Karnataka state drought conditions are assessed via drought indices. Over the past several decades, several indices of drought (DI) have been developed and presented, although some of them are region-specific and have problems regarding their applicability to other climatic circumstances. Additionally, choosing the best DI time step to illustrate the drought condition is difficult because of the DIs' various time steps. The study compares the Standardized Precipitation Index (SPI), Statistical Z-Score, China Z-Index (CZI), Rainfall Anomaly Index (RAI), and Rainfall Departure (RD) to determine which one is most appropriate for the districts of the Karnataka state that are prone to both dry and rainy conditions. This study has pointed out that the best drought indices are SPI and RD, and the least accountable drought indice is China Z index. Droughts were most common in 22 districts in 2009, which represent around 70.97% of the state's landmass. In comparison with the rest of the districts, the Ramanagara district noticed the worst drought conditions in 2003, with rainfall reaching 92.47 mm and SPI -3.68, RAI-6.04, MCZI -2.39, and Z score −2.62. Overall, the results of the study will aid in the organization and improvement of drought, flood, agriculture, and water resource management approaches in the state.