With reduced size, the flight Reynolds number of the nano rotor decreases, leading to a sharp drop in the aerodynamic efficiency of the nano rotor. Therefore, improving the aerodynamic performance of the nano rotor at low Reynolds numbers through flow control methods becomes imperative. In this study, from the perspective of bionics, flexible materials are employed in nano rotor design. Seven different layouts of flexible membrane rotor blades are designed and fabricated. The influence of leading and trailing edge flexibility, as well as membrane occupancy ratio on rotor blade propulsion characteristics, is explored through propulsion performance tests in hover.Results show that among several layouts proposed in this study, the layout with both reinforced leading and trailing edges of the flexible membrane nano rotor blade exhibits excellent propulsive performance. However, the propulsion performance of the flexible membrane rotors doesn't vary linearly with the ratio of membrane area to the whole rotor area. The appropriate ratio or flexibility can increase the propulsive performance of the rotor, especially at medium and high collective angles. At 7000 RPM and a 20° collective angle, the Figure of Merit of the flexible membrane nano rotor increases up to 4.2% when comparing with the nano rotor without membrane. This improvement becomes more significant with higher collective angles. The structural natural vibration characteristics of each flexible membrane with different layouts are analyzed through modal tests, ensuring the accuracy of the finite element model for flexible membrane rotors. Numerical analysis of the fluid-structure coupling of a flexible membrane rotor with different layouts indicates that rotor structural vibrations is highly consistent with fluctuation of aerodynamic parameters. The deformation of the flexible membrane under aerodynamic forces enhances local blade camber, but reduces angles of attack. This, subsequently, minimizes the size of laminar separation bubbles and the intensity of the blade tip vortices at high collective angles. Consequently, rotor power coefficients decrease, and overall aerodynamic performance improves.