Current study investigates the voltage-induced actuation of alcohol droplets on a Teflon/Pt/Glass substrate, emphasizing the influence of alkyl chain length on microfluidic droplet behavior. The wetting and electrowetting properties of different alcohols with increasing carbon chain length, namely, methanol, ethanol, 1-propanol, and 1-butanol, are examined by using both experimental techniques and the simulations of classical molecular dynamics (MD). An increase in the wetting nature of these alcohol droplets is observed with the increase in carbon chain length. A greater penetration into the Teflon surface is observed for alcohols with longer alkyl chain lengths from MD simulations. The evaporative nature of alcohol droplets and the consequent effect of evaporation on wetting are also examined. Voltage-modified change in contact angle, droplet displacement or spreading, and voltage-induced work of spreading, are investigated to study the actuation of such alcohol droplets. A unique, voltage-triggered directional displacement/spreading of the droplets towards ground electrode is observed, in contrast to the conventional electrowetting behavior. These insights underscore the influence of molecular interactions in voltage-actuated droplet dynamics, having significant implications as a design parameter in the development of digital microfluidics-based lab-on-a-chip devices.
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