Chitosan Gel Beads Research Articles

Development of Chitosan Polysaccharide-Based Magnetic Gel for Direct Red 83:1 Removal from Water.

Water pollution caused by dyes is a significant environmental issue, necessitating the development of effective, cost-efficient decolorization methods suitable for industrial use. In this study, a Chitosan-Fe polymeric gel was synthesized, characterized, and tested for removing the azo dye Direct Red 83:1 from water. The polymeric magnetic chitosan was analyzed using various techniques: Field Emission Scanning Electron Microscopy (FE-SEM) revealed a porous structure, Differential Scanning Calorimetry (DSC) and Thermal Gravimetric Analysis (TGA) demonstrated the thermal stability, Infrared Spectrophotometry (IR) indicated the successful coordination of iron at the C3 position, and X-ray Powder Diffraction (XRD) confirmed the crystalline nature of the polymeric structure. Optimal conditions for kinetic and isotherm models were found at 1 g and pH 7.0. Adsorption behavior of Direct Red 83:1 onto magnetic chitosan gel beads was studied through kinetic tests and isotherm curves. The maximum adsorption capacity was 17.46 mg/g (qmax). The adsorption process followed pseudo-second-order kinetics (R2 = 0.999) and fit the Temkin isotherm (R2 = 0.946), suggesting heterogeneous surface adsorption. The newly synthesized Chitosan-Fe polymeric gel demonstrated good adsorption properties and facilitated easy separation of purified water.

Simple and modified chitosan gel beads from a natural source as a bio-sorbent for water defluoridation: Experimental and computational perspectives

Water contaminated with fluoride (F -) is widely acknowledged as a major global issue that poses serious health and environmental risks. Adsorption is one of the many fluoride removal treatment methods that has been widely and successfully investigated. In this work, we describe a simple process for making both cross-linked and uncross-linked chitosan gel beads from shrimp waste. SEM, FTIR, XRD and TGA analysis confirmed the successful synthesis of the non-cross-linked chitosan gel beads (Cs beads) and cross-linked chitosan gel (Cs-Ech beads) whose swelling behavior, stability and fluoride removal efficiency were studied. The adsorption conditions were also optimised. An adsorption capacity of 16.59 mg/g was achieved after just 30 min and at pH = 6.8, 10 mg/L and T = 25 °C. It was shown that chitosan gel beads cross-linked with epichlorohydrin removed more fluoride than non-cross-linked chitosan gel beads. The rate of adsorption of fluoride ions is determined by the pseudo-first order kinetic equation. On the other hand, equilibrium data was best described by Langmuir adsorption isotherms. Density functional theory calculations (DFT) based on quantitative analyses were used to explore the interfacial interaction mechanisms, offering valuable perspectives on the inter- and intra-molecular interactions. Further studies on weak interaction were conducted, focusing on the binding contribution of electrostatic interaction and vdW potential. DFT results confirmed the strong adsorption capacity and coordination behavior of F - ions on the cross-linked Cs-Ech, suggesting that the Ech group offers preferred adsorption sites.

Nano‑selenium functionalized chitosan gel beads for Hg(II) removal from apple juice

The presence of potentially toxic elements and compounds poses threats to the quality and safety of fruit juices. Among these, Hg(II) is considered as one of the most poisonous heavy metals to human health. Traditional chitosan-based and selenide-based adsorbents face challenges such as poor adsorption capacity and inconvenient separation in juice applications. In this study, we prepared nano‑selenium functionalized chitosan gel beads (nanoSe@CBs) and illustrated the synergistic promotions between chitosan and nanoSe in removing Hg(II) from apple juice. The preparation conditions, adsorption behaviors, and adsorption mechanism of nanoSe@CBs were systematically investigated. The results revealed that the adsorption process was primarily controlled by chemical adsorption. At the 0.1 % dosage, the adsorbent exhibited high uptake, and the maximum adsorption capacity from the Langmuir isotherm model could reach 376.5 mg/g at room temperature. The adsorbent maintained high adsorption efficiency (> 90 %) across a wide range of Hg(II) concentrations (0.01 to 10 mg/L) and was unaffected by organic acids present in apple juice. Additionally, nanoSe@CBs showed negligible effects on the quality of apple juice. Overall, nanoSe@CBs open up possibilities to be used as a safe, low-cost and highly-efficient adsorbent for the removal of Hg(II) from juices and other liquid foods.

