Changes In Curvature Research Articles

Redistribution of Epithelium and Stroma and Their Relationship With Corneal Curvature After 1-Month Cessation of Overnight Orthokeratology.

To investigate the changes in the thickness of epithelium and stroma and their relationship with corneal curvature following the cessation of overnight orthokeratology for a period of 1 month. This prospective study consecutively included 20 juveniles (20 right eyes) who had undergone overnight orthokeratology for a minimum of one year and were willing to discontinue the treatment. The study measured and compared epithelial and corneal curvature using optical coherence tomography and Medmont topographer at the first day of cessation and 1 month after cessation. In addition, changes in uncorrected visual acuity and refractive error before and after the cessation of the treatment were analyzed. The study found a significant increase in the thickness of the epithelium in the central 2-mm area after the cessation of the treatment (t = -4.807, P <0.001). Moreover, the stroma in the paracentral area (2-5 mm) and peripheral area (5-6 mm) showed a general thinning trend ( P =0.016, P =0.016). Regarding the correlation analysis, the change in central epithelial thickness (ΔCET) was significantly correlated with the change in paracentral corneal curvature (ΔPCCC) (r=0.610, P =0.007) and the change in peripheral corneal curvature (ΔPCC) (r=0.597, P =0.009). Similarly, the change in central stromal thickness (ΔCST) was significantly correlated with the change in central corneal curvature (ΔCCC) (r=0.500, P =0.035), ΔPCCC (r=0.700, P =0.001), and ΔPCC (r=0.635, P =0.005). The study found that the corneal remodeling induced by orthokeratology was reversible after the cessation of the treatment. Specifically, changes in the epithelium were found to be more prominent in the central area, while changes in the stroma were more pronounced in the paracentral and peripheral areas. In addition, the study established a significant correlation between central corneal remodeling and changes in curvature.

Climate change impacts on precipitation and water resources in Northwestern China

A statistical analysis is conducted on the hourly precipitation at 105 national meteorological stations in the Xinjiang region of China from 2011 to 2020. The purpose of this analysis is to determine the total quantity of precipitation during the warm and cold seasons, as well as the precipitation frequency at each station. The results of the analysis indicate that there is a more pronounced inter-annual variation in precipitation during the warm and cold seasons in Xinjiang, where the total amount of precipitation during the warm season is significantly higher than that during the cold season, with the warm season experiencing at least twice as much precipitation. In terms of the inter-annual incremental amount of precipitation, both the warm and cold seasons exhibit a trend of increasing and then decreasing over the years. However, the curvature change is more prominent in the cold season compared to the warm season, suggesting that the inter-annual variation in precipitation during the warm season remains relatively stable. The spatial distribution characteristics of the total precipitation in Xinjiang indicate that warm-season precipitation is more scattered, while cold-season precipitation is mainly concentrated in the northern region of the territory. This pattern holds true at low, medium, medium–high, and high altitudes. The cumulative precipitation during the warm season is always higher than that in the cold season, and this difference becomes more prominent with increasing altitude. This indicates that warm-season precipitation in Xinjiang is closely related to its complex topographic structure, particularly the convective weather generated by topographic clouds. On the other hand, precipitation in the cold season is mainly concentrated in the low- and medium-altitude stations, and there is not much correlation between precipitation and altitude. Precipitation is mainly affected by the mesoscale and the direct influence of large-scale weather systems. Analysis of precipitation in extreme moments reveals that during the warm season, extreme precipitation events occur mainly from the evening to early morning (19:00–03:00 the next day), accounting for 75.24% of the 105 stations. In contrast, during the cold season, extreme precipitation events occur between 03:00 and 18:00, corresponding to 74.29% of the stations. The relationship between precipitation and altitude differs in the warm and cold seasons. In the warm season, there is a linear relationship between precipitation and altitude, with a slope of 0.72 and a correlation coefficient of 0.52, indicating that precipitation increases with increasing altitude. However, in the cold season, the linear relationship between precipitation and altitude is very inconspicuous, with a slope of −0.05 and a correlation coefficient of −0.05, suggesting that there is no significant relationship between precipitation and altitude during this season. These findings provide valuable insights into the changing patterns of precipitation gradients at different altitudes and seasons in Xinjiang. This information can be used for the site selection of smokestack operations in high-altitude areas and for ground and air weather modification operations in low-altitude areas. Additionally, these data contribute to the understanding of precipitation patterns in Xinjiang, further improving the effectiveness of weather modification efforts and increasing the utilization of airborne water resources.

