Changes In Height Research Articles

Research on enhancement of screening performance of a novel drum screen based on the Discrete Element Method simulation

Screening is one of the most basic technologies for size classification of granular materials. Based on discrete element method simulations, a new built-in component was developed to address the problems of particle piling and poor segregation in drum screening process, and the particle dynamics and spatial distribution were carefully investigated. The results showed that, increasing the blade length will enhance the particle spreading, and a gap between the rotating blade end and the screen wall can lead to proper size segregation; Built-in slits can act as a ‘secondary screen’ by changing the volume ratio of large and small particles, and the curved-end blades can not only push the particles forward but also exert pressure on the ones underneath them; The screening efficiency changes non-linearly with the change in baffles' height; Contrastively, the screening efficiency of the optimized built-in component drum screen is significantly increased up to 82.34%.

Improving Biocompatibility of Polyurethanes Apply in Medicine Using Oxygen Plasma and Its Negative Effect on Increased Bacterial Adhesion.

Polyurethanes (PUs) are versatile polymers used in medical applications due to their high flexibility and fatigue resistance. PUs are widely used for synthetic blood vessels, wound dressings, cannulas, and urinary and cardiovascular catheters. Many scientific reports indicate that surface wettability is crucial for biocompatibility and bacterial adhesion. The use of oxygen plasma to modify PUs is advantageous because of its effectiveness in introducing oxygen-containing functional groups, thereby altering surface wettability. The purpose of this study was to investigate the effect of the modification of the oxygen plasma of polyurethane on its biocompatibility with lung tissue (A549 cell line) and the adhesion of Gram-positive bacteria (S. aureus and S. epidermidis). The results showed that the modification of polyurethane by oxygen plasma allowed the introduction of functional groups containing oxygen (-OH and -COOH), which significantly increased its hydrophilicity (change from 105° ± 2° to 9° ± 2°) of PUs. Surface analysis by atomic force microscopy (AFM) showed changes in PU topography (change in maximum height from ∼110.3 nm to ∼32.1 nm). Moreover, biocompatibility studies on A549 cells showed that on the PU-modified surface, the cells exhibited altered morphology (increases in cell surface area and length, and thus reduced circularity) without concomitant effects on cell viability. However, serial dilution and plate count and microscopic methods confirmed that plasma modification significantly increased the adhesion of S. aureus and S. epidermidis bacteria. This study indicate the important role of surface hydrophilicity in biocompatibility and bacterial adhesion, which is important in the design of new medical biomaterials.

A Framework for Communicating and Building a Digital Twin Model of the Electric Car

The Fourth Industrial Revolution has had a huge impact on manufacturing processes and products. With rapidly growing technology, new solutions are being implemented in the field of digital representations of a physical product. This approach can provide benefits in terms of cost and testing time savings. In order to test and reflect the operation of an electric car, a digital twin model was designed. The paper collects all the information and standards necessary to transform the idea into a real and virtual model of an electric car. The significance and impact of the study on the improvement of the project are described. The research stand, correlations of components (DC and AC motors, shaft, and wheel of the electric car), and development prospects are presented in the paper. The communication method with the research stand is also presented. The digital twin should communicate in real time, which means obtaining the correct output when the input changes; the input is the AC motor current, and the output is the rotational speed of the DC motor. The relation between inputs and outputs are tested. The kinematics of the electric car are modelled in LabVIEW. The results obtained are compared with historic racing data. The track is also modeled based on satellite data, taking into account changes in terrain height, using the SG Telemetry Viewer application. The parameters of the electric car engine model are tuned based on actual data on the car’s speed and current in the electric motor. The achieved results are presented and then discussed.

Correlation between Disc Imaging Observations and Clinical Efficacy after Percutaneous Endoscopic Lumbar Discectomy: A 1-Year Follow-up Study.