Polydopamine modified cerium-based MOFs/ chitosan aerogel beads for the efficient phosphate removal

The metal organic frameworks (MOFs) are considered as the effective adsorbents for phosphate removal, while their ultrafine powders limit their practical application. In this study, we fabricate two chitosan (CS) gel beads added with different cerium-based MOFs and coated with PDA for phosphate adsorption. The MOFs doped in beads are CM1 and CM2, in which the Ce(III)/Ce(IV) ratio is 0.36 and 1.46, indicating CM2 is Ce(III) dominated and more suitable for phosphate removal. However, during the process of preparing gel beads, the mixture of chitosan and CM1/CM2 are added drop-by-drop to NaOH solution, leading to the decrease of Ce(III) contents in both of the two beads on account of oxidization. On this basis, in order to improve the phosphate uptake performance and enhance the mechanical strength, polydopamine (PDA) is applied to be coated on the outside. The adsorption capacities of CS-CM1 and CS-CM2 are no more than 20 mg/g higher than that of pure CS, which is also quite equal with the phosphate uptake of CS@PDA (63 mg/g). Due to the reduction of PDA, the content of Ce(III) increasing evidently in the two adsorbents. The maximum phosphate adsorption capacities are 146.8 mg/g and 114.8 mg/g for CS-CM1@PDA and CS-CM2@PDA, respectively. CS-CM2@PDA exhibits the largest treatment volume of ∼1166 BV in the fix-bed column study, much higher than that of CS-CM1@PDA (976 BV). The main reason is that Ce(III) could form binding with phosphate through ligand exchange and precipitation. Those inner-sphere interactions are much stronger than the electrostatic attraction between Ce(IV) and phosphate. Thus, due to this strong affinity, CS-CM2@PDA possessing a higher content of Ce(III) can capture phosphate more easier at low concentration. In summary, owing to reduction of PDA, the Cerium-based MOFs are successfully introduced in CS to realize excellent phosphate removal and exhibit a great prospect in application.

A renewable and functionalized chitosan gel bead for statically and dynamically capturing aquatic Hg(II) with a prominent capacity

Porous gel beads have aroused considerable interest in the field of wastewater treatment because of their enhanced adsorption capacity and ease of separation. Herein, a facile yet efficient method to synthesize porous chitosan gel beads (PBCSB) through the amide reaction and integrated with a porogenic process was proposed and further optimized. The well-preserved honeycomb internal structure was beneficial for aquatic Hg(II) to approach the surface and diffuse into the interior of the gel beads. The as-prepared adsorbent at a diameter of 3–5 mm possessed ultra-high adsorption ability (1139.82 mg g−1) toward Hg(II), declining the concentration from 500 mg L-1 to 0.017 mg L-1. Furthermore, the PBCSB could attain a high removal Hg(II) rate (>80%) even at pH 1 and maintained excellent Hg(II) adsorption performance (94.24%-99.99%) within five regeneration cycles. In the multi-component solution, the Kd of Hg(II) was 4–5 orders of magnitude higher in comparison with that of others. The superior adsorption performance was attributed to the complexation between Hg(II) and the functional groups involving sulfur, nitrogen, and oxygen based on the XPS analysis and density functional theory (DFT) calculation. The fixed-bed column filled with PBCSB exhibited a stable and satisfactory performance under different conditions. The findings confirmed the inherent superior performance, renewability, and application potential for selective capture Hg(II) from real industrial wastewater.

Efficient adsorption of arsenic in groundwater by hydrated iron oxide and ferromanganese oxide chitosan gel beads

To address the arsenic contamination in groundwater, the hydrated iron oxide gel beads (CS-HFO) and iron manganese oxide gel beads (CS-FMO) adsorbents were prepared. The CS-HFO and CS-FMO adsorbents had porous and adsorption-friendly pore structures inside, with the average pore sizes of 3.45 nm and 7.78 nm, respectively. As compared to the CS-HFO adsorbent, the CS-FMO adsorbent had rich adsorption sites and oxidation capacity and displayed better adsorption performance. According to the Langmuir model, the saturation adsorption of As(V) and As(III) for CS-FMO adsorbent was calculated as 26.65 mg/g and 35.96 mg/g, respectively. After 10 cycles of regeneration, the CS-HFO and CS-FMO adsorbents demonstrated excellent sustainable arsenic removal ability, while the adsorption efficiencies of CS-FMO adsorbent for As(V) and As(III) were maintained over 60 % and 95 %, respectively. In addition, the competing pollutants and fixed-bed column experiments confirmed the high selectivity of the CS-HFO and CS-FMO adsorbents, which showed great promise for the future application of arsenic contamination removal from the actual groundwater environment.

