Measures to control the expanding use of synthetic cannabinoids demand new analytical methodology to identify and determine compounds within this rapidly evolving class. Herein, we identify seven synthetic cannabinoids (AM-2201, UR-144, XLR-11, A796,260, 5F-AKB48, PB-22 and 5F-PB-22) present in eleven herbal products sold in Victoria, Australia, prior to their ban in 2014, using a combination of GC-MS, HPLC, ESI-MS, and NMR. In aid of this work, we synthesised the synthetic cannabinoids AM-2201 and 5F-AKB48. We then explore for the first time, the chemiluminescence detection of synthetic cannabinoids using three commonly used reagents: permanganate, manganese(IV), and tris(2,2′‐bipyridine)ruthenium(III). Using the permanganate reagent, no chemiluminescence signal was obtained, but the manganese(IV) and tris(2,2′‐bipyridine)ruthenium(III) reagents gave analytically useful responses with all synthetic cannabinoids under investigation except 5F-AKB48. Calibration curves for PB-22, 5F-PB-22, AM-2201 and 5F-AKB48 prepared using HPLC with UV absorbance and/or chemiluminescence detection were used to determine the total cannabinoid content extracted with methanol (1mL) from of six of the herbal products (10 mg), which ranged from 0.072 to 0.77 mg.