In 1984, a paper published by Wolock and Horowitz in the American Journal of Orthopsychiatry drew attention to what they described as ‘the neglect of neglect’ in the prevailing understandings of and responses to child maltreatment. Thirty years on, this expression still resonates even though child neglect has moved out of the shadows and become a central concern for child welfare practitioners and policy makers, and the focus of much research activity. But, while considerably more is now known about the aetiology, identification and assessment of neglect, effective interventions have proved harder to develop. Why is this so, and what can we do about it? The papers in this special issue help us to consider these two questions in more detail. We take as a starting point that child neglect is a complex phenomenon with a range of possible inter-connecting ‘causes’, and that continuing chronic neglect has been shown to have a range of adverse effects on children’s health, development and wellbeing. These effects are wide-ranging, cumulative and damaging over the long-term. If neglect is unlikely to be mono-causal, it seems equally unlikely that any one intervention is going to be successful across the board. Therefore, a variety of intervention responses will be needed, including early intervention strategies that attempt to engage families as soon as neglect is identified, but also encompassing later intervention responses that can be used with families where early identification has not been possible and/or where neglect has become entrenched. This special issue gives us a chance to draw together some reflections on current knowledge and some new ideas about ‘what works’ in practice with families where neglect is a feature of family dynamics. The challenges of developing appropriate responses to neglect are perhaps most usefully understood from a transactional ecological perspective (Brandon et al., 2008) that recognises the complex interplay of factors that can compromise parents’ abilities to offer satisfactory care to their children. Such an approach can also help to make sense of the relational difficulties of this work, in terms of engaging parents in the intervention process. While we know that the long-term effects of neglect are pernicious, practitioners need also to be aware that neglect can be fatal. In the paper that opens this special issue, Brandon et al. (2014) present the results of a study that re-analysed data from 800 serious case reviews (where deaths or very serious maltreatment are examined in detail) in England, interrogating in-depth anonymised information