Rationale & ObjectiveUsing OVERTURE (NCT01430494) study data on patient-perceived health, healthcare utilization, and productivity in autosomal dominant polycystic kidney disease (ADPKD), this research was conducted to characterize the burden of illness in ADPKD patients and assess whether patient-reported outcomes (PRO) assessment scores predict clinical and health-economic outcomes. Study DesignAnalyses of data from a prospective, observational study. Setting & ParticipantsThe study cohort comprised 3409 individuals with ADPKD in 20 countries, ages 12–78 years, in chronic kidney disease (CKD) stages G1–G5 and Mayo risk subclasses 1A–1E. PredictorsScores on PRO instruments, including disease-specific assessments (ADPKD-Impact Scale [ADPKD-IS], ADPKD-Urinary Impact Scale [ADPKD-UIS]) and generic measures. OutcomesClinical variables (e.g., height-adjusted total kidney volume [htTKV], estimated glomerular filtration rate [eGFR], abdominal girth) and health-economic outcomes. Analytical ApproachAssociations among variables were evaluated using Spearman correlations, logistic regression, and generalized linear mixed-effects repeated-measures models. ResultsBaseline CKD stage and Mayo risk classification showed little correlation with baseline PRO scores, although scores on disease-specific instruments and measures of physical functioning were worse at more severe CKD stages. PRO scores predicted hospitalizations and sick days at 6–18 months, with associations strongest for the ADPKD-IS. Whereas PRO scores were not associated with htTKV and eGFR, worse PRO scores were associated with greater abdominal girth. Poor baseline ADPKD-IS scores were positively associated with occurrence of ADPKD-related symptoms up to 18 months, including kidney pain (odds ratio [OR] 5.30, 95% confidence interval [CI] 2.75–10.24), hematuria (OR 4.58, 95% CI 1.99–10.53), and urinary tract infection (OR 4.41, 95% CI 1.93–10.11; P<0.001 for all). LimitationsMaximum 18 months of follow-up to assess outcomes. ConclusionsPRO scores predicted clinical and health-economic outcomes such as hospitalization and absence from work, underscoring the importance of quality of life assessment of individuals with ADPKD.