Chief Component Research Articles

Antimicrobial activity of some Essential oils and Extracts from Natural sources on Skin and Soft tissue infection causing microbes: An In-vitro Study

Introduction: Skin and soft tissue infections (SSTIs) constitute the diverse group of infections with varied clinical presentation and severity. SSTI’s are the most common infections treated in hospital today posing diagnostic and therapeutic challenges. Natural herbs have been widely used as a potential source of therapeutic substances all over the world. A study was conducted to determine the antimicrobial effect of some natural extracts on important SSTI causing pathogens. Materials and methods: In this study the antimicrobial potential of essential oil of Cinnamomum zeylanicum, Eugenia caryophyllata, oil of Cymbopogon citratus, Melaleuca alternifolia, Mentha piperita, Ocimum sanctum and extracts of Curcuma longa, Azadirachta indica and Cassia fistula were analysed against common skin and soft tissue infections (SSTIs) causing microorganisms. The organisms include methicillin resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), Streptococcus pyogenes, Streptococcus agalactiae, Cutibacterium acnes, E.coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Bacteroides fragilis. The antimicrobial assay was performed by agar punch well method with different concentrations of essential oil and extracts. High performance liquid chromatography (HPLC) was performed in order to identify the active constituents present in the extracts. Further a formulation was made, with the powdered extract (neem, turmeric, bark of golden shower) and cinnamon oil as the chief component to look for any probable synergetic activity. Results and discussion: In this study all the essential oils showed good antimicrobial activity than the crude extracts. Significant activity against the Gram negative organisms was exhibited by all the products used in the study. Cinnamon and Clove oil had an excellent activity against all the organism whereas tea tree, mint and Tulsi oil showed better results against the Gram positive organisms including acne vulgaris causing organisms. HPLC results emphasised the presence of eugenol and cinnamaldehyde in clove and cinnamon oil respectively. A significant zone of inhibition was observed from the formulation prepared. Hence we indicate that the natural products used in this study have therapeutic properties and therefore could be considered as an alternative medication in treatment of SSTIs.

Bovine Milk: A1 and A2 Beta Casein Milk Proteins and their Impact on Human Health: A Review

Milk is the ideal food for all age groups of human being. Milk consists of 87 per cent water and the remaining 13 per cent is the milk sugar lactose, protein, fat, vitamins and minerals. Casein is the chief component of the milk proteins of which about 30 per cent is beta-casein. The major beta-casein variants are A1 and A2. Beta-casein consist a chain of 229 amino acids. Cows that produce milk contain proline amino acid are called as A2 cows. A2 milk is found basically in indigenous cows and buffaloes of India. Around 5,000 years ago, a mutation occurred in this proline amino acid, converting it to histidine amino acid at 67 th position. Cows that have this mutated beta casein protein are called A1 cows. Different mutations bovine beta casein produce 13 genetic variants and out of these A1 and A2 are the most common. A1 β-casein is enzymatically broken down in the intestine to produce beta-casmorphin-7 (β-CM-7) which is an opioid peptide similar to morphine. BCM-7 interacts with the human gastrointestinal tract, internal organs and brainstem. BCM-7 adversely affects the immune response and is also considered as a risk factor for chronic heart diseases (CHD) and juvenile insulin dependent type I diabetes mellitus (DM-I). The original beta casein protein in bovine milk was A2. A2 is more comparable to the human beta casein than A1 in terms of digestive breakdown. Indigenous dairy breeds of cow (Red Sindhi, Sahiwal, Tharparkar, Gir and Rathi) and buffalo produce A2 milk and India is endowed with rich A2 dairy animals.

A Review on the Emergence of Graphene in Photovoltaics Industry

Graphene is considered one of the most significant materials of contemporary time, establishing a high impact in every research field domain and recently setting foot in the commercial market. The exclusive characteristics have made it one of the essential materials for many energy generating devices. Before using graphene electrodes, lithium was mostly used by energy-producing devices, but after the graphene invention, the electrode situation changed. Lithium-ion batteries are now getting attached to graphene electrodes to increase the device's efficiency and energy production rate. This review comprehensively covers the present scenario of leading graphene industries entering the photovoltaics market and highlighting the pristine futuristic vista where it might reign as a chief component in most energy devices. The light weightiness, cost-effective fabrication charge than other 2D materials is more promising for assembling in solar cell industries. It has also spread over benchmark prototypes in solar cars, space crafts, robotics, and artificial intelligence. The article also canvassed the science behind its mechanism in photovoltaics as well as emphasized ingenious modifications by several research institutions and conglomerate industries to exploit this wonder material for the welfare of humankind.