The connection between alterations in the disc structure following percutaneous endoscopic lumbar discectomy (PELD) and symptoms in patients postsurgery has not been reported yet. The purpose of the present study was to discuss the potential correlation between the changes in the morphological characteristics of various reference surfaces of the intervertebral disc after percutaneous endoscopic lumbar discectomy (PELD) and clinical outcomes, to identify the morphological parameters that affect efficacy and provide an evidence-based foundation for assessing postoperative efficacy. From October 2019 to October 2021, after percutaneous endoscopic lumbar discectomy (PELD), 98 individuals were enrolled. MRI DICOM data of the lumbar spine were obtained before and after surgery, specifically around 3 months. The morphological parameters of the operated and adjacent segments of the discs were measured using T2-weighted images from three reference planes. Outcomes were assessed using the Oswestry disability index (ODI), visual analogue pain scores for the back and leg (VAS-back/VAS-leg), Japanese Orthopaedic Association (JOA) scores, and recovery rates. Postoperative changes in disc parameters and outcomes were compared between patients with different severity and types of LDH based on the MSU staging. Patients completed the questionnaire during outpatient follow-up appointments 3, 6, and 12 months after the surgery. The follow-up period was 14.69 ± 4.21 months, ranging from 12 to 24 months. Parameters such as area and circumference of intervertebral discs in the cross-section were not associated with the change in the efficacy index. Postoperatively, a negative correlation between the variation of the disc height, disc height index, and protrusion distance and the difference in VAS scores for low back pain at 3 and 6 months was observed among the two sagittal change parameters. Differences between changes in disc imaging parameters and postoperative efficacy were not statistically significant between various types of lumbar disc herniation. For the patients after percutaneous endoscopic lumbar discectomy, the changes in parameters such as disc area and circumference in the cross-sectional plane are not associated with efficacy, and the changes in disc height and herniation distance in the sagittal plane provide a morphologic basis for the assessment of short-term postoperative efficacy. In addition, the changes in disc morphologic parameters and postoperative efficacy do not differ between various types of lumbar disc herniation.

Bottom-hole pressure inversion method for nature gas wells based on blowout combustion flame shape parameters

In response to the challenges associated with the difficulty of obtaining critical well control parameters, particularly bottom-hole pressure, during a well blowout fire, a comprehensive computational fluid dynamics (CFD) model for analyzing well blowout fires is developed based on fluid mechanics and combustion theory, considering factors such as gas composition, pressure, wellhead diameter, wind speed, and temperature, and is validated by published experiment date. Then, a CFD simulation database is constructed by conducting a sensitivity analysis of the flame height to investigate the correlations among flow field, operating conditions and flame parameters. Subsequently, an approach incorporates an AutoEncoder (AE) to reduce the dimensionality of the highly correlated raw data, and a Bayesian Optimization-based Radial Basis Function Network (BO-RBFN) to explore the inherent patterns within the established CFD dataset and then establishes a fuzzy relation between immeasurable wellhead flow velocity and well blowout fires operating parameters, achieving an accurate prediction of wellhead flow velocity. Furthermore, utilizing the wellhead gas velocity and the calculated wellhead pressure as the initial conditions, the bottom hole pressure during blowout fire is inversed based on wellbore temperature and pressure model. As a result of this study, a model integrating numerical model, databases, intelligent algorithms is developed for determining bottom-hole pressure in the presence of a blowout fire. And the proposed deep learning-based approach demonstrated exceptional accuracy in predicting wellhead gas flow velocity, with an average absolute difference of less than 2% between validation set and test set. In addition, as the ambient temperature, wellhead pressure, and wellhead diameter increase, the height of the blowout flame increases. In contrast, as the gas temperature and wind speed increase, the height of the blowout flame gradually decreases. Notably, only marginal changes in flame height resulted from alterations in gas composition. This study can quantitatively reveal the cause of well blowout and evaluate the severity of well blowout, and have practical significance in guiding the design and execution of subsequent rescue operations for uncontrolled blowouts fires.

