Chloride Release Research Articles

CNSC-69. GLIOBLASTOMA-NETWORK CONNECTIVITY IS REGULATED THROUGH ALTERATIONS IN CHLORIDE HOMEOSTASIS AND GABAERGIC SIGNALING

Abstract The specific pathophysiological mechanisms underlying glioma-related epilepsy, which presents an unfavorable clinical course, are still not well explored. To identify the candidate pathways involved in glioblastoma-induced neuronal hyperexcitability, we used high-density electrode arrays in vivo in humans to record local field potentials from cortically projecting gliomas and identified hyperexcitable intratumoral regions with elevated functional connectivity to the brain. Single-cell RNA sequencing (13,730 cells analyzed) of the functionally connected intratumoral regions identified several circuit assembly and GABAergic signaling genes elevated in glioma-intrinsic neurons, including the sodium-potassium-chloride co-transporter 1 (NKCC1), which accumulates chloride in the cells. We hypothesized that the hyperexcitable behavior of glioma-intrinsic neurons in glioblastoma is mediated by elevated NKCC1 and chloride dysregulation and that inhibiting NKCC1 would reinforce the inhibitory action of GABA and rescue the neuronal hyperresponsive phenotype. Single-nucleus (sNuc-seq) sequencing was performed on neuron-glioblastoma co-cultures (54,000 cells analyzed) to determine NKCC1-facilitated GABAergic signaling in glioblastoma-mediated neuronal responses. Mechanistic and functional studies using perforated whole-cell patch-clamp recordings, multielectrode array, calcium, and chloride imaging for validating therapeutic vulnerabilities to NKCC1 silencing by shRNA knockdown and by the FDA-approved drug bumetanide were performed using in vitro and organotypic mouse slice culture models. sNuc-seq revealed an upregulation of neuronal NKCC1 and GABAA receptors when co-cultured with NKCC1-high-expressing glioblastoma cells, indicating the strong association between neuronal NKCC1 and GABAergic signaling. Electrophysiological analysis of glioblastoma-neuron co-cultures demonstrated increased network burst synchrony and a positive shift in the GABA reversal potential (EGABA). This increase was eliminated in the presence of NKCC1 inhibition using bumetanide and shRNA knockdown, which correlated with a significant decrease in intracellular neuronal chloride. Mechanistically, glioma NKCC1 downregulation significantly decreased GAP43-mediated tumor microtube (TMT) formation. Whether this reduced TMT formation also results in decreased chloride release by glioma cells, thereby altering neuronal chloride equilibrium, is currently under investigation. Collectively, these findings aim to identify a new mechanism of glioma-associated epilepsy, which may provide a novel approach to treatment.

Direct detection of the chloride release and uptake reactions of Natronomonas pharaonis halorhodopsin

Membrane transport proteins undergo multistep conformational changes to fulfill the transport of substrates across biological membranes. Substrate release and uptake are the most important events of these multistep reactions that accompany significant conformational changes. Thus, their relevant structural intermediates should be identified to better understand the molecular mechanism. However, their identifications have not been achieved for most transporters due to the difficulty of detecting the intermediates. Herein, we report the success of these identifications for a light-driven chloride transporter halorhodopsin (HR). We compared the time course of two flash-induced signals during a single transport cycle. One is a potential change of Cl--selective membrane, which enabled us to detect tiny Cl--concentration changes due to the Cl- release and the subsequent Cl--uptake reactions by HR. The other is the absorbance change of HR reflecting the sequential formations and decays of structural intermediates. Their comparison revealed not only the intermediates associated with the key reactions but also the presence of two additional Cl--binding sites on the Cl--transport pathways. The subsequent mutation studies identified one of the sites locating the protein surface on the releasing side. Thus, this determination also clarified the Cl--transport pathway from the initial binding site until the release to the medium.

