Addition Of Chitosan Research Articles

Impact of chitosan-incorporated toothpaste on roughness, gloss, and antifungal potential of acrylic resin

This study aimed to test the efficacy of different silica-based toothpastes with or without chitosan, as a method of cleaning the acrylic surfaces of denture prostheses. Acrylic resin specimens were prepared to evaluate surface roughness and gloss (n = 10), and Candida albicans adhesion/inhibition (n = 2). Two toothpastes with different degrees of abrasiveness were used: Colgate (CT) and Elmex (EX), with or without 0.5% chitosan (Ch) microparticles (CTCh or EXCh, respectively). The negative control was brushed with distilled water. Brushing was simulated with a machine. Surface roughness and gloss were analyzed before and after brushing. Candida albicans incidence/inhibition was tested qualitatively to determine the acrylic resin antifungal activity. The roughness and gloss data were analyzed with a generalized linear model, and the Kruskal Wallis and Dunn tests, respectively (α = 5%). Brushing with toothpastes increased roughness and reduced gloss, compared with the negative control (p < 0.05). CT showed a more significantly different change in roughness and gloss, in relation to the other groups (p < 0.05). Addition of chitosan to CT reduced its abrasive potential, and yielded results similar to those of EX and EXCh. Specimens brushed with CT showed a higher potential for Candida albicans adherence, despite its higher antifungal action. Addition of chitosan to the toothpaste made both toothpaste and brushing more effective in inhibiting Candida albicans. CT had the potential to increase roughness, reduce gloss, and increase Candida albicans adherence. In contrast, chitosan added to CT showed greater antifungal potential, and a higher synergistic effect than EX.

Synthesis of Biofoam from Cassava Peel Starch, Banana Peel Starch and Chitosan as Additives

Biodegradable Foam (Biofoam) material has been made for application of styrofoam substitute food packaging material from a mixture of starch with chitosan as an additive. The purpose of this study was to determine the effect of molding temperature on biofoam products and to determine the effect of chitosan addition on the physical, mechanical, and biodegrability properties of biofoam made from cassava peel starch (a) and banana peel starch (b) which is close to commercial biofoam standards. The production of biofoam uses variations in molding temperature of 125, 150 and 175 °C and variations in chitosan weight with variations of 0, 1, 2 and 3 grams. The resulting biofoam product was then tested for density, water absorption, compressive strength, biodegradation and functional groups with Fourier Transform Infrared (FTIR). Based on the results of the study, it is known that biofoam that is close to commercial standards is found in the addition of 3 gr chitosan weight with a molding temperature of 125 °C with a density value of 0.423gr/cm3, water absorption of 42.54% and compressive strength of 0.0045 Mpa. As for biodegradation, biofoam products will decompose 55.17% for 55 days in 0 g chitosan weight with a thermopressing temperature of 175 °C. The spectrum results obtained on biofoam have C-H, C-O, C-N, N-H, C=O and O-H functional groups.

Analysis of the morphological and mechanical characterization of aluminium matrix composite reinforced with chitosan

Recent studies acknowledge that convectional ceramic particulate could be replaced by several agricultural by-products in the development of aluminium matrix composites because of its selected for their low cost and relative ubiquity. This study explores the development of aluminium matrix composite from AA6061 alloy reinforced with chitosan particulates at weight proportions (3, 6, 9, and 12 wt%). The study further characterizes the developed composites using Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), X-ray Diffractometer (XRD), hardness, tensile and thermal and electrical conductivity test techniques. Results indicated that increasing chitosan content up to 10 wt% enhanced the hardness performance, while tensile strength of the composites increased sporadically, as SEM images observed reinforcement links embedded in grain boundaries. However, the thermal and electrical conductivity diminished due to the addition of chitosan particulates to the alloy matrix. The overall study showed the great potential of chitosan polymer as reinforcement to aluminium alloy.