Variation in body size and weight status among Hindu and Muslim Indian males born in the 1890s through the 1950s

Hindus and Muslims represent the two largest religions in India, and also differ in nutritional status, health-related habits and standard of living associated with economic disparities. In this context, the present study considered estimated secular changes in body size, proportions, and weight status among Hindu and Muslim Indian men. The data are from anthropological surveys in the 1970s which included measurements of height, weight and sitting height of 43,950 males 18–84 years (birth years 1891–1957). Leg length was estimated; the BMI and sitting height/height ratio were calculated. Heights of men 35 + years were adjusted for estimated height loss with age. Weight status was also classified relative to WHO criteria for the BMI. Anthropometric characteristics of the two groups were compared with MANCOVA with age and geographic region as covariates. Linear regression of height on year of birth was also used to estimate secular change in each group. Heights, weights, and BMIs tended to be, on average, greater among Muslim than Hindu men at most ages, while distributions by weight status between groups were negligible. Sitting height was greater among Muslim men but estimated leg length did not differ between groups; the sitting height/height ratio thus suggested proportionally shorter legs among Muslim men. Results of the regression analyses indicated negligible differences in secular change between groups across the total span of birth years but indicated a decline in adjusted heights of men in both groups born between 1891 through 1930s and little secular change among those born in the 1930s through 1957. The variation in heights, weights and BMIs between Muslim and Hindu men at most ages suggested variation in socio-economic status and dietary habits between the groups, whereas the negligible estimated secular changes in height between groups likely reflected economic, social, and nutritional conditions during the interval of British rule and the transition to independence.

Efficacy of Alveolar Ridge Preservation in Periodontally Compromised Molar Extraction Sites: A Systematic Review and Meta-Analysis.

To investigate the efficacy of alveolar ridge preservation (ARP) in periodontally compromised molar extraction sites. An electronic search was performed on 10th November 2023 across five databases, seeking randomised/non-randomised controlled trials (RCTs/NCTs) that included a minimum follow-up duration of four months. The RoB2 and Robins-I tools assessed the risk of bias for the included studies. Data on alveolar ridge dimensional and volumetric changes, keratinized mucosal width, and need for additional bone augmentation for implant placement were collected. Subsequently, a meta-analysis was carried out to derive the pooled estimates. Six studies were incorporated in the present review, and a total of 135 molar extraction sockets in 130 subjects were included in the meta-analysis. ARP was undertaken in 68 sites, and 67 sites healed spontaneously. The follow-up time ranged from 4 to 6 months. The meta-analysis of both RCTs and NCTs showed significant differences in mid-buccal ridge width changes at 1 mm level below ridge crest with a mean difference (MD) of 3.80 (95% CI: 1.67-5.94), mid-buccal ridge height changes (MD: 2.18; 95% CI: 1.25-3.12) and volumetric changes (MD: 263.59; 95% CI: 138.44-388.74) in favour of ARP, while the certainty of evidence is graded low to very low. Moreover, ARP appeared to reduce the need for additional sinus and bone augmentation procedures at implant placement with low certainty of evidence. Within the limitations of this study, alveolar ridge preservation in periodontally compromised extraction sites may, to some extent, preserve the ridge vertically and horizontally with reference to spontaneous healing. However, it could not eliminate the need for additional augmentation for implant placement. Further, longitudinal studies with large sample sizes and refined protocols are needed.

Growing Rod versus Posterior Spinal Fusion Treatment of Juvenile Idiopathic Scoliosis: Unique Characteristics and Surgical Outcomes.

Progressive spinal curvature in juvenile idiopathic scoliosis (JIS) is challenging to treat. When conservative management fails, treatments include growing rods (GRs) or posterior spinal fusion (PSF). The purpose of this study is to compare the patient characteristics and outcomes of GR and PSF treatment of JIS. We performed a retrospective review of demographic, radiographic, and surgical data for all JIS patients requiring surgical treatment between 2012 and 2020. Patients who underwent any GR treatment were compared to PSF patients. A total of 36 patients (13 GR, 23 PSF) were reviewed. PSF patients had a larger pre-operative spinal height (p = 0.002), but similar pre-operative major curve magnitudes (p = 0.558). PSF treatment resulted in similar change in the T1-S1 length (p = 0.002), but a greater correction of the curve magnitude (p < 0.055) compared to GR patients. Eight patients initially treated with GRs later underwent definitive PSF treatment. This subset of patients had a greater spinal height before PSF (p = 0.006), but similar immediate post-PSF T1-S1 lengths (p = 0.437) and smaller changes in spinal height from PSF (p = 0.020) than primary PSF patients. At final follow-up, patients who underwent primary PSF versus PSF after GR had similar spinal heights (p = 0.842). The surgical intervention chosen to manage progressive JIS often differs based on patient characteristics. While this choice may impact immediate outcomes, the outcomes at final follow up are similar.

