Chonbuk National University Medical School Research Articles

Statistical Analysis of Legal Autopsy Cases Performed in the Jeollabuk-do Province of Korea in 2016

This study aimed to obtain basic regional data of legal autopsy cases observed in the Jeollabuk-do province concerning causes and manner of death. We investigated 170 autopsy cases (114 males [67.0%] and 56 females [33%]) performed at the Department of Forensic Medicine, Chonbuk National University Medical School, in 2016. Of these, seven (4.1%) were children aged <10 years. Regarding the manner of death, there were 95 unnatural deaths (55.9%), 69 natural deaths (40.6%), and six deaths from unknown causes (3.5%). Among the 95 unnatural deaths, 29 suicides (30.5%), 10 homicides (10.5%), 52 accidental deaths (54.7%), and four undetermined deaths (4.2%) were recorded. Concerning causes of unnatural death, there were 39 traumatic injury-related deaths (41.2%), 10 asphyxiations (10.5%), 25 poisonings (26.3%), 13 thermal injury-related deaths (13.7%), and eight deaths due to drowning (8.4%). The most common cause of unnatural death was injury from falls (n=15), followed by agrochemical poisoning (n=12), traffic injury (n=12), and death from fire (n=11). Of 69 natural deaths, 31 were from cardiac diseases (44.9%), eight from cerebral or vascular diseases (11.6%), 12 from digestive system diseases (17.4%), one from respiratory system disease (1.4%), five from endocrine/metabolic/nutritional disorders (7.2%), and nine due to causes of unknown origin (including sudden manhood and sudden infant death syndromes) (13.1%).

Basic research to guide alterations in an outcome-based curriculum

The purpose of this study is to provide basic information that can be used to guide alterations in an outcome-based curriculum by analyzing the current curriculum. A survey was administered to 103 juniors, 90 seniors, and 97 professors in Chonbuk National University Medical School on the importance of subgraduate and graduate outcomes, the appropriate curriculum to graduate, operational satisfaction, and self-judged achievement. There were significantly meaningful gaps in the importance of graduate and subgraduate outcomes. However, students considered other competencies, except for medical research, more important. The survey data on the appropriate curriculum for graduation and on the operational satisfaction with the curriculum show that overall reorganization of the curriculum is needed. Students felt that they achieved 50 to 60 of 100 with regard to graduate outcomes. Further, students recognize that there are no differences in achievement level between genders. But, they believe that seniors achieve more than juniors. A multilateral basic analysis can be useful to guide the improvement of an outcome-based curriculum to help graduates acquire the ability to provide basic medical treatment.

Effects of Topiramate on Language Functions

Investigators at Chonbuk National University Medical School, Korea, report the effects of topiramate on language functions in 38 newly diagnosed epileptic patients, mean age 10 +/- 2 years and 8 months.

Eggerthella lentaBacteremia after Endoscopic Retrograde Cholangiopancreatography in an End-Stage Renal Disease Patient

Eggerthella lenta Bacteremia after Endoscopic Retrograde Cholangiopancreatography in an End-Stage Renal Disease Patient Jaehyeon Lee, Yong Gon Cho, Dal Sik Kim, Hye Soo Lee Department of Laboratory Medicine, Chonbuk National University Medical School, Chonbuk National University Hospital Regional Center for National Culture Collection for Pathogens, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea

A Case of Gait Disturbance due to Chronic Bilateral Subdural Hematoma Mimicking Cervical Spondylotic Myelopathy

A Case of Gait Disturbance due to Chronic Bilateral Subdural Hematoma Mimicking Cervical Spondylotic Myelopathy Jin-Yeong Park, M.D.*, Woo-Chull Chung, M.D.*, Ji-Hun Song, M.D.* , Chae-Geun Kim, M.D.*, Se-Jin Kim, M.D.*, Ki-Soo Kim, M.D.*, and Kyung-Jin Song, M.D. Department of Orthopaedic Surgery, Chonbuk National University Medical School, Jeonju, *Department of Orthopaedic Surgery, St. Carollo Hospital, Suncheon, Korea

Hemorrhagic Cystitis with Giant Cells in Rheumatoid Arthritis Treating with Tacrolimus