Reduction of fluorides present in drinking water in the municipality of Calera de Víctor Rosales Zacatecas, using chitosan gel beads

The quality of water distributed to the population in Zacatecas shows a deficit due to contaminants such as fluorinated compounds that exceed the limits allowed in the volumes of water used as a source of public supply. The objective of this work is to reduce the concentration of fluorides present in the drinking water of the municipality of Calera de Víctor Rosales, Zac., by using PVA cross-linked chitosan gel beads. An initial sample from a public supply was characterized, showing a fluoride concentration of 5.3 ppm, a value higher than the limit set in NOM-127-SSA1-1994. Batch experimentation was carried out at different degrees of sample dissolution with stirring conditions temperature of 450 rpm and 18.5 oC, respectively, in volumes of 150 mL and 0.3 g of chitosan gel beads. The adjustment of the experimental data to the various models of isotherms and adsorption kinetics was carried out; of these, the Freundlich isotherm and the pseudo-second order kinetic model are the models with the highest correlation to the experimental data. In addition, an average fluoride decrease of 80.08% was achieved in the samples with the established conditions.

Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads for highly efficient and sustainable removal of cationic dyes

Developing recyclable and efficient adsorbents for cationic dyes removal from wastewater is crucial for ensuring green ecology and drinking water safety. Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS). The GO@Fe3O4 sample was prepared based on GO by the chemical co-precipitation method, which not only reduced the aggregation of Fe3O4 but also increases the specific surface area of the composite gel beads. The prepared gel beads were used to adsorb methylene blue (MB), neutral red (NR), and safranine T (ST). The experimental results showed that the adsorption capacity of SA/GO@Fe3O4/CS gel beads for MB, NR, and ST reached 21.325 mg/g, 44.654 mg/g and 44.313 mg/g. After five recycles, the removal rates could still reach more than 90% of the original, exhibiting a high recovery rate. Therefore, this paper provides a strategy for the preparation of high efficiency and recyclable cationic dye adsorbents with a large specific surface area.

Preparation and Characterization of Aminoglycoside-Loaded Chitosan/Tripolyphosphate/Alginate Microspheres against E. coli.

Although aminoglycosides are one of the common classes of antibiotics that have been widely used for treating infections caused by pathogenic bacteria, the evolution of bacterial resistance mechanisms and their inherent toxicity have diminished their applicability. Biocompatible carrier systems can help sustain and control the delivery of antibacterial compounds while reducing the chances of antibacterial resistance or accumulation in unwanted tissues. In this study, novel chitosan gel beads were synthesized by a double ionic co-crosslinking mechanism. Tripolyphosphate and alginate, a polysaccharide obtained from marine brown algae, were employed as ionic cross-linkers to prepare the chitosan-based networks of gel beads. The in vitro release of streptomycin and kanamycin A was bimodal; an initial burst release was observed followed by a diffusion mediated sustained release, based on a Fickian diffusion mechanism. Finally, in terms of antibacterial properties, the particles resulted in growth inhibition of Gram-negative (E. coli) bacteria.

Preparation of EDTA-modified magnetic attapulgite chitosan gel bead adsorbent for the removal of Cu(II), Pb(II), and Ni(II)

Attapulgite (ATP) has a unique porous layered chain structure and is an excellent environment-friendly decolorizer. However, its high viscosity makes it difficult to separate. First, it was combined with magnetic Fe3O4 nanoparticles to obtain Fe3O4-ATP that is easy to recycle and reuse. Then, Fe3O4-ATP nanoparticles were embedded in chitosan (CS) gel beads, and glutaraldehyde was used for cross-linking and curing. Lastly, ethylenediaminetetraacetic acid (EDTA) was successfully connected to Fe3O4-ATP/CS gel beads through amidation reaction, which further increased the capability of the adsorbent to adsorb heavy metal ions. The prepared magnetic composite adsorbent is a sphere with a rough surface and porous structure. The maximum adsorption capacity of the prepared Fe3O4-ATP/EDTA/CS adsorbent for Pb(II), Cu(II), and Ni(II) is 368.32, 267.94, and 220.31 mg g−1, respectively. After 5 times of repeated use, Fe3O4-ATP/EDTA/CS still showed good adsorption capacity for Cu(II), Pb(II), and Ni(II). Fe3O4-ATP/EDTA/CS has a large adsorption capacity for heavy metal ions, a wide pH applicability, good reuse, and rapid magnetic separation. In addition, Cu(II) loaded Fe3O4-ATP/EDTA/CS also showed good catalytic degradation performance for bisphenol A. This study prepared a new type of adsorbent with good adsorption performance and provided a promising method for the treatment of wastewater.