Evaluation of markers of thrombosis and fibrinolysis in malaria patients in tertiary care hospital in Central India

Background: Cases of malaria are known to be associated with variable degrees of coagulopathy asevident from abnormalities of screening coagulation assays in a large number of patients during theillness. However, attempts to use laboratory parameters as indicators of the severity of theunderlying coagulopathy and for monitoring disease progression have met with only partial success.Methods: This prospective study was conducted in the department of Pathology in RuxmanibenDeepchand Gardi Medical College, Ujjain. Blood samples of all the patients diagnosed positive withmalaria were collected in vials containing ethylene tetra-acetic acid tri potassium salt forhematological parameters and in trisodium citrate tubes for coagulation assays. Result: Out of thetotal positive cases, PT was prolonged in 65% of total cases, Percentage positivity for prolonged PTfor falciparum and vivax is 60% and 68.5% respectively. APTT has raised 47% of malaria positivecases with percentage positivity for falciparum and vivax 48% and 45.7% respectively. 55% of totalcases showed raised levels of fibrin degradation products, which included 48% of falciparum casesand 60% of vivax cases. Out of 120 positive cases of malaria, D- Dimer was raised 41.7% cases.Conclusion: As blood is the chief component affected by malaria, not only proper examination ofperipheral smears is required for detection and species identification, but a careful evaluation ofother laboratory parameters should be done irrespective of the malarial species for the earlydiagnosis of compensatory and non-compensatory consumptive coagulopathy.

Automated GSM-based un-locker system

This work presents the design and construction of an SMS-based unlocker system that will allow users to lock or unlock a specific door without using the conventional method. The chief component used in the design of this device is the Atmega328 microcontroller (IC1). The device was designed in modules that include the system power supply unit, microcontroller unit, PIR motion sensor, and GSM SIM900 module. These discrete parts or components on their own are made up of smaller components. The different modules were put together in a particular pattern to form the circuit design. SMS from the authorized user’s mobile phone enables the Arduino controller to automatically unlock the security door when necessary. Basically, it reads the SMS and acts according to the message command, hence allowing the authorized owner to remotely control the door from anywhere using a mobile phone and preventing unauthorized access to the door. The GSM based door unlocking system constructed worked effectively when tested in homes and office doors and is thus recommended in every home for security purposes.

A holistic approach for melanoidin removal via Fe-impregnated activated carbon prepared from Mangifera indica leaves biomass

Melanoidins are dark brown coloured complex amino‑carbonyl biopolymer comprising the chief component present in the distillery wastewater with high organic load. In this study, melanoidin removal from a simulated wastewater system was examined via Fe-impregnated activated carbon. Initially, three different leaf-waste biomass (Ficus benghalensis, Ficus religiosa and Mangifera indica) were utilized for preparing the activated carbon followed by impregnation of iron. Further, these prepared activated carbons were characterized via SEM equipped with EDX, XRD, FTIR, and BET analyses. A Box-Behnken design of experiments was employed for evaluating the effect of various parameters onto the melanoidin removal. With the adsorbent dose (62.5 mg/L), initial melanoidin concentration (550 mg/L), temperature (40 °C) and contact time (75 min) and Fe-adsorbent ratio (30%), the maximum melanoidin removal (85.6%) was achieved from waste leaf biomass of M. indica, depicting its potential for the melanoidin removal from wastewater.

Interspecific Inhibitory Interference of Nicotiana plumbaginifolia Viv. on Pisum sativum L.

