Changes In Uric Acid Levels Research Articles

Implementasi Evidance Based Nursing Pada Pasien Gout Rematik: Studi Kasus

<div class="WordSection1"><p align="center"><strong></strong><em><strong>ABSTRACT</strong></em></p><p><em><strong>Background:</strong> Health problems that are often found and spread throughout the world, one of which is Gout Arthritis or what we know as Gout. When uric acid levels get higher and pass normal levels, the uric acid will gradually settle and crystallize. Sedimentation This causes the joint to become inflamed which is marked by signs and symptoms such as pain, swelling, and redness in the joints. <strong>Methods:</strong> In the implementation, complementary therapy was applied to gouty arthritis patients, namely warm ginger compresses and bay leaf water decoction.. <strong>Results:</strong> Significant results on the pain scale and changes in uric acid levels were before the intervention scale of pain 8 with uric acid levels of 8.7 mg / dl and after the intervention scale of pain 2 with uric acid levels of 7.8 mg / dl. <strong>Concluion:</strong> The application of complementary therapy of warm ginger compresses and bay leaf decoction which was done showed improvement in patients suffering from gout. Therefore, the application of evidence-based nursing can be recommended in providing nursing care.</em></p><p><em><strong>Keywords : Complementary, Family, Gout Athritis<br /></strong></em></p><p align="center"><em><strong> </strong></em></p><strong></strong><br clear="all" /><strong> </strong></div>

Spot test for determination of uric acid in saliva by smartphone-based digital images: A new proposal for detecting kidney dysfunctions

Changes in uric acid levels in biological fluids may be indicative of certain diseases related to kidney dysfunctions. Analytical methods recommended for the quantification of uric acid, such as high-performance liquid chromatography, are typically time-consuming and require high-cost equipment. In this study, a simple and cost-effective approach was developed for the determination of uric acid in saliva, by combining a spot test with smartphone-based digital image colorimetry. It was based on the reduction of Cu(II) to Cu(I) by uric acid, followed by complexation with 2,2′-biquinoline-4,4′-dicarboxylic acid (BCA), resulting in a violet product. Derivatization reactions and photometric measurements were both carried out in Eppendorf® tubes to facilitate the manipulation of biological samples. A smartphone camera and a free application (PhotoMetrix® 1.8) were used to capture the image and convert it to RGB values. Photometric measurements were based on reflected radiation in the G channel, corresponding to the complementary color of the product, yielding a linear response between 25 and 150 µmol L−1. The coefficient of variation (n = 10) and the limit of detection were 1.4% and 8 µmol L−1, respectively. Both reagent consumption (8.3 µg Cu(II), 3.8 mg ammonium acetate, and 156 µg BCA per determination) and waste volume (900 µL per determination) were minimized. The results agreed with those obtained by HPLC, demonstrating that the approach is a reliable alternative for large scale clinical analysis.

Prognostic significance of uric acid change in acute ischemic stroke patients with reperfusion therapy.

Uric acid (UA) is an important endogenous free radical scavenger that has been found to have a neuroprotective effect. However, there is uncertainty about the relationship between UA change and outcome in acute ischemic stroke (AIS) patients with reperfusion therapy. We consecutively enrolled AIS patients with reperfusion therapy. UA was measured upon admission and during hospitalization. The change in UA levels (ΔUA) was determined by calculating the difference between admission UA and the lowest UA among all follow-up measurements, with a positive ΔUA suggesting a decrease in UA levels. Functional outcome was assessed by modified Rankin Scale (mRS) at 3months. Poor outcome was defined as mRS >2. A total of 361 patients were included (mean age 68.7±13.9years, 54.3% males). The mean UA on admission was 355±96.1μmol/L. The median ΔUA was 121μmol/L (IQR 50-192μmol/L) and 18 (5%) patients had increased UA levels. UA on admission was positively associated with good outcome (p for trend=0.017). When patients were classified into quartiles by ΔUA, patients with the largest decrease in UA (Q4: 199-434μmol/L) had a higher risk of poor outcome at 3months compared to patients with the least decrease in UA (Q1: 0-57μmol/L) (OR 2.55, 95% CI 1.09-5.98, p=0.031). The risk of poor outcome increased with ΔUA (p for trend=0.048). In patients with reperfusion therapy, high UA on admission was associated with a good 3-month outcome, while a greater decrease in UA was associated with poor outcome.

