Reply to the letter regarding "Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis".

Archana A Gupta,Harisha Dewan,Yaser Ali Alhazmi,Shankargouda Patil,Luca Testarelli,A Thirumal Raj,Sameena Parveen,Saranya Varadarajan,Supriya Kheur

doi:10.17305/bjbms.2021.6006

Abstract

Dear Editor, We thank Dr. Jian Xie for the valuable inputs on our paper titled 'Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis [1].' The first concern of Dr. Xie was that we had included two studies that were based on the same population. We re-examined these papers, one was published in 2010 [2] and the other in 2017 [3] by the same group of authors. Given the significant time difference between the two papers, we did not want to presume they were from the same sample population. There is no clear evidence that they are from the same sample population. Read more in PDF.

Highlights

Dear Editor, We thank Dr Jian Xie for the valuable inputs on our article titled “Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis [1].” The first concern of Dr Xie was that we had included two studies that were based on the same population
The second and the third comment were the differences in the risk of oral cancer concerning specific populations/culture/lifestyle. We agree with this point and that a statistical analysis to avoid the confounding factors would be vital
Elimination or accounting for the confounders through statistical analysis must have been performed by the individual studies

Summary

Introduction

Dear Editor, We thank Dr Jian Xie for the valuable inputs on our article titled “Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis [1].” The first concern of Dr Xie was that we had included two studies that were based on the same population. Y. Patil Dental College and Hospital, Dr D.

Results

Conclusion