Mode-dependent analysis of a fiber optic curvature sensor with sensitive zone

In this paper, mode-dependent analysis of fiber optic curvature sensor with precision machined structural imperfections (teeth) as sensitive zone is conducted. Using controlled input or light source launching conditions sensor response is measured for different modes excited in the multimode optical fiber. Study shows that as curvature changes there is significant difference in how sensitive zone affects low and high order modes propagating through the fiber. Obtained measurement results provide further insight into FOCS response and open possibilities for development of new measurement approaches which represent a significant step forward for FOCS based measurement systems. Guidelines for maximizing sensor sensitivity, increasing measurement reliability and even avoiding intensity based measurement by measuring changes in the width of the sensor’s output light intensity distribution are discussed in this work.

Scleral lens induced short term corneal changes in eyes with Pellucid Marginal Degeneration

PurposeTo investigate the short-term effect of scleral lens (SL) on corneal curvature and corneal oedema in Pellucid Marginal Degeneration (PMD) eyes. MethodsCorneal anterior, posterior curvature and corneal thickness were measured in 14 eyes of 14 PMD participants with Schiempflug imaging at different corneal diameters and meridians at baseline and after 6 h of SL wear. ResultsThere was a significant flattening (up to 0.26 mm) of the anterior corneal curvature noted in the inferotemporal quadrant (from 210 to 255 degree at 2 mm, 8 mm and 10 mm corneal diameter), inferonasal quadrant (from 285 to 345 degree at 6 mm and 8 mm corneal diameter), and inferiorly at 2 mm and 10 mm corneal diameter (p < 0.05). Similarly, posterior corneal curvature showed statistically significant steepening mostly in inferotemporal quadrants (from 195 to 255 degree from 4 mm to 8 mm corneal diameter) and inferonasally at 2 mm and 4 mm corneal diameter (p < 0.05). A statistically significant increase in the corneal thickness noted in different corneal diameters with corneal oedema ranging from 2.10 % to 4.00 % after 6 h of SL wear. A gradual increase in corneal oedema was noted form centre to periphery. The baseline central fluid reservoir thickness (FRT) was 341.07 ± 139.8 which reduced to 276.71 ± 114.32 µm after 6 h of lens wear. No significant correlation was noted between corneal oedema with different parameters like initial and final FRT, change in anterior and posterior corneal curvature, and lens thickness (p > 0.05). ConclusionsShort-term SL wear induced a clinically acceptable range of corneal oedema. A clinically significant flattening in anterior curvature and minimal steepening in posterior curvature were noted. Practitioners should be careful while measuring corneal parameters in PMD eyes wearing SL, as these alterations can provide false impression of disease progression.

Study on the shape prediction of doubly curved shallow shell in flexible rolling process

Flexible rolling (FR) is a novel process for manufacturing doubly curved shallow shells with various shapes based on a pair of small-diameter bendable rolls. In this paper, the fundamental reason for bi-directional bending of the sheet metal in FR is explained. For the purpose of predicting the forming radii in the transverse and longitudinal directions more effectively, the exit velocity is divided into linear velocity and interference velocity, with the latter so small as to be considered to cause only elastic deformation of the sheet. The theoretical calculation model of the pre-curvature radius resulted from linear velocity is established. Using the mechanical theory of the doubly curved shallow shell, the transverse and longitudinal curvature changes caused by the interference velocity are derived and solved by the analytical approach, which are added to the transverse and longitudinal pre-curvatures respectively so that the actual curvature radii are obtained. In order to verify the reliability of the proposed shape prediction method of FR, numerical simulations and forming experiments for convex and saddle-shaped parts are carried out. Through measurement and comparison, it is found that the simulated and experimental results are extremely consistent with the theoretical data. Besides, the effect of important parameters on elastic deformation is investigated by means of the deduced formulas.