336 Corresponding to:Wan-Hee Yoo, Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine of Chonbuk National University Hospital-Chonbuk National University, San 2-20, Geumam-dong, Deokjin-gu, Jeonju 561-180, Korea. E-mail:ywhim@jbnu.ac.kr

Persistent generalized lichen nitidus successfully treated with 0.03% tacrolimus ointment

ejd.2013.2200 Auteur(s) : Jin Park1,2, Joo-Ik Kim1, Dae-Woo Kim1, Su-Ran Hwang1, Si-Gyun Roh2,3, Han-Uk Kim1,2, Seok-Kweon Yun1,2 seok-kweonyun@jbnu.ac.kr 1 Department of Dermatology, 2 Research Institute of Clinical Medicine, 3 Plastic and Reconstructive Surgery, Chonbuk National University Medical School, 20, Geonji-ro (Geumam-dong), Deokjin-gu, Jeonju, 561-712, South Korea Generalized lichen nitidus (LN) is characterized by multiple, shiny, skin-colored papules covering the whole body. The clinical course [...]

Pituitary apoplexy in T3 thyrotoxicosis

A 58-year-old male was brought to our emergency department because of acute onset of visual disturbances and headache. His past medical history revealed no specific illness. He was a nonsmoker. On history taking, we learned that the patient had experienced weight loss with decreased sexual activity for several months. On physical examination, beard and axillary hair were decreased. The thyroid gland was mildly enlarged on palpation. Examination of vital signs revealed a blood pressure of 120/60 mmHg, heart rate of 80/min, respiration rate of 18 breaths/min, and body temperature of 36.5 C. Radiologic examinations with brain computed tomography (CT) showed a mass in the pituitary gland. Laboratory tests revealed as follows: a serum sodium of 134 (135–150) mmol/L, serum glucose of 6.6 mmol/L, FSH of 0.9 (1.4–18.1) IU/L, LH of \0.07 (1.5–9.3) IU/L, testosterone of\0.01 (0.09–0.37) nmol/L, prolactin of 456.5 (78.3–691.3) pmol/L, IGF-1 of 9.0 (9.3–38.0) nmol/L, free T4 of 19.10 (11.5–22.7) pmol/L, TSH of \0.01 (0.55–4.78) mIU/L, and ACTH of 5.87 pmol/L. The random cortisol level was not measured before hydrocortisone was administered. Sellar magnetic resonance imaging (MRI) showed a 27 9 35 9 24 mm pituitary mass that was bulging into suprasellar area and contained a fluid–fluid level (Fig. 1a). Pituitary macroadenoma with hemorrhage was highly suspected. Standard ophthalmologic examination showed bilateral hemianopsia. Therefore, a high dose of hydrocortisone was administered intravenously immediately. However, neurosurgery was performed on this patient because of persistence of the visual field defect despite steroid treatment. Endonasal transsphenoidal surgery for pituitary adenoma was performed. The final pathologic diagnosis was pituitary adenoma originating from a gonadotrope. On the other hand, a diffuse goiter was detected on palpation and the free T4 level was in the high range of normal as described earlier. Therefore, we measured the free T3 level and thyroid autoantibody. Results revealed a free T3 of 9.7 (3.1–6.8) pmol/L, anti-TPO antibody of 600 (*34) IU/mL, and anti-TSH receptor antibody of 33.82 (*1.75) IU/L. Thyroid scan with pertechnetate revealed a diffuse toxic goiter that was compatible with primary hyperthyroidism (Fig. 1b). Therefore, antithyroid drug was started with physiologic replacement of hydrocortisone. Pituitary apoplexy is a life-threatening clinical syndrome characterized by sudden onset of headache, and visual impairment caused by the rapid enlargement of the pituitary adenoma usually due to hemorrhage. Various predisposing factors of pituitary apoplexy, such as systemic hypertension, alteration of intracranial pressure gradients, head trauma, pituitary irradiation, pregnancy, cerebral angiography, anticoagulation, dynamic study of pituitary gland, hemodialysis, and surgeries including cardiac surgery, have been reported. Among these factors, hypertension was the most common predisposing factor. It is also well known that thyroid dysfunction results in changes in cardiac output, cardiac contractility, blood pressure, vascular resistance, and rhythm disturbances [1]. Therefore, theoretically, it is possible that primary thyroid dysfunction causes pituitary apoplexy in patients with pituitary adenoma. However, clinically, the association between pituitary apoplexy and thyroid dysfunction has been unclear, and only one case of pituitary apoplexy caused by primary K. A. Lee T. S. Park H. S. Baek H. Y. Jin (&) Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Hospital, Chonbuk National University Medical School, Chonbuk National University, Geonji Road #20, Deokjin-gu, Jeonju 561-712, South Korea e-mail: mdjinhy@jbnu.ac.kr