Roots of weeds that are left behind in the soil after removal of their aerial parts can reduce the growth of crops. Here we conducted an assessment to evaluate the allelopathic interference of Nicotiana plumbaginifolia roots and its rhizosphere soil on the growth of Pisum sativum L., identification of chemicals involved, the role of charcoal, the role of N and other macronutrients. Growth responses of P. sativum were analysed for (a) rhizosphere soil with and without N supplementation and (b) soil amendment with Nicotiana roots. Scanning electron microscopy-energy dispersive spectrometry (SEM–EDS) analysis of the rhizosphere soil was conducted to look for concentration of essential nutrients. Rhizosphere soil showed an inhibitory effect even with N supplementation. SEM–EDS showed a healthy concentration of essential nutrients. Root residues of Nicotiana integrated with soil do cause a reduction in seedling length (root length, shoot length) and dry biomass of recipient plant. However, a partial alleviation in growth inhibition occurred upon the addition of activated charcoal. Soils amended with root residues were rich in phenolics as compared to control. Overall, 34 compounds were reported upon GC–MS analysis which can be considered responsible for the allelopathic suppression of P. sativum. The chief component was guanosine (26.21%) followed by n-hexadecanoic acid (18.61%), oleic acid (18.29%), palmitoleic acid (4.80%), -(-)nicotine (5.09%) and solasodine (2.54%). These results show a definite role of putative allelochemicals that exerted allelopathic effects on P. sativum.

Effects of anthropogenic discharge and hydraulic deposition on the distribution and accumulation of microplastics in surface sediments of a typical seagoing river: The Haihe River

Microplastics pollution in river systems has generated great concern; however, few studies have focused on the contributions of multiple influencing factors to microplastics in river systems. In the current study, we utilized data on microplastics in surface sediments from the Haihe River, a seagoing river in northern China to establish a generalized additive model (GAM) for quantifying the effects of multiple factors on the distribution of microplastics. A high abundance of microplastics (4980 ± 2462 items∙kg−1 dry weight) was found. Small particles (< 1000 µm) accounted for a dominant proportion (44.8−61.0%). Polyethylene (PE) was the chief component with an averaged fraction of 49.3%, in which low- and high-density polyethylene contributed 90.7% and 9.3% of the PE, respectively. Microplastics abundance was positively correlated with sediment TOC and the silt fraction (p < 0.05) but negatively correlated with the sand fraction (p < 0.05). The GAM could explain approximate 60% of the total microplastics abundance, and dam (28.5%), sediment TOC (22.9%), and sewage effluent (17.6%) were the main contributors to total variations in microplastics abundance. Local sewage effluent acted as an important point source of microplastics discharge, and the dam on the river greatly affected the deposition and accumulation of microplastics.

An Experimental Study on The Influence of Nano Silica on the Strength and Durability Characteristics of Self Compacting Concrete

Self-compacting concrete (SCC) is also considered as a concrete which can be placed and compacted under its own weight with little or no vibration without segregation or bleeding. The use of SCC with its improving productions techniques is increasing everyday in concrete production. It is used to facilitate and ensure proper filling and good structural performance of heavily reinforced structural members. Recently, nano particles have been gaining increasing attention and have been applied in many fields to fabricate new materials with novel functions due to their unique physical and chemical properties. Degradation of concrete members exposed to aggressive sulphuric acid environments is a key durability issue that affects the life cycle performance and maintenance costs of vital civil infrastructure. Sulphuric acid in groundwater, chemical waste or generated from the oxidation of sulphur bearing compounds in backfill can attack substructure concrete members. Moreover, concrete structures in industrial zones are susceptible to deterioration due to acid rain of which sulphuric acid is a chief component. In this work 40Mpa self-compacting concrete is developed using modified Nan-Su method of mix design. Slump flow, J-Ring, V-funnel tests are conducted to justify the fresh properties of SCC and are checked against EFNARC (2005) specifications. Specimens of dimensions 150x150x150mm were cast without nano silica and with two nano silica are added in different percentages(1%, 1.5% and 2% by weight of cement) to SCC. To justify the compressive strength for 7 and 28days, specimens are tested under axial compression. Durability properties were also studied by immersing the specimensin5% HCl and5% H2SO4. The particle packing in concrete can be improved by using Nano-silica which leads to densifying of the micro and nanostructure resulting in improved mechanical properties. Nano-silica addition to cement based materials can also control the degradation of the fundamental C-S-H (calcium-silicate-hydrate) reaction of concrete caused by calcium leaching in water as well as block water penetration and therefore lead to improvements in durability.