Zinc-Phthalocyanine Loaded PLGA-PVA-Chitosan Nanosystem for the Enhancement of Antidiabetic Activity.

Zinc, one of the most common nutraceutical agents, proved to be effective for diabetes as it regulates the blood glucose level by inhibiting glucagon secretion. However, the hepatotoxicity of zinc creates necrosis, hepatic glycogen depletion, and apoptosis of hepatocytes at the concentration of 10 μg/kg. Phthalocyanine, a blue-colored compound, is an aromatic macrocyclic compound with good antioxidant ability owing to its heterocyclic nitrogen conjugation. The conjugation of zinc with phthalocyanine aimed to reduce the toxicity associated with zinc and enhance the antidiabetic activity at a lower dose. Hence, the present research work possessed the insights of the synthetic aspect of zinc with phthalocyanine along with its entrapment in the poly(lactic-co-glycolic acid) (PLGA)-chitosan nanosystem via oral administration in the treatment of diabetes. A nanoprecipitation technique was implemented for the synthesis of PLGA chitosan nanoparticles, and formulation was further optimized using a central composite design. Twenty trials provided by the software selected optimum concentrations of PLGA, poly(vinyl alcohol) (PVA), and chitosan in consideration with particle size up to 335.6 nm, zeta potential 27.87 mV, and entrapment efficiency of 75.67 ± 8.13%. Addition of chitosan to the nanocarrier system for controlling the release of the drug for 3 days was accompanied by the improvement in the glucose level within 28 days. The delivery of the nanoparticles showed enhancement in the cholesterol, triglyceride, alkaline phosphatase (ALP), urine parameters, and pro-inflammatory cytokines. The application of DoE (design of experiments) for the optimization of the nanoparticles established a controlled release formulation for diabetes, which displayed safety and effectiveness in streptozotocin (STZ)-induced diabetic rats.

Evaluation of the impact of tragacanth/xanthan gum interpolymer complexation with chitosan on pharmaceutical performance of gels with secnidazole as potential periodontal treatment

Periodontitis consists a group of dental disorders that affect about 70 % of the world population. The therapy mainly relies on mechanical removing bacterial biofilm, nevertheless, local or systemic antibacterial agents play a key role in treating the acute conditions. Secnidazole is a newer derivative of commonly used metronidazole with high safety profile and broad spectrum of antimicrobial activity. The aim of the study was to evaluate the applicability of polyelectrolyte complex-based hydrogels composed of anionic tragacanth with addition of xanthan gum and cationic chitosan as carriers for buccal/intra pocket delivery of secnidazole. Prepared hydrogels with 5 % and 10 % (w/w) drug content were evaluated pharmaceutically towards inter alia physicomechanical, rheological and thermal properties, drug release kinetics, swelling behavior or antimicrobial activity. Cytotoxicity against human primary umbilical vein endothelial cells was also assessed with two independent method. Stable compositions with secnidazole were obtained, however, various miscibility of the drug with the polymers was noted. By adding chitosan, antibacterial activity and swelling performance of the gels were improved, nevertheless, drop of the mucoadhesiveness was also recorded. Hydrogels with 5 % secnidazole were selected as effective antimicrobial compositions with the highest cytocompatibility. They might be considered as promising for oromucosal application with special attention given to SEC as an alternative locally administered antimicrobial agent.

