BackgroundPresimulation preparation is critical to prepare learners to participate fully in clinical simulations; however, many do not complete assigned presimulation activities. Research QuestionWhich presimulation preparation activities will senior nursing students choose and perceive as helpful? MethodsA quasi-experimental study evaluated senior nursing student (n = 115) pre-simulation preparation preferences. Students had access to eight activities including a case study and a virtual simulation game (VSG). Participants indicated which activities they completed, and rated the case study and VSG in terms of usability, engagement, and impact on learning. ResultsOverall, 57% of participants completed the paper-based case study and 37% played the VSG. Participation in any preparation resulted in significant improvements in competence (t = 2.3; p = .02). Learners rated VSG higher than case study in terms of usability (t = 2.6; p = .01), engagement (t = 2.8; p = .01) and impact on learning (t = 2.4; p = .02). ConclusionResults revealed nursing students have different preferences for pre-simulation preparation. Although more students completed the case study than the VSG, those who played the game rated it higher. This supports providing a choice in presimulation preparation activities.