A study of antioxidant and antibacterial activity using honey mediated Chromium oxide nanoparticles and its characterization

Honey is authenticated as the world’s prehistoric food source with incomparable therapeutic, biochemical, physical, and curative values. Chromium oxide nanoparticles were precipitously generated by reduction of potassium dichromate solution in collaboration with natural honey holding carbohydrates as a chief component which perform as reducing agent. The outcome suggests that water soluble carbohydrates have aldehyde group cause the formation of Cr2O3 nanoparticles. The properties of the prepared Cr2O3 nanoparticles were characterized using several techniques such as UV–Visible, FT-IR, SEM, EDAX, XRD and AFM. The FT-IR studies reveals that the broad band of low intensity at 1165.00 cm−1 can be found to be the surface Cr-O stretching vibrations. The SEM image illustrates the rocky structure of the prepared nanoparticle. The AFM image exhibits the topography of Cr2O3nanoparticles in 3.13 µm resolution for 2D and 3D view with current passing over the probe with the scanning area of 9.842 pm2. The XRD result concludes the average size of Cr2O3 nanoparticles as 24.7205 nm. The antioxidant study shows the fluctuation in percentage of antioxidant activity as the concentration varies. The antibacterial activity explains clearly that the prepared sample has zone inhibition with the 3 pathogens studied. Thus the honey medicated nanoparticle synthesis provides a simple, cost effective, reproducible, rapid, and safe method with numerous applications.

Novel green phosphorene sheets to detect tear gas molecules - A DFT insight

The green phosphorene (GP) nanosheet, one of the allotropes of layered phosphorene is employed to detect the existence of tear gas molecules. The tear gas molecules such as 1-bromo-2-butanone, bromoacetone, and bromobenzyl cyanide are examined with the service of the ATK-VNL package by employing density functional theory (DFT) method. The geometrical stability of the chief component is affirmed with the support of formation energy and electronic fingerprints of GP nanosheet like electron density, band structure, and projected density of states (PDOS) spectrum are estimated. In this research work, using DFT technique, for the first time, surface adsorption characteristics of the target molecules on GP nanosheet are explored with the assistance of adsorption energy, average energy gap variation, and Bader charge transfer, which further suggest the deployment of GP in sensing the presence of tear gas molecules.

Evaluation of cardioprotection and bio-efficacy enhancement of stevioside and diltiazem in rats

BackgroundCardiovascular diseases and resultant complications of cardio-therapeutic regimens are one of the leading causes of mortalities in developing countries. Diltiazem is a calcium channel blocker primarily used in treatment of supraventricular arrhythmias, systemic hypertension, and hypertrophic cardiomyopathy. Stevioside, the chief component of Stevia plant, is a natural sweetener that has significant therapeutic properties. Stevioside is a known bioenhancer that acts by synergizing pharmacological activities of other drugs. Present study was designed to evaluate cardioprotective activity of stevioside and possible bioenhancement upon co-administration with diltiazem. Standard cardiotoxicity models—isoproterenol-induced myocardial infarction and ischemia-reperfusion injury (IRI) through modified Langendorff setup was used to test this hypothesis. Rats were randomly divided into control groups (normal—physiological saline and toxic—isoproterenol, 150 mg/kg, s.c., and IRI induced in normal control animals) and treatment groups (diltiazem—17.5 mg/kg, p.o., stevioside—100 and 200 mg/kg, p.o. and combination groups). At the end of the treatment period, animals were sacrificed and biochemical, electrocardiographic, and histopathological changes were measured.ResultsPre-treatment with stevioside prevented leakage of biomarkers and normalized serum and perfusate levels of CK-MB, CK-NAC, LDH, AST, and ALT enzymes. It displayed lipid-lowering effect on TC and TG levels dose dependently. STV also showed protective action on levels of tissue antioxidant enzymes (SOD and Catalase), electrocardiographic parameters (HR, RR, QRS, QT, PR), and heart tissue histopathology when compared to concurrent toxic control groups. Combination of stevioside (200 mg/kg) and diltiazem (17.5 mg/kg) exerted a more significant pharmacodynamic response, significantly restored biomarkers, antioxidants levels, and myocardial histology, and normalized electrocardiographic parameters.ConclusionStevioside and diltiazem both displayed cardioprotective effect when given alone. Co-administration displayed improved restorative action on antioxidant status, biomarkers, electrocardiographic parameters, and histology.