Influence of chitosan addition on the properties and characteristics of acrylic acid-chitosan based superabsorbent prepared through gamma irradiation technique and its application for urea loading

Influence of chitosan addition on the properties and characteristics of acrylic acid-chitosan based superabsorbent prepared through gamma irradiation technique and its application for urea loading

An emerging sustainable approach for development and characterization of gluten-based nanocomposite films reinforced with starch nanocrystals in conjugation with chitosan

The present study aimed to access the influence of starch nanocrystals (SNCs) with chitosan on functionality of gluten-based bionanocomposite films. Films were reinforced with SNCs (1, 2, and 3 %) along with chitosan (1.5 % and 2.5 %) and characterized for their functional, barrier, morphological, biodegradable, and antimicrobial properties. Results showed that water absorption capacity, solubility, and water vapour transmission rate were significantly (P < 0.05) reduced with the incorporation of SNCs and chitosan, however, highest tensile strength (40.82 MPa) and elongation at break (31.09 %) were observed in 2 % of SNCs and 2.5 % of chitosan. The multifunctional films have high opacity (lightness value >90) confirming with higher thickness (0.17–0.22 mm) of films. X-ray diffraction studies interpret no significant change in A-type crystallinity of the base biopolymer. Field emission scanning electron microscopy showed that bionanocomposite films have fewer surface cracks, less configuration, and crystallinity changes in the composite structure of biopolymer. Fourier transform infrared spectra revealed no differences in the bands, suggesting a positive molecular association confirming the synergistic effect of polyvinyl alcohol (PVOH) and SNCs on gluten in comparison to control film. However, chitosan in films enhanced antioxidant and antimicrobial properties, showing 13.05 mm and 16.66 mm of a zone of inhibition against Staphylococcus aureus and Escherichia coli, respectively. Furthermore, all films showed noticeable degradation >95 % within 55 days under soil conditions. In summary, the addition of SNCs and chitosan produced a stronger/antibacterial film comparable to plastic films for commercialized food packaging industries.

Obtention and Study of Polyurethane-Based Active Packaging with Curcumin and/or Chitosan Additives for Fruits and Vegetables-Part I: Analysis of Morphological, Mechanical, Barrier, and Migration Properties.

Several polyurethane-formulated films with curcumin and/or chitosan additives for food packaging have been previously obtained. The study examines the effect of the additives on the film's morphological, mechanical, barrier, and migration properties. Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), water contact angle, thermogravimetric and differential thermal analysis (TGA and DTGA), differential scanning calorimetry (DSC), dynamic mechanical thermal analysis (DMTA), oxygen transmission rate (OTR), water vapor transmission rate (WVTR), and the overall and specific migration tests were conducted. The results show that the presence of chitosan significantly increased the overall migration and mechanical properties, such as the elongation at break, tensile strength, and Young's modulus of most polyurethane formulations, while curcumin had a minor influence on the mechanical performance. Based on the results, formulations with curcumin but without chitosan are suitable for food packaging.

ANALYSIS OF GROWTH PERFORMANCE AND FEED EFFICIENCY OF GIANT GOURAMY (Osphronemus gouramy) THROUGH THE ADDITION OF CHITOSAN AND PROBIOTICS

The purpose of this study was to determine the optimum level of addition of chitosan and probiotics in feed to increase the growth rate and daily feed consumption of giant gouramy (Osphronemus gouramy). The method used in this research is an experimental method of completely randomized design (CRD), which consists of five treatments and three replications. The treatments used were (A) without giving chitosan and probiotics (control), (B) giving chitosan at 7.5 g/kg feed and probiotics at 10 ml/kg feed, (C) giving chitosan at 7.5 g /kg feed and probiotics at 15 ml/kg feed, (D) chitosan at 7.5 g/kg feed and probiotics at 20 ml/kg feed, (E) chitosan at 7.5 g/kg feed and probiotics of 25 ml/kg feed. The parameters measured were absolute length absolute weight, specific growth rate, feed utilization efficiency ratio (EPP), survival rate, and water quality. Data were analyzed using the Anova test at the 5% level. The results showed that the addition of different concentrations of chitosan and probiotics to commercial feeds could affect growth, and EPP but did not affect the survival rate of giant gouramy. The results obtained during the study showed that treatment C with the addition of chitosan of 7.5 g/kg of feed and probiotics of 15 ml/kg of feed resulted in the highest absolute length growth of 4.87 cm, the highest absolute weight growth of 19,35 g, the highest daily growth rate was 46,08%, the feed efficiency was 91,5% and survival rate was 97,78%. Whereas in terms of the effectiveness of treatment B with the addition of chitosan 7.5 g/kg of feed and less probiotics, namely as much as 10 ml/kg of feed, the treatment was as good as treatment C.