Subacute painful thyroiditis accompanied by scrub typhus infection

Subacute painful thyroiditis occurs in association with viral infections [1, 2]. It has been proposed that many viruses are involved in its pathogenesis, and they include coxsackie, influenza, adenoviruses, and echoviruses. So far, however, no studies have reported the relationship between subacute painful thyroiditis and scrub typhus infection. We experienced two cases of subacute painful thyroiditis accompanied by scrub typhus infection. The first case is a 69-year-old woman who was admitted to the Department of Gastroenterology in Korea, in autumn. The patient had a 5-day history of myalgia, fever, sore throat, anterior neck pain, and diarrhea. The patient had a hobby of gardening. On history taking, eschar had peeled off several days ago. It is well known that Korea is an endemic area of scrub typhus. Considering her hobby, we checked anti-tsutsugamushi antibody titer by immunofixation assay (IFA). Total amount of antibody (IgM or IgG) to Orientia tsutsugamushi was in the ratio of 1:320. We also evaluated her neck pain. Laboratory findings showed free T4 69.2 pmol/L (normal range: 11.5–22.7), TSH 0.01 uU/mL (normal range: 0.35–5.50), and normal thyroid auto-antibodies (thyroid peroxidase, thyroglobulin, and TSH receptor). There were no antibodies against other viral infections. Neck ultrasound showed a multifocal hypoechoic area in the thyroid gland, accompanied by the decreased vascularity. Thyroid scan showed no increased uptake in both lobes. These findings are suggestive of scrub typhus infection and subacute thyroiditis. She was given doxycycline, b-blockers, and nonsteroidal antiinflammatory drugs (NSAIDs). After 2–3 weeks, she achieved an improvement in neck pain and generalized illness, and had a decrease in free T4 level to 27.6 pmol/L (Table 1). The second case is a 57-year-old woman who was admitted in autumn to the Department of Endocrinology in Korea with a chief complaint of a 7-day history of myalgia, fever, sore throat, neck pain, palpitation and decreased oral intake. She had tenderness in the both thyroid lobes, but had no eschar. Considering not only the fact that Korea is an endemic area but also the prevalence of scrub typhus is relatively higher during autumn, we measured anti-tsutsugamushi Ab titer by IFA, and it was 1:640. To evaluate the neck pain and palpitation, we examined the thyroid status. Laboratory findings showed free T4 122.5 pmol/L (normal range: 11.5–22.7), TSH 0.01 uU/mL (normal range: 0.35–5.50), and normal thyroid auto-antibodies. Neck ultrasound showed a mild inflammation of the thyroid, accompanied by the normal vascularity. Thyroid scan showed no increased uptake in both lobes. She was diagnosed with subacute thyroiditis accompanied by scrub typhus infection. She was given doxycycline, b-blockers, NSAIDs, and steroids (10 mg). After 2 weeks, she achieved an improvement in the symptoms, and had a decrease in free T4 level to 80.6 pmol/L (Table 1). On continuing the treatment with doxycycline for several days, anti-tsutsugamushi Ab titer fell to 1:160. Subacute painful thyroiditis is a transient inflammatory disease, and it is characterized by pain and tenderness of the thyroid gland. To our knowledge, our patients are the S. Kim T. S. Park H. S. Baek H. Y. Jin (&) Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine of Chonbuk National University, Chonbuk National University Hospital, Chonbuk National University Medical School, 634-18, Keum-Am Dong, Jeonju 561-712, South Korea e-mail: mdjinhy@jbnu.ac.kr

Distribution of Yeast and Mold Species Isolated from Clinical Specimens at 12 Hospitals in Korea during 2011

Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Kyungpook National University of Medicine, Daegu, Chungnam National University of Medicine, Daejeon, Pusan National University Yangsan Hospital, Yangsan, The Catholic University of Korea College of Medicine, Seoul, Ajou University School of Medicine, Suwon, Yonsei University Wonju College of Medicine, Wonju, Chung-Ang University College of Medicine, Seoul, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Chonbuk National University Medical School, Jeonju, Yonsei University College of Medicine, Seoul, Korea

Acquired progressive kinking of the hair in a Korean female adolescent

The Journal of DermatologyVolume 40, Issue 1 p. 80-81 Letters to the Editor Acquired progressive kinking of the hair in a Korean female adolescent Ki-Hun Song, Corresponding Author Ki-Hun Song Department of Dermatology, Chonbuk National University Medical School, Jeonju, KoreaCorrespondence: Ji-Hyun Yi, M.D., Jun & Jung Dermatologic Clinic, 711-3, Pyunghwa-dong, Wansan-gu, Jeonju 560-842, Jeollabukdo, Korea. Email: [email protected]Search for more papers by this authorJin Park, Jin Park Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, KoreaSearch for more papers by this authorSeok-Kweon Yun, Seok-Kweon Yun Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, KoreaSearch for more papers by this authorHan-Uk Kim, Han-Uk Kim Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, KoreaSearch for more papers by this authorJi-Hyun Yi, Ji-Hyun Yi Jun & Jung Dermatologic Clinic, Jeonju, KoreaSearch for more papers by this author Ki-Hun Song, Corresponding Author Ki-Hun Song Department of Dermatology, Chonbuk National University Medical School, Jeonju, KoreaCorrespondence: Ji-Hyun Yi, M.D., Jun & Jung Dermatologic Clinic, 711-3, Pyunghwa-dong, Wansan-gu, Jeonju 560-842, Jeollabukdo, Korea. Email: [email protected]Search for more papers by this authorJin Park, Jin Park Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, KoreaSearch for more papers by this authorSeok-Kweon Yun, Seok-Kweon Yun Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, KoreaSearch for more papers by this authorHan-Uk Kim, Han-Uk Kim Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, KoreaSearch for more papers by this authorJi-Hyun Yi, Ji-Hyun Yi Jun & Jung Dermatologic Clinic, Jeonju, KoreaSearch for more papers by this author First published: 05 October 2012 https://doi.org/10.1111/j.1346-8138.2012.01660.xCitations: 1 Conflict of interest: none. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume40, Issue1January 2013Pages 80-81 RelatedInformation

Effects of topical application of growth factors followed by microneedle therapy in women with female pattern hair loss: A pilot study

canaliculi). They present at or shortly after birth, and most cases are associated with other systemic conditions. Uncombable hair syndrome is similar to APKH; however, the SEM cross-section appears triangular, which is different from the presentation of APKH. Diffuse partial woolly hair (DPWH) and environmental factors such as trauma, radiation and drugs should also be ruled out. DPWH comprises predominantly normal straight hairs intermingled with thinner curly hairs. DPWH usually involves the whole hair shaft and patients complain of hair loss. Acquired progressive kinking of the hair can progress to hair thinning and androgenetic alopecia or resolve to normal hairs. Better prognosis may be expected in female or prepubertal patients and those with involvement of non-androgen-dependent areas of the scalp. There are no effective treatments for APKH. Topical minoxidil is regarded as an alternative treatment; however, it is generally unable to prevent androgenetic alopecia. Ki-Hun SONG, Jin PARK, Seok-Kweon YUN, Han-Uk KIM, Ji-Hyun YI Department of Dermatology, Research Institute of Clinical Medicine, Chonbuk National University Medical School, and Jun & Jung Dermatologic Clinic, Jeonju, Korea

A Case of Simultaneous Presentation of Thyroid Crisis and Diabetic Ketoacidosis

Received: 14 April 2011, Accepted: 15 September 2011 Corresponding author: Tae Sun Park Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonbuk National University Hospital, Chonbuk National University Medical School, 20 Geonji-ro, Deokjin-gu, Jeonju 561-712, Korea Tel: +82-63-250-1794, Fax: +82-63-254-1609, E-mail: pts@chonbuk.ac.kr A Case of Simultaneous Presentation of Thyroid Crisis and Diabetic Ketoacidosis Kyung Ae Lee, Kyung Taek Park, Hea Min Yu, Heung Yong Jin, Ji Hyun Park, Hong Sun Baek, Tae Sun Park Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Korea

