Chinese Medicine Health Research Articles

Correlations of cognitive function with serum levels of homocysteine, sex hormone binding globulin, and leptin in patients with schizophrenia

Objective: To investigate the correlations of cognitive function with serum levels of homocysteine (Hcy), sex hormone binding globulin (SHBG), and leptin in patients with schizophrenia. Methods: This was retrospective study. This study included 58 patients with schizophrenia (SCZ) as observation group and 60 clinically healthy individuals as control group admitted to Xiangshan County Hospital of Traditional Chinese Medicine Medical and Health Group Third Hospital from March 2022 to June 2023. Serum levels of Hcy, SHBG, and leptin in the two groups were measured, and Pearson correlation analysis was conducted to investigate the correlations between the Hcy, SHBG, and leptin levels and the psychiatric symptoms and cognitive function in the observation group. Results: The Hcy and SHBG levels in the observation group were significantly higher than those in the control group (p<0.05, respectively), and the leptin level was lower than that in the control group (p<0.05). The observation group scored significantly lower than the control group for each dimension of the MCCB (p<0.05, respectively). In the observation group, Hcy was positively correlated with negative symptoms and the PANSS total score (p<0.05, respectively) and was negatively correlated with scores for the leptin was negatively correlated with negative symptoms and the PANSS total score (p<0.05, respectively) and was positively correlated with scores for speed of processing (SOP), WMS-III, BVMT, and MSCEIT (p<0.05, respectively). Conclusions: Increased levels of Hcy and SHBG and decreased leptin are strongly associated with the occurrence of cognitive impairment in SCZ cases. Therefore, clinical observation and monitoring of these markers can help identify changes in patient conditions. doi: https://doi.org/10.12669/pjms.40.10.8923 How to cite this: Xu Y, Qian X, Zhang M, Liang M. Correlations of cognitive function with serum levels of homocysteine, sex hormone binding globulin, and leptin in patients with schizophrenia. Pak J Med Sci. 2024;40(10):2319-2323. doi: https://doi.org/10.12669/pjms.40.10.8923 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

An Investigation into Tourists' Intentions to Participate in Traditional Chinese Medicine (TCM) Wellness and Rehabilitation Tourism: Insights from In-Depth Interviews at the Luofu Mountain Tourist Area

This study aims to explore the flourishing of TCM (Traditional Chinese Medicine) health and rehabilitation tourism in Chinese tourist attractions and the driving factors behind tourists' participation intentions, with a specific focus on Luofu Mountain. Firstly, by elucidating the background and value of TCM health tourism and the rationale for choosing Luofu Mountain as a case study, the core objective of this research is established: to identify the key factors that drive tourists to engage in this unique tourism experience, providing strategic references for scenic area management and industry upgrades. The research covers a wide range of topics, including tourist demand analysis and tourism product innovation, employing a combination of theoretical construction and empirical research. Multiple methods, such as in-depth interviews and quantitative surveys, are used to gain insights into tourists' motivations and experiences. The article is well-structured, with a highlight on using in-depth interviews to reveal the deep psychological factors influencing tourists' participation intentions and the seamless integration of theory and practice. In the literature review section, this paper systematically discusses the theoretical foundations of TCM health and rehabilitation tourism and the theoretical framework of tourists' participation intentions. It also compares domestic and international research progress to identify research gaps. By comparing Luofu Mountain with international cases, this study assesses its strengths and weaknesses, providing policy insights and improvement suggestions. Methodologically, the paper details a carefully designed sampling strategy and data collection and analysis processes, with particular attention to the data analysis and thematic analysis of in-depth interviews. Based on the case of Luofu Mountain, it reveals the behavioral patterns of tourists participating in TCM health tourism and extracts key strategies for product design and service enhancement. In the policy analysis chapter, the paper deconstructs the effects of current policies on Luofu Mountain, identifies areas for improvement, and proposes a tailored set of policy recommendations. Finally, it summarizes the main research findings, including key factors influencing tourist behavior and optimization measures, while reflecting on the study's limitations and suggesting future research paths.

