Introduction: Chronic pancreatitis is a painful, progressive, inflammatory condition of pancreas. Various surgical strategies for the treatment of pain relief in chronic pancreatitis have been described, although the application of minimally invasive surgery is less frequently reported. This study is an attempt to examine the outcome of laparoscopic procedures in the management of chronic pancreatitis in comparison to open surgery from a tertiary care centre located in the more disease prevalent southern part of India. Methods: This is a prospective comaparitve study of patients undergoing surgery for pain relief in chronic calcific pancreatitis, either by laparoscopy or open method, between 2015-2017. The primary endpoint is postoperative pain relief at 3 months, 6 months and 1 year. Results: During the study period, 24 patients underwent laparoscopic modified frey's procedure and 26 patients underwent open procedure. There was a statistically significant difference favourable to the open group regarding shorter operative times (185 min vs 247.5 min; P = 0.002), however laparoscopic arm had lesser blood loss (120 mL vs 240 mL; P = 0.002), a shorter hospital stay (5 d vs 7 d; P = 0.004) and comparable pain relief score (Izbicki's score) at 3 months, 6 months and 1 year follow up. Post-operative weight gain and endocrine insufficiency rates were comparable in both arms. Conclusion: Laparoscopic surgery is safe, effective and feasible technique for chronic pancreatitis in selected patients in the presence of adequately dilated pancreatic duct and has a comparable outcome in short term follow-up when compared to open surgery.