Experimental and molecular dynamics simulation study on antifouling performance of antimicrobial peptide‐modified aluminum alloy surfaces

Marine biofouling poses a major challenge to ship navigation and hinders the development of the shipping industry. Urgent action is required to tackle this problem through the implementation of innovative strategies. Antimicrobial peptides have garnered considerable attention due to their outstanding effectiveness, wide range of activity, and eco‐friendly characteristics. This study involved grafting the antibacterial peptide andricin 01 (AIGHCLGATL) onto the surface of an aluminum alloy, thereby creating a modified surface with antibacterial properties. In summary, amino groups were introduced onto the surface of aluminum alloys through the silanization process using (3‐aminopropyl) triethoxysilane (APTES), and then the peptides were covalently immobilized on the treated surface using glutaraldehyde as a cross‐linking agent. The successful modification of the peptide was confirmed by Fourier transform‐infrared spectroscopy (FT‐IR) and X‐ray photoelectron spectroscopy (XPS) analysis. The antimicrobial peptide‐modified aluminum alloy surfaces exhibited significant bactericidal activity, killing 75.3% of Bacillus sp. and 85.5% of Escherichia coli, while achieving antifouling efficiencies of 88.6% and 90.7% against Bacillus sp. and E. coli, respectively. Furthermore, molecular dynamics simulations showed that the inserted of the peptides into the phospholipid membrane caused a change in the local membrane curvature, which eventually led to membrane rupture. These results provide valuable information for the application of antimicrobial peptides in the field of antifouling and the elucidation of antifouling mechanisms.

Thermodynamic geometry of a system with unified quantum statistics.

We investigate the thermodynamic characteristics of unified quantum statistics, a framework exhibiting a crossover between Bose-Einstein and Fermi-Dirac statistics by varying a generalization parameter δ. An intrinsic statistical interaction becomes attractive for δ≤0.5, maintaining positive thermodynamic curvature across the entire physical range. In the range 0.5<δ<1, the system predominantly displays Fermi-like behavior at high temperatures. Conversely, at low temperatures, the thermodynamic curvature is positive, resembling bosonic behavior. Further temperature reduction induces a transition into the condensate phase. We introduce a critical fugacity (z=Z^{*}) at which the thermodynamic curvature changes sign. Below (z<Z^{*}) and above (z>Z^{*}) this critical point, the statistical behavior mimics fermions and bosons, respectively. We explore the system's statistical behavior for various δ values with respect to temperature, determining the critical fugacity and temperature-dependent condensation. Finally, we analyze specific heat as a function of temperature and condensation phase transition temperature for different δ values in various dimensions.

Changes in Posterior Cornea and Posterior-To-Anterior Curvature Radii Ratio 1 Year After LASIK, PRK, and SMILE Treatment of Myopia.