Research Progress in Integrated Chinese and Western Medicine Health Management for School-Age Children with Asthma

Objective: The purpose of this study is to investigate the application of Chinese and Western medicine in the health management of school-age children with asthma and its research progress, with a view to providing a more comprehensive and effective management strategy for the clinic. Methods: Using the method of literature review, this study systematically searched and analyzed the relevant studies on the combination of Chinese and Western medicine in the health management of school-aged children with asthma in recent years, focusing on Chinese medicine treatment, Western medicine treatment, and the combined health management of Chinese and Western medicine. Results: Chinese medicine treatment, Western medicine treatment, and the health management mode of combining Chinese and Western medicine showed unique advantages in school-age asthmatic children. Through the comprehensive use of Chinese medicine’s diagnosis and treatment, Chinese medicine conditioning, Chinese medicine characteristic therapy, and Western medicine’s modern medical methods, it not only effectively relieved asthma symptoms but also significantly improved the quality of life of the children. At the same time, this management mode also focuses on the psychological guidance and family care of the children, forming an all-round and multi-level health management system. Conclusion: The health management strategy of combining Chinese and Western medicine has a broad application prospect in school-age asthmatic children, and its specific interventions and mechanisms of action should be further studied to provide more scientific and systematic guidance for clinical practice.

Research on the Development Strategy of Panxi Sunshine Health and Wellness Homestays and Hotels Based on Traditional Chinese Medicine Health Preservation

This study is the first phase of research results from the student innovation project “Yunqiao Sunshine Health and Wellness Homestay” group at Chengdu Normal University. By analyzing the current state of the Sunshine Health and Wellness Tourism Area economy in the Panxi region of Sichuan, local policies, and the current state of Sunshine Health and Wellness homestays and hotels, this paper proposes the possibility of developing Sunshine Health and Wellness homestays and hotels through traditional Chinese medicine (TCM) health preservation methods. It also proposes development strategies for such hotels through a market survey SWOT analysis.

The Current Status of Traditional Chinese Medicine Health Care Literacy of the Elderly and Its Influencing Factors--Based on a Survey of 460 Elderly People

Objective: To understand the current status of knowledge and beliefs of Chinese medicine health care and its influencing factors among the elderly in Henan Province, and to provide reference for improving their Chinese medicine health care literacy. Methods: Using convenience sampling, 460 elderly people in Henan Province were selected to carry out a questionnaire survey on the current status of knowledge and beliefs of Chinese medicine and health care, and their influencing factors were analysed. Results: The standard score of knowledge of TCM health care for the elderly in Henan Province was (56.72±15.35), the standard score of attitude was (79.57±15.91), and the standard score of behaviour was (42.17±22.25); the residence place, education level, monthly disposable income, previous occupation, type of medical insurance, the presence of old-age insurance, the presence of chronic diseases, and the presence of relatives engaged in TCM-related occupations were statistically significant (P<0.05) in terms of the scores on the three dimensions of knowledge, attitude, and behaviour of TCM health care and the total score; senior high school/vocational high school/junior college (OR= 0.329, 95% CI: 0.137-0.791), workers (OR= 4.295, 95% CI: 1.023-18.044), and those who suffered from chronic diseases ( OR= 1.964, 95% CI: 1.171~3.294) significantly affect the knowledge score; business unit (OR= 0.135, 95% CI: 0.024~0.754), and having chronic disease (OR= 1.918, 95% CI: 1.168~3.151) significantly affect the attitude score; and 3001~5000 yuan (OR= 0.292, 95% CI: 0.105~0.812), workers (OR= 5.180, 95% CI: 1.311~20.47), others (OR= 4.698, 95% CI: 1.112~19.839), having old age insurance (OR= 1.641, 95% CI: 1.028~2.620), and suffering from chronic diseases (OR= 2.152, 95% CI: 1.280~3.617) and so on significantly influenced the behavioural scores. Conclusion: The attitude level of TCM health care among the elderly in Henan Province is good, and the knowledge and behaviour level needs to be improved. Long-term and stable health knowledge education for the elderly population should be carried out to strengthen the elderly's knowledge of TCM health care and further strengthen their beliefs in TCM health care in order to promote the formation of their TCM health care health behaviours.