Serum uric acid is associated with disease severity and may predict clinical outcome in patients of pulmonary arterial hypertension secondary to connective tissue disease in Chinese: a single-center retrospective study

BackgroundPrevious studies have shown that serum uric acid (UA) levels are correlated with the severity of idiopathic pulmonary arterial hypertension (IPAH) and are predictors of disease prognosis. Still, few studies have explored the value of serum UA in pulmonary arterial hypertension secondary to connective tissue disease (CTD-PAH). This retrospective study aimed to investigate the clinical value of serum UA levels in patients with CTD-PAH.MethodsFifty CTD-PAH patients were enrolled in our study, from which baseline UA levels, respective variations, and additional clinical data were collected. The potential association between baseline UA level and severity of CTD-PAH was investigated. Furthermore, the relationship between baseline UA and survival rate of CTD-PAH patients, as well as between UA variations and survival rate of pulmonary hypertension secondary to connective tissue disease (CTD-PH) patients was discussed.ResultsBaseline serum UA levels were positively correlated with pulmonary vascular resistance (PVR). During the follow-up period, 3 CTD-PAH and 12 CTD-PH patients died. Kaplan-Meier survival curves showed lower survival rate in patients with hyperuricemia than in patients with normouricemia, in both groups (CTD-PAH group p = 0.041, CTD-PH group p = 0.013). Concerning serum UA variations, patients with persistent hyperuricemia showed the lowest survival rate when compared with patients with steady normouricemia (p = 0.01) or patients with decresing serum UA levels, i.e. undergoing from a status of hyperuricemia to a status of normouricemia (p = 0.023).ConclusionBaseline serum UA levels might predict severity of CTD-PAH. Together with baseline values, changes of uric acid level may predict the clinical prognosis of the disease.

Effect of the Stems Lemongrass (Cymbopogon citratus) in Pallumara and Pepes Anchovy (Stolephorus Sp.) to Uric Acid Levels of Hyperuricemia Elderly Women

BACKGROUND: Compliance with food-base dietary guidelines has been known delivered positive effect on nutrition and public health.
 AIM: The aim of the study was to assess the effect of lemongrass stems in pallumara and anchovy pepes on changes in uric acid levels in elderly women in hyperuricemia.
 METHODS: This research is a quasi-randomized pre-test-post-test control group design experiment. The study sample was elderly women with hyperuricemia who met the inclusion and exclusion criteria of 45 persons divided into two intervention groups and one control group. The first group was given lemongrass stems in pallumara anchovy, the second group was given lemongrass stems in anchovy pepes, and the control group only consumed family food. Data were analyzed using paired t test, one-way ANOVA, Chi-square, and Kruskal–Wallis.
 RESULTS: The results showed that a significant change in uric acid levels in both intervention groups (p = 0.001 < 0.05), whereas the control group was not significant. There was a difference in changes in uric acid levels between the intervention group and the control group (p = 0.000 < 0.05).
 CONCLUSION: It was concluded that the large difference in uric acid levels between the intervention group and the control group was 26.5% and 28.3%. It is recommended to use lemongrass in preventing elevated blood uric acid levels.

PENGARUH SENAM ERGONOMIS TERHADAP PERUBAHAN KADAR ASAM URAT PADA PENDERITA ASAM URAT

Abstract : Uric acid disease occurs due to the buildup of uric acid in the body. One of its causes is due to lack of physical activity which make the transport of residual burning (uric acid) in the body becomes disturbed. The objective of this research was to find out the effect of ergonomic gymnastic toward the changes of uric acid level on patients of uric acid in community health center of Lingkar Timur Bengkulu city. The design of this research was quasi experimental with pre and post test with control group design. The samples consisted of 26 respondents. There were 13 respondents of intervention group and 13 respondents of control group. The technique of sampling for this research was simple random sampling. To analyze the data, paired sample t-test was used at α < 5%. The result of this research shows that the average of uric acid level before given intervention was 7,50mg/dl on intervention group and 7,25mg/dl on control group. The average of uric acid after given intervention was 6,60mg/dl on intervention group and 7,70mg/dl on control group. The conclusion of this research is there was the effect of ergonomic gymnastic toward the changes of uric acid on patients of uric acid p(0,000).For the researcher, it is better to do it for a longer period of time and do the measurement after the exercise is done so as to get a significant change in uric acid levelsKeyword :Uric Acid, Ergonomic Gymnastic

