The most common anthropozoonoses on the African continent are coxiellosis and Rift Valley fever. It is known that detection of specific IgG antibodies in the blood sera of farm animals is one of the indicators of the pathogen circulation in a certain territory. The aim of the work was to identify specific IgG antibodies in the blood sera of farm animals collected on the territory of the Republic of Guinea to pathogens of zoonotic infectious diseases: coxiellosis, brucellosis, glanders, CCHF, West Nile and Rift Valley fevers, using enzyme immunoassay (ELISA). Materials and methods. A panel of 970 samples of blood sera from farm animals inhabiting all landscape-geographical zones of Guinea was compiled for the work. Identification of specific antibodies was carried out using enzyme immunoassay with preparations recommended for veterinary studies. Results and discussion. Specific antibodies to zoonoses were detected in 700 out of 1074 samples (65.2 % of the total), including: to Coxiella burnetii – in 172 (16.0 %); to Brucella spp. – in 212 (19.7 %); viruses of Rift Valley fever – 85 (7.9 %); CCHF – in 139 (12.9 %) and West Nile fever – in 92 (8.6 %). Antibodies to Burkholderia mallei were not found in the tested material. Positive samples were registered in all landscape-geographical zones. Thus, an urgent task is to continue studying the circulation of pathogens of zoonoses and anthropozoonoses in the territory of the Republic of Guinea and to organize regular monitoring over the spread of zoonotic infectious diseases in collaboration with veterinary services, which will allow timely forecasting and coordinating prophylactic (anti-epidemic) measures to prevent cases of diseases.