Traditional Chinese medicine health literacy among rural older adults: a cross-sectional study.

The purpose of this study was to understand the current status of traditional Chinese medicine (TCM) health literacy among rural older adults people and its influencing factors. This study used a random number table method to select one prefecture from Henan Province, China and used a convenience sampling method to select 200 rural older adults who met the inclusion criteria in a township in northern Henan from March to April 2023. A cross-sectional survey was conducted using a general information questionnaire and a traditional Chinese medicine health literacy questionnaire, and the influencing factors of rural older adults were analyzed using univariate analysis of variance (ANOVA) and multiple linear regression. The total TCM health literacy score of 200 rural older adults people was 84.14 ± 6.709. One-way ANOVA revealed that six factors, including education level, marital status, type of occupation, presence of family members engaged in medical-related work, main economic sources, and monthly income, influenced the TCM health literacy score of rural older adults people (p < 0.05). Multiple linear regression analysis revealed that education level, occupation type, and the presence of family members engaged in medical-related work were the factors influencing the TCM health literacy of rural older adults. The TCM health literacy level of rural older adults people is at the lower to middle level, and health educators should strengthen the publicity and education of TCM healthcare knowledge for rural older adults people to improve their TCM health literacy level and thus enhance their quality of life.

The Impact of Virtual Reality Training Combined with Traditional Chinese Medicine Health Preservation Therapy on Cognitive Function, Neurological Function, and Physical Function of Stroke Patients.

The aim of this study was to investigate the effects of virtual reality training combined with traditional Chinese medicine health preservation therapy on cognitive function, neurological function, and physical function of stroke patients. The patients were randomly divided into an experimental group (receiving virtual reality training combined with traditional Chinese medicine health preservation therapy) and a control group (receiving conventional rehabilitation treatment combined with traditional Chinese medicine health preservation therapy). A series of cognitive, neurological, and physical function assessments were conducted to collect and analyze data from both groups before treatment, after treatment, and during follow-up. The application of traditional Chinese medicine health preservation concepts was also explored. After treatment, the experimental group had significantly higher scores in the Mini-Mental State Examination (MMSE) compared to the control group. The overall effective rate of neurological function in the experimental group was higher than that in the control group. The Fugl-Meyer Assessment (FMA) scores for upper limb function in the experimental group were significantly higher than those in the control group. The degree of improvement in the Modified Barthel Index scores after treatment was significantly better in the experimental group compared to the control group (all P < 0.05). The results of this study demonstrate that virtual reality training combined with traditional Chinese medicine health preservation therapy significantly improves cognitive function, neurological function, and physical function in stroke patients. This approach provides new insights and methods for stroke rehabilitation therapy and is worthy of promotion.

Traditional Chinese Medicine Culture, Senior Tourism and Elderly Care Industry: Analysis and Discussion on the Integrated Development Under the Background of Big Health

In the era of the rise of the concept of Big Health, traditional Chinese medicine culture, senior tourism and elderly care industry show a trend of integration. Combining traditional Chinese medicine health and ecological tourism, a new form of business is taking shape in the elderly care industry, which is the &amp;quot;cross-border&amp;quot; cooperation between traditional Chinese medicine and tourism. This paper sought to analyze the integrated development and potential of traditional Chinese medicine culture, senior tourism and elderly care industry; discuss the realistic dilemma of the integrated development under the background of big health. This Thesis makes an in-depth study on the standardization degree and influence of the integration of traditional Chinese medicine culture and Senior Tourism and Elderly Care Industry through literature review method, and reveals the problems and challenges in the current traditional Chinese medicine culture and Senior Tourism and Elderly Care Industry .The feasibility of traditional Chinese medicine culture and Senior Tourism and Elderly Care Industry was studied in depth by means of various evaluation indicators and sample survey.