Self-assembly of coconut residue fiber with chitosan: Effect of three pre-treatments on the self-assembly process and bile salt adsorption

Self-assembly with chitosan is a promising method for improving bile salt (BS) adsorption by coconut residue fiber (CRF). To study the self-assembly process, three pre-treatments were performed and investigated using microrheological analysis. The effects of the pretreatments on the self-assembly of CRF and the BS adsorption were evaluated. During self-assembly, CRFs underwent Brownian-like motion, and the addition of chitosan facilitated the formation of inter-particle interactions between CRFs in the system. These interactions were small in extent, large in number, and slow to state change, in addition to relatively high strength and longer maintenance, all of which contributed to the binding to BS. The conventional pretreatments failed to effectively improve the BS adsorption of the self-assembled CRFs and weakened the inter-particle interactions in the system. These results suggest that chitosan assists in the adsorption of self-assembled CRF to BS through a combination of H-bonds and other weak intermolecular forces.

CHARACTERIZATION OF CORN STARCH EDIBLE FILMS BY THE ADDITION OF CHITOSAN AS A VEGETABLE OIL PACKAGING MATERIAL

Abstract - Vegetable oil packaging materials use a type of synthetic polymer that is harmful to the body and the environment. Edible film as an environmentally friendly packaging material can be a solution for vegetable oil packaging material. Edible films are made from natural ingredients such as starch and chitosan. The objective of this study is to determine the best conditions of addition of chitosan in making edible film in terms of its physio-chemicals and determine the best glycerol concentration in terms of its physical properties. The composition of raw materials in the form of corn starch is 5 grams and the composition of chitosan is (0,5%, 1% and 1,5% b/v). Glycerol concentrations vary in (4%, 5% and 6% v/v). the result of the analysis of the physical properties of the edible film through the analysis of the physical tensile strength test, namely the best composition on the addition of 1 gr chitosan as well as the elongation analysis at termination. Analysis of the solubility of the edible film at a concentration of 1 gr as well the analysis of water vapor permeability. Whereas the analysis of the best antioxidant capacity in the composition of chitosan is 1,5 gr. Keywords: corn starch, chitosan, edible film

Chitosan modifies the substrate and influences growth of chili seedlings

ABSTRACT The addition of chitosan to soil has been shown to promote plant development, although its actions on the soil and the plants remain unclear. Chili (Capsicum annum L.) seedlings were grown in a greenhouse (20–33°C, 65%–70% RH) on a substrate (topsoil, rice husk charcoal, and coconut coir) at a ratio of 2:1:1 (v/v) amended with 0%, 1%, or 10% (w/w) chitosan powder. Shoot and root dry weights of chili seedlings grown in a substrate containing 1% chitosan exhibited a 2.5-fold and 1.6-fold increase compared to those in 0% and 10% chitosan treatments, respectively. Leaf chlorophyll content was 2.7-fold higher at 20 days after transplanting. Chitosan at 1% improved the cation exchange capacity (CEC), substrate organic matter, and plant essential nutrient absorption (P, K, Ca, Mg, Mn, Cu, and Zn). In contrast, the substrate added with 10% chitosan had a negative effect on chili seedlings, possibly due to an excess of total available nitrogen (1.54% or 1.6 times higher) and organic matter (30% or 1.6 times higher). Seedlings exhibited leaf chlorosis, poor root development, and fewer essential nutrients in tissues than the control and 1% chitosan treatments. Use of 1% chitosan appears to promote chili growth by improving substrate characteristics.

Efficacy of Chlorhexidine after Oral Surgery Procedures on Wound Healing: Systematic Review and Meta-Analysis.

Our objective was to evaluate qualitatively and quantitatively, through a systematic review and meta-analysis, available evidence on the efficacy of chlorhexidine (CHX) when applied after oral surgery on wound healing and related clinical parameters. MEDLINE/PubMed, Embase, CENTRAL, Web of Science, and Scopus were searched for studies published before January 2023. The quality of the methodology used in primary-level studies was assessed using the RoB2 tool; meta-analyses were performed jointly with heterogeneity and small-study effect analyses. Thirty-three studies and 4766 cases were included. The results point out that the application of CHX was significantly more effective, compared to controls where CHX was not employed, providing better wound healing after oral surgery (RR = 0.66, 95% CI = 0.55-0.80, p < 0.001). Stratified meta-analyses confirmed the higher efficacy of 0.20% CHX gel vs. other vehicles and concentrations (p < 0.001, respectively). Likewise, the addition of chitosan to CHX significantly increased the efficacy of surgical wound healing (p < 0.001). The use of CHX has also been significantly beneficial in the prevention of alveolar osteitis after any type of dental extraction (RR = 0.46, 95% CI = 0.39-0.53, p < 0.001) and has also been effective when applied as a gel for a reduction in pain after the surgical extraction of third molars (MD = -0.97, 95% CI = -1.26 to -0.68, p < 0.001). In conclusion, this systematic review and meta-analysis demonstrate on the basis of evidence that the application of CHX exerts a beneficial effect on wound healing after oral surgical procedures, significantly decreasing the patient's risk of developing surgical complications and/or poor wound healing. This benefit was greater when CHX was used at 0.20% in gel form with the addition of chitosan.

Polysaccharides affect the utilization of β-carotene through gut microbiota investigated by in vitro and in vivo experiments

This study aimed to evaluate the effects of six polysaccharides on the utilization of β-carotene from the perspective of gut microbiota using both in vitro simulated anaerobic fermentation systems and in vivo animal experiments. In the in vitro experiments, the addition of arabinoxylan, arabinogalactan, mannan, inulin, chitosan, and glucan led to a 31.07–79.12% decrease in β-carotene retention and a significant increase in retinol content (0.21–0.99-fold) compared to β-carotene alone. Among them, the addition of chitosan produced the highest level of retinol. In the in vivo experiments, mice treated with the six polysaccharides exhibited a significant increase (2.51–5.78-fold) in serum β-carotene content compared to the group treated with β-carotene alone. The accumulation of retinoids in the serum, liver, and small intestine increased by 13.56–21.61%, 12.64–56.27%, and 7.9%-71.69%, respectively. The expression of β-carotene cleavage enzymes was increased in the liver. Genetic analysis of small intestinal tissue revealed no significant enhancement in the expression of genes related to β-carotene metabolism. In the gut microbiota environment, the addition of polysaccharides generated more SCFAs and altered the structure and composition of the gut microbiota. The correlation analysis revealed a strong association between gut microbes (Ruminococcaceae and Odoribacteraceae) and β-carotene metabolism and absorption. Collectively, our findings suggest that the addition of polysaccharides may improve β-carotene utilization by modulating the gut microbiota.

Effect of chitosan addition on proximate composition, antioxidant activity, and sensory acceptance of biscuits containing red and purple roselle extract

