Imaging Cherenkov Research Articles

Imaging Cherenkov emission for quality assurance of high-dose-rate brachytherapy

With advances in high-dose-rate (HDR) brachytherapy, the importance of quality assurance (QA) is increasing to ensure safe delivery of the treatment by measuring dose distribution and positioning the source with much closer intervals for highly active sources. However, conventional QA is time-consuming, involving the use of several different measurement tools. Here, we developed simple QA method for HDR brachytherapy based on the imaging of Cherenkov emission and evaluated its performance. Light emission from pure water irradiated by an 192Ir γ-ray source was captured using a charge-coupled device camera. Monte Carlo calculations showed that the observed light was primarily Cherenkov emissions produced by Compton-scattered electrons from the γ-rays. The uncorrected Cherenkov light distribution, which was 5% on average except near the source (within 7 mm from the centre), agreed with the dose distribution calculated using the treatment planning system. The accuracy was attributed to isotropic radiation and short-range Compton electrons. The source positional interval, as measured from the light images, was comparable to the expected intervals, yielding spatial resolution similar to that permitted by conventional film measurements. The method should be highly suitable for quick and easy QA investigations of HDR brachytherapy as it allows simultaneous measurements of dose distribution, source strength, and source position using a single image.

Space application: The AMS RICH

A Ring Imaging Cherenkov detector is on board the Alpha Magnetic Spectrometer, for mass and charge identification of charged cosmic rays. AMS is a high-energy particle physics magnetic spectrometer in space, which was successfully installed at the International Space Station on May 2011 to perform accurate measurements of Galactic Cosmic Rays fluxes in the rigidity range from 1 GV to a few TV. The RICH detector provides AMS the capability to measure the light nuclei isotopic composition of CRs, in the kinetic energy range from a few GeV/nucleon to about 10 GeV/nucleon, so far largely uncovered by previous experiment. In addition, the RICH is a key detector in indirect search for Dark Matter looking at the antiproton and anti-deuteron rare species.The detector has shown stable response during the past 8 years of continuous data taking and no significant indication of degradation has been observed. Once accounted for the extreme environmental conditions of the detector in space and their variation in time, the performances in velocity end charge measurements match the requirements. The different stages of the AMS-RICH construction, from design to commissioning through space qualification and characterization tests, are addressed in this paper, in the aim of highlighting the important aspects which contributed to the success of this detector, only of its kind operative in a long duration mission in space.

The Great Markarian 421 Flare of 2010 February: Multiwavelength Variability and Correlation Studies

Abstract We report on variability and correlation studies using multiwavelength observations of the blazar Mrk 421 during the month of 2010 February, when an extraordinary flare reaching a level of ∼27 Crab Units above 1 TeV was measured in very high energy (VHE) γ-rays with the Very Energetic Radiation Imaging Telescope Array System (VERITAS) observatory. This is the highest flux state for Mrk 421 ever observed in VHE γ-rays. Data are analyzed from a coordinated campaign across multiple instruments, including VHE γ-ray (VERITAS, Major Atmospheric Gamma-ray Imaging Cherenkov), high-energy γ-ray (Fermi-LAT), X-ray (Swift, Rossi X-ray Timing Experiment, MAXI), optical (including the GASP-WEBT collaboration and polarization data), and radio (Metsähovi, Owens Valley Radio Observatory, University of Michigan Radio Astronomy Observatory). Light curves are produced spanning multiple days before and after the peak of the VHE flare, including over several flare “decline” epochs. The main flare statistics allow 2 minute time bins to be constructed in both the VHE and optical bands enabling a cross-correlation analysis that shows evidence for an optical lag of ∼25–55 minutes, the first time-lagged correlation between these bands reported on such short timescales. Limits on the Doppler factor (δ ≳ 33) and the size of the emission region ( ) are obtained from the fast variability observed by VERITAS during the main flare. Analysis of 10 minute binned VHE and X-ray data over the decline epochs shows an extraordinary range of behavior in the flux–flux relationship, from linear to quadratic to lack of correlation to anticorrelation. Taken together, these detailed observations of an unprecedented flare seen in Mrk 421 are difficult to explain with the classic single-zone synchrotron self-Compton model.

Intraoperative 68Ga-PSMA Cerenkov Luminescence Imaging for Surgical Margins in Radical Prostatectomy: A Feasibility Study.

