Abstract
Although aminoglycosides are one of the common classes of antibiotics that have been widely used for treating infections caused by pathogenic bacteria, the evolution of bacterial resistance mechanisms and their inherent toxicity have diminished their applicability. Biocompatible carrier systems can help sustain and control the delivery of antibacterial compounds while reducing the chances of antibacterial resistance or accumulation in unwanted tissues. In this study, novel chitosan gel beads were synthesized by a double ionic co-crosslinking mechanism. Tripolyphosphate and alginate, a polysaccharide obtained from marine brown algae, were employed as ionic cross-linkers to prepare the chitosan-based networks of gel beads. The in vitro release of streptomycin and kanamycin A was bimodal; an initial burst release was observed followed by a diffusion mediated sustained release, based on a Fickian diffusion mechanism. Finally, in terms of antibacterial properties, the particles resulted in growth inhibition of Gram-negative (E. coli) bacteria.
Highlights
Microbial infections have become a major problem in public health, and it has been anticipated that if no prior action is taken, these infections could lead to 10 million people dying every year by 2050 [1]
The obtained results indicated that the Ch/TPP microspheres are formed with better consistency when a 6:8 w/w TPP to chitosan mass ratio (w/w) has been employed, while in the case of Ch/ /TPP/Alg ones, a
We report the synthesis and characterization of novel chitosan gel beads as a valuable platform for controlled release of the aminoglycosides streptomycin and kanamycin A
Summary
Microbial infections have become a major problem in public health, and it has been anticipated that if no prior action is taken, these infections could lead to 10 million people dying every year by 2050 [1]. This threat is majorly due, on the one hand, to the increased emergence of drug-resistant microbes, which poses the serious risk of reversing previous medical progress in this field and bringing back many bacterial infections from the past. Drug delivery vehicles have been widely employed to encapsulate and deliver conventional antibiotics, improving their therapeutic index while minimizing their adverse effects [5,6,7]. These have shown unprecedented advantages such as enhancement of the effectiveness of existent antibiotics, by enhancing the physicochemical properties and stability of antibiotics and prolongation of antibiotic release, in addition to the capability of targeted delivery to the site of infection as an effective antimicrobial therapy [8,9,10]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