A Case of Diabetic Foot Ulcer Caused byArcanobacterium haemolyticumandStreptococcus agalactiae

A Case of Diabetic Foot Ulcer Caused by Arcanobacterium haemolyticum and Streptococcus agalactiae Moon Suk Choi, Dal Sik Kim, Sam Im Choi, Yong Gon Cho, Hye Soo Lee Department of Laboratory Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Chonbuk National University Hospital Culture Collection for Pathogens, Jeonju, Korea

A Case of Mixed Epithelial and Mesenchymal Hamartoma of Nasopharynx

Received November 28, 2011 Revised February 1, 2012 Accepted February 13, 2012 Address for correspondence Myoung Jae Kang, MD Department of Pathology, Chonbuk National University Medical School, Chonbuk National University Hospital, San 2-20 Geumam-dong, Deokjin-gu, Jeonju 561-180, Korea Tel +82-63-250-2262 Fax +82-63-250-1229 E-mail rock52@hanmail.net Mixed epithelial and mesenchymal hamartoma in the nasopharynx is extremely rare. Hamartomas of the nasal cavity or nasopharynx are classified as epithelial, mesenchymal and mixed epithelial and mesenchymal types. We report an incidentally detected lesion arising in a 42-year-old female patient. The mass was resected endoscopically and was diagnosed as mixed epithelial and mesenchymal hamartoma. We report and discuss the pathological features and differential diagnosis of this rare nasopharyngeal hamartoma. Korean J Otorhinolaryngol-Head Neck Surg 2012;55:191-3

Multiple Arterial Aneurysms in Behcet's Disease

302 Corresponding to:Wan-Hee Yoo, Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine of Chonbuk National University Hospital-Chonbuk National University, San 2-20, Geumam-dong, Deokjin-gu, Jeonju 561-180, Korea. E-mail:ywhim@jbnu.ac.kr

How Can We Differentiate Schizoaffective Disorder from Mood Disorder with Psychotic Feature?

Chul-Hyun Park, MD, Tae-Won Park, MD, PhD, Jong-Chul Yang, MD, PhD, Keun-Young Oh, MD, Hyeong-Tai Kim, MD, Hong-Bae Eun, MD, PhD, Guang-Biao Huang, MD and Young-Chul Chung, MD, PhD Department of Psychiatry, Chonbuk National University Hospital & Research Institute of Clinical Medicine, Jeonju, Department of Psychiatry, Chonbuk National University Medical School and Institute for Medical Science, Jeonju, Maemsarang Hospital, In-san Medical Foundation, Wanju, Korea

Insulin-like Growth Factor-binding Protein-3 (IGFBP-3) Blocks the Effects of Asthma by Negatively Regulating NF-κB Signaling through IGFBP-3R-mediated Activation of Caspases

Insulin-like growth factor-binding protein-3 (IGFBP-3) is a multifunctional protein known for modulating mitogenic and metabolic actions of IGFs as well as exerting a variety of biological actions not involving IGFs. Here, we show that IGFBP-3 blocks specific physiological consequences of asthma in an IGF-independent manner in vitro and in vivo. IGFBP-3 treatment effectively reduced all physiological manifestations of asthma examined in vivo (airway hyper-responsiveness, cellular and pathological changes in bronchoalveolar lavage fluid and lung tissue, and expression of numerous proinflammatory molecules). These unique IGFBP-3 effects were further confirmed in IGFBP-3-transgenic mice, thus strengthening the notion of IGFBP-3 actions within the respiratory system. Using human epithelial cells, we demonstrated the following: 1) IGFBP-3 blocks TNF-α-induced expression of proinflammatory molecules; 2) IGFBP-3 attenuates the TNF-α-induced migratory response of eosinophils; and 3) IGFBP-3 negatively regulates TNF-α-induced expression of the key NF-κB regulatory molecules IκBα and p65-NF-κB at the post-translational level. We identified that IGFBP-3 degrades IκBα and p65-NF-κB proteins through IGFBP-3 receptor (IGFBP-3R)-mediated activation of caspases thereby inhibiting TNF-α-induced activation of NF-κB signaling cascades. This unique IGFBP-3/IGFBP-3R action was further confirmed by demonstrating complete inhibition of IGFBP-3 action in the presence of caspase inhibitors as well as IGFBP-3R siRNAs. Non-IGF-binding IGFBP-3 mutants further proved the IGF-independent action of IGFBP-3. Our findings indicate that IGFBP-3 inhibits airway inflammation and hyper-responsiveness via an IGF-independent mechanism that involves activation of IGFBP-3R signaling and cross-talk with NF-κB signaling. The IGFBP-3/IGFBP-3R system therefore plays a pivotal role in the pathogenesis of asthma and can serve as a newly identified potential therapeutic target for this debilitating disease.