Study on the Sharing Behavior of Chinese Users towards Short Videos on Traditional Chinese Medicine Health in the New Media Environment

Study on the Sharing Behavior of Chinese Users towards Short Videos on Traditional Chinese Medicine Health in the New Media Environment

Tao Hongjing's Medical Health Preservation Philosophy

In the 21st century, the medical paradigm has transitioned from "disease medicine" to "health medicine," with the developmental trend shifting from "treating diseases" to maintaining a "healthy" state. Tao Hongjing, representing the field of health preservation studies during the Southern and Northern Dynasties in ancient China, contributed distinctive principles and methods to traditional Chinese medicine (TCM) health preservation, constituting a crucial aspect of TCM health preservation academic thought. His concise and cost-effective health preservation theories and methods encapsulate profound health preservation insights and philosophical contemplation, earning commendation from successive generations of medical practitioners and holding remarkable research value. Against the backdrop of implementing the "Healthy China" strategy and advocating "universal health," Tao Hongjing's health preservation philosophy holds significant reference value for enhancing human health awareness and promoting harmonious social development, providing strong practical guidance. This paper focuses on Tao Hongjing's medical health preservation philosophy, utilizing works such as Record of Nurturing Life for Longevity, Zhen Gao, Compendium of Materia Medica Annotations, Records of Renowned Physicians, and Collected Works of Tao's Seclusion ( ) as research materials to thoroughly explore Tao Hongjing's medical health preservation methods and academic characteristics.

Analysis of the Research Status of Traditional Chinese Medicine Pension Industry Based on Bibliometrics

At present, the problem of population aging in China is becoming increasingly prominent, and the combination of traditional Chinese medicine and elderly care is becoming a hot topic. In this paper, VOSviewer was used to statistically and visually analyze the literature related to traditional Chinese medicine pension in CNKI database from 2013 to 2023. Firstly, we collected and sorted out the research literature on the Chinese medicine pension industry in recent years, and then used bibliometric methods to quantitatively analyze the quantity, quality and research fields of the literature. The study found that the number of research literature on the elderly care industry of traditional Chinese medicine has increased year by year, the research quality has been continuously improved, and the research field has gradually expanded. At the same time, we also found that the research hotspots of traditional Chinese medicine for the elderly care industry are mainly focused on elderly care services, traditional Chinese medicine health preservation, rehabilitation treatment, etc (Ge &amp; Xu, 2023). In addition, this paper also puts forward the shortcomings and development directions of the research on the Chinese medicine pension industry in China and hopes that this study can provide useful reference and guidance for the development of the Chinese medicine pension industry. Based on the China National Knowledge Infrastructure (CNKI) database as the main data source, this paper uses the topic search method in advanced search to search the CNKI database, and confirms that “Chinese medicine for the elderly” is used to read a large number of literature and understand the health care of traditional Chinese medicineAs the theme, the document format was set to see the full text only and Chinese and English extensions, the search time range was set from January 1th, 2013 to December 31th, 2023, the document type was set to academic journals, and the journal source category was set to all journals, a total of 149 articles were obtained, excluding news, publicity, interviews, correspondence and other literature that did not meet the research theme, and finally a total of 149 articles were obtained by manual screening 126 articles in Chinese. VOSviewer is an open-source network analysis tool, mainly used for scientific literature analysis, which can help users carry out visual analysis and network construction and is suitable for analyzing the research status of a certain field. In this paper, the VOSviewer visual analysis tool was used to process and analyze the literature data of 126 academic journals included in CNKI from 2013 to 2023, and the knowledge map of Chinese medicine pension in China was drawn, so as to visually analyze the author cooperation, hot topics and cutting-edge trends of Chinese medicine pension research in China.