OP0168 CARDIOVASCULAR EVENT ASSOCIATED WITH INITIATING ALLOPURINOL AND FEBUXOSTAT - ACUTE GOUT ATTACK AND CARDIOVASCULAR GOUT ATTACK

Background:When serum uric acid rapidly increases or decreases due to such as alcohol consumption or fasting, free urate crystals are formed, which induce an acute joint inflammation referred to as an acute gout attack. In 86.4% of patients with gout, dual energy computed tomography demonstrated the deposition of urate crystals in vasculature, and urate crystals have been observed in coronary arteries and various tissues in 10.9% of patients with a heart transplant. However, whether hyperuricemia and urate crystal directly cause cardiovascular disease is not well known. We previously reanalyzed the CARES trial to calculate the mortality rates based on the median duration of exposure to study drugs and the median follow-up duration. A sharp increase in mortality was observed after allopurinol and febuxostat were discontinued. Even in view of the Sick-Stopper Effect, for about 40-fold increase in mortality following drug discontinuation, we postulated that the sharp increase in mortality may be associated with rapid changes in uric acid level (rebound hyperuricemia), and that withdrawal of hypouricemic agent leads to an acute inflammatory response due to an abrupt increase in serum uric acid level with subsequent free urate crystal formation in the cardiovascular system (cardiovascular gout attack)(1).Objectives:Based on this hypothesis that some cardiovascular events may be cardiovascular gout attacks, we investigated the association between the cardiovascular event and initiation of hypouricemic agent, when is accompanied by acute gout attack and/or fluctuation of uric acid, in gout patients.Methods:Using the Korean National Health Insurance Service (KNHIS) database, which covers the entire Korean population, we conducted a population-based cohort study among gout patients who initiated allopurinol or febuxostat between 2012 and 2018. The initiators were defined as those who had no prior dispensing of any urate-lowering therapy for at least 60 months before the first dispensing date (i.e. index date) of either allopurinol or febuxostat. We excluded patients with a diagnosis of cancer and patients treated with benzbromarone. We investgated a composite cardiovascular event of hospitalized myocardial infarction, ischemic stroke, and cerebral hemorrhage.Results:We identified hospitalizations for cardiovascular event (acute myocardial infarction (n = 3538), cerebral infarction (n = 5127), and cerebral hemorrhage (n = 1593)) that occurred within 2 year before and 2 year after initiation of allopurinol or febuxostat. Of these, 4333 cardiovascular event (0.014 per person-time, 95% confidence interval [CI], 0.014 to 0.015) occurred in 2 years before initiation of allopurinol or febuxostat, 1032 cardiovascular event (0.081 per person-time, 95% confidence interval [CI], 0.076 to 0.086) occurred in 30 days before initiation of allopurinol or febuxostat. And, 83 cardiovascular event (0.030 per person-time, 95% CI, 0.024 to 0.037) occurred in 7 days after initiation of allopurinol or febuxostat. (Figure)Figure 1Conclusion:Initiation of febuxostat and allopurinol was significantly associated with acute myocardial infarction, cerebral infarction, and cerebral hemorrhage. Considering that allopurinol and febuxostat usually are initiated a few weeks after a acute gout attack. Acute gout attack and/or fluctuation of uric acid level might be significantly associated with cardiovascular event. Some of cardiovascular events might be cardiovascular gout attack.

Renal insufficiency in overt hypothyroidism

Hypothyroidism is a common endocrine disorder worldwide. In hypothyroidism, there is altered regulation of renal hemodynamics and basal metabolic rate. This hospital-based case-control study was done to evaluate the changes in uric acid level in hypothyroid subjects. This study includes 25 hypothyroid cases with age and sex-matched controls. Serum total thyroid profile was estimated by ChemiluminiscenceImmunoassay (CLIA) and uric acid by the Uricase method in fully automated Vitros 5600. The mean uric acid level is increased in hypothyroid. Triiodothyronine(T3)&Thyroxine(T4)levelof hypothyroid patients showed a significant negative correlation with uric acid with 'r' values of 0.45 and 0.51, respectively. A positive correlation was observed between Thyroid-stimulating hormone (TSH) and uric acid (p=0.22) in hypothyroid subjects. The raise in uric acid is hypothyroid subjects is due to hemodynamic changes like reduction in renal plasma flow and disordered thyroid state affects purine metabolism, leading to hyperuricemia and gout. Hence, these parameters should be monitored regularly in hypothyroid patients.