The purpose of this study was to compare changes in the posterior curvature and the posterior-anterior radii ratio of the cornea, 1 year postoperatively in laser in situ keratomileusis (LASIK), photorefractive keratectomy (PRK), and small incision lenticule extraction (SMILE). This retrospective study was performed at a single surgical center. 199 eyes were included in the study from 119 patients with manifest refraction spherical equivalents from -7.61 to -2.54 D. 67 eyes underwent LASIK, 89 underwent PRK, and 43 underwent SMILE. Both preoperative and 1-year postoperative front and back sagittal keratometry were measured at 4- to 6-mm zones around the corneal vertex. Corneal asphericity (Q-value) was measured at an 8-mm zone around the corneal vertex. The average change in the posterior-anterior radii ratio after LASIK, PRK, and SMILE did not differ between surgery groups at 4 mm (LASIK: -0.075, PRK: -0.073, SMILE: -0.072, P = 0.720), 5 mm (LASIK: -0.072, PRK: -0.068, SMILE: -0.068, P = 0.531), or 6 mm (LASIK: -0.075, PRK: -0.071, SMILE: -0.072, P = 0.456) zones. Anterior Q-value significantly positively increased after all 3 surgeries ( P < 0.001). The posterior Q-value also significantly positively increased after LASIK ( P < 0.001) and SMILE ( P < 0.001), but not after PRK ( P = 0.227). Both anterior and posterior keratometric power decreased significantly after LASIK, PRK, and SMILE for all diameters. The change in the posterior-anterior radii ratio was not influenced by the type of refractive surgery performed, as indicated by statistically identical preoperative, postoperative, and delta values. In addition, the posterior cornea exhibited paracentral flattening after LASIK, SMILE, and PRK and increased oblateness after LASIK and SMILE.

A self-referenced interferometer for in situ cryogenic wafer curvature measurements.

A self-referenced interferometer to measure time-varying curvature in mechanically unstable environments is needed in many applications. One application that demands this measurement technique with fast data acquisition, 2D sensitivity, and insensitivity to vibration is the measurement of thermal strain in thin films in operational environments. The diverging beam interferometer described here demonstrates an angular sensitivity to the local curvature using interferograms captured by a CMOS camera. Two-dimensional Fourier analysis is used to extract curvature changes. The interferometer demonstrates an experimental sensitivity to curvature changes on the order of 10-4 m-1 and is used to measure thermal stresses in a cryogenic environment of a polycrystalline titanium nitride thin film on a silicon wafer that exhibits anisotropic curvature.

Experimental study of the effect of gas discharge on ionic liquid electrospray

Ionic liquid electrospray (ILE) in an atmospheric environment is often accompanied by the gas discharge phenomenon. It interferes with the normal operation of the electrospray and the measurement of experimental parameters. In this study, electrospray experiments were conducted on the ionic liquid EMI-BF4. The observations revealed that the operating modes of the ionic liquid depend on the voltage polarity at high voltages. Additionally, a correspondence between the operating mode of ILE and the current signal in the circuit was established. The shape of the liquid cone formed at the needle tip bore a striking resemblance to the plume of corona discharge, suggesting that the motion trajectory of electrons influenced the curvature of the liquid cone. Steamer theory provided a clear explanation for the change in curvature as the voltage increased.

Improvement of Curvature Change Rate (Parameter) in Two-Line Rural Roads

The studies in various countries show that one of the main causes of accidents on rural roads still remains the drivers’ errors in choosing safe speed, which can be attributed to the errors of perceiving the road alignment. The current practice shows that the engineering safety improvement measures as well as accident prevention measures such as intersection design, traffic signs and equipment, facilities for vulnerable road users, access management, and human behaviour are not always effective. Probably, one of the alternatives to solve this problem is a design methodology that is used in the European Union countries and based on road safety criteria and road safety module. This methodology is aimed at ensuring design consistency between the elements of road alignment in a way that the driver intuitively chooses safe speed or the probability of errors in perceiving the road alignment is minimum. The article presents experimental research carried out in Vilnius Gediminas Technical University, the objective of which is to determine the accuracy of road safety module and to suggest possible alternatives for its improvement.

Altering optical zone diameter, reverse curve width, and compression factor: impacts on visual performance and axial elongation in orthokeratology

