Event Abstract Back to Event Quantifying Circular-Linear Associations: Hippocampal Phase Precession Richard Kempter1, 2*, Christian Leibold3, 4 and Robert Schmidt1, 2 1 Humboldt-Universität zu Berlin, Bernstein Center for Computational Neuroscience Berlin, Germany 2 Humboldt-Universität zu Berlin, Institute for Theoretical Biology, Germany 3 University of Munich, Bernstein Center for Computational Neuroscience Munich, Germany 4 University of Munich, Department of Biology II, Germany When a rat crosses the place field of a hippocampal pyramidal cell, this cell typically fires a series of action potentials. The phases of these spikes, measured with respect to theta oscillations of the field potential, decrease as a function of the spatial distance traveled (Figure 1). This relation between phase and position of spikes is called phase precession. The degree of association between the circular phase variable and the linear spatial variable is commonly quantified through, however, a linear-linear correlation coefficient: the circular variable is converted to a linear variable by restricting the phase to a chosen range. Here we show how and why this procedure can bias estimates of the correlation as well as the slope and offset of the regression line, and that there is a strong dependence on noise and sample size. To overcome these problems, we introduce a new measure to quantify circular-linear associations. This approach is based on the minimization of a circular error, and it leads to a robust estimate of the slope and phase offset of the regression line. Finally, a correlation coefficient for circular-linear data is derived that is a natural analog of the Pearson's product moment correlation coefficient for linear-linear data. Figure 1: Phase precession in the rat CA1 region from pooled data (top row) and single trials (bottom rows). Spike data (black dots) has been fitted with different methods (grey: linear-linear; red: circular-linear fit constrained to negative slopes; blue: circular-linear fit allowing both positive and negative slopes). Figure 1 Keywords: computational neuroscience Conference: Bernstein Conference on Computational Neuroscience, Berlin, Germany, 27 Sep - 1 Oct, 2010. Presentation Type: Presentation Topic: Bernstein Conference on Computational Neuroscience Citation: Kempter R, Leibold C and Schmidt R (2010). Quantifying Circular-Linear Associations: Hippocampal Phase Precession. Front. Comput. Neurosci. Conference Abstract: Bernstein Conference on Computational Neuroscience. doi: 10.3389/conf.fncom.2010.51.00009 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 08 Sep 2010; Published Online: 22 Sep 2010. * Correspondence: Dr. Richard Kempter, Humboldt-Universität zu Berlin, Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany, r.kempter@biologie.hu-berlin.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Richard Kempter Christian Leibold Robert Schmidt Google Richard Kempter Christian Leibold Robert Schmidt Google Scholar Richard Kempter Christian Leibold Robert Schmidt PubMed Richard Kempter Christian Leibold Robert Schmidt Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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