Dual-trigger release of berberine chloride from the gelatin/perfluorohexane core–shell structure

BackgroundThe development of smart nanocarriers that enable controlled drug release in response to internal and external triggers is an emerging approach for targeted therapy. This study focused on designing pH-sensitive, ultrasound-responsive gelatin/perfluorohexane (PFH) nanodroplets loaded with berberine chloride as a model drug.ResultsThe nanodroplets were prepared using an emulsion technique and optimized by varying process parameters like homogenization rate, polymer concentration, surfactant, drug, and perfluorocarbon content. The optimal formulation yielded nanodroplets with a particle size of 281.7 nm, a drug encapsulation efficiency of 66.8 ± 1.7%, and a passive drug release of 15.4 ± 0.2% within 24 h. Characterization confirmed successful encapsulation and pH-responsive behavior. Ultrasound stimulation significantly enhanced drug release, with 150 kHz being more effective than 1 MHz in triggering acoustic droplet vaporization while minimizing heat generation. After 10 min of radiation, the optimal formulation showed 89.4% cumulative drug release. The nanodroplets displayed stability over 1 month at 4°C.ConclusionsOverall, the dual-triggered nanodroplets demonstrate excellent potential for controlled delivery and targeted release of berberine chloride.Graphical abstract

Electrochemical chlorine evolution reaction to improve the desalination of sea sand

Sea sand, a vital sand and gravel resource, is rich in chloride, which causes corrosion of steel reinforcements. This study investigates the effect of the electrochemical chlorine evolution reaction (CER) on the desalination of sea sand. The results indicate that the chlorine removal efficiency (RE) of sea sand increased from 48.76 to 56.40 % under optimal conditions: a current density of 15 mA/cm2, an electrolysis time of 1 min, and a sodium sulphate-supported electrolyte concentration of 0.05 mol/L. After 30 days of resting, the dissolved chlorine content in sea sand was 0.154 %, which was 21.03 % lower than that of the control group. The electrically active chlorine-mediated desalination process demonstrated excellent dechlorination ability, facilitated the transformation of metal and organic chlorine into liquid and gaseous forms, and reduced the slow release of chloride from sea sand. Therefore, CER is expected to be an efficient method for sea sand desalination.

Investigation on chloride releasing from coral aggregates to cement paste in coral aggregate concrete

Coral aggregate concrete (CAC) is one of the most commonly used building materials in construction on marine islands, but the chlorides contained in the coral aggregates (CA) could affect the durability of CAC with steel bars embedded. In this paper, an analytical solution for the diffusion of chlorides from CA into the cement paste in CAC was derivated and the model was established. Studies on chloride releasing behaviours in CAC through an experimental setup of CAC interface specimens with five mixes were conducted. From the analytical model, the chloride diffusion coefficient DCl can be obtained and, different from other reported chloride diffusion coefficient from harden specimen, this coefficient could be the only factor that describes the chloride transport in CAC from the mixing stage. The chloride releasing rate αCl from CA was also calculated and quantified. The results show that the chloride release rate from CA decayed with time and significant chloride release occurred in the first 30 days from the mixture of raw materials, the released amount of chlorides from CA was positively correlated to the average pore size of cement pastes, and the chloride diffusion coefficient of CA in this study was 2–3 magnitudes higher than that of hardened cement paste.

The oxidation mechanism of Morphine with Antimony trichloride

In this communication the oxidation route of morphine with antimony trichloride is provided. The deliquescent reagent is partially hydrolysed to antimonyl chloride with concomitant release of hydrogen chloride. The reactive species is obtained by protonation of the oxychloride. The electro donor phenol group in morphine forms an organometallic ester of gem-chlorohydrin type which eliminates hydrogen chloride. Protonation of the oxo-antimonite creates a δ+ at the aryl oxygen, favouring a nucleophilic reaction at ortho-position. Reaction of dichloro-hydroxy-antimony at this site produces a ketone and separation of antimony mono-hydroxide (Redox step). Aromaticity is recovered by enolization and the electro donor phenol gives rise to an ortho-quinone with separation of antimony mono-chloride and a chloride ion (Second redox step). Another cyclic reaction mechanism can operate involving five atoms. Finally, a bimolecular electron transfer yields two atoms of elemental antimony.