Patient Re-Identification Based on Deep Metric Learning in Trunk Computed Tomography Images Acquired from Devices from Different Vendors

During radiologic interpretation, radiologists read patient identifiers from the metadata of medical images to recognize the patient being examined. However, it is challenging for radiologists to identify “incorrect” metadata and patient identification errors. We propose a method that uses a patient re-identification technique to link correct metadata to an image set of computed tomography images of a trunk with lost or wrongly assigned metadata. This method is based on a feature vector matching technique that uses a deep feature extractor to adapt to the cross-vendor domain contained in the scout computed tomography image dataset. To identify “incorrect” metadata, we calculated the highest similarity score between a follow-up image and a stored baseline image linked to the correct metadata. The re-identification performance tests whether the image with the highest similarity score belongs to the same patient, i.e., whether the metadata attached to the image are correct. The similarity scores between the follow-up and baseline images for the same “correct” patients were generally greater than those for “incorrect” patients. The proposed feature extractor was sufficiently robust to extract individual distinguishable features without additional training, even for unknown scout computed tomography images. Furthermore, the proposed augmentation technique further improved the re-identification performance of the subset for different vendors by incorporating changes in width magnification due to changes in patient table height during each examination. We believe that metadata checking using the proposed method would help detect the metadata with an “incorrect” patient identifier assigned due to unavoidable errors such as human error.

The Thousand-Pulsar-Array programme on MeerKAT – XII. Discovery of long-term pulse profile evolution in seven young pulsars

ABSTRACT A number of pulsars are known to have profile evolution on time-scales of months, often correlated with spin-down rate changes. Here, we present the first result from 3 yr of monitoring observations from MeerKAT as part of the Thousand Pulsar Array programme. This programme obtains high-fidelity pulse profiles for ∼ 500 pulsars, which enabled the detection of subtle changes in seven sources not previously known to exhibit long-term profile evolution. A 2D Gaussian convolution is used to highlight correlated emission variability in both the pulse phase and observing epoch direction. Simulations show that for one additional source the observed profile variability is likely to originate from stochastic single-pulse shape variability (jitter). We find that it is common for long-term profile variability to be associated with changes in polarization fractions, but not with polarization position angle (PA) changes. PA changes are expected if emission height changes or precession is responsible for the profile variability. PSR J1741−3927 is the only pulsar in our sample that shows correlated PA variability, and this is associated with orthogonal polarization mode activity. For the six other pulsars limits on possible emission height changes and impact angle changes are derived. These limits are consistent with the small changes in the total intensity profile shape. None of the sources show detectable spin-down variability correlated with the emission changes, which are thought to be driven by magnetospheric current fluctuations. Therefore, the absence of correlated spin-down rate variability allows upper limits to be placed on changes in the magnetospheric charge density.

A study to evaluate the effect of Lactobites bar as a galactagogue to increase the production of milk in lactating women and promote overall healthy recovery of lactating mothers

Breastfeeding is widely acknowledged as the preferred and recommended mode of infant nutrition. However, women who have undergone cesarean deliveries may face an increased risk of inadequate breast milk production, which can be addressed through various techniques, including the use of galactagogues, which stimulate breast milk production. Galactagogues are synthetic or plant molecules that induce, maintain, and increase milk production.In this current real-world evidence study, 53 lactating women were enrolled. During the study, they received lactobites bar for 28 days. The intestinal health of the baby, incidences of formula feeding, the volume of breast milk, baby's anthropometric measures: such as changes in height, changes in the quality of hair and skin of the mother were evaluated. The feeling of wellness in the mother and haemoglobin levels were also assessed during the study.The haemoglobin levels were significantly increased in mothers who were given lactobites bar. A significant increase was observed in hours of night and day sleep, stool frequency per day, vol. of breast milk [baseline vs 28 day: 30.19 ± 34.4 vs 448.06 ± 651.11; P&amp;#60;0.05], no. of diapers per day, height [baseline vs 28th day: 47.39±1.72 vs 50.1±1.62; P&amp;#60;0.05], changes in quality of hair and skin of mother, and the feeling of wellness in mother [baseline vs 28th day: 0.04 ± 0.19 vs 1.88 ± 0.32; P&amp;#60;0.05]. A significant reduction was observed in formula feeding incidence (&amp;#60;0.001). No side effects were reported. Lactobites bar can be used as a galactagogue to increase the human milk volume in lactating women.