PurposeTo investigate the effects of modifications in back optical zone diameter (BOZD), reverse curve width (RCW), and compression factor (CF) on refractive error changes and axial elongation in myopic children undergoing orthokeratology (ortho-k) over a 12-month period. MethodIn this retrospective study, data from 126 myopic children undergoing ortho-k fitting were analyzed. Subjects were categorized into four distinct groups based on lens design parameters: Group A (BOZD 6.0 mm, RCW 0.6 mm, CF 0.75 D); Group B (BOZD 6.0 mm, RCW 0.6 mm, CF 1.25 D); Group C (BOZD 5.4 mm, RCW 0.9 mm, CF 1.25 D); and Group D (BOZD 5.0 mm, RCW 1.1 mm, CF 1.25 D). The study evaluated uncorrected visual acuity (UCVA), corneal topography, and axial length (AL) at intervals, using Linear Mixed Models (LMMs) for time-based changes, and ANOVA or Kruskal-Wallis tests for group differences in AL elongation. A multivariable regression analysis identified factors independently associated with AL elongation. ResultsWithin the first day and week, all four groups displayed significant improvements in UCVA and alterations in corneal curvature, which subsequently stabilized. Although UCVA variations between groups were subtle, Group D had less corneal curvature change than Groups A and B initially and exhibited significantly less AL elongation after one year. No significant difference in corneal curvature change or AL elongation was observed between Group C and the other groups. Multiple regression analysis indicated that older baseline age, greater baseline spherical equivalent refractive error, and smaller BOZD were associated with less AL elongation. ConclusionThe study reveals a positive correlation between BOZD and axial length growth over the 12-month period. A pure 0.5 D CF increment demonstrates a nonsignificant impact. This study provides new ideas into optimizing the parameters of ortho-k lenses.

Motorizing the buckled blister for rotary actuation.

Snap-through bistability was widely exploited for rapid hopping in micro-electro-mechanical systems and soft robots. However, considerable energy input was required to trigger the transition between discrete buckling states blocked by potential wells. Here a dynamic buckling mechanism of a buckled blister constrained inside an outer ring is explored for eliciting rotary actuation via a localized change of curvature in the blister. Due to rotational invariance of the buckled blister, lower energy supply is required to initiate the snap-through of buckling compared to conventional bistable mechanism. The controllability in rotational speed and output torque of the bimetallic blister-based rotator inside a rigid stator is exhibited, and the locomotion is demonstrated with two elastic rings via localized pneumatic actuators. With broad choices of stimulus and material for rings, the findings illustrate the promising potential of two nested rings to create active motions for diverse applications including gearless motors, peristaltic pumps, and locomotive robots.

Computational fluid dynamics investigation on the irrigation of a real root canal with a side-vented needle

BackgroundRoot canal therapy is one of the main treatments for root canal diseases, and effective irrigation is the key to successful treatment. Side-vented needle is one of the commonly used needle types in clinic. In the real root canal, due to the influence of the curvature of the root canal, the irrigation flow field in different needle directions shows obvious differences. At the same time, changes in root canal curvature and working depth will lead to changes in irrigation efficiency and the flow field. Both the mainstream of the irrigation flow and the shear stress near the wall changes significant. Consequently, either the replacement in the root canal or the removal efficiency of the smear layers is apparently modified.Materials and methodsIn this paper, the permanent root canal of the maxillary first molar prepared until 15/04 were scanned by micro-CT, and then imported into the software for 3D reconstruction. The key parameters of flushing efficiency of 30G side needle at different working depths of 4.75 mm, 5 mm, 5.25 mm and 5.5 mm were compared. Meanwhile, the simulated models with different curvatures of 0°, 5°, 10°, 20° and 30° based on the real root canal were reconstructed to investigate the curvature effect on the irrigation efficiency.ResultsThe results show that moderate working depth (such as 4.75 mm and 5.25 mm in present paper) helps to improve the replacement capacity of irrigation flow. At the same time, the apical pressure decreased as the working depth increased. The curvature of the root canal seriously affects the removal depth of the smear layers of the root canal. A root canal with a large curvature (especially 20° and 30°) can significantly improve the difficulty of irrigation.Conclusions(1) Moderate working depth helps to improve the displacement capacity, the ERD of the irrigation flow is generally improved at the working depths of 4.75 mm and 5.25 mm, and the apical pressure will decrease with the increase of working depth. (2) The large curvature of the root canal can significantly improve the difficulty of irrigation. The curvature of the root canal can severely influence the removal depth of the smear layer on the wall. It can be found both the span and the depth of the ESS for little curvatures (5° and 10°) root canals are higher than those for large curvatures (20° and 30°).

