Changes in shoreline positions along the Rio Grande do Sul coast, southern Brazil, are analyzed to determine the spatial and temporal variability of shoreline movements at a regional scale. Using a kinematic Differential Global Positioning System (DGPS) survey method, the 618-km long shoreline of Rio Grande do Sul has been mapped on five occasions between November 1997 and April 2002. These data show that the coastline responds differently to hydrodynamic and meteorological forcing along the three major coastal sectors. The observed differences occur especially in the magnitude of changes, in the time interval in which the shoreline returns to a previous position, and in the length scale of dominant shoreline changes. Here changes in shoreline position are examined with respect to grain size, shoreline orientation, storms, El Nino–Southern Oscillation (ENSO) events, and gradients of longshore sediment transport. Data analyses and modeling indicate that the alongshore variability in the patterns of shoreline change through time is closely related to shoreline orientation and the associated gradients of longshore sediment transport. Results indicate also that variability in wave energy and storminess influence seasonal changes, whereas ENSO events influence interannual changes. This study demonstrates the importance of understanding the drivers of shoreline change at a regional scale and has applications in studies concerned with coastal engineering and shoreline response to climate change.