Feminization of the health workforce in China: exploring gendered composition from 2002 to 2020.

Feminization of health workforce has been globally documented, but it has not been investigated in China. This study aims to analyze changes in the gendered composition of health workforce and explore the trend in different types of health workforce, health organizations and majors within China's health system. The data were collected from China Health Statistical Yearbook from 2002 to 2020. We focused on health professionals including doctors, nurses, and pharmacists in health organizations. Trend analysis was employed to examine the change in the ratio of female health workforce over 18years. The estimated average annual percent change (AAPC) was estimated, and the reciprocals of variances for the female ratios were used as weights. In China, health professionals increased from 4.7 million in 2002 to 10.68 million in 2020. Health professionals per 1000 population increased from 3.41 in 2002 to 7.57 in 2020. The ratio of female health professionals significantly increased from 63.85% in 2002 to 72.4% in 2020 (AAPC = 1.04%, 95% CI 0.96-1.11%, P < 0.001). Female doctors and pharmacists increased 4.7 and 7.9 percentage points from 2002 to 2020. Female health workers at township health centers, village clinics, centers for disease control and prevention had higher annual increase rate (AAPC = 1.67%, 2.25% and 1.33%, respectively) than those at hospital (0.70%) and community health center (0.5%). Female doctors in traditional Chinese medicine, dentistry and public health had higher annual increase rate (AAPC = 1.82%, 1.53% and 1.91%, respectively) than female clinical doctor (0.64%). More women are participating in the healthcare sector in China. However, socially lower-ranked positions have been feminizing faster, which could be due to the inherent and structural gender norms restricting women's career. More collective and comprehensive system-level actions will be needed to foster a gender-equitable environment for health workforce at all levels.

Application of artificial intelligence in the field of Traditional Chinese Medicine health preservation in the era of big data

TCM means Traditional Chinese Medicine. TCM Museums are becoming more and more common with peoples increasing demand for health concepts. However, because there is no unified industry standard and the quality of projects is uneven, potential customers in need are discouraged. With the rapid development of information technology, we are in an era of big data filled with a large amount of information. In the context of the big data era, artificial intelligence, as a cutting-edge technology, complements each other, and its integrated application is widely used in many industry fields. This paper discusses the application of artificial intelligence in the field of TCM health preservation in the era of big data from three aspects: health monitoring, personalized recommendation of TCM health preservation scheme and publicity of TCM health preservation knowledge. From the discussion of these three aspects, we can explore more possibilities of integrating big data and artificial intelligence into TCM health preservation, which can not only help TCM Museums improve service quality, but also effectively realize peoples personalized self-health management.

The mediating effect of traditional Chinese medicine (TCM) health literacy between TCM culture promotion and residents' health status.