Our objective was to assess the feasibility and accuracy of Cerenkov luminescence imaging (CLI) for assessment of surgical margins intraoperatively during radical prostatectomy. Methods: A single-center feasibility study included 10 patients with high-risk primary prostate cancer (PC). 68Ga-prostate-specific membrane antigen (PSMA) PET/CT scans were performed followed by radical prostatectomy and intraoperative CLI of the excised prostate. In addition to imaging the intact prostate, in the first 2 patients the prostate gland was incised and imaged with CLI to visualize the primary tumor. We compared the tumor margin status on CLI to postoperative histopathology. Measured CLI intensities were determined as tumor-to-background ratio. Results: Tumor cells were successfully detected on the incised prostate CLI images as confirmed by histopathology. Three of 10 men had histopathologically positive surgical margins (PSMs), and 2 of 3 PSMs were accurately detected on CLI. Overall, 25 (72%) of 35 regions of interest proved to visualize a tumor signal according to standard histopathology. The median tumor radiance in these areas was 11,301 photons/s/cm2/sr (range, 3,328-25,428 photons/s/cm2/sr), and median tumor-to-background ratio was 4.2 (range, 2.1-11.6). False-positive signals were seen mainly at the prostate base, with PC cells overlaid by benign tissue. PSMA immunohistochemistry revealed strong PSMA staining of benign gland tissue, which impacts measured activities. Conclusion: This feasibility showed that 68Ga-PSMA CLI is a new intraoperative imaging technique capable of imaging the entire specimen's surface to detect PC tissue at the resection margin. Further optimization of the CLI protocol, or the use of lower-energy imaging tracers such as 18F-PSMA, is required to reduce false-positives. A larger study will be performed to assess diagnostic performance.

Forward production of nuclear fragments in CC collisions at beam energy 20.5 GeV/nucleon

The inclusive differential cross sections for forward production of nuclear fragments at an angle of 0∘ in CC collisions at beam energy 20.5 GeV/nucleon (SNN=6.3GeV) are presented. Measurements have been performed at the U-70 Accelerator Complex (Protvino) using a combined spectrometer on base of the beamline. Fragments selection was carried out by measuring of ionization in scintillation counters taking into account the data from threshold Cherenkov counters and hadron calorimeter. Fragment mass was determined through Cherenkov light emission angle measured in the spectrometer of ring imaging Cherenkov radiation. Data are given for fragments with charge 1≤Z≤6, atomic number 1≤A≤10 and A/Z<3.4 with momenta from 20 to 210 GeV/c. The measurements are compared with Fritiof model, statistical models and theoretical parameterizations. The discovered differences between theory and experiment are discussed.

Machine learning for imaging Cherenkov detectors

Imaging Cherenkov detectors are largely used in modern nuclear and particle physics experiments where cutting-edge solutions are needed to face always more growing computing demands. This is a fertile ground for AI-based approaches and at present we are witnessing the onset of new highly efficient and fast applications. This paper focuses on novel directions with applications to Cherenkov detectors. In particular, recent advances on detector design and calibration, as well as particle identification are presented.

Simultaneous muon and reference hadron measurements in the compressed baryonic matter experiment at FAIR

The mission of the Compressed Baryonic Matter (CBM) experiment at the future Facility for Antiproton and Ion Research (FAIR) in Darmstadt is to explore the QCD phase diagram at high net baryon densities likely to exist in the core of neutron stars. The CBM detector system is designed to perform multi-differential measurements of hadrons and leptons in central gold-gold collisions at beam energies between 2 and 11 A GeV with unprecedented precision and statistics. In order to reduce the systematic errors of the lepton measurements, which generally suffer from a large combinatorial background, both electrons and muons will be measured with the same acceptance. Up to now, no di-muon measurements have been performed in heavy-ion collisions at beam energies below 158 A GeV. The main device for electron identification, a Ring Imaging Cherenkov (RICH) detector, can be replaced by a setup comprising hadron absorbers and tracking detectors for muon measurements. In order to obtain a complete picture of the reaction, it is important to measure simultaneously leptons and hadrons. This requirement is fulfilled for the RICH, which has a low material budget, and only little affects the trajectories of hadrons on their way to the Time-of-Flight (TOF) detector. In contrast, the simultaneous measurement of muons and hadrons within the same experimental acceptance poses a substantial challenge. This article reviews the simulated performance of the CBM experiment for muon identification, together with the possibility of simultaneous hadron measurements.

RICH detectors development for hadron identification at EIC: design, prototyping and reconstruction algorithm

The extended experimental physics program accessible with the proposed Electron-Ion Collider (EIC) strongly demands for excellent particle identification (PID) of the final state hadrons. In this context two Ring Imaging Cherenkov (RICH) detectors are under development within the EIC PID consortium (EIC-eRD14 Collaboration) explicitly formed to investigate and develop PID detectors for EIC. We present the current status of development of the two RICHes: a modular RICH detector which consists of an aerogel radiator, a Fresnel lens, a mirrored box, and pixelated photon sensor; a dual-radiator RICH, consisting of an aerogel radiator and C2F6 gas in a mirror-focused configuration.

