Chronic Kidney Disease Dataset Research Articles

Comparative Study of Classification Models with Genetic Search Based Feature Selection Technique

Feature selection plays a very important role to retrieve the relevant features from datasets and computationally improves the performance of a model. The objective of this study is to evaluate the most important features of a chronic kidney disease (CKD) dataset and diagnose the CKD problem. In this research work, the authors have used a genetic search with the Wrapper Subset Evaluator method for feature selection to increase the overall performance of the classification model. They have also used Bayes Network, Classification and Regression Tree (CART), Radial Basis Function Network (RBFN) and J48 classifier for classification of CKD and non-CKD data. The proposed genetic search based feature selection technique (GSBFST) selects the best features from CKD dataset and compares the performance of classifiers with proposed and existing genetic search feature selection techniques (FSTs). All classification models give the better result with proposed GSBFST as compared to without FST and existing genetic search FSTs.

Ensemble swarm behaviour based feature selection and support vector machine classifier for chronic kidney disease prediction

Kidney Disease and kidney failure is the one of the complicated and challenging health issues regarding human health. Without having any symptoms few diseases are detected in later stages which results in dialysis. Advanced excavating technologies can always give various possibilities to deal with the situation by determining important realations and associations in drilling down health related data. The prediction accuracy of classification algorithms depends upon appropriate Feature Selection (FS) algorithms decrease the number of features from collection of data. FS is the procedure of choosing the most relevant features, removing irrelevant features. To identify the Chronic Kidney Disease (CKD), Hybrid Wrapper and Filter based FS (HWFFS) algorithm is proposed to reduce the dimension of CKD dataset. Filter based FS algorithm is performed based on the three major functions: Information Gain (IG), Correlation Based Feature Selection (CFS) and Consistency Based Subset Evaluation (CS) algorithms respectively. Wrapper based FS algorithm is performed based on the Enhanced Immune Clonal Selection (EICS) algorithm to choose most important features from the CKD dataset. The results from these FS algorithms are combined with new HWFFS algorithm using classification threshold value. Finally Support Vector Machine (SVM) based prediction algorithm be proposed in order to predict CKD and being evaluated on the MATLAB platform. The results demonstrated with the purpose of the SVM classifier by using HWFFS algorithm provides higher prediction rate in the diagnosis of CKD when compared to other classification algorithms.

High throughput human plasma N-glycan analysis using DNA analyzer and multivariate analysis for biomarker discovery

Carbohydrates form the majority of organic compounds found in nature and their presence on proteins influences many important bioactivities. Therefore, glycan profiling shows potential in clinical applications. This work demonstrates the use of a high-throughput GlycanAssure™ sample preparation technology and multi-capillary DNA analyzer for the analysis of the major N-linked glycans (N-glycans) found in human plasma. The application involves two biomarker studies: (1) in profiling patients with chronic kidney disease and (2) in differentiating heart disease patients with normal controls in response to an antiplatelet drug from hypo-responders. Due to complexity of the study data, bio-statistical methods were applied to data processing. 37 N-glycan peaks were observed from separation results, with confirmed structure for most glycans. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used to build models to differentiate the patient groups. The percentages of correct classification of the models reached 95.45% for the chronic kidney disease dataset and 85.42% for the anti-platelet drug response dataset. Given that blood N-glycan profiles had been shown to reflect certain disease states, this high-throughput platform could potentially be used for the simultaneous screening of multiple glycan biomarkers, with as little as one drop of blood sample.

Diagnosis of Chronic Kidney Disease Based on Support Vector Machine by Feature Selection Methods.

As Chronic Kidney Disease progresses slowly, early detection and effective treatment are the only cure to reduce the mortality rate. Machine learning techniques are gaining significance in medical diagnosis because of their classification ability with high accuracy rates. The accuracy of classification algorithms depend on the use of correct feature selection algorithms to reduce the dimension of datasets. In this study, Support Vector Machine classification algorithm was used to diagnose Chronic Kidney Disease. To diagnose the Chronic Kidney Disease, two essential types of feature selection methods namely, wrapper and filter approaches were chosen to reduce the dimension of Chronic Kidney Disease dataset. In wrapper approach, classifier subset evaluator with greedy stepwise search engine and wrapper subset evaluator with the Best First search engine were used. In filter approach, correlation feature selection subset evaluator with greedy stepwise search engine and filtered subset evaluator with the Best First search engine were used. The results showed that the Support Vector Machine classifier by using filtered subset evaluator with the Best First search engine feature selection method has higher accuracy rate (98.5%) in the diagnosis of Chronic Kidney Disease compared to other selected methods.

WebMAC: A web based clinical expert system

Disease diagnosis at early stages can enable the physicians to overcome the complications and treat them properly. The diagnosis method plays an important role in disease diagnosis and accuracy of its treatment. A diagnosis expert system can help a great deal in identifying those diseases and describing methods of treatment to be carried out; taking into account the user capability in order to deal and interact with expert system easily and clearly. A good way to improve diagnosis accuracy of expert systems is use of ensemble classifiers. The proposed research presents an expert system using multi-layer classification with enhanced bagging and optimized weighting. The proposed method is named as “M2-BagWeight” which overcomes the limitations of individual as well as other ensemble classifiers. Evaluation of the proposed model is performed on two different liver disease datasets, chronic kidney disease dataset, heart disease dataset, diabetic retinopathy debrecen dataset, breast cancer dataset and primary tumor dataset obtained from UCI public repository. It is clear from the analysis of results that proposed expert system has achieved high classification and prediction accuracy when compared with individual as well as ensemble classifiers. Moreover, an application named “WebMAC” is also developed for practical implementation of proposed model in hospital for diagnostic advice.