as those who consumed alcohol more than once a week.Results The combination of AH and frequent alcohol consumption increased the risk of all-cause death 4.1 times compared to that for persons without these risk factors (p<0.001). This was true for all age groups of the total cohort (higher relative risk, RR, was observed for persons aged 20-39 years) and for men (except for the group aged 40-59 years). RR of cardiovascular death was 5.3 (p<0.001) for frequent alcohol users with AH. It was established that frequent alcohol consumption additionally increased RR of all-cause death for persons with AH (RR 1.89; p<0.05) primarily at the expense of persons aged 20-39 years. Prediction of 27‑year survival for frequent alcohol users with AH was 35.3 %.Conclusion A combination of AH with frequent alcohol consumption considerably increases the risk of all-cause and cardiovascular death. Frequent alcohol consumption significantly impairs the prediction of 27-year survival for persons with AH by additionally (1.9 times) increasing the risk of all-cause death. Binary AH combinations with frequent alcohol consumption exert a more pronounced adverse effect on young men and women.
Highlights
Изучить влияние сочетания артериальной гипертензии (АГ) с частым употреблением алкоголя на формирование риска смерти от сердечно-сосудистых заболеваний (ССЗ) и от всех причин по результатам 27‐летнего проспективного когортного исследования
Являясь одной из причин дисфункции эндотелия, а также обладая способностью оказывать прокоагулянтный эффект, избыточное употребление алкоголя становится одним из важных патогенетических звеньев сосудистого тромбообразования, что в случаях сочетания с АГ в значительной мере способствует увеличению риска смерти от ССЗ
Yusuf S, Joseph P, Rangarajan S, Islam S, Mente A, Hystad P et al Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high-income, middle-income, and lowincome countries (PURE): a prospective cohort study
Summary
Изучить влияние сочетания артериальной гипертензии (АГ) с частым употреблением алкоголя на формирование риска смерти от сердечно-сосудистых заболеваний (ССЗ) и от всех причин по результатам 27‐летнего проспективного когортного исследования. Томска (1546 человек в возрасте 20–59 лет, из них 630 мужчин и 916 женщин) изучена распространенность АГ и употребления алкоголя (1988–1991 гг.), проведен анализ прогностической значимости сочетанного влияния АГ и частого употребления алкоголя в формировании риска смерти от всех причин и от ССЗ. Установлено, что сочетание АГ и частого употребления алкоголя увеличивает риск смерти от всех причин в 4,1 раза по сравнению с таковым у лиц без этих факторов риска (p
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