A potential catalyst - TiO2/ZnO based chitosan gel beads for the reduction of nitro-aromatic compounds aggregated sodium borohydride and their antimicrobial activity

Metal catalysed reduction of nitro aromatic compounds to aniline derivatives is a convenient and significant synthetic pathway in several applications. TiO2/Zinc oxide has gained much more recent attention as a significant catalyst in the catalytic reduction of nitro aromatic compounds by sodium boro hydride. In this sample, metallic ZnO particles were stabilised by simple green thermal treatment on the chitosan nano composites in water.TiO2/ZnO based Chitosan gel beads exhibited outstanding catalytic behaviour in the hydrogenation of 1-nitro benzene, 2-nitro aniline when NaBH4 was used as the hydrogen source. The tests of catalytic activity were replicated by varying the quantity of the catalyst, the concentration of NaBH4, the quantity of nitro aromatic compounds and the temperature. The decreasing reaction was greatly influenced by the temperature of the reaction medium and concentration of NaBH4. Selected reduction reactions went to completion in just (0.15 min) raised temperatures at 45οC. These conclusions indicate that the newly prepared TiO2/ ZnO based Chitosan gel beads can open up a new perspective on catalytic reduction reactions. Antimicrobial activities of TiO2/Zn nano particles grafted with chitosan have been tested against pathogenic microorganisms such as A. Niger, Bacillus subtilis, Escherichia coli.

Methyl Orange Removal from Aqueous Solution by Sorption onto Porous Polysaccharide-Based Adsorbents: Optimization by Taguchi Design

The removal of methyl orange (MO) dye using porous chitosan (CS) gel beads was investigated in a batch mode. The newly formed porous CS gel beads were synthesized by using a solidification bath containing mixture of NaOH-Na2CO3 at ratio of 1:1. Orthogonal array of L9 (33) was used to generate nine sets of experiments based on three controlling factors: initial dye concentration (30 ppm, 50 ppm, 90 ppm), adsorbent dosage (0.35 g, 0.5 g, 1 g) and pH of MO (pH 3, 7, 11).The highest mean of Signal to Noise (S/N) ratio was chosen to obtain maximum adsorption capability of newly formed porous CS gel beads. The optimum operating conditions to maximise the removal percentage (R% ) were identified as 1 g of adsorbent dosage, 30 mg/L of initial MO concentration at pH 3, whereas maximum equilibrium uptake capacity (qe) of 10.41 mg/g was achieved by dosing 0.35 g of adsorbent dosage into 90 mg/L of initial MO concentration at pH 3. ANOVA studies were also carried out to study the contribution percentage of each designed parameter. The results indicated that the initial concentration and pH of MO dye solution have the biggest contribution to R% and qe , respectively.

Bio-sorptive Removal of Methyl Orange by Micro-Grooved Chitosan (GCS) Beads: Optimization of Process Variables Using Taguchi L9 Orthogonal Array

Batch biosorption studies of methyl orange (MO) dye removal using newly formed micro-grooved chitosan (GCS) gel beads were synthesized by using NaOH-based gelling solution supplemented with Na2CO3 at different volume ratios (v/v) of NaOH-to-Na2CO3. The newly formed GCS gel beads with the best adsorption capacity corresponding to the volume ratio of NaOH–Na2CO3 were selected as potential biosorbent in subsequent adsorption studies. Taguchi orthogonal array of L9 (33) was adopted to investigate the simultaneous variations of three controlling factors, namely: pH of MO (pH 3, 7, 11), initial concentration of MO (30 ppm, 50 ppm, 90 ppm) and new GCS adsorbent dosage (0.35 g, 0.5 g, 1 g). The dye removal percentage (removal%) was found to be between (30.09 ± 4.66)% and (98.15 ± 0.23)%. The average uptake capacity (qe) of MO by GCS adsorbent was varied from (1.22 ± 0.03)mg/g to (9.14 ± 0.00)mg/g. The highest mean of S/N ratio was selected to obtain maximum adsorption performance. The optimum operating condition for the highest removal% was achieved at pH 3 with 1 g of adsorbent dosage and 30 ppm of MO concentration, whereas the maximum qe was identified at pH 3 with adsorbent dose of 0.35 g and 90 ppm of MO concentration. The morphology of GCS gel beads before and after adsorption was analysed using field emission scanning electron microscopy (FESEM). The adsorption results were best fit to two parameter Harkins–Jura isotherm (R2 = 0.9979). This affirmed that the adsorption of MO dye solution by GCS gel beads was a multilayer adsorption.

