The Relevance of High Pulse Pressure and Renal Function in Patients with Chronic Kidney Disease: Analysis for each Stage of Chronic Kidney Disease

Eiji Kose,Akihiko Kikkawa,Taesong An

doi:10.15344/2456-3501/2018/137

Abstract

Background: In our previous study, we showed that high pulse pressure (PP) is associated with decreased renal function in chronic kidney disease (CKD) patients. In recent years, there were a few reports that CKD stage classification focused on glomerular filtration rate, which is associated with the occurrence of cardiovascular disease, deterioration of renal prognosis, and life prognosis. We aim to examine the relationship between increased PP and renal function according to each CKD stage classification. Methods: The present study includes 104 participants with CKD (stage G3a-G5) who visited the Nephrology Medicine Department of Yokosuka Kyousai Hospital between September 2006 and October 2011. The participants were categorized on the basis of PP: ≥65 mmHg was the High PP group, and

Highlights

Materials and MethodsReceived: March 29, 2018 Accepted: May 08, 2018 Published: May 10, 2018Keywords: Arteriosclerosis, Chronic kidney disease, Pulse pressure, Renal functionThe prevalence of chronic kidney disease (CKD) is steadily increasing
We aim to examine the relationship between increased Pulse pressure (PP) and renal function according to each CKD stage classification
Renal function deteriorated between the baseline and 12 months later at CKD stage G4-G5 in both, the Low and High PP groups; there were no significant differences at CKD stage G3a-G3b in both the groups

Summary

Introduction

Materials and MethodsReceived: March 29, 2018 Accepted: May 08, 2018 Published: May 10, 2018The prevalence of chronic kidney disease (CKD) is steadily increasing. In Japan, the number of patients with CKD is approximately 13,300,000 or 13% of the adult population [1]. Diseases such as diabetes mellitus, hypertension, and obesity, and smoking are known contributors to the progression of CKD or onset of arteriosclerosis [2,3] and increase the risk of cardiovascular disease (CVD) [4]. Ankle-brachial index (ABI) and pulse wave velocity (PWV) are useful indicators of arteriosclerosis, which are associated with renal dysfunction [6]. A previous report showed that high PP was associated with decrease in renal function in CKD patients [9]. We examine the relationship between high PP and renal function according to each CKD stage classification

Objectives

Results

Conclusion