A Review on Pharmacovigilance Process In India

Peoples are using more potent drugs with various medical conditions. pharmacovigilance helps in safe and convenient use of pharmaceutical drugs. Voluntary recording of adverse drug reactions (ADRs) is a chief component of pharmacovigilance. Adverse drug reactions have become a dominant health related problems in developing countries like India. The main objective of pharmacovigilance is the assessment of benefit-risk profile of drug for better potency and safety in patients. In terms of volume India pharmaceutical industries is third largest in the world so India has a core of clinical research and drug design &amp; development. This review article explains the need of pharmacovigilance in pharma companies, the growth of pharmacovigilance in different centuries and current status of pharmacovigilance in the country.&#x0D;

Interaction studies of aniline on pristine and Al-doped ε-Arsenene nanosheets – A first-principles insight

The ε-form of Arsenene Nanosheet (ε-AsNs) is exercised as a chief component in the present study. In addition, substitution doping of a group-IIIA element – Aluminium on ε-AsNs is performed. The electronic properties, namely, the energy band gap and electron difference density are evaluated for the isolated ε-AsNs and Al-doped ε-AsNs along with the aniline interacted chief component. Further, the interaction properties, namely, the Bader charge transfer, binding energy together with average energy gap deviation are also dealt with in the current report. The findings propound the utility of Al-doped ε-AsNs to sense the ubiquity of aniline vapor.

5‐HT2 Receptor Activation Differentially Modulates Linker Histone Kinetics and Histone Deacetylase Activity

IntroductionAlterations to chromatin dynamics and histone modification represent crucial processes metazoan cells employ to influence regulation and gene expression. As such, modification to the mobility of the linker histone, the chief component of chromatin compaction and higher‐order chromatin architecture, significantly impacts downstream transcriptional regulation and cellular processing. At present, the contributions of serotonergic signaling to not only heritable epigenetic modification but also higher‐order chromatin structure are a matter of intense research focus. Through both in vitro and in vivo assays, our lab has shown that serotonin 5‐HT2A receptor agonists (psychedelics) exhibit differential efficacy and potency in their ability to prevent inflammatory pathway activation. Modulation to both overall chromatin structure and epigenetic signaling may represent a potential mechanism that psychedelics employ to promote their long‐lasting, therapeutic effects.ObjectivesWe sought to evaluate the impact of chromatin compaction and histone acetylation on 5‐HT2A functional selectivity in human embryonic kidney cells stably expressing the 5‐HT2A receptor.MethodsWe utilized fluorescence recovery after photobleaching (FRAP) to probe the kinetics of the linker histone H1c transiently transfected into the aforementioned HEKH2A cell line. We concurrently measured histone deacetylase (HDAC) activity following exposure to numerous 5‐HT2A agonists.Results5‐HT itself minimally impacts H1c mobility, whereas compounds such as psilocin and the highly selective 5‐HT2 agonist (R)‐2,5‐dimethoxy‐4‐iodoamphetamine [(R)‐DOI] significantly slow H1c kinetics. Interestingly, these changes to linker histone mobility do not correlate with putative epigenetic regulation, as 5‐HT2A compounds with anti‐inflammatory properties reduce histone deacetylase (HDAC) activity, whereas antagonism of the 5‐HT2A receptor induces HDAC activity.ConclusionTogether, this data illustrates that agonism of 5‐HT2A receptors induce unique changes to chromatin architecture and HDAC activity, a conceivable mechanism psychedelics might employ to promote their potent therapeutic properties. Translationally, while HDAC inhibitors have emerged as attractive agents in cancer therapy and asthma treatment, their utility is limited by off‐target toxicity. 5‐HT2A receptor activation represents a potentially more promising therapeutic strategy to modulate histone acetylation patterns for therapeutic effects.Support or Funding InformationSupport from this work was provided in part by the Eleusis Benefit Corporation and the LSU Foundation.

Graphdiyne nanosheets as a sensing medium for formaldehyde and formic acid – A first-principles outlook

Formaldehyde and formic acid (in its vapor form) are considered as target vapors in the current study, and the ability of graphdiyne nanosheet to detect target vapors is scrutinized. First and foremost, the stable conduct of the intended prime material, graphdiyne nanosheet is ascertained with the help of cohesive formation energy. Furthermore, the electronic characteristics like band structure, the projected density of states spectrum and electron density are investigated for the solitary and target vapor adsorbed graphdiyne nanosheet. Finally, the adsorption characteristics of the target vapor on the chief component namely the Bader charge transfer, adsorption energy and average energy gap variation are assessed for all the cases. The investigation, as a whole, suggests the deployment of graphdiyne nanosheet as a chief component in detecting formaldehyde and formic acid vapors.

Efficacy and safety of core stability training on gait of children with cerebral palsy: A protocol for a systematic review and meta-analysis.