Effects of processing conditions on the release of sodium chloride from fat crystal ‘shell’ stabilised water-in-oil emulsions

Over the last two decades, water-in-oil fat crystal stabilised Pickering emulsions have been increasingly studied for the controllable release of encapsulated (water-soluble) species. The stability inherent to Pickering emulsions has been shown to be enhanced by sintering to form an interfacial lipid 'shell' around the droplets, which improves the retention and prolongs the delivery of the enclosed species. Using a scraped surface heat exchanger/pin stirrer setup, the present work shows that processing conditions used to produced W/O emulsions with dispersed droplets enclosed in lipid shells, have a significant impact upon the subsequent release of NaCl enclosed within them. The best performing emulsion structure produced here is reported to retain about 98% of its initial salt load over a period of 100 days. NaCl release profiles were also used to calculate the interfacial rate constants for the transferal of salt across the lipid shells. Interfacial rate constants ranged from 5.5 to 3593.2×10−3 nm2/s and were significantly (up to three orders of magnitude) lower than those reported in literature for similar systems. Analysis revealed that depending on the specific conditions employed, the processing environment can enhance or compromise lipid shell integrity. Overall, the current study offers significant direction in terms of the optimum processing requirements that are necessary to produce fat-continuous emulsion microstructures that can successfully regulate the release of NaCl, paving the way for the successful development of food formulations of controlled salt-perception.

A novel soluble di-iron monooxygenase from the soil bacterium Solimonas soli.

Soluble di-iron monooxygenase (SDIMO) enzymes enable insertion of oxygen into diverse substrates and play significant roles in biogeochemistry, bioremediation and biocatalysis. An unusual SDIMO was detected in an earlier study in the genome of the soil organism Solimonas soli, but was not characterized. Here, we show that the S. soli SDIMO is part of a new clade, which we define as 'Group 7'; these share a conserved gene organization with alkene monooxygenases but have only low amino acid identity. The S. soli genes (named zmoABCD) could be functionally expressed in Pseudomonas putida KT2440 but not in Escherichia coli TOP10. The recombinants made epoxides from C2 C8 alkenes, preferring small linear alkenes (e.g. propene), but also epoxidating branched, carboxylated and chlorinated substrates. Enzymatic epoxidation of acrylic acid was observed for the first time. ZmoABCD oxidised the organochlorine pollutants vinyl chloride (VC) and cis-1,2-dichloroethene (cDCE), with the release of inorganic chloride from VC but not cDCE. The original host bacterium S. soli could not grow on any alkenes tested but grew well on phenol and n-octane. Further work is needed to link ZmoABCD and the other Group 7 SDIMOs to specific physiological and ecological roles.

Investigation of the uptake and catalytic effect of calcium and potassium‐based additives under low‐temperature pyrolysis of polyvinyl chloride

AbstractManaging plastic waste containing polyvinyl chloride is difficult due to the release of hazardous substances such as hydrogen chloride. Alkaline metal has been proven to minimize the release of hydrogen chloride during thermal degradation of polyvinyl chloride. However, most past studies conducted heating experiments under a high temperature which promotes the production of aromatic hydrocarbons. In this study, low‐temperature pyrolysis was utilized which focuses on the dehydrochlorination stage while minimizing further degradation of hydrocarbons. The effectiveness of calcium oxide, calcium carbonate and potassium carbonate in minimizing the release of hydrogen chloride was also evaluated. Among those three additives, calcium oxide and potassium carbonate have shown some potential in uptaking hydrogen chloride. Especially when the molar ratio of additive to PVC is 1:1.6, calcium oxide reduced the generation of hydrogen chloride to as low as 20%. Potassium carbonate also exhibits an uptake effect but has a slight catalytic effect when the molar ratio is less than 1:1. On the other hand, calcium carbonate not only shows little to no uptake effect, but also promotes the thermal degradation of hydrocarbon.