Monsoon Planet: Bimodal Rainfall Distribution due to Barrier Structure in Pressure Fields

Abstract Monsoon systems transport water and energy across the globe, making them a central component of the global circulation system. Changes in different forcing parameters have the potential to fundamentally change the monsoon characteristics as indicated in various paleoclimatic records. Here, we use the Atmosphere Model developed at the Geophysical Fluid Dynamics Laboratory (GFDL-AM2) and couple it with a slab ocean in order to analyze the monsoon’s sensitivity to changes in different parameters on a planet with idealized topography (varying land position, slab depth, atmospheric CO2 concentration, solar radiation, sulfate aerosol concentration, and surface albedo). This Monsoon Planet concept of an aquaplanet with a broad zonal land stripe allows us to reduce the influence of topography and to access the relevant meridional monsoon dynamics. In simulations with monsoon dynamics, a bimodal rainfall distribution develops during the monsoon months with one maximum over the tropical ocean and the other one over land. The intensity and extent of the monsoon depend on the relative height of a local maximum in the surface pressure field that is acting as a barrier and is determining the coastward moisture transport. Changes in the barrier height occur during the course of one year but can also be induced when varying different parameters in the sensitivity analysis (e.g., the increase of atmospheric CO2 reduces the barrier height, resulting in an increase of rainfall, while aerosols have the opposing effect). This bimodal rainfall structure separated by a pressure barrier is also present in reanalysis data of the West African monsoon. Significance Statement Monsoon rainfall directly impacts the livelihood of millions of individuals in the tropics. Because monsoons transport energy and water around the globe, their influence reaches far beyond the tropics, and changes in their dynamics affect the climate both locally and globally. The individual monsoon systems are subject to various forcing factors that determine the monsoon characteristics in partly opposing ways. Here, we implement a model setup of the Monsoon Planet to study the monsoon’s sensitivity to various forcings in a simplified design, allowing us to gain new insights into monsoon dynamics. We find that a local maximum in the pressure field is acting as a barrier for moisture transport and thus determines the monsoon characteristics over land.

Maximum tree height in European Mountains decreases above a climate-related elevation threshold

Mountain forests face important threats from global change and spatio-temporal variation in tree height can help to monitor these effects. In this study, we used the Global Ecosystem Dynamics Investigation space-borne laser sensor to examine the relationship between maximum tree height and elevation, and the role of climate, in the main European mountain ranges. We found a piecewise relationship between elevation and maximum tree height in all mountain ranges, supporting the existence of a common breakpoint that marks the beginning of tree development limitations. Temperature and precipitation were identified as the most important drivers of tree height variation. Additionally, we predicted significant upward displacement of the breakpoint for the period 2080-2100 under climate change scenarios, potentially increasing the area without growth limitations for trees. These findings contribute to understanding the impacts of global warming on mountain forest ecosystems and provide insights for their monitoring and management.

Scenario for the formation of vortexlike structures in a presubstorm arc, taking into account changes in the arc height during its evolution