Fast Sampling and Read-Out for Ground-Based Imaging Cherenkov Telescopes

The SCT telescope has been proposed as a medium-sized telescope for the Cherenkov Telescope Array. One of the major upgrades is the design of the new Front End Electronics Module (FEEM). New FEEMs aim to read-out and digitize the SiPM pre-amplified signals down to the single photoelectron (phe). This phe signal is assumed equivalent to a signal with 2 mV peak amplitude and 500 MHz maximum bandwidth. FEEM should have a linear response up to 2 V for a required dynamic range of 1000 phe. FEEM noise equivalent of 0.5 phe - 1 mV of RMS noise - is an acceptable value. Due to the severe mechanical constraints, and to have a very compact electronics and low noise performance, FEEM consists of two stacked-up submodules, one dedicated to the power supplies and the other to house the FPGA, which reads out and sends digitized data to the main backplane. An FEEM is capable of digitizing 64 analog channels with a sampling frequency of 1 GSamples/s.

Data acquisition and trigger system for imaging atmospheric Cherenkov telescopes of the LHAASO

The Wide Field of View Cherenkov Telescope Array is an important part of the Large High Altitude Air Shower Observatory. The array adopts atmospheric Cherenkov imaging technology. The data acquisition and trigger system is central to each telescope's electronics readout system. To acquire as many Cherenkov events as possible, the system uses a two-level trigger design and partial readout technology. A telescope uses silicon photomultiplier tubes as the detector, whose status (e.g., in terms of the temperature and voltage) is monitored by the system. The instruction protocol of the system is presented.

Statistics of VHEγ-rays in temporal association with radio giant pulses from the Crab pulsar

Aims.The aim of this study is to search for evidence of a common emission engine between radio giant pulses (GPs) and very-high-energy (VHE,E &gt; 100 GeV)γ-rays from the Crab pulsar.Methods.We performed 16 h of simultaneous observations of the Crab pulsar at 1.4 GHz with the Effelsberg radio telescope and the Westerbork Synthesis Radio Telescope (WSRT), and at energies above 60 GeV we used the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) telescopes. We searched for a statistical correlation between the radio and VHEγ-ray emission with search windows of different lengths and different time lags to the arrival times of a radio GP. A dedicated search for an enhancement in the number of VHEγ-rays correlated with the occurrence of radio GPs was carried out separately for the P1 and P2 phase ranges, respectively.Results.In the radio data sample, 99444 radio GPs were detected. We find no significant correlation between the GPs and VHE photons in any of the search windows. Depending on phase cuts and the chosen search windows, we find upper limits at a 95% confidence level on an increase in VHEγ-ray events correlated with radio GPs between 7% and 61% of the average Crab pulsar VHE flux for the P1 and P2 phase ranges, respectively. This puts upper limits on the flux increase during a radio GP between 12% and 2900% of the pulsed VHE flux, depending on the search window duration and phase cuts. This is the most stringent upper limit on a correlation betweenγ-ray emission and radio GPs reported so far.

Optical imaging method to quantify spatial dose variation due to the electron return effect in an MR-linac.

Treatment planning systems (TPSs) for MR-linacs must employ Monte Carlo-based simulations of dose deposition to model the effects of the primary magnetic field on dose. However, the accuracy of these simulations, especially for areas of tissue-air interfaces where the electron return effect (ERE) is expected, is difficult to validate due to physical constraints and magnetic field compatibility of available detectors. This study employs a novel dosimetric method based on remotely captured, real-time optical Cherenkov and scintillation imaging to visualize and quantify the ERE. An intensified CMOS camera was used to image two phantoms with designed ERE cavities. Phantom A was a 40cm×10cm×10cm clear acrylic block drilled with five holes of increasing diameters (0.5, 1, 2, 3, 4cm). Phantom B was a clear acrylic block (25cm×20cm×5cm) with three cavities of increasing diameter (3, 2, 1cm) split into two halves in the transverse plane to accommodate radiochromic film. Both phantoms were imaged while being irradiated by 6MV flattening filter free (FFF) beams within a MRIdian Viewray (Viewray, Cleveland, OH) MR-linac (0.34T primary field). Phantom A was imaged while being irradiated by 6MV FFF beams on a conventional linac (TrueBeam, Varian Medical Systems, San Jose, CA) to serve as a control. Images were post processed in Matlab (Mathworks Inc., Natick, MA) and compared to TPS dose volumes. Control imaging of Phantom A without the presence of a magnetic field supports the validity of the optical image data to a depth of 6cm. In the presence of the magnetic field, the optical data shows deviations from the commissioned TPS dose in both intensity and localization. The largest air cavity examined (3cm) indicated the largest dose differences, which were above 20% at some locations. Experiments with Phantom B illustrated similar agreement between optical and film dosimetry comparisons with TPS data in areas not affected by ERE. There are some appreciable differences in dose intensity and spatial dose distribution observed between the novel experimental data set and the dose models produced by the current clinically implemented MR-IGRT TPS.

