<h2>Abstract</h2><h3>Background</h3> Studies have shown that neuroleptics regulate expression of the transcription factor FosB/ΔFosB in the striatum, including the accumbens and caudate-putamen; however, the striatum is also divided into another structural dimension, the striosome and matrix compartments. The precise distribution of FosB/ΔFosB induced by chronic neuroleptics in these striatal compartments is poorly understood. <h3>Methods</h3> Rats received either single acute injections or chronic injections of clozapine (0 or 20 mg/kg, intraperitoneally [IP]), olanzapine (0 or 5 mg/kg, IP), or haloperidol (0 or 1.5 mg/kg, IP) for 25 days. The levels and compartmental distribution of FosB/ΔFosB were examined. <h3>Results</h3> Chronic clozapine induced clustered FosB/ΔFosB expression within striosomes of the caudate-putamen. This pattern was due to increased levels of FosB/ΔFosB in striosomes within the ventrolateral caudate-putamen and reduced levels of basal FosB/ΔFosB in the matrix in the entire caudate-putamen. In contrast, chronic haloperidol increased FosB/ΔFosB equally within the matrix and striosomes throughout the entire caudate-putamen. Chronic olanzapine induced an intermediate pattern. <h3>Conclusions</h3> The relative absence of FosB/ΔFosB expression in the matrix correlates with the lack of parkinsonism of atypical neuroleptics. Expression of FosB/ΔFosB in the matrix may contribute to parkinsonism of typical neuroleptics.