Nowadays there is a variety of ways to control postsurgical pain syndrome. However, according to scientists, about 30-75% of patients suffer from postoperative pain of average and high intensity. Due to low cost, execution speed and high clinical efficiency, national and international gynaecologists give preference to minimally invasive operational interventions, among which the most common is curettage of uterine cavity (CUC). Notwithstanding the foregoing, the question of postoperative pain, caused by a performance of above-mentioned surgery, still remains understudied. Nobody knows the intensity of pain syndrome, occurring in the postoperative period of CUC, time response characteristics of its development, the influence of applied anaesthetic technique. Objective: to study the influence of various combinations and dosages of preparations used for providence of monitored anaesthesia care of CUC on the intensity and time response characteristics of postsurgical pain syndrome. Materials and methods: 128 women took part in the investigation, who were undergone the CUC on an outpatient basis for diagnostic or therapeutic purposes. The monitored anaesthesia care was conducted with the use of different drug combinations and their dosages. The intensity of postsurgical pain syndrome was registered with the help of measurement and performance analysis of vital functions, determining the levels of cortisol, insulin and serum glucose of patients, the mathematical calculation of the cortisol-insulin index, assessing the level of pain according to VAS and quality of life questionnaires, which included questions regarding the intensity of pain, conducted statistical processing of the data.Results: it was made clear that, when conducting the curettage of uterine cavity under common intravenous anaesthesia and with additional anaesthesia with non-steroidal anti-inflammatory drugs (NSAIDs), the development of the pain syndrome had a progressive vector within 3 hours after the end of operational intervention. Reducing the dosage of drugs for noninhalation narcosis lengthens the regressive stage of the postoperative pain syndrome. Performing intraoperative application anaesthesia with a solution of bupivacaine has a significant preventive analgesic effect and reduces the duration of the pain syndrome to a maximum of 1 hour. Such type of analgesia of postoperative period of CUC shows positive psycho-emotional and social effect for patients in outpatient gynecology departments. It was found the existence of a psychological factor associated with following invasive intervention and possible sensations of pain, which disappears during the first hour of the postoperative period of CUC.