Plasma magnesium and the risk of new-onset hyperuricaemia in hypertensive patients.

We aimed to evaluate the relationship of plasma Mg with the risk of new-onset hyperuricaemia and examine any possible effect modifiers in hypertensive patients. This is a post hoc analysis of the Uric acid (UA) Sub-study of the China Stroke Primary Prevention Trial (CSPPT). A total of 1685 participants were included in the present study. The main outcome was new-onset hyperuricaemia defined as a UA concentration ≥417 μmol/l in men or ≥357 μmol/l in women. The secondary outcome was a change in UA concentration defined as UA at the exit visit minus that at baseline. During a median follow-up duration of 4·3 years, new-onset hyperuricaemia occurred in 290 (17·2 %) participants. There was a significantly inverse relation of plasma Mg with the risk of new-onset hyperuricaemia (per sd increment; OR 0·85; 95 % CI 0·74, 0·99) and change in UA levels (per sd increment; β -3·96 μmol/l; 95 % CI -7·14, -0·79). Consistently, when plasma Mg was analysed as tertiles, a significantly lower risk of new-onset hyperuricaemia (OR 0·67; 95 % CI 0·48, 0·95) and less increase in UA levels (β -8·35 μmol/l; 95 % CI -16·12, -0·58) were found among participants in tertile 3 (≥885·5 μmol/l) compared with those in tertile 1 (<818·9 μmol/l). Similar trends were found in males and females. Higher plasma Mg levels were associated with a decreased risk of new-onset hyperuricaemia in hypertensive adults.

Effect of Poorna Chandrodayam Chendooram (PCM-Metallic Drug) on Lipid Profile, Liver Function and Kidney Function Parameters of Rats

Poorna Chandrodayam Chendooram (PCM), a Siddha Herbal preparation which is used for its effect on liver function, kidney function and lipid profile after administrations into the biological system. The existing study was intended at evaluating the Liver, kidney and Lipid profile of Normal and PCM treated in investigational animal model. The experimental animal model was of Male rats. Male rats were divided into Two groups: control rats and Poornachandrodaya chenduram treated Rats. Triglycerides (TG) Total cholesterol (TC), and low density lipoprotein (LDL) were decreased in experimental groups whereas high density lipoprotein (HDL) were a little increased in male rats. The Total protein and albumin Level of plasma were enhanced very high significantly. In case of bilirubin, the decline was negligible for rats. The serum glutamic pyruvic transaminase (sGPT), serum glutamic oxaloacetic transaminase (sGOT) and alkaline phosphatase (ALP) content in the plasma were diminished very high significantly in the experimental groups. Creatinine, and urea were diminished in male where only change of uric acid level was significant increased. It is confirmed that Metal base drug PCM is a safe and effective drug. It is evident that the trial drug eliminate the toxic substances from the body and enhances the longevity of life.

PERAN AIR REBUSAN DAUN SALAM (SYZGIUM POLYANTHUM) DALAM MENURUNKAN KADAR ASAM URAT

Background: Uric acid is a final product or a waste that is resulted from the metabolism of purines. A high level of uric acid (hyperuricemia) will cause several health problems, such as vascular inflammation, smooth muscle proliferation, and vascular lesion in kidneys. The syzygium polyanthum leaves contain bioactive substances that may affect the level of uric acid in blood.&#x0D; Objective: This study aimed to determine the influence of boiled water of syzygium polyanthum leaves to the changes of uric acid levels in the target area of Puskesmas Pandak 1 Bantul.&#x0D; Methods: This study employed pre- and post-test without control group design. The population consisted of all patients with hyperuricemia in the target area of Puskesmas Pandak 1 Bantul. Sample was selected with a concecutive sampling, gaining a total number of 24 respondents. Data were analyzed with the Wilcoxon test. The dose of boiled water of syzygium polyanthum leaves intake was 0.36g/ KgBW, once a day for 14 days.&#x0D; Result: This research showed that the boiled water of syzygium polyanthum leaves decreased hyperuricemia (uric acid levels), along with the significancy value of 0.009 (p &lt;0.05). At the pre-test time, the average level of uric acid reached 7.279 mg/dl, and after the treatment, it decreased to 6.76 mg/dl.&#x0D; Conclusion: This study has established evidence that the boiled water of syzygium polyanthum leaves is able to decrease hyperuricemia (uric acid level in blood).&#x0D; Keywords: Syzygium polyanthum, boiled water of syzygium polyanthum leaves, hyperuricemia