Traditional Chinese medicine (TCM) is a medical system with a long history and unique theories and techniques, playing a crucial role in maintaining and promoting human health. Disseminating TCM cultural knowledge is essential for enhancing the TCM health literacy and health status of people. This study aimed to investigate how TCM health literacy mediated the relationship between the TCM cultural ambiance and people's health status. A multi-stage random sampling method was employed to select 22,125 permanent residents in Jiangsu Province for a survey aimed at examining the popularization of TCM culture. The survey categorized the intensity of TCM cultural ambiance into four grades (0-3) based on the promotion activities in various settings, including street/community, medical service institutions, and educational/work institutions. Furthermore, the survey evaluated TCM health literacy, overall health status, and prevalence of chronic diseases using the 2017 Chinese Citizens TCM Health Literacy Survey Questionnaire. The regression analysis was used to examine the correlation between the TCM cultural ambiance and TCM health literacy and health status. Also, a mediation model was applied to explore the mediating effect of TCM health literacy on the TCM cultural ambiance and the public's self-assessment of health and reporting of chronic diseases. The rate of popularization of TCM culture was 79.3% in Jiangsu Province, with a TCM health literacy level of 14.76%. The average score for public self-assessment of health was 37.80 ± 9.70, and the prevalence of chronic diseases was reported at 32.66%. A positive correlation was observed between cultural promotion ambiance and TCM health literacy. The impact of the cultural promotion ambiance on health literacy also increased with the increase in promotion grade (P < 0.001). The correlation analysis showed no statistically significant correlation of promotion grade 1 [β = 0.21, 95% confidence interval (CI): -0.26 to 0.67] with the health status of residents, whereas promotion grades 2 (β = 1.47, 95% CI: 1.12-1.83) and 3 (β = 4.61, 95% CI: 4.19-5.04) were positively correlated with self-health evaluation. TCM health literacy was positively correlated with self-health evaluation (β = 2.10, 95% CI: 1.72-2.48) and negatively correlated with the risk of chronic diseases (odds ratio = 0.53, 95% CI: 0.48-0.58). The analysis of the mediating effect revealed that the TCM cultural ambiance directly impacted self-health evaluation and the prevalence of chronic diseases, with coefficients of 1.131 and -0.027 (P < 0.001), respectively. TCM health literacy had a significant mediating effect on the relationship between the cultural promotion ambiance and self-health evaluation, as well as with the prevalence of chronic diseases (P < 0.001). The mediating effect accounted for 17.8% and 42.2% of the total effect, respectively. TCM health literacy served as a mediating factor in the positive relationship between the TCM cultural ambiance and health status. Theoretically, it can improve the overall health of residents by intensifying the dissemination of TCM culture and enhancing their health literacy.

The impact of confirmed cases of COVID-19 on residents’ traditional Chinese medicine health literacy: A survey from Gansu Province of China

Since the outbreak of the new crown epidemic in China in early 2020, the number of confirmed cases of COVID-19 has continued to increase, and the Chinese government’s policy of "static management" in the first round of the epidemic may affect the health behavior adjustment of Chinese residents. Using survey data on the TCM health literacy of 4016 residents in China (Gansu Province), a causal inference approach was used to explore the impact of the emergence of confirmed cases of COVID-19 on residents’ TCM health literacy. We found that the emergence of confirmed cases can increase by 3.5%-7.0% in residents’ TCM health literacy. Among them, the TCM health literacy of uneducated residents has not improved significantly, and the residents with secondary education have increased significantly by 8%. For those with higher education, the number of residents increased significantly by 6%. At the same time, the emergence of confirmed cases will increase the residents’ practical TCM health literacy and decrease theoretical TCM health literacy. Through heterogeneity analysis, we explored the impact mechanism of confirmed cases on residents’ TCM health literacy. We believe that the emergence of confirmed cases will make residents more inclined to participate in TCM-free clinics, theme activities, and other ways to acquire TCM knowledge.

A Randomized Phase 2 Study to Evaluate Efficacy and Safety of AR36 for Prevention of Acute Mountain Sickness

AR36 is a pharmaceutical-grade plant extract used to support cardiovascular health in traditional Chinese medicine. Studies suggest that AR36 may prevent acute mountain sickness (AMS) during gradual ascent to high altitude. This randomized, placebo-controlled Phase 2 trial aimed to evaluate dosing regimens and assess efficacy and safety of AR36 for AMS prevention during rapid ascent. Participants received placebo, low-dose AR36 (225 mg twice daily for 14 d prior and 5 d at altitude), or high-dose AR36 (12 d placebo, 300 mg twice daily for 2 d prior and 5 d at altitude). The primary efficacy outcome was 1993 Lake Louise Scoring System (LLSS) score on the morning after ascent. Safety was assessed through the proportion of treatment-emergent adverse events (TEAEs). One hundred thirty-two participants were randomized. Mean±SD age was 31.4±8.6 (range, 19-54) y. Baseline characteristics did not differ across groups. Lake Louise Scoring System scores on Day 16 in the placebo, low-dose, and high-dose groups were 4.03 (2.88), 4.42 (3.17), and 3.5 (2.31), respectively (placebo versus low-dose, P=0.462; placebo versus high-dose, P=0.574; n=110). The incidence of AMS on Day 16 was 66.7% in the placebo, 61.1% in the low-dose, and 55.3% in the high-dose group (P=0.66). The proportion of TEAEs in the placebo, low-dose, and high-dose groups was 38.4% (81), 28.4% (60), and 33.2% (70), respectively (P=0.205; n=127). There was no statistical difference between groups in LLSS, incidence of AMS, or TEAEs. AR36 did not improve LLSS or AMS incidence using the current regimens. AR36 was well tolerated.

