The Late Jurassic extensional Bisbee Basin in northwestern Mexico and southwestern United States lay between the Pacific magmatic arc and subduction zone and the cratonic Comanche shelf. Aptian to late Albian fluvial, deltaic, and shallow marine sediments and patch reefs of the Bisbee Group filled the basin. The upper Barremian(?)–lower Aptian Cerro de Oro Formation and its equivalent Rancho La Colgada Formation are overlain by the Morita, Mural, Cintura, and La Juana formations. The paralic Morita Formation and the marine Mural Limestone grade southeast into the marine Agua Salada and Lampazos formations, which correlate with deep-water facies in the Chihuahua trough and Tamaulipas Basin. Three late Aptian to middle Albian long-term depositional cycles were approximately 2.5 myr in duration.Foraminifers, calcareous algae, bivalves, rudists, corals, dinoflagellates and scarce ammonites compose the Mural Limestone biostratigraphy. First-occurrence datums of Aptian–Albian benthic Foraminifera are integrated with planktonic Foraminifera and rudists and define biostratigraphic zones that correlate with the Comanche shelf. In the Chihuahua trough and Tamaulipas Basin planktonic Foraminifera and nannofossils identify global zones. Stage boundaries on the Sonora shelf are correlated by a comprehensive biostratigraphic database.Carbon isotope chemozones correlate with Tethyan chemostratigraphy. The lower Aptian OAE 1a and uppermost Aptian–lowest Albian OAE1b chemozone are in the Lampazos section. The negative δ13C excursions and fossil evidence correlate with global Jacob, Kilian, Paquier, and Leenhardt levels. Low-oxygen water masses flooded the shallow shelf and even affected coral-rudist buildups.