22-LB: Baseline and Short-Term Change in Plasma Uric Acid on Fenofibrate Predict Cardiovascular Risk: A Post Hoc Analysis of FIELD

Background: Fenofibrate increases renal clearance of uric acid (UA). Relationships between baseline and short-term changes in plasma UA with fenofibrate and subsequent cardiovascular risk in patients with type 2 diabetes (T2D) are unknown. Method: Post hoc analyses of the FIELD trial explored the relationships between CVD events and 1) baseline UA level; and 2) short-term change in UA level over 6-week single-blind active fenofibrate run-in. Results: The FIELD trial showed 11% fewer cardiovascular events in patients with T2D assigned to fenofibrate compared to placebo over 5 years (HR = 0.89, 95% CI: 0.80-0.99, p = 0.035). Baseline UA (n=9622) ranged between 0.11 to 0.79 mmol/L (mean = 0.33, SD = 0.078). Each 0.1 mmol/L higher baseline UA increased CVD events by 21% (HR = 1.21 95% CI: 1.13-1.29, p &amp;lt; 0.001; Fig. 1A), and remained after adjusting for other classic risk factors (HR = 1.12, 95% CI: 1.04-1.21, p = 0.002). Fall in UA level with fenofibrate run-in also predicted lower CVD risk, adjusted for baseline UA and irrespective of trial treatment allocation (HR = 0.86, 95% CI: 0.76-0.97, p = 0.015; Fig. 1B). Discussion: Baseline and short-term fenofibrate-induced lowering of UA predict cardiovascular risk in patients with T2D, irrespective of long-term trial treatment allocation. The reduction in total CVD events with fenofibrate was not shown to be mediated through lowering of UA levels. Disclosure J.Y. Cao: None. B. Waldman: None. R.L. OConnell: None. D. Sullivan: None. V. Gebski: None. A.S. Januszewski: None. I. Marschner: None. R. Scott: None. M. Taskinen: Advisory Panel; Self; Novo Nordisk A/S. Consultant; Self; Akcea Therapeutics, Chiesi USA, Inc. Research Support; Self; Amgen Inc., Novo Nordisk A/S. Speaker’s Bureau; Self; Amgen Inc. R. Simes: None. N. McGill: None. A.J. Jenkins: Advisory Panel; Self; Abbott, Australian Diabetes Society, Medtronic. Research Support; Self; Abbott, GlySens Incorporated, Medtronic, Mylan. Speaker’s Bureau; Self; Eli Lilly and Company, Novo Nordisk Inc. A.C. Keech: None.

Jus semangka menurunkan kadar asam urat

Abstract: As the population of the elderly increases, health problems such as Gout indicated by Hyperuricemia might also appear. Hyperuricemia can be prevented by increasing the intake of Vitamin C, B5, B6, and E. Therefore, the purpose of this research was to find out the effects of watermelon juice on the change in uric acid level in the elderly living in Dupak Bangunsari RT V RW 4 Surabaya. The research used quasi- experiment design. The populations involved 16 old people with Hyperuricemia, in which half of them, 8 people, were taken as the samples done by applying the random allocation technique classified as follows: 8 people in experiment group and 8 people in control group. The watermelon juice therapy was chosen as the independent variable, where as the dependent variable was the change of uric acid level. Furthermore, the uric acid level measuring tool was used to collect the data which were then recorded on the recapitulation and watermelon juice sheet. The result of analysis done by applying Fischer’s Exact test and SPSS for Windows showed that ρ = 0.001 &lt; α = 0.05 which meant that the research hypothesis was accepted illustrating that there were some effects of watermelon juice on the change in uric acid level in the elderly living in the above mentioned region. The research has come to a conclusion that there were some effects of watermelon juice on the change in uric acid level. Hence, the old people with Hyperuricemia should consume more Vitamin C, B5, B6, and E and change their life pattern into the healthy one.

