Abstract
Dear Editor: We have read with a great interest the article by Gupta et al. [1] who performed a meta-analysis exploring the association between chronic mechanical irritation and oral squamous cell carcinoma. The conclusion of the meta-analysis is that chronic oral mucosa irritation has a significant association with oral squamous cell carcinoma, and the nature of association could be that of a potential co-factor (dependent risk factor) rather than an independent risk factor. Read more in PDF.
Highlights
Dear Editor: We have read with a great interest the article by Gupta et al [1] who performed a meta-analysis exploring the association between chronic mechanical irritation and oral squamous cell carcinoma
There could be a biased result from the repeated inclusion of studies, which were in the same study population, duplicate populations in duplicate studies should be excluded from the research
People belonging to different age groups, gender or ethnic groups and even to different cultures or particular lifestyles may have varying degrees of tumor susceptibility, which we always call individual differences [5]
Summary
Dear Editor: We have read with a great interest the article by Gupta et al [1] who performed a meta-analysis exploring the association between chronic mechanical irritation and oral squamous cell carcinoma. There could be a biased result from the repeated inclusion of studies, which were in the same study population, duplicate populations in duplicate studies should be excluded from the research. We have found that there were two studies, the references 29 and 30, that might be the repeated articles included and affected the reliability of the results significantly.
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