The effects of protein-rich extract from Rhizoma Gastrodiae against cerebral ischemia/reperfusion injury via regulating MAPK and PI3K/AKT signaling pathway

BackgroundRhizoma Gastrodiae is a highly valuable traditional Chinese medicine and functional health food that has been used in China to treat neurological disorders for thousands of years. Rhizoma Gastrodiae contains various of biological activities, such as antioxidative, neuroprotective, learning improvement, anxiolytic, and antidepressant effects. However, no studies have been conducted to explore the effects of the protein components in Rhizoma Gastrodiae (GEPS) and its potential protective effects against ischemic stroke.Our main goal was to investigate the effects of GEPS on ischemia/reperfusion (I/R) injury and its possible mechanisms. MethodsA middle cerebral artery occlusion (MCAO) induced focal cerebral ischemia mouse model and an oxygen-glucose deprivation (OGD/R) injury model in HT22 cells were established. A neurobehavioral test was performed 24 h after MCAO, and brain infarction was measured. A Morris water maze experiment was conducted on Day 14 after reperfusion in mice. Hematoxylin and eosin (HE) and TUNEL staining were performed to assess apoptotic neuronal death. Immunohistochemical analysis was used to detect BDNF and GAP43 expression. The content of SOD, MDA, GSH-PX and ROS were detected. The protein expression was analyzed using Western blotting. Cell viability was determined by MTT assay. Cell apoptosis was examined by flow cytometry. ResultsGEPS reduced apoptosis, decreased cerebral infarction, improved neurological defects, and ameliorated oxidative stress in the ischemic penumbra. In addition, GEPS increased the expression of BDNF and GA43 in the penumbra. Mechanistically, GEPS counteracted MCAO-induced PI3K/AKT inhibition and activation of MAPK signaling pathways. ConclusionGEPS has a clear neuroprotective effect on I/R injury, and its mechanism may be linked to the PI3K/AKT and MAPK signaling pathways.

Evaluation of community basic public health service effect in a city in Inner Mongolia Autonomous Region--based on entropy weight TOPSIS method and RSR fuzzy set.