P3800Fifteen years changes of uric acid level and prevalence of hyperuricemia in hypertensive subjects

P3800Fifteen years changes of uric acid level and prevalence of hyperuricemia in hypertensive subjects

The relationship between dialysis adequacy and the rate of change in uric acid level by hemodialysis

Aim: Although one of the commonly used methods for determining dialysis adequacy is the urea kinetic model, it is not the gold standard. Different parameters are needed to determine dialysis adequacy. In our study, we investigated the relationship between urea reduction rate (URR) and Kt/V which are used to assess dialysis adequacy and the rate of change in uric acid, a purine metabolite, by hemodialysis.Methods: A total of 133 patients who had undergone hemodialysis treatment due to renal failure between March 2010 and September 2010 were evaluated retrospectively. Urea kinetic modeling was used to measure dialysis adequacy. The following formula was used to do this; Kt/V=-ln(R-0.008xT)+(4-3.5xR)xUF/W[R; postdialysis blood ureanitrogen (BUN)/predialysis BUN, T; duration of dialysis (hr), UF; total ultrafiltration during dialysis (L), W; patient weight after dialysis (kg)]. The urea reduction rate was calculated using the formula; URR(%)=100x(1-postdialysis BUN/predialysis BUN). Uric acid reduction rate (UARR) was calculated using the formula; UARR(%)=100x(1-Uric acid after/Uric acid before). The relationship between URR and Kt/V ratios which are used to assess dialysis adequacy and UARR is evaluated.Results: Median urea, uric acid and creatinine reduction rates were 72%, 74% and 63.9%, respectively. There was a statistically significant correlation between reduction rates of uric acid, creatinine and urea after dialysis (p&lt;0.001). There was a statistically significant relationship between URR and Kt/V which are used to assess dialysis adequacy,and UARR (p&lt;0,001). According to the ROC analysis in our study, we defined UARR value that will demonstrate dialysis adequacy as at least 65.8% (sensitivity 97.9% and specificity 82.6%, area under the ROC curve=0.880, p&lt;0.001).Conclusion: A significant relationship was found between the URR and Kt/V ratios which are used to assess dialysis adequacy and UARR. We also determined in our study that the UARR value that shows dialysis adequacy should be at least 65.8%. To our knowledge, this is the first study to evaluate the relationship between UARR and dialysis adequacy. However, thefindings need to be confirmed by large, prospective, clinical trials.

Uric acid is an independent predictor of cardiac allograft vasculopathy after heart transplantation.

Cardiac allograft vasculopathy (CAV) is a major complication after heart transplantation (HT). Uric acid (UA) may play a role in CAV due to its role in stimulating T-cell-mediated immunity. Sirolimus is associated with CAV attenuation through a number of mechanisms, including immune-mediated effects. We aimed to determine whether UA is an independent predictor of CAV and whether conversion to sirolimus as primary immunosuppression modulates UA levels. We retrospectively analyzed a cohort of 224 patients who underwent HT between 2004 and 2015 and had serial coronary intravascular ultrasound (IVUS) studies. Serum UA levels were measured at baseline and last follow-up IVUS in all participants. CAV progression was assessed by measuring the change in plaque volume (ΔPV) and plaque index (ratio of plaque volume to vessel volume [ΔPI]) between last follow-up and baseline IVUS after correction for time of follow-up. Patients with high (≥7 mg/dl) compared with low (<7 mg/dl) UA had increased median ΔPV (0.33 [interquartile range 0.08 to 0.93] vs 0.07 [-0.17 to 0.38] mm3/mm/year; p < 0.001) and ΔPI (2.0% [0.31% to 3.9%] vs 0.33% [-1.2% to 2.0%]; p < 0.001). Elevated UA levels were associated with a significantly increased risk of developing significant CAV progression (ΔPV >0.50 mm3/mm) (hazard ratio 2.2, 95% confidence interval 1.1 to 4.6; p = 0.037). Sirolimus resulted in decreased UA levels (5.8 ± 1.4 vs 5.2 ± 1.5; p = 0.002) and patients converted to sirolimus and had low UA levels had the least CAV progression (p < 0.001). After adjustment for potential confounders, change in UA level was also an independent predictor of CAV progression. UA is an independent predictor of CAV after HT. Sirolimus is associated with decreased UA levels and may explain one of the mechanisms by which sirolimus attenuates CAV progression.

The value of fixed rasburicase dosing versus weight-based dosing in the treatment and prevention of tumor lysis syndrome.

