The first one-cc or one-cubic-centimeter computer (OCCC) that integrates a sensor, ultra-wideband impulse radio (UWB-IR) transmitter, computing engine, and battery is demonstrated. Cross-layer integration includes SPIKE control, which achieves a record low power communication of 3.4-nW/bps with reduced operating time. Miniaturization techniques, such as wafer-level chip-size packaging and flip-chip packaging, were used to shrink the module to a volume of 1 cc. The fabricated OCCC is shown to operate as designed, communicating at distances of 10 and 30 m and at transmission rates of 10.7 Mbps and 258 kbps, respectively. The life of a 150-mAh battery in an OCCC that operates once every five minutes is estimated to be longer than 10 years. The communication-location integration (CLI) technique, which achieves 22-cm location accuracy with only a 1.3% chip area overhead, is also proposed.