By analyzing 23 evaluation indicators included in 14 national basic public health service programs in a region of Hohhot City, Inner Mongolia Autonomous Region, China, the performance of basic public health services in the region in 2021 were analyzed to clarify the implementation and conduct of relevant programs. We also use this study as a basis to radiate the work of municipal basic public health services centered on the region and the outstanding problems reflected and to provide theoretical contents and suggestions that can be referred to for the same regions in central and western China as well as worldwide. Using the TOPSIS method as the basis for the data analysis method, the evaluation indexes are ranked in terms of their proximity to the idealized target, and combined with the entropy value method, Technique for order preference by similarity to an ideal solution (TOPSIS) and rank-sum ratio (RSR) were used to rank 14 basic health care providers by grade. A comprehensive evaluation of the performance of basic public health services in a region of Hohhot City, Inner Mongolia Autonomous Region in 2021 was conducted through a joint model of entropy -weighted TOPSIS and RSR, making full use of the characteristics and advantages of the fuzzy joint, and conducting a comprehensive analysis from the perspective of the ratio weight and the method of graded calculation, making the study more distinguishable and measureable. In this study, for the regional basic public health services, a total of 23 evaluation indicators of basic public health service projects were included, among which the top three indicators with the weight of the entropy value method indicators were found to include the rate of Chinese medicine health management for the elderly, the rate of health management for the elderly, and the BCG vaccination rate after the analysis of the weight of the indicators; After the entropy-weighted TOPSIS evaluation showed that the Ci values of the regions were found to be between 0.378 and 0.715 through the calculation of the positive and negative ideal values of each indicator; RSR staging method evaluation showed that three community health centers (X2, X10, X12) had excellent evaluations of basic public health services; The number of evaluations as poor and moderate are 2 (X3, X9) and 9 (X1, X4, X5, X6, X7, X8, X11, X13, X14), respectively; Finally, the results of the entropy-weighted TOPSIS method and the fuzzy joint model of RSR staging method are basically consistent with the overall trend of the above two methods, and the reliability and credibility of the research results are high. The entropy-weighted TOPSIS and RSR joint model can evaluate the effectiveness of basic public health services in a more comprehensive and holistic way. The results of the RSR staging results and the related weight ratio analysis show that the basic public health service programs in Hohhot, Inner Mongolia Autonomous Region are relatively balanced, but there are some differences; The same genus of elderly Chinese medicine health management rate, health management rate of the elderly, BCG vaccination rate several indicators accounted for a higher weight, its correlation with the key population-related items is high, suggesting that the future key population health service items should be focused on, and future research should be suggested from two key research.

The roles of ERIANIN in tumor and innate immunity and its' perspectives in immunotherapy.

Traditional Chinese medicine has been used in China for thousands of years. In 2022, the 14th Five-Year Plan for the Development of Traditional Chinese Medicine was released, aiming to enhance traditional Chinese medicine health services and improve policies and systems for high-quality traditional Chinese medicinal development by 2025. ERIANIN, the main component of the traditional Chinese medicine Dendrobium, plays an important role in anti-inflammatory, antiviral, antitumor, antiangiogenic, and other pharmacological effects. ERIANIN has broad-spectrum antitumor effects, and its tumor-suppressive effects have been confirmed in the study of various diseases, such as precancerous lesions of the stomach, gastric cancer, liver cancer, lung cancer, prostate cancer, bladder cancer, breast cancer, cervical cancer, osteosarcoma, colorectal cancer, leukaemia, nasopharyngeal cancer and melanoma through the multiple signaling pathways. Thus, the aim of this review was to systematically summarise the research on ERIANIN with the aim of serving as a reference for future research on this compound and briefly discuss some future perspectives development of ERIANIN in combined immunotherapy.

Optimization of Rare Ginsenosides and Antioxidant Activity Quality of Ginseng Jiaosu Based on Probiotic Strains and Fermentation Technology

The primary active components of plant ginseng are saponins, and rare saponins play a specific antitumor action. In this study, Lactobacillus that can efficiently transform rare saponins were screened as fermentation strains of ginseng enzymes. The fermentation process was optimized to investigate the changes in various biochemical indicators and antioxidant activities of the enzymes before and after fermentation. The results showed that Lactiplantibacillus plantarum had the highest conversion efficiency for diol saponins, among which the content of rare ginsenoside-CK increased by 256%. The optimum optimizing method was a 1 : 1 : 10 ratio of ginseng extract/concentrated apple juice/water, fermentation time of 16 days, initial pH of 6.0, fermentation temperature of 37°C, and sterilization amount of 1.0%. The contents of rare ginsenoside-Rh1, ginsenoside-F2, ginsenoside-Rg3, and ginsenoside-CK increased by 18.48%, 135.73%, 343.03%, and 441.80%, respectively, and the process was stable and controllable. After fermentation, the scavenging rates for hydroxyl radical, DPPH radical, and superoxide anion radical were increased by more than 9%, and new organic acids were produced. In general, this study established an efficient, stable, and controllable ginseng fermentation process to improve the rare saponin content and biological activity of ginseng enzymes, which can provide new ideas for traditional Chinese medicine and medicinal health food in China.