Rasburicase is a recombinant urate oxidase enzyme used for the treatment and prevention of tumor lysis syndrome. Our objective was to assess the efficacy of indication-based, low-dose rasburicase administration compared to the Food and Drug Administration-approved weight-based dosing. This was a retrospective cohort study utilizing data from a tertiary medical center including patients admitted from 2012 to 2016, who received at least one dose of rasburicase. The primary outcome was achieving a uric acid level less than 7.5 mg/dl after a single dose of rasburicase in the preprotocol (Food and Drug Administration-approved weight-based dosing) and postprotocol (indication-based, low-dose) groups. Secondary outcomes included the change in uric acid levels between the pre- and postprotocol groups, adherence to the new institutional protocol, need for repeat rasburicase doses, and a cost analysis. Sixty-four patients received at least one dose of rasburicase between 1 January 2012 and 1 December 2016. Twenty-seven (79.4%) doses in the preprotocol group and 28 (82.4%) doses in the postprotocol group successfully achieved a uric acid level less than 7.5 mg/dl after a single dose of rasburicase (p=1.000). The average total monthly cost of rasburicase was reduced by 59.9% after adoption of the new protocol. Indication-based, low-dose rasburicase displayed significantly more value when compared to weight-based dosing as shown by achieving cost savings without compromising clinical efficacy.

The influence of low purine diet and physical activity on changing of uric acid levels in hyperuricemia

Hyperuricemia is caused by elevated levels of uric acid in the blood due to excessive production or reduced disposal. Factors that contribute to increased uric acid production are the consumption of foods that contain lots of purine and uric acid, obesity, drug use, physical activity and certain diseases in the blood. The purpose of this study was to determine the effect of low purine diet and physical activity on changes in uric acid levels in hyperuricemia in tourism areas. The research was conducted in Sanur Urban Village of Denpasar, with the sample is woman age 30-60 years old as much 38 people. The research is an experimental research with pretest-posttest control design. Subjects were divided into two groups, group 1 applied a low purine diet and physical activity and group 2 as a control only applied a low purine diet. A low purine diet is consumed daily for 6 weeks. Physical activity is yoga exercises performed for 60 minutes with a frequency of 3 times a week for 6 weeks. To know the change in blood uric acid level before and after intervention using the Paired t-test.

Effect of oral antihypertensive drugs on biochemical dosages in the elderly

Objective: to compare serum levels of uric acid, glucose, potassium and sodium in elderly users and non-users of oral antihypertensive drugs. Methods: observational, case-control study, including 232 elderly people with mean age 68.9 ± 7.4 years, of which 116 use and 116 do not use oral antihypertensive drugs, of both genders, non-diabetic and with no renal disease. After venous blood collection, glucose and uric acid were measured by colorimetric method; and sodium and potassium by the ion-selective electrode method. Results: there was an association between use of antihypertensive drugs and elevations in serum uric acid levels (p=0.040). And, among the classes, diuretic drugs demonstrated in this study relation with changes in uric acid levels (p=0.02) when compared to the other classes. Conclusion: the use of antihypertensive drugs, especially diuretics, has been associated with an increase in serum uric acid levels in hypertensive users of oral antihypertensive drugs.

EXCRETION OF CREATININE, URIC ACID AND MICROPROTEINS BY GENERAL BODY MASSAGE APPLIED AFTER EXERCISE

Sports massage science has become an area of interest among many athletes’ instructors, trainers and also sports physiologists. This study was conducted to analyze the effects of massage on uric acid, creatinine and microprotein parameters. The study included 42 participants, 21 in the study group (Ex) and 21 in the control group (C). The first urine samples (urine) were taken within 2-3 hours after the submaximal exercise. After urinary excretions of the subjects were completely finished, the massage protocol was applied to the subjects at the same time of the day. Submaximal exercise was applied to both groups. Following the exercise, massage was applied to the study group. Massage was not applied to the control group. Analyzes were performed by taking urine samples from the subject group twice before and after massage. A statistically significant difference was found in the level of uric acid and creatinine before and after massage which was applied after submaximal exercise (p 0.05). In accordance with the data obtained, although it was determined that massage had effects on the measured parameters; it was not clear in what ways these effects were. It is estimated that the change in uric acid levels may be due to antioxidant properties and massage may cause this change by affecting the antioxidant defense system. It is suggested to take the level of creatinine, uric acid and microprotein into account for performance improvement and regulation and balancing the resting period of the athletes. Article visualizations: