Abstract
Background: Cases of malaria are known to be associated with variable degrees of coagulopathy asevident from abnormalities of screening coagulation assays in a large number of patients during theillness. However, attempts to use laboratory parameters as indicators of the severity of theunderlying coagulopathy and for monitoring disease progression have met with only partial success.Methods: This prospective study was conducted in the department of Pathology in RuxmanibenDeepchand Gardi Medical College, Ujjain. Blood samples of all the patients diagnosed positive withmalaria were collected in vials containing ethylene tetra-acetic acid tri potassium salt forhematological parameters and in trisodium citrate tubes for coagulation assays. Result: Out of thetotal positive cases, PT was prolonged in 65% of total cases, Percentage positivity for prolonged PTfor falciparum and vivax is 60% and 68.5% respectively. APTT has raised 47% of malaria positivecases with percentage positivity for falciparum and vivax 48% and 45.7% respectively. 55% of totalcases showed raised levels of fibrin degradation products, which included 48% of falciparum casesand 60% of vivax cases. Out of 120 positive cases of malaria, D- Dimer was raised 41.7% cases.Conclusion: As blood is the chief component affected by malaria, not only proper examination ofperipheral smears is required for detection and species identification, but a careful evaluation ofother laboratory parameters should be done irrespective of the malarial species for the earlydiagnosis of compensatory and non-compensatory consumptive coagulopathy.
Highlights
William Osler has said that “Humanity” has but 3 great enemies; fever, famine, and war; of these by far the greatest, by far the most terrible is fever”.Malaria is the most important protozoal parasitic disease of humans
Result: Out of the total positive cases, Prothrombin time (PT) was prolonged in 65% of total cases, Percentage positivity for prolonged PT for falciparum and vivax is 60% and 68.5% respectively
As blood is the chief component affected by malaria, proper examination of peripheral smears is required for detection and species identification, but a careful evaluation of other laboratory parameters should be done irrespective of the malarial species for the early diagnosis of compensatory and non-compensatory consumptive coagulopathy
Summary
William Osler has said that “Humanity” has but 3 great enemies; fever, famine, and war; of these by far the greatest, by far the most terrible is fever”.Malaria is the most important protozoal parasitic disease of humans. WHO estimated worldwide prevalence of malaria is about 300- 500 million per annum. It is present in more than 100 countries around the world. Cases of malaria are known to be associated with variable degrees of coagulopathy as evident from abnormalities of screening coagulation assays in a large number of patients during the illness. Blood samples of all the patients diagnosed positive with malaria were collected in vials containing ethylene tetra-acetic acid tri potassium salt for hematological parameters and in trisodium citrate tubes for coagulation assays. Result: Out of the total positive cases, PT was prolonged in 65% of total cases, Percentage positivity for prolonged PT for falciparum and vivax is 60% and 68.5% respectively. APTT has raised 47% of malaria positive cases with percentage positivity for falciparum and vivax 48% and 45.7% respectively. Conclusion: As blood is the chief component affected by malaria, proper examination of peripheral smears is required for detection and species identification, but a careful evaluation of other laboratory parameters should be done irrespective of the malarial species for the early diagnosis of compensatory and non-compensatory consumptive coagulopathy
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
