Human papilloma virus (HPV) could be found in oral potentially malignant disorders (OPMD) with multiple clinical presentations. However, there are dysplastic intraepithelial lesions associated with HPV harboring histopathologic findings that should be differentiated from classic epithelial dysplasias. The aim of this study is to present a series of cases of HPV-associated oral epithelial dysplasia, highlighting the role of local factors. Age, gender, location site, tobacco use, alcohol habit, chief complaint, clinical presentation, chronic mechanical irritation, degree of epithelial dysplasia, and polymerase chain reaction (PCR)-HPV genotype were recorded. Further research is needed to address clinical aspects of HPV epithelial dysplasia and its prognosis. Oral HPV infection is not similar to cervical infection due to the presence of other factors that could modify the behavior of the virus. Human papilloma virus (HPV) could be found in oral potentially malignant disorders (OPMD) with multiple clinical presentations. However, there are dysplastic intraepithelial lesions associated with HPV harboring histopathologic findings that should be differentiated from classic epithelial dysplasias. The aim of this study is to present a series of cases of HPV-associated oral epithelial dysplasia, highlighting the role of local factors. Age, gender, location site, tobacco use, alcohol habit, chief complaint, clinical presentation, chronic mechanical irritation, degree of epithelial dysplasia, and polymerase chain reaction (PCR)-HPV genotype were recorded. Further research is needed to address clinical aspects of HPV epithelial dysplasia and its prognosis. Oral HPV infection is not similar to cervical infection due to the presence of other factors that could modify the behavior of the virus.