High-throughput radio-TLC analysis

IntroductionRadio thin layer chromatography (radio-TLC) is commonly used to analyze purity of radiopharmaceuticals or to determine the reaction conversion when optimizing radiosynthesis processes. In applications where there are few radioactive species, radio-TLC is preferred over radio-high-performance liquid chromatography due to its simplicity and relatively quick analysis time. However, with current radio-TLC methods, it remains cumbersome to analyze a large number of samples during reaction optimization. In a couple of studies, Cerenkov luminescence imaging (CLI) has been used for reading radio-TLC plates spotted with a variety of isotopes. We show that this approach can be extended to develop a high-throughput approach for radio-TLC analysis of many samples. MethodsThe high-throughput radio-TLC analysis was carried out by performing parallel development of multiple radioactive samples spotted on a single TLC plate, followed by simultaneous readout of the separated samples using Cerenkov imaging. Using custom-written MATLAB software, images were processed and regions of interest (ROIs) were drawn to enclose the radioactive regions/spots. For each sample, the proportion of integrated signal in each ROI was computed. Various crude samples of [18F]fallypride, [18F]FET and [177Lu]Lu-PSMA-617 were prepared for demonstration of this new method. ResultsBenefiting from a parallel developing process and high resolution of CLI-based readout, total analysis time for eight [18F]fallypride samples was 7.5 min (2.5 min for parallel developing, 5 min for parallel readout), which was significantly shorter than the 48 min needed using conventional approaches (24 min for sequential developing, 24 min for sequential readout on a radio-TLC scanner). The greater separation resolution of CLI enabled the discovery of a low-abundance side product from a crude [18F]FET sample that was not discernable using the radio-TLC scanner. Using the CLI-based readout method, we also observed that high labeling efficiency (99%) of [177Lu]Lu-PSMA-617 can be achieved in just 10 min, rather than the typical 30 min timeframe used. ConclusionsCerenkov imaging in combination with parallel developing of multiple samples on a single TLC plate proved to be a practical method for rapid, high-throughput radio-TLC analysis.

A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer.

Intraoperative Cerenkov luminescence imaging (CLI) can effectively improve the performance of tumor surgery. Nevertheless, the existing approaches are still unsatisfying to the clinical demands of open surgery. This study develops a novel intraoperative in vivo CLI approach to investigate the potential and value of Cerenkov luminescence (CL) image-guided surgery. A system characterized with high sensitivity (19.61 kBq mL-1 18 F-FDG) and desirable spatial resolution (88.34 μm) is developed. CL image-guided surgery is performed on colorectal cancer (CRC) models of mice and swine. Tumor surgery is guided by the static CL images, and the resection quality is evaluated quantitatively and contrasted with other imaging modalities exemplified by bioluminescence imaging (BLI). The in vivo results demonstrated the effectiveness of the proposed intraoperative CLI approach for removing primary and metastatic CRC. Safety of performing in vivo CL image-guided surgery is verified as well through radiation measurements of related staffs. Overall, the developed intraoperative in vivo CLI approach can efficiently improve the cancer treatment.

Cherenkov imaging for total skin electron therapy (TSET).

Total skin electron therapy (TSET) utilizes high-energy electrons to treat malignancies on the entire body surface. The otherwise invisible radiation beam can be observed via the optical Cherenkov photons emitted from interactions between the high-energy electron beam and tissue. With a time-gated intensified camera system, the Cherenkov emission can be used to evaluate the dose uniformity on the surface of the patient in real time. Fifteen patients undergoing TSET in various conditions (whole body and half body) were imaged and analyzed. Each patient was monitored during TSET via in vivo detectors (IVD) in nine locations. For accurate Cherenkov imaging, a comparison between IVD and Cherenkov profiles was conducted using a polyvinyl chloride board to establish the perspective corrections. With proper corrections developed in this study including the perspective and inverse square corrections, the Cherenkov imaging provided two-dimensional maps proportional to dose and projected on patient skin. The results of ratio between chest and umbilicus points were in good agreement with in vivo point dose measurements, with a standard deviation of 2.4% compared to OSLD measurements. Cherenkov imaging is a viable tool for validating patient-specific dose distributions during TSET.