The purpose of this research was to produce biscuits containing red and purple roselle extract with the addition of chitosan to improve the biscuits’ proximate composition, total phenolic, antioxidant activity, and sensory acceptance. The research used a completely randomized design with seven factors containing red and purple roselle extract, and chitosan, respectively; C1 (0:0:1)%; C2 (10:0:0)%; C3(0:10:0) %; F1(4:6:1)%; F2 (6:4:1)%; F3(4:6:2)%; and F4(6:4:2)%. Proximate composition (moisture, protein, fat, carbohydrate, ash and fibre) was determined using standard methods. The total phenolic content of roselle extract biscuits was measured using the Folin-Ciocalteau method, whereas the determination of antioxidant activity was carried out by applying the 2,2- Diphenylpicrylhydrazyl (DPPH) method. The proximate analysis of the biscuits produced high moisture content ranging from 3.25 to 3.94% W/W, protein content from 6.68 to 7.43% W/W, and fat content (19.13-19.74% W/W). The ash content varied from 1.62 to 1.72% W/W, fibre content ranged from 3.32 to 5.06% W/W, and carbohydrate contents were 62.50-65.40% W/W. The concentration of 1% chitosan in the biscuit formulation was also more effective in increasing the phenolic content and antioxidant activity (IC50), respectively 3.36 mg/100 g and 71.81 ppm in the F1 biscuits samples (red roselle 4% and purple 6%). Similarly, in F1 with the addition of 1% chitosan to sample biscuits containing red (4%) and purple (6%) roselle extract, the panellists received good acceptance of the aroma, colour, texture, taste, and overall biscuits made. Biscuits containing 6% purple roselle and 1% chitosan in the formulation could be provided with a significant contribution to increasing total phenol, antioxidant activity, and sensory acceptance compared to the others. Therefore, roselle extract and chitosan can be used as additional biscuit supplements that can increase nutritional content and antioxidant activity.

ADDITION OF BENTONITE AND CHITOSAN FILLING TO POLYURETHANE COATING PAINT IN AN EFFORT TO INCREASE RESISTANCE AGAINST HEAT AND ANTIBACTERIA

The increasing market demand for polyurethane is due to its various functions, including being used as a coating material, adhesives, elastomers and hard foams.Polyurethane is a polymeric material that contains a functional group (-NHCOO-) in its main chain. In principle, polyurethane can be produced by reacting two reactive materials, polyol and isocyanate. Various researches are intensively carried out to synthesize polyurethane in order to improve the performance of polyurethane.Bentonite and chitosan are widely used as filler materials in polyurethane matrices to retain heat and improve the mechanical properties of polyurethane. The addition of bentonite and chitosan to polyurethane will affect the mechanical properties, thermal properties, and morphological structures which can be seen based on the FTIR test, TGA test, SEM test and Antibacterial test.In this study, variations of Bentonite and Chitosan 5.7.9% will be used, then the mixing process with Polyurethane will be carried out. The results showed that the results of the FTIR analysis showed that the mixing of Polyurethane and bentonite did not affect the wavelength absorption of the Polyurethane functional groups themselves. This was due to the mixing process which took place only physical bonds without chemical bonds. The results of thermogravimetric analysis (TGA) showed changes in the weight of the material when heated and it could be concluded that the best sample was B:K 9%, because it experienced less weight loss. Based on the results of the Morphological Structure test with a Scanning Electron Microscopy (SEM) chitosan chain dispersed well into the bentonite interlayer, as shown by testing using the SEM tool. The results of the antibacterial test showed that the more chitosan and bentonite added, the better the ability to inhibit the growth of Escherichia coli bacteria. In testing the activity of these bacteria it can be seen that chitosan and bentonite are better at inhibiting the growth of Escherichia coli than Staphylococcus aureus.

Chitosan Modification-Enhanced Silencing Effect of Ad5-shPDGF-D Vector in Breast Cancer Cell Line MDA-MB-231.