Background:Cerebral palsy (CP) is a common disability in children featured with pathological gait and limb function limitation due to muscle weakness. Improving limb function and quality of life is currently considered to be highlighted. Physiotherapy is a chief component of rehabilitation for children with CP, correcting gait and improve walking capacity through muscle strength training. Standard rehabilitation programs for CP have not been determined. Core stability training (CST), which coordinates limb balance via trunk control, is widely used in sports competition. And it is gradually introduced into the rehabilitation of children with cerebral palsy with a positive impact on the patients’ gait performance. By screening published literatures, this study aims to conduct a meta-analysis to systematically evaluate the effectiveness and safety of CST in gait of children with CP.Methods:Randomized controlled trials (RCTs) and controlled clinical trials (CCTs) on CST in the treatment of children with CP were searched from 6 databases. Moreover, the reference lists of conference papers and included literatures will be manually searched to avoid omissions. Literature screening and data extraction were performed independently by 2 researchers. RCTs carry out the risk of bias analysis evaluation from seven aspects through the Cochrane Collaboration's risk of bias tool. Fixed or random effect model will be performed to analyze the outcomes. When higher heterogeneity occurs (I2 > 50%), the sensitivity or subgroup analysis will also be conducted to find potential factors. And the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach is used for assessing the quality of evidence.Results:The study will evaluate the effect of CST on gait of children with CP from multiple outcomes, including walking speed, endurance, stride length, and safety.Conclusion:Based on evidence-based medicine, the conclusion of this study can demonstrate the effectiveness and safety of CST in gait correction for children with CP.PROSPERO registration number:PROSPERO CRD 42019134094.

Schematizing Insured Healthcare Dossiers in Cloud using Blockading Maneuver Sequence Amplification (BMSA)

Blockade technology in healthcare industry captures the focus in the newfangled years. As a major development it has resulted in the inclusion even in marketing commerce. This progression has enriched the user preoccupied with pharmaceutical sector consequently endorsing possible manipulations and potentials. This conduct in blockading maneuver is done by calculating total file numerals through tokenization which subsequently processed by encryption. Whereas Cloud-Based Manufacturing delegates on-demand ingress to manufacturing stratagems, a reliable emissary is required for transactions between the users who aspire to suffice manufacturing services. Therefore it results in counting to the lines that are availed in an indicted block by the usage of that exacting value derived by division. The health records enclosed in a block is encrypted by blockading maneuver accordingly. In the previous works only permission is accessed to the user and encrypts the whole file. This concept of blockage advances in displaying contents in attendance and also permits to read the intact block. The files are stocked up in a block to encrypt them each. This method in endowing two strategies upshots in reducing decryption time. Ensuring data availability and uploading data by the user in encrypted form is scrutinized as a chief component in this line of attack.

Whole slide imaging system using deep learning-based automated focusing.

The auto focusing system, which involves moving a microscope stage along a vertical axis to find an optimal focus position, is the chief component of an automated digital microscope. Current automated focusing algorithms, especially those deployed in cost effective microscopy systems, often cannot match the efficiency of a skilled human operator in keeping a sample in focus. This work presents an auto focusing system that utilises the recent advances in machine learning, namely deep convolutional neural networks (CNN). It improves upon prior work in this domain. The results of the focusing algorithm are demonstrated on an open data set. We describe the practical implementation of this method on a low cost digital microscope to create a whole slide imaging system (WSI). Results of a clinical study using this WSI system are presented. The study demonstrates the efficacy of this system in a practical scenario.

Expedition on surface adsorption of N-nitrosodiethylamine from rubber fumes on blue phosphorene sheets – a first-principles insight

In recent days, humans are easily exposed to many work-related health issues. N-nitrosodiethylamine (NDE), which is considered to be a harmful carcinogenic agent released from rubber-based industries imparts a long-lasting effect on human health and immunity system. The current research investigates the ability of the two-dimensional nanomaterial, blue phosphorene nanosheet (BPNS) to detect the presence of NDE in the environment. Besides, the electronic and structural characteristics of BPNS are initially explored and NDE target vapour is permitted to interact with the chief component, BPNS. We have also designed blue phosphorene device to study the adsorption properties of NDE vapours based on current–voltage characteristics. The adsorption attributes are accounted for the target vapour adsorbed chief component, the results suggest that BPNS can be employed in detecting NDE vapours.