Remoción de arsénico presente en el agua potable del municipio de Ojocaliente, Zac. empleando perlas de gel de quitosano

There is a great problem for the supply of drinking water in Mexico, the state of Zacatecas is no exception, in addition to this the water in the region has the presence of heavy metals, fluorine compounds, arsenic and high hardness. The objective of this work is to remove the arsenic present in the drinking water of the municipality of Ojocaliente, Zac. using chitosan gel beads. The initial sample was characterized giving an As concentration of 70 ppb, a high value in reference to the Official Mexican Standard NOM-127-SSA1-1994 for water for human consumption. A series of experiments were carried out at different concentrations, using drinking water sampled in Ojocaliente, Zac., The operation was in batches at an average temperature of 19 ° C and 250 rpm, in aliquots of 50 ml and 0.3 g of gel chitosan beads. The isotherm and kinetics model that fit the data was determined, being Langmuir and Pseudo first order, respectively, and 20% of the arsenic present in the water was removed in a separation step.

Synthesis of Modified Chitosan Gel Beads and Adsorption Performance of Cu(II)

In the present study, millimeter CS-TPP@MnFe2O4 gel beads (particle size 3–4 mm) were prepared by the sol-gel process using the embedding method, and its performance of Cu(II) and influence factors were studied. The effect of various parameters such as the gel bead addition amount, adsorption time, temperature, pH, and competitive substances (anion and cationic) was studied. The surface and properties of gel beads were characterized by X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). The experimental results showed that the optimal pH for adsorption of Cu(II) by CS-TPP@MnFe2O4 was 5–7, the adsorption of Cu(II) reached equilibrium at 24 h, and the maximum adsorption capacity could reach 125.70 mg g−1 at 298.15 K by Langmuir isotherm model. K+, Na+, Cl−, NO3−, and SO42− had little effect on the adsorption, and Ca2+, Mg2+, and H2PO4− inhibited the adsorption, and SiO32− and humic acid (HA) promoted the adsorption of Cu(II) by the adsorbent. After five adsorption-desorption experiments, the desorption rate of gel beads reached 89.3%, and the adsorption capacity of Cu(II) was still high. In conclusion, the CS-TPP@MnFe2O4 gel beads are a type of stable and effective materials to remove Cu(II) from water.

Comparative study of adsorption of fluoride ions on chitosan gel beads and cross-linked chitosan gel beads

Abstract The presence of fluoride in water has become a major concern worldwide because of its chronic cancerogenic behavior in humans. In order to remove fluoride from the aqueous solution, we synthesized chitosan gel beads (CB) and cross-linked chitosan gel beads (CCB) in a batch reactor. Thus, a series of experiments were carried out to study the influence on the adsorption capacity of certain parameters such as initial fluoride concentration, adsorbent mass, pH solution and contact time. The results obtained show that the percent removal of fluoride reached a maximum of 62% after 25 min for chitosan gel beads and 72% after 30 min for cross-linked chitosan gel beads. Adsorption kinetics of the fluoride ions on the two adsorbents is well described by the pseudo-first-order model and that the adsorption isotherms are followed by the Langmuir model.

Arsenic Sorption on Chitosan-Based Sorbents: Comparison of the Effect of Molybdate and Tungstate Loading on As(V) Sorption Properties

Modified chitosan gel beads, prepared by molybdate and tungstate coagulation methods, were tested for As(V) removal from solutions in the range of 5–200 mg As L−1. The sorbent is efficient at removing As(V) from acid solutions (optimum pH close to 3), the sorption capacities for As uptake in molybdate- and tungstate-loaded beads are 75 and 44 mg As g−1 of dry mass, respectively. The mechanism of As(V) sorption is related to the ability of molybdate and tungstate ions to complex As(V) ions in acid solutions. As(V) sorption process is mainly influenced by the presence of phosphate ions, but there is no influence of co-ions as nitrate and chloride. Arsenic desorption can be performed using phosphoric acid solutions. Arsenic adsorption proceeds in acidic solutions with a partial release of molybdate and tungstate and with residual concentrations of arsenic above the regulations for drinking water. For that reason, this material is a candidate for the treatment of industrial effluents.