Gene therapeutics are being developed to treat metastatic breast tumors, which are mostly resistant to conventional therapies. Targeting platelet-derived growth factor-D (PDGF-D) is a viable approach because it is known to play roles in angiogenesis and tumor growth. The success of gene therapy is largely dependent on delivery vectors, but both viral and nonviral delivery vectors have their disadvantages. Evolving hybrid vectors are being used to overcome those disadvantages. In this study, we aimed to prepare a recombinant adenovirus type-5 (Ad5)/chitosan hybrid vector to deliver shPDGF-D in a breast cancer cell line by the noncovalent coating of the Ad5 surface with chitosan, a natural polymer. The Ad5/chitosan hybrid vector was prepared by the noncovalent coating of the Ad5 surface with different molecular weights (low and high) and different amounts of chitosan (12.5, 25, and 50 μg), and the effect of silencing PDGF-D was investigated in the MDA-MB-231 cell line. In vitro characterization studies showed that the noncovalent chitosan coating increased the size of the Ad5 particle and changed the surface charge from -16.53 mV to slightly neutral. In vitro cell culture studies also showed that the addition of chitosan with both low (73.61%) and high (65.86%) molecular weight increased the PDGF-D silencing efficiency of the Ad5 vector (42.44%) at 48 hours. While low-molecular-weight chitosan had faster effects, high-molecular-weight chitosan provided a more sustained effect in PDGF-D silencing. The results indicate that noncovalent chitosan modification may improve the therapeutic effects of the Ad5 vector, offering the potential for further in vitro and in vivo experiments.

Effect of Sorbitol and Chitosan Addition on Tensile Strength and Degradation Rate of Biodegradable Plastic from Rice Bran Starch

The increasing use of plastic can cause enviromental pollution because plastic takes a very long time to decompose in the soil. Solutions that can be used to accelerate the process of plastic decomposition in the soil by replacing plastic making materials with natural polymer materials. Natural polymers are polymers produced from organic monomers, one of which is starch. Starch is one of the natural polymer materials used in the manufacture of biodegradable plastics, one of the natural materials containing starch is rice bran waste. From rice bran waste starch, bioderadable plastic can be made by adding chitosan and sorbitol by varying then succesively, namely 5:2:8, 5:3:7, 5:5:5, 5:7:3, 5:10:0, then making samples, then the samples are printed and tensile strength testing and degradation testing are carried out. From the tensile strength test results, the values obtained were 0.69 Mpa, 0.74 Mpa, 1.50 Mpa, 1.98 Mpa and 2.28 Mpa, respectively. The finel weight of the sampel after degradation is 0 gram, 0 gram, 0.0189 gram, 0.0226 gram, 0.1017 gram. It is concluded that biodegardable plastic with good tensile strength is in the variation of starch 5 grams, without sorbitol and chitosan 10 grams and for good degradation test in the variation of starch 5 grams, sorbitol 8 ml, chitosan 2 grams and variation of starch 5 grams, sorbitol 7 ml, chitosan 3 grams.

INCREASING THE EFFECTIVENESS OF CHITOSAN GELS TO PROTECT THE OESOPHAGEAL MUCOSA

The troublesome symptoms of gastro-oesophageal reflux disease are a serious health, medical, and social problem for patients. The main problem is gastro-oesophageal acid reflux. In this study, I investigated hydrogels that could prevent the destruction of the oesophageal mucosa. I investigated the effect of chitosan and poloxamer 407 on the protective properties of gels. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity. Preparations containing 25% poloxamer 407 showed the highest pH. Texture tests showed the effect of the poloxamer concentration on the adhesion performance of the tested gels. The findings suggest that the gels can be used to treat advanced acid reflux.

CHITOSAN GELS TO PREVENT REFLUX DISEASE

Reflux disease is one of the most frequently diagnosed conditions in developed countries. The problem is both the acidic content of the stomach and the alkaline content of the intestines. In each case, the oesophageal mucosa is destroyed. I analysed hydrogels that prevent irritation of the oesophageal mucosa. Specifically, I investigated the effect of chitosan and sodium alginate on the properties of gels protecting the oesophagus. Gels containing chitosan and 1.0% sodium alginate can be used to treat advanced alkaline reflux. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity, making it possible to neutralise acid reflux. Texture studies showed the influence of chitosan and sodium alginate on the adhesiveness of the tested gels.