Activity in a prebreakup auroral arc in the form of vortexlike structures, the appearance/disappearance of which is preceded by an increase/decrease in the brightness of the arc, was studied in the context of a magnetospheric substorm, large-scale ionospheric convection, the situation in the interplanetary medium, and triangulation measurements of the arc height. The structures are observed in the premidnight hours and represent a superposition of two auroral forms: a large-scale bend in the arc that outlines the polar boundary of the diffuse auroras and smaller luminous tongues of luminosity (mini-torches) elongated along the convection on the western slope of the bends. The structures as a whole move against convection, towards substorm activity to the east of the observation area. We attribute the appearance of structures to the propagation of a disturbance deep into the magnetosphere, generated as a result of interaction of the magnetopause with a solar wind inhomogeneity, on the front of which Bz turns southward. The results of triangulation measurements show that the increase in brightness in the prebreakup arc shortly before the appearance of vortexlike structures is accompanied by a decrease in the height of the lower edge of the arc, which we explain by the appearance of a parallel electric field above the arc, which accelerates the precipitating electrons. The role of such a field in the formation of the torchlike structures is discussed in the framework of the interchange instability of the pole boundary of diffuse auroras.

Analysis of pre-operative factors affecting vault after posterior chamber phakic intraocular lens implantation

Objective: To analyze the early changes in vault height and its influencing factors after implantation of posterior chamber phakic intraocular lenses (pIOL). Methods: A retrospective case series study was conducted, including patients who underwent pIOL implantation at Zhongshan Ophthalmic Center, Sun Yat-sen University, from September 2020 to August 2021, and completed a 3-month follow-up. Data were collected from myopic or myopic astigmatism patients. Preoperative ocular examinations, including Pentacam anterior segment analysis system, Sirius anterior segment analysis system, ultrasound biomicroscopy (UBM), and IOLMaster optical biometry, were performed to measure parameters such as refractive power, corneal curvature, corneal horizontal diameter, anterior chamber volume, anterior chamber depth, pupil diameter, sulcus-to-sulcus diameter (STS), and lens thickness. The degree and position of implanted pIOL, as well as vault height measured by anterior segment optical coherence tomography (AS-OCT) at 1 day, 1 week, 1 month, and 3 months postoperatively, were recorded. Statistical analyses were conducted using repeated measures analysis of variance, Pearson correlation analysis, and multiple linear regression analysis. Results: A total of 314 patients (314 eyes) were included, with 52 male (16.56%) and 262 female (83.44%) patients, and an average age of (26.44±4.60) years. The preoperative equivalent spherical power was (-8.09±2.41) D. Postoperative vault heights at 1 day, 1 week, 1 month, and 3 months were (671.88±273.02) μm, (652.26±272.21) μm, (615.08±259.69) μm, and (591.14±250.71) μm, respectively, with statistically significant differences among groups (P<0.001). Eyes with vault height>750 μm showed a greater decrease in early postoperative vault height (P<0.001). The eyes implanted with 12.1 mm pIOL had the lowest postoperative vault height, while those with 13.2 mm had the highest (P>0.05). Factors correlated with vault height at 1 day postoperatively included corneal horizontal diameter, anterior chamber depth, preoperative cylinder power, angle degree, lens thickness, and pIOL cylinder power. Factors correlated with vault height at 3 months postoperatively included corneal horizontal diameter, anterior chamber depth, preoperative cylinder power, anterior chamber volume, angle degree, lens thickness, axial length, pIOL spherical and cylinder power. Factors associated with changes in early postoperative vault height included corneal curvature K2, anterior chamber depth, anterior chamber volume, pupil diameter, horizontal STS, vertical STS, axial length, and preoperative spherical power (all P<0.05). Multiple linear regression analysis revealed that lens thickness significantly influenced vault height at 1 day postoperatively, anterior chamber volume significantly influenced vault height at 3 months postoperatively, and pupil diameter significantly influenced changes in early postoperative vault height (all P<0.05). Conclusions: Vault height after pIOL implantation is unstable in the early postoperative period and gradually decreases within 3 months. A higher baseline vault height is associated with a greater decrease. Anterior chamber volume, pupil diameter, and lens thickness are influencing factors on vault height during the first 3 months postoperatively.

