Case 1: A 52-year-old Caucasian retired police officer presented 3 years prior to diagnosis with the chief complaint of inability to exercise due to breathlessness. The patient was a long-distance walker who had given up this recreational activity due to dyspnea on exertion. He experienced an intermittent nonproductive cough without wheezing, chest pain, arthritis, or fevers. His past medical history was notable for childhood asthma, sinus polypectomy, seasonal allergies, and tobacco use of 37 pack years. His physical exam was only notable for mild obesity, oxygen desaturation on room air from 94% to 82% after walking 1500 ft, and scattered crackles throughout his lung fields bilaterally. Pulmonary function tests revealed no obstruction, mild restriction, and a moderate gas transfer defect. An elevated lactate dehydrogenase (LDH) of 360 was noted on his chemistry panel. Chest radiographs at initial presentation in 12/00 and at diagnosis 11/02 revealed bilateral interstitial/alveolar infiltrates (Figure 1). CT scanning revealed progression of bilateral ground glass alveolar infiltrates from presentation 1/01 to 11/02 (Figures 2A‐2F). Based on the characteristic CT findings, the patient underwent a bronchoalveolar lavage that was diagnostic for pulmonary alveolar proteinosis (PAP) (Figure 3). Due to marked dyspnea and abnormal lung function, the patient was treated with whole lung lavage that led to a marked improvement in his exercise tolerance and pulmonary function tests, although only mild improvement on CT (Figures 2H‐2I). Case 2: A 49-year-old Caucasian state employee presented with persistent cold-like symp
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