Stress-Relief Engineering in a N-Doped C-Modified Hierarchical Nanoporous Si Anode with a Microcurved Pore Wall Structure for Enhanced Lithium Storage.

The commercialization of alloy-type anodes has been hindered by rapid capacity degradation due to volume fluctuations. To address this issue, stress-relief engineering is proposed for Si anodes that combines hierarchical nanoporous structures and modified layers, inspired by the phenomenon in which structures with continuous changes in curvature can reduce stress concentration. The N-doped C-modified hierarchical nanoporous Si anode with a microcurved pore wall (N-C@m-HNP Si) is prepared from inexpensive Mg-55Si alloys using a simple chemical etching and heat treatment process. When used as the anode for lithium-ion batteries, the N-C@m-HNP Si anode exhibits initial charge/discharge specific capacities of 1092.93 and 2636.32 mAh g-1 at 0.1 C (1 C = 3579 mA g-1), respectively, and a stable reversible specific capacity of 1071.84 mAh g-1 after 200 cycles. The synergy of the hierarchical porous structure with a microcurved pore wall and the N-doped C-modified layer effectively improves the electrochemical performance of N-C@m-HNP Si, and the effectiveness of stress-relief engineering is quantitatively analyzed through the theory of elastic bending of thin plates. Moreover, the formation process of Li15Si4 crystals, which causes substantial mechanical stress, is investigated using first-principles molecular dynamic simulations to reveal their tendency to occur at different scales. The results demonstrate that the hierarchical nanoporous structure helps to inhibit the transformation of amorphous LixSi into metastable Li15Si4 crystals during lithiation.

Impact Analysis of Section Seismic Capacity in Potential Plastic Hinge Zone of Engineered Cementitious Composite Based on OpenSees

In this paper, OpenSees is used to analyze the moment-curvature (M-φ) curves of the bottom cross section of 4×40m continuous girder piers under the same reinforcing conditions, which are completely made of C40 concrete, partially made of Engineered Cementitious Composite material concrete(ECC) outsourced concrete, and completely made of ECC concrete, and then evaluate its seismic performance. Meanwhile, the yield curvature and ultimate curvature changes of the abutment section under different axial compression ratios are investigated. The results show that the yield curvature and ultimate curvature of ECC are larger than those of ordinary concrete, and the deformation capacity of ECC is stronger under the same axial force. The results also show that the yield moment and yield curvature of the section gradually increase with the increase of axial compression ratio, and the curvature ductility of the section deteriorates.

Neutralizing coffee-ring effect using gradual structures for uniform particle distribution

The coffee-ring effect is a process that takes place when a tiny drop of liquid-containing particles disappears, resulting in a distinct deposit around the edge of the spill resembling a ring. One of the primary causes of this effect is the uneven distribution of particles due to dissimilar evaporation rates on the droplet surface and contact line pinning effects. In this research, a microwell with a gradual structure has been developed to regularize the slippery Wenzel wettability of the surface and control the particle distribution. The mobility and pinning of droplet contact lines during the evaporation process are greatly influenced by this structure. The uniform curvature of the sidewall structure is predisposed to contact line depinning and thus helps the sliding of droplets to further neutralize the coffee-ring effect. Contact line pinning is predominantly observed at the corners of the structure, which are encircled by the ends and bottoms of the microwell's sidewalls. The curvature changes at this point, enhancing van der Waals' forces and resulting in a uniform monolayer of sediment being deposited at the microwell's bottom. The restraining efficacy of microwells of gradual structure on coffee rings with polystyrene spheres was confirmed, and the impact of microwell diameter, particle diameter, and loading efficacy on particle deposition distribution was investigated. The results show that the gradient configuration permits a single layer and even distribution of particles, enabling the sediment's dimensions to be anticipated and evaluated.