Regularities and mechanism of heavy metal cations sorption and (or) proton desorption by chitosan from aqueous solutions

The sorption process of heavy metal ions from aqueous solutions using chitosan flakes and chitosan beads was studied. Chitosan gel beads were prepared using covalent crosslinking of chitosan chains by epichlorohydrin with ionic gelation by sodium tripolyphosphate. The capability of chitosan beads to absorb the heavy metal ions from aqueous solutions was studied, and the physicochemical characteristics of the sorbent were evaluated using SEM and FTIR on the model solution treatment. It was found that competitive proton sorption takes place in acidic media, which results in a transformation of amino groups into inactive ammonium-salt form and decreases in heavy metal sorption onto chitosan from aqueous acidic media. Batch adsorption experiments were performed to examine the influence of various factors such as the initial concentration of metal salts, pH, and agitation duration on the process. It was established that metal ion sorption is pH dependent and has an optimum effect at a pH of 6.0. Following the Langmuir equation, the maximum sorption of Cu2+ions is estimated to be 1,6 mol/kg of modified chitosan. The kinetic study revealed that the adsorption kinetics are well-fitted to the kinetic equation of pseudo second order. Thus, sorption of heavy metal ions by chitosan is considered to be a competitive process that occurs on amino groups of the sorbent with equivalent coordinated participation of metal cations, protons, and anions.

Efficiency of Ag(0)@chitosan gel beads in catalytic reduction of nitroaromatic compounds by sodium borohydride

Metal-catalysed reduction of nitroaromatic compounds to aniline derivatives is a useful and important synthetic route in many applications. Metallic silver particles have gained much recent interest as efficient catalysts in catalytic reduction of nitroaromatic compounds by sodium borohydride. In the study metallic Ag particles were stabilized on glutaraldehyde cross-linked chitosan gel beads in water by a simple and green thermal treatment. Ag(0)@chitosan gel beads exhibited an excellent catalytic activity in hydrogenation of 4-nitrophenol, 2-nitroaniline, 4-nitro-o-phenylenediamine and 2,4-dinitrophenol when NaBH4 was used as the hydrogen source. The catalytic activity tests were repeated by varying the catalyst dose, NaBH4 concentration, the amount of nitroaromatic compounds and temperature. The reduction reactions were greatly affected by the temperature of reaction medium and the concentration of NaBH4. At elevated temperatures, for example at 43 °C, some reduction reactions went to completion in just 8 s. The study revealed that Ag(0)@chitosan gel beads can be used in catalytic reduction of nitroaromatic compounds to anilines by NaBH4. This catalytic system can be tested an alternative to the catalytic systems requiring use of expensive transition metals such as palladium and platinum.

Magnetic iron oxide nanoparticles (MIONs) cross-linked natural polymer-based hybrid gel beads: Controlled nano anti-TB drug delivery application.

The nanosized rifampicin (RIF) has been prepared to increase the solubility in aqueous solution, which leads to remarkable enhancement of its bioavailability and their convenient delivery system studied by newly produced nontoxic, biodegradable magnetic iron oxide nanoparticles (MIONs) cross-linked polyethylene glycol hybrid chitosan (mCS-PEG) gel beads. The functionalization of both nano RIF and mCS-PEG gel beads were studied using various spectroscopic and microscopic techniques. The size of prepared nano RIF was found to be 70.20 ± 3.50 nm. The mechanical stability and swelling ratio of the magnetic gel beads increased by the addition of PEG with a maximum swelling ratio of 38.67 ± 0.29 g/g. Interestingly, this magnetic gel bead has dual responsive assets in the nano drug delivery application (pH and the magnetic field). As we expected, magnetic gel beads show higher nano drug releasing efficacy at acidic medium (pH = 5.0) with maximum efficiency of 71.00 ± 0.87%. This efficacy may also be tuned by altering the external magnetic field and the weight percentage (wt%) of PEG. These results suggest that such a dual responsive magnetic gel beads can be used as a potential system in the nano drug delivery applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1039-1050, 2018.