Abstract
BACKGROUND: Periampullary neoplasms are of pathologic and clinical significance, out of proportion to the small size of the structure. These neoplasms have different long term follow up following resection despite having similar histology.METHODS: A prospective study was done in the department of Pathology, Sree Gokulam Medical College and Research Foundation from Dec 2013 to May 2015 for a period of 18 months. This cross-sectional study included a total of eighteen cases. Study was commenced after approval from institutional ethical committee. RESULTS: In the present study, females predominated M:F of 1:3.5. The median age for the malignant lesions ranged from 55 yrs to 60yrs and for benign lesions were 30-39years. The most common clinical presentation were neoplastic lesions accounted for 80% of the total lesions and non neoplastic lesions such as chronic calcific pancreatitis for 20%.CONCLUSION: Pancreatic adenocarcinoma accounted for most number of lesions. Tumor variables such as perineural invasion and margin status positivitiy were seen in pancreatic carcinomas. DOI: 10.21276/APALM.1190
Highlights
Periampullary neoplasms are of pathologic and clinical significance, out of proportion to the small size of the structure
Neoplastic lesions accounted for 80% of the total lesions and non neoplastic lesions such as chronic calcific pancreatitis for 20% (See Table 1)
Among the neoplastic lesions adenocacinoma of periampullary region accounted for 75% and others were pancreatic endocrine tumors, Intraductal papillary mucinous neoplasms of the pancreas (IPMN) and Mucinous cystadenoma
Summary
Periampullary neoplasms are of pathologic and clinical significance, out of proportion to the small size of the structure. These neoplasms have different long term follow up following resection despite having similar histology.[1] It was Dr William Halstead who performed successful local resection of periampullary neoplasm in a 58year old woman with obstructive jaundice.[2] Dr Allen O Whipple revolutionised and popularised the procedure and which was later named as “Whipples procedure”.[3]. This procedure proved effective for many patients who had carcinomas arising in the terminal portion of the common bile duct, in the ampulla or periampullary region in the duodenum, as well as for endocrine and other tumors. Tumor variables such as perineural invasion and margin status positivitiy were seen in pancreatic carcinomas
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