Removal of random-valued impulse noise from Cerenkov luminescence images.

Cerenkov luminescence imaging(CLI) is an emerging molecular imaging technology able to optically visualize radioactive decay signals from medical isotopes and has found wide application in tumor diagnose, cancer therapy, drug development, intraoperative guidance, and so on. When Cerenkov luminescence data are collected, the high-energy particles from the radioactive nucleus will be detected by the sensitive CCD camera and lead to impulse noise. To suppress the impulse noise and improve the contrast of the useful signal to the background, the detection-based fuzzy switching median filtering framework is proposed in this paper. Several experiments were conducted respectively to investigate the statistical feature of the noise and to evaluate the performance of the proposed noise removal framework. The results show that the signal-to-noise ratio is improved after noise elimination. The proposed filtering framework outperforms the classical median filter in terms of root mean squared error and the structural similarity index. It also preserves the maximum value and the mean value in the regions of interest better than the median filter does. In addition, compared with the FLICMCDD algorithm, the proposed method works much faster while getting similar results. Graphical abstract.

Performance evaluation of Cerenkov luminescence imaging: a comparison of 68Ga with 18F

BackgroundCerenkov Luminescence Imaging (CLI) is an emerging technology for intraoperative margin assessment. Previous research only evaluated radionuclide 18-Fluorine (18F); however, for future applications in prostate cancer, 68-Gallium (68Ga) seems more suitable, given its higher positron energy. Theoretical calculations predict that 68Ga should offer a higher signal-to-noise ratio than 18F; this is the first experimental confirmation. The aim of this study is to investigate the technical performance of CLI by comparing 68Ga to 18F.ResultsThe linearity of the system, detection limit, spatial resolution, and uniformity were determined with the LightPath imaging system. All experiments were conducted with clinically relevant activity levels in vitro, using dedicated phantoms. For both radionuclides, a linear relationship between the activity concentration and detected light yield was observed (R2 = 0.99). 68Ga showed approximately 22 times more detectable Cerenkov signal compared to 18F. The detectable activity concentration after a 120 s exposure time and 2 × 2 binning of 18F was 23.7 kBq/mL and 1.2 kBq/mL for 68Ga. The spatial resolution was 1.31 mm for 18F and 1.40 mm for 68Ga. The coefficient of variance of the uniformity phantom was 0.07 for the central field of view.Conclusion68Ga was superior over 18F in terms of light yield and minimal detection limit. However, as could be expected, the resolution was 0.1 mm less for 68Ga. Given the clinical constraints of an acquisition time less than 120 s and a spatial resolution < 2 mm, CLI for intraoperative margin assessment using 68Ga could be feasible.

Imaging Cherenkov photon emissions in radiotherapy with a Geiger-mode gated quanta image sensor.

The emission of Cherenkov photons from human and animal tissue can be observed during clinical x-ray or particle beam irradiation. However, imaging this weak emission with the necessary single-photon sensitivity in the clinical room is challenging because of milliwatt-level ambient room lighting and the presence of stray high-energy radiation. In this Letter, we demonstrate, to the best of our knowledge, the first Cherenkov imaging with a time-gated quanta image sensor employing a large single-photon avalanche diode (SPAD) array. Detecting single Cherenkov photons was possible with high photon avalanche gain, fast temporal gating, and moderately high ∼7% photon detection probability. Single-bit digitization and active SPAD quenching enabled stray x-ray noise suppression and photon-noise-limited imaging in a clinical environment. This type of imaging allows the knowledge of location, shape, and surface dose of the therapeutic beam radiotherapy with the stability of solid state-based detection.

Using Cherenkov Imaging to Assess Field Overlap in Cranial-Spinal Irradiation (CSI)

Using Cherenkov Imaging to Assess Field Overlap in Cranial-Spinal Irradiation (CSI)

Cherenkov imaging of total skin electron irradiation (TSEI)

Total Skin Electron Irradiation (TSEI) utilizes high-energy electrons to treat skin cancers, mostly mycosis fungoides. The otherwise invisible radiation beam can be visualized using the optical Cherenkov light emitted from interaction between incident electron beams and tissue during radiation therapy. Using a gated camera system with built-in intensifier, the Cherenkov emission can be used to evaluate the dose uniformity on the surface of the patient in real-time. Each patient was also monitored on the skin surface using in-vivo diode or OSLD dosimeters.