Multiple chromosomes particle swarm optimization-based coverage path planning for complex surfaces spray painting

Coverage path planning for complex three-dimensional surfaces spray painting is one of the challenging problems in robotics. In this article, we propose a multiple chromosomes particle swarm optimization approach to address the coverage path planning problem for complex three-dimensional surfaces spray painting. Firstly, a layered segmentation method, which is composed of three-dimensional hole identification and region partition, is proposed to divide the complex surface into multiple simple regions with little curvature change and no holes. Secondly, a zigzag path is determined in each region by considering the practical aspects for spray painting. Thirdly, by taking short distance, few turns and high coverage rate into account, a multiple chromosomes particle swarm optimization algorithm is presented to connect the zigzag paths of the regions. Experimental tests are carried out on a complex surface, and the results validate the effectiveness of the proposed approach.

Efficacy comparison of combining cross-linking and refractive laser ablation in progressive keratoconus: systematic review and meta-analysis

ObjectiveThis study assessed the effect of combining corneal collagen cross-linking (CXL) with refractive laser ablation techniques for the treatment of keratoconus, a progressive corneal disorder. MethodsWe performed a systematic review and meta-analysis to assess the effect of combined CXL and refractive techniques. We included all published clinical trials or observational studies published by September 1, 2023. We calculated and compared the standardized mean difference (SMD) between CXL alone and CXL plus laser ablation for uncorrected distance visual acuity, best-corrected distance visual acuity, spherical equivalent manifest refraction, sphere and cylinder, flat keratometry (K1), steep keratometry (K2), and central corneal thickness. ResultsWe identified 13 studies that fulfilled our inclusion and exclusion criteria. The average follow-up was 21.3 ± 11.8 months. The CXL plus laser ablation group showed improvement in uncorrected distance visual acuity logMAR (SMD, –0.35; 95% CI, –0.67 to –0.04; p = 0.029), best-corrected distance visual acuity logMAR (SMD, –0.17; 95% CI, –0.30 to –0.03; p = 0.014), spherical equivalent manifest refraction (SMD, –0.28; 95% CI, 0.06–0.50; p = 0.013), and change in maximal corneal curvature (Kmax; SMD, –0.41; 95% CI, –0.69 to –0.13; p = 0.004) compared with CXL alone. However, central corneal thickness decreased further among patients who underwent CXL plus laser ablation (SMD, –0.37; 95% CI, –0.66 to –0.07; p = 0.016). No effect was observed in terms of sphere (p = 0.878), cylinder (p = 0.859), K1 (p = 0.907), or K2 (p = 0.169). Ectasia was not observed as an adverse effect resulting from the additional corneal ablation performed during the CXL treatments. ConclusionsThis study showed that combining refractive laser ablation techniques with standard or accelerated CXL treatment improved visual and refractive outcomes and anterior corneal curvature values.

Non-linear electro-rheological model of a membrane immersed in Tanner-Power law fluids applied to outer hair cells: Shear-thinning mechanisms

Flexoelectric actuation employs an applied electric field to induce membrane curvature, which is the mechanism utilized by the outer hair cells (OHC) present in the inner ear. The model developed for this study, representing the OHC, integrates two key components: (i) an approximation of the flexoelectric membrane shape equation for circular membranes attached to the inner surface of a circular capillary, and (ii) the coupled capillary flow of contacting liquid viscoelastic phases characterized by the Tanner-Power law rheological equation of state. A second-order non-linear differential equation for average curvature has been derived, and a robust numerical method has been programmed. This model simplifies to a linear model used previously. The main challenge involves identifying and describing the enhancement in curvature change rate. It was observed that low symmetry, low viscosity, and soft membrane and shear-thickening behavior of the phases enhance the curvature change rate. Additionally, there exists a critical electric field frequency value that maximizes the curvature change rate (resonance effect). The current theory, model, and computational simulations add to the ongoing development comprehension of how biological membrane shape actuation through electromechanical couplings.