The perceptual and physiological speech characteristics of two children treated for brainstem tumours were examined. The differential patterns of performance across the speech profiles of both subjects reflect the variability in severity of dysarthria evident in the brainstem tumour population. Each subject's results were compared with a non-neurologically impaired control group. The perceptual profiles were compiled from a perceptual speech analysis, the Frenchay Dysarthria Assessment; the Children's Speech Intelligibility Measure, and the Fisher-Logemann Test of Articulation Competence. The subject's physiological profiles included the results of the instrumental assessments of the four motor speech subsystems: respiratory, laryngeal, velopharyngeal and articulatory. Case 1, although perceptually reported as not having dysarthric speech, was shown to have a velopharyngeal deficit on instrumental assessment measures. In contrast, Case 2 was found to have deficits across the laryngeal, velopharyngeal and articulatory systems on both perceptual and physiological measures. The case studies provide the first comprehensive perceptual and physiological profiles of the speech outcomes following treatment for brainstem tumours. In addition, the study allowed comparison between the speech profiles of these children with known lesion sites and lower motor neurone (LMN) dysarthria.