A Comparative Study of Lubrication Performance for Bs 080M46 Medium Carbon Steel Using Ring Compression Test and Finite Element Simulation

This study investigates the impact of lubrication on friction factors during the hot ring compression test of BS 080M46 medium carbon steel. Hot forging processes are crucial in industries due to the strength and durability of forged products, but friction-related issues can arise. Four lubrication conditions are focused: dry, oil to black graphite, water to black graphite, and water to colorless graphite. The ring compression test procedure, including sample dimensions and lubrication application, is explained. By employing predictive calibration curves generated through FEM which monitored height and internal diameter changes during compression. The study successfully aligns FEM simulation results with experimental data, thereby enhancing the accuracy of friction factor estimations and visualizing material behavior under various lubrication conditions. Results indicate that lubrication significantly affects friction factors, with oil to black graphite performing the best, yielding a friction factor of 0.15. A comparison between theoretical and experimental friction factors shows varying agreement levels, with water-to-black graphite, and water-to-colorless graphite respectively demonstrating excellent alignment with 0.990% and 0.971%. This study has practical implications for selecting lubricants in industrial applications, potentially enhancing manufacturing processes and product quality.

Biological Control Effect of Antagonistic Bacteria on Potato Black Scurf Disease Caused by Rhizoctonia solani

Potato black scurf, caused by Rhizoctonia solani, is a severe soil-borne disease that affects the quality and production of potatoes worldwide. In our study, we used Paenibacillus polymyxa YF and Bacillus amyloliquefaciens HT to determine the antagonistic ability of R. solani, with a particular focus on the antagonistic action of P. polymyxa YF to R. solani and its biocontrol effect on potato black scurf. In fermentation, filtrate assay, 50% filtrate of P. polymyxa YF and B. amyloliquefaciens HT inhibited the growth of R. solani by 85.55% and 82.86%, respectively. Microscopic observations showed notable morphological changes with mycelial collapse, atrophy, and deformation following treatment with the antagonistic filtrates. Moreover, cell membrane permeability results showed increased conductivity in bacteria-treated samples compared to the control. P. polymyxa YF exhibited stable colonization on potato plants and secreted various extracellular enzymes (protease, amylase, and cellulase), along with the synthetic substances with growth-promoting effects, such as siderophores and Indole-3-acetic acid (IAA). Whether it is in the excised tissue inoculation or potted experiment, the negative control showed the highest rank of disease symptoms. In the pot experiment, after YF treatment, physiological parameters showed remarkable changes in plant height, root length, stem thickness, and dry and fresh weight. Compared to blank control, the activities of the four resistant enzymes increased significantly in the P. polymyxa YF treatment group. The upregulation in the P. polymyxa YF group was 4.04, 0.54, 0.46, and 3.10 times, respectively. PCR analysis identified genes in both bacterial strains coding for antimicrobial lipopeptides, including fenB, ituC, and srfAA, which are associated with fengycin, iturin, and surfactin synthesis. These findings demonstrated that P. polymyxa YF has a prominent antagonistic effect on R. solani, suggesting its potential as an effective biological control agent for controlling potato black scurf.

Osteotomy Correction Angle Cut-off Points Can Guide the Operation to Prevent a Significant Decrease in Patella Height.

Patients who undergo a biplanar ascending medial open-wedge high tibial osteotomy with an excessive correction angle might experience patella infera and even knee pain after surgery. The purpose of this study was to identify the cut-off points for the degree of knee varus correction of open-wedge high tibial osteotomy, which is related to the symptomatic patellar position change. This retrospective study included 124 patients (mean age 61.69 ± 6.28 years; 78 women, 46 men) with varying degrees of varus knee osteoarthritis. All patients had undergone standard biplanar medial open-wedge high tibial osteotomy. They were divided into nine groups according to the change in hip-knee-ankle angle. Plain radiographs and three-dimensional CT images were obtained preoperatively and 18 months postoperatively. Patellar height was assessed using the Caton-Deschamps index, the Insall-Salvati index, and the Blackburne-Peel index. The patellofemoral index and patellar tilt were used to evaluate the degree of horizontal displacement of the patella. The varus correction, medial-proximal tibial angles, joint line convergence angles, and hip-knee-ankle angles were also measured. The subjective score was evaluated using the Western Ontario and McMaster Universities osteoarthritis index (WOMAC). There were significant changes in patella indexes in each group after surgery, among which there was no significant difference in patellar height changes for Groups A to F (p > 0.05), which were significantly lower than those in Group G, H, and I (p < 0.001). The patellar tilt and patellofemoral index also followed the same trend. The improvement in WOMAC scores for Groups G, H, and I was also significantly less for Groups A to F (p < 0.001). The patellar height, patellar tilt, and patellofemoral index all changed significantly in parallel with increasing degrees of osteotomy correction. The cut-off points for correction angle are 12.5° to 13.4°. When the correction angle is larger than this range, the patellar position can be significantly affected. Postoperative patellofemoral joint pain may be related to the changes in patella position.