Comparative microwave catalytic pyrolysis of cellulose and lignin in nitrogen and carbon dioxide atmospheres

In this paper, a cleaner pyrolysis strategy combining microwave heating, catalyst and carbon dioxide was explored for converting biomass components into higher quality products. Catalytic pyrolysis was more favorable for the decomposition and conversion of complex biomass structures. For furfural residue pyrolysis, potassium sulfate contained in sample served as the main catalytic component. Potassium sulfate promoted the increase of phenols in bio-oil. Notably, carbon dioxide atmosphere promoted the decomposition of substances and exerted a significant effect on biomass pyrolysis, which increased bio-oil yield and declined gas yield. When the pyrolysis atmosphere was changed from nitrogen to carbon dioxide, the ID/IG ratio decreased from 1.07 to 0.74, indicating that carbon dioxide decreased defect structure in biochar. Carbon dioxide enriched the porous structure and surface roughness of biochar. Also, carbon dioxide as a carrier gas was found to be more effective than nitrogen in improving the heating values of biochar and the acidity of bio-oil under carbon dioxide was lower than that under nitrogen, which was conducive to the subsequent utilization of biochar and bio-oil. Carbon dioxide promoted the production of alcohols, alkenes, and alkanes in bio-oil. Beneficially, the interaction of cellulose and lignin inhibited the release of hydrogen chloride. At last, this study also provides insights into the mechanism of catalyst and CO2 on biomass microwave pyrolysis.

Evaluation of Plastic Depletion by Replacing Eco-Dining Palm-Plates (Areca Catechu)

Background: In today's world, take-away materials predominantly consist of non-biodegradable plastics, known for their longevity and the release of harmful toxins during decomposition. To tackle this problem, the following article delves into the advantages and substitutes for plastic takeaway utensils and tableware, focusing on products made from palm (areca) and coconut tree by-products. It delves into the revival of traditional methods and knowledge rummage-sale in the southern then central parts of the India to create sustainable dining products. The article includes a market analysis, design considerations, life cycle analysis, and in-depth research on fabrication. Disposable plates, such as those made it from the polythene, polypropylene, polystyrene, polycarbonate, and polyvinyl chloride pose health risks, As a result of the release of noxious compounds, including melamine, vinyl chloride, biphenyl A, and phthalates. Therefore, an increasing trend is emerging in favour of utilizing use and throw plates crafted from plant leaves, which are both renewable and decomposable, however it is offering substantial antioxidant and medicinal properties. Results: In India, the classical way of using leaf dining plates carries profound cultural values, religious beliefs, medicinal, and socio-economic significance. The art of crafting these leaf plates serves as a livelihood for tribal communities residing in the states such as Orissa, Madhya Pradesh, Chhattisgarh, and Andhra Pradesh, These palm plates hold a crucial role in the offerings presented during religious rituals (Naivedyam) and the distribution of Prasadam to devotees. They find extensive use in serving meals at weddings, religious festivities, communal gatherings, and a wide array of other events. India embraces a variety of plant leaves not just as dining plates but also for their utility in wrapping, steaming, grilling, frying, and as materials for food packaging. Conclusion: In summary, biodegradable palm plates possess significant promise in the global market, granted they adhere to quality, design criteria. To promote the continued use of Leaf plates and discourage the adoption of plastic alternatives, it is imperative for the government to establish requisite regulations, which local authorities should rigorously enforce. Furthermore, spreading awareness among school and college students regarding the importance of these leaf plates is pivotal for nurturing their sustained adoption.

A New Perspective on Hydrogen Chloride Scavenging at High Temperatures for Reducing the Smoke Acidity of PVC Cables in Fires V: Comparison between EN 60754-1 and EN 60754-2

Regulation (EU) No 305/2011 lays down harmonized conditions for marketing construction products in the European Union. One of its consequences has been the introduction of the product standard EN 50575 and standard EN 130501-6, concerning power, control, and communication cables permanently installed in buildings to prevent the risk of a fire and its consequences. EN 13501-6 provides the reaction to fire classifications for cables, the test methods to be performed, the requirements to meet a specific reaction to fire, and additional classifications for smoke production, flaming droplets, and acidity. It requires EN 60754-2 as the technical standard to assess acidity, and it defines three classes: a1, a2, and a3 (the less performant). Due to the release of hydrogen chloride during the combustion, acidity is the weak point of PVC cables, which are not yet capable of achieving the a1 or a2 classes required for specific locations according to fire risk assessments. EN 13501-6 does not include EN 60754-1, used in harmonized standards outside the scope of Regulation (EU) No 305/2011. EN 60754-1 and EN 60754-2 are common standards for determining halogen gas content, and acidity/conductivity, respectively. While they involve the same type of test apparatus, they differ in heating regimes, final temperatures, and detection methods. In particular, EN 60754-2 requires testing at temperatures between 935–965 °C in the tube furnace, where the sample burns, the smoke is collected in bubblers, and pH and conductivity are measured as an indirect assessment of acidity. On the other hand, the temperature regime of EN 60754-1 is a gradual heating run, followed by isothermal heating at 800 °C. The paper shows that when potent acid scavengers are used in PVC compounds, performing EN 60754-2 with the thermal profile of EN 60754-1 or at 500 °C in isothermal conditions, the evolution of hydrogen chloride changes significantly up to 10 times less than the test performed in isothermal at 950 °C. The reason lies behind the kinetic of hydrogen chloride release during the combustion of PVC compounds: the higher the temperature or faster the heat release, the quicker hydrogen chloride evolution and the lower the probability for the acid scavenger to trap it. Thus, these findings emphasize the “fragility” of EN 60754-2 as a tool for assessing risks associated with the release of hydrogen chloride during fires.

Uncovering the metabolic pathway of novel Burkholderia sp. for efficient triclosan degradation and implication: Insight from exogenous bioaugmentation and toxicity pressure

Triclosan (TCS), a synthetic and broad-spectrum antimicrobial agent, is frequently detected in various environmental matrices. A novel TCS degrading bacterial strain, Burkholderia sp. L303, was isolated from local activated sludge. The strain could metabolically degrade TCS up to 8 mg/L, and optimal conditions for TCS degradation were at temperature of 35 °C, pH 7, and an increased inoculum size. During TCS degradation, several intermediates were identified, with the initial degradation occurring mainly through hydroxylation of aromatic ring, followed by dechlorination. Further intermediates such as 2-chlorohydroquinone, 4-chlorocatechol, and 4-chlorophenol were produced via ether bond fission and C–C bond cleavage, which could be further transformed into unchlorinated compounds, ultimately resulting in the complete stoichiometric free chloride release. Bioaugmentation of strain L303 in non-sterile river water demonstrated better degradation than in sterile water. Further exploration of the microbial communities provided insights into the composition and succession of the microbial communities under the TCS stress as well as during the TCS biodegradation process in real water samples, the key microorganisms involved in TCS biodegradation or showing resistance to the TCS toxicity, and the changes in microbial diversity related to exogenous bioaugmentation, TCS input, and TCS elimination. These findings shed light on the metabolic degradation pathway of TCS and highlight the significance of microbial communities in the bioremediation of TCS-contaminated environments.

THE INFLUENCE OF THE CONCENTRATION OF CHLORINE-CONTAINING CONDENSING AGENTS IN THE SYNTHESIS OF CARBOXYLIC ACID ANILIDESТ

Chlorine-containing condensing agents (PCl3, TiCl4, SiCl4) are widely used in the synthesis of carboxylic acid arylamides by the reaction of arylamines with carboxylic acids in stoichiometric amounts, and often in excess (40–150 mol % relative to the latter). To find the optimal amount of the condensing agent used, the acylation of aniline with 3-hydroxy-2-naphthoic acid in boiling ortho-xylene was studied in the PCl3 concentration range of 0–10 mol % from 3-hydroxy-2-naphthoic acid. It has been established that phosphorus tri-chlorochloride plays the role of a condensing agent and a catalyst, while 3-hydroxy-2-naphthoic acid anilide is formed along two routes with different rates, which can be separated kinetically. The first route includes the rapid synthesis of acid chloride, its interaction with aniline to obtain the target product. The second route is implemented due to phosphorous acid, which is formed from phosphorus trichloride and is a true acylation catalyst.
 The maximum yield of anilide 3-hydroxy-2-naphthoic acid decreases with increasing catalyst concentration, approximately propor-tional to the amount of aniline phosphite formed from it in the mass, which, apparently, is not reactive when interacting with the starting acid.
 Similar patterns were also found in the acylation of aniline with benzoic and salicylic acids in the presence of phosphorus trichloride; benzoic acid in the presence of titanium tetrachloride; 3-hydroxy-2-naphthoic acid in the presence of silicon tetrachloride. They allow a new look at the role of these products (PCl3, TiCl4, SiCl4) as condensing agents and/or ca­talysts in the synthesis of amides of carboxylic acids.
 Taking into account the obtained results, in practice it is better to use PCl3 as a catalyst in an amount not exceeding 2–2.5%, or even to replace it with phosphorous acid. This allows to completely get rid of the release of hydrogen chloride, significantly reduce the consumption rates for raw materials, simplify the entire technological process, reduce the amount of waste, ensure the yield of 3-hydroxy-2-naphthoic acid anilide close to quantitative, create a direct catalytic amidation technology that fully meets the criteria «green» chemistry processes.

Anaerobic degradation of hexachlorocyclohexane: Factors influencing the reactor start-up

This study examined the anaerobic degradation of technical-hexachlorocyclohexane (t-HCH)-a persistent organic pollutant (POP), using a batch reactor and the influence of pH, active biomass as volatile suspended solids (VSS), total suspended solids, total organic carbon, chloride release, and elemental composition on an Upflow Anaerobic Sludge Blanket (UASB) reactor start-up. Chloride release, a direct indicator of HCH degradation, was measured to confirm the process. During the initial sludge acclimatization, only 49.23 % degradation efficiency was seen after 45 days with an initial concentration of 1.0 g l−1. However, when electron donors and co-substrates were added to the sludge, the degradation time was shortened to 15 days with an increase in efficiency up to 60.17 %. When this adapted sludge was taken in a UASB reactor start up at 100 mg l−1 HCH, this degradation effectiveness was significantly improved when organic loading rate (OLR) was decreased to 50 mg l−1 d−1 assuming 48 h hydraulic retention time (HRT) in a UASB reactor start up at 100 mg l−1 HCH. During the original UASB reactor start-up, 92.37 %, 90.64 %, 85.72 %, and 83.26 % degradation of the alpha, gamma, beta, and delta isomers, with evidence of pentachlorocyclohexene as a transitory intermediate was observed. The major determining variables for reactor start-up were found to be neutral pH, mesophilic temperature, addition of co-substrate (glucose), VSS, HRT, and OLR. The study's innovation is that it examines the efficacy of the degradation process during sludge acclimatization and gives useful details about the variables to consider when starting up a UASB reactor. This research gives a biodegradation trend, which may be required before venturing for anaerobic degradation of recalcitrant substances like t-HCH.

Synergistic influence of diatomite and MoS2 nanosheets on the self-alkali-activated cementation of the municipal solid waste incineration fly ash and mechanisms

The solidification/stabilization technique recommended for the disposal of municipal solid waste incineration (MSWI) fly ashes in developed countries was inappropriate for the treatment in most developing counterparts. In this study, the diatomite and MoS2 nanosheets were synergistically employed to activate the self-alkali-activated cementation of the MSWI fly ashes to achieve efficient solidification, the immobilization of heavy metals (HMs), and the inhibition of chloride release. The compressive strength of 28.61 MPa and the leaching toxicities (mg/L) of Zn, Pb, Cu, Cd, and Cr of 2.26, 0.87, 0.5, 0.06, and 0.22 were obtained from the hardened mortars. Diatomite significantly influenced the self-alkali-activated cementation of the MSWI fly ashes while MoS2 nanosheets played both roles in intensifying the stabilization of HMs and strengthening the binding process by inducing the formation of sodalite and kaolinite, enhancing the growth rates of nucleation, and transforming the layered cementation to the partial and full three-dimensional cementation in the hardened matrix. This study not only verified the feasibility of diatomite and MoS2 in activating the self-alkali-activated cementation of the MSWI fly ashes but also supplied a reliable technique for the harmless disposal and efficient utilization of MSWI fly ashes in developing countries.

Corrosion of alloy 690 in simulated steam generator chemistry with boiling-effect of chloride and sulfate impurities

Enrichment of impurities occurs in steam generators of nuclear plants due to intense boiling conditions prevailing within them. In this work, deposition and release of chloride and sulfate impurities were studied using a dedicated water circulation loop with Alloy 690 as steam generator tubing. Electrochemical impedance spectroscopy was employed to follow in-situ the corrosion behavior in non-boiling, boiling and after-boiling conditions. Deposition/release of impurities is quasi-first-order vs. concentration. Interpretation of electrochemical impedance data using an updated version of the Mixed-Conduction Model allows to obtain reaction orders of oxide growth and corrosion release with respect to chloride and sulfate additives.

Research of bittern concentration processes lake Karaumbet and Barsakelmes

The conducted studies on the concentration of brine from lakes Karaumbet and Barsakelmes under conditions close to industrial ones showed the possibility of obtaining practically pure sodium chloride and magnesium chloride melt. To do this, the evaporation process must be carried out in two stages. The evaporation to a density of 1.550 g/sm3 increases the content of magnesium chloride from 7.20% to 28.24%. At the same time, the content of sodium ions decreases from 8.05% to 0.91%. The evaporation at the first and second stages must be carried out to a density of 1.340-1.345 g/sm3, which contributes to the release of sodium chloride into the precipitate. The evaporation of the mother liquor makes it possible to obtain practically pure sodium chloride. The content of magnesium chloride after evaporation in the first stage is 15-16%.

Analyzing Precipitation Acidity Changes Post Train Derailment and Vinyl Chloride Release in East Palestine, Ohio: Exploring Biomedical and Environmental Ramifications

Analyzing Precipitation Acidity Changes Post Train Derailment and Vinyl Chloride Release in East Palestine, Ohio: Exploring Biomedical and Environmental Ramifications

Determination of optimal conditions and kinetic laws of hydrogen chloride separation reaction from simm-dichloroethane (1,2-dichloroethane)

In the work, a catalytic optimal system was selected for the hydrochlorination of important components of chlorinated organic waste in the production of vinyl chloride. Information on the active and selective effect of various substances increasing the speed of the reaction in the hydrogen chloride release reaction was given. Operating modes of the reactor selected for oxidative chlorination of ethylene with hydrogen chloride in the presence of oxygen, designed for oxidative chlorination of ethylene with hydrogen chloride in the presence of atmospheric oxygen, were calculated. Also, the operating modes of the reactor were calculated, the kinetic equations of the rate of formation were constructed, and the equations of the relationship between the reactants and the reaction products were studied. As a result of the experiments, important kinetic parameters of simm-dichloroethane were determined to create a model of the simm-dichloroethane (1,2-dichloroethane) synthesis process. Kinetic studies were carried out in a temperature range of 300-350 ℃ in an ideal displacement flow reactor. In it, the reaction proceeded with no more than 70% conversion of sym-dichloroethane (1,2-dichloroethane). In addition, the material and heat balance of the reactor designed for oxidative chlorination of ethylene with hydrogen chloride in the presence of air oxygen was calculated. The purpose of the work is to study the optimal conditions and kinetic laws of hydrogen chloride separation reaction from simm-dichloroethane (1,2-dichloroethane).