Critical Role for CD38-mediated Ca2+ Signaling in Thrombin-induced Procoagulant Activity of Mouse Platelets and Hemostasis

CD38, a multifunctional enzyme that catalyzes the synthesis of intracellular Ca(2+) messengers, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), is known to be expressed on platelets. However, the role of CD38 in platelets remains unclear. Our present results show that treatment of platelets with thrombin results in a rapid and sustained Ca(2+) signal, resulting from a coordinated interplay of Ca(2+)-mobilizing messengers, inositol 1,4,5-trisphosphate, cADPR, and NAADP. By dissecting the signaling pathway using various agents, we delineated that cADPR and NAADP are sequentially produced through CD38 internalization by protein kinase C via myosin heavy chain IIA following phospholipase C activation in thrombin-induced platelets. An inositol 1,4,5-trisphosphate receptor antagonist blocked the thrombin-induced formation of cADPR and NAADP as well as Ca(2+) signals. An indispensable response of platelets relying on cytosolic calcium is the surface exposure of phosphatidylserine (PS), which implicates platelet procoagulant activity. Scrutinizing this parameter reveals that CD38(+/+) platelets fully express PS on the surface when stimulated with thrombin, whereas this response was decreased on CD38(-/-) platelets. Similarly, PS exposure and Ca(2+) signals were attenuated when platelets were incubated with 8-bromo-cADPR, bafilomycin A1, and a PKC inhibitor. Furthermore, in vivo, CD38-deficient mice exhibited longer bleeding times and unstable formation of thrombus than wild type mice. These results demonstrate that CD38 plays an essential role in thrombin-induced procoagulant activity of platelets and hemostasis via Ca(2+) signaling mediated by its products, cADPR and NAADP.

A Clinical Study of the Warthin's Tumor of the Salivary Gland

Received November 29, 2010 Revised January 24, 2011 Accepted February 1, 2011 Address for correspondence Yunsu Yang, MD Department of OtolaryngologyHead and Neck Surgery, Chonbuk National University Medical School, 20 Geonji-ro, Deokjin-gu, Jeonju 561-712, Korea Tel +82-63-250-1980 Fax +82-63-250-1986 E-mail yang2002@chonbuk.ac.kr Background and ObjectivesZZThe aim of this study was to define the clinical characteristics and treatment outcome of the salivary Warthin’s tumor in order to work out a therapeutic strategy. Subjects and MethodZZThe medical records of 64 patients who underwent surgery and were pathologically diagnosed with Warthin’s tumor at our department from January 1997 to December 2009 were reviewed retrospectively. ResultsZZThere were 60 (94%) males and 4 (6%) females with an overall male-to-female ratio of 15 : 1. The average age was 59.8±9.2 years (range from 35 to 78). All tumors were found in the parotid gland. Of the 66 tumors, 31 (48%) occurred in the right side, 28 (44%) tumors occurred in left side, and 5 (8%) tumors occurred in bilaterally. A superficial parotidectomy was performed in 38 (59%) patients, lumpectomy in 25 (39%) patients and bilateral lumpectomy in one patient. There were 18 (28%) postoperative complications. The most common complication was transient facial palsy that occurred in 11 (17%) patients. Recurrence occurred in 2 (3%) patients, oneipsilaterally and the other contralaterally. All recurrences were found in patients who underwent superficial parotidectomy. ConclusionZZWarthin’s tumor has a very low recurrence rate with a benign nature. The study shows that lumpectomy is an effective surgical treatment for Warthin’s tumor with an advantage of reducing facial nerve palsy and recurrence rate. Korean J Otorhinolaryngol-Head Neck Surg 2011;54:213-6