In normal operation conditions of nuclear power plants, the distribution of primary coolant between fuel channels would be considered almost uniform. When different number of Reactor Circulation Pumps (RCPs) are switched off, known as an abnormal condition, this uniform distribution is disturbed and different conditions occur for each channel depending on its position in the core. In this research, the normal and abnormal condition (with one or two tripped RCPs) for a VVER-1000/446 is investigated. For evaluation of the core neutronic calculations and thermal power distribution, USNRC’s PARCS system code is employed. Then a thermal-hydraulics module was developed for performing the T/H calculation of the core zone. The input velocity of each channel in abnormal condition was calculated based on developed CFD model in downcomer and lower plenum of Reactor Pressure Vessel (RPV) by ANSYS-CFX. The results show that, in normal operation, the hot channel is related to the central fuel assembly of the reactor core with the highest relative power equal to 1.29 and total power of 23.74 MW. In this case, the minimum inlet velocity, the maximum coolant outlet velocity, and the maximum fuel temperature are 5.6 (m/s), 330.96 (°C), and 1345.8 (°C), respectively. In the cases of operation with one and two tripped RCPs, the hot channel is related to the fuel assemblies with the lowest inlet velocities. The lowest velocities are 0.32 m/s, 0.24 m/s, and 0.22 m/s respectively for the condition with one tripped pump, two tripped pumps placed oppositely, and two tripped pumps placed contiguously. The hot channel numbers in these cases are 158, 102, and 90, respectively. In these channel, the condition of outlet flow would be superheated, but the fuel temperature (1006.3, 1050.9, and 987.9) do not reach the maximum allowable margin. The study confirms the necessity of the coolant distribution consideration in OLCs as well as events that may disturb the symmetry of the coolant flow. It also showed that the lateral fuel assemblies are more at risk in this situation because of a significant reduction in coolant flow. Likewise, the investigations proved the safe continuation of the operation in PLOFA conditions with the preventive algorithm of the emergency protection system and without any need for immediate mitigation actions or operator intervention.