The application and modification of WRF-Hydro/Glacier to a cold-based Antarctic glacier

Abstract. The McMurdo Dry Valleys (MDV) are home to a unique microbial ecosystem that is dependent on the availability of freshwater. This is a polar desert and freshwater originates almost entirely from surface and near-surface melt of the cold-based glaciers. Understanding the future evolution of these environments requires the simulation of the full chain of physical processes from net radiative forcing, surface energy balance, melt, runoff and transport of meltwater in stream channels from the glaciers to the terminal lakes where the microbial community resides. To establish a new framework to do this, we present the first application of WRF-Hydro/Glacier in the MDV, which as a fully distributed hydrological model has the capability to resolve the streams from the glaciers to the bare land that surround them. Given that meltwater generation in the MDV is almost entirely dependent on small changes in the energy balance of the glaciers, the aim of this study is to optimize the multi-layer snowpack scheme that is embedded in WRF-Hydro/Glacier to ensure that the feedbacks between albedo, snowfall and melt are fully resolved. To achieve this, WRF-Hydro/Glacier is implemented at a point scale using automatic weather station data on Commonwealth Glacier to physically model the onset, duration and end of melt over a 7-month period (1 August 2021 to 28 February 2022). To resolve the limited energetics controlling melt, it was necessary to (1) limit the percolation of meltwater through the ice layers in the multi-layer snowpack scheme and (2) optimize the parameters controlling the albedo of both snow and ice over the melt season based on observed spectral signatures of albedo. These modifications enabled the variability of broadband albedo over the melt season to be accurately simulated and ensured that modelled surface and near-surface temperatures, surface height change and runoff were fully resolved. By establishing a new framework that couples a detailed snowpack model to a fully distributed hydrological model, this work provides a stepping stone to model the spatial and temporal variability of melt and streamflow in the future, which will enable some of the unknown questions about the hydrological connectivity of the MDV to be answered.

HPMC/PVP K90 Dissolving Microneedles Fabricated from 3D-Printed Master Molds: Impact on Microneedle Morphology, Mechanical Strength, and Topical Dissolving Property.

Three-dimensional (3D) printing can be used to fabricate custom microneedle (MN) patches instead of the conventional method. In this work, 3D-printed MN patches were utilized to fabricate a MN mold, and the mold was used to prepare dissolving MNs for topical lidocaine HCl (L) delivery through the skin. Topical creams usually take 1-2 h to induce an anesthetic effect, so the delivery of lidocaine HCl from dissolving MNs can allow for a therapeutic effect to be reached faster than with a topical cream. The dissolving-MN-patch-incorporated lidocaine HCl was constructed from hydroxypropyl methylcellulose (HPMC; H) and polyvinyl pyrrolidone (PVP K90; P) using centrifugation. Additionally, the morphology, mechanical property, skin insertion, dissolving behavior, drug-loading content, drug release of MNs and the chemical interactions among the compositions were also examined. H51P2-L, H501P2-L, and H901P2-L showed an acceptable needle appearance without bent tips or a broken structure, and they had a low % height change (<10%), including a high blue-dot percentage on the skin (>80%). These three formulations exhibited a drug-loading content approaching 100%. Importantly, the composition-dependent dissolving abilities of MNs were revealed. Containing the lowest amount of HPMC in its formulation, H901P2-L showed the fastest dissolving ability, which was related to the high amount of lidocaine HCl released through the skin. Moreover, the results of an FTIR analysis showed no chemical interactions among the two polymers and lidocaine HCl. As a result, HPMC/PVP K90 dissolving microneedles can be used to deliver lidocaine HCl through the skin, resulting in a faster onset of anesthetic action.