<p indent="0mm">At the beginning of 21st century, a study suggested that Northwest China’s climate is becoming warmer and more humid. However, there were doubts about this conclusion because the humidification changes on a small scale only last for a short period, and also suspicions about the development, duration, and impact of the warming-wetting trend in this region. This paper sets out several factors, such as the area, intensity of humidification, and comprehensiveness of the wetness index, to characterize the wetting degree. Furthermore, by using measured climate data, CRU data, climate scenario predictions, and ecological and hydrological data, we systematically analyze temporal and spatial evolution of the warming-wetting trend in Northwest China. Studies have shown that Northwest China has experienced two warming periods during the last century, i.e., the 1940s, and the period from the 1960s to the present (the current warming period). The latter is more substantial. The precipitation in the west and east part of Northwest China has a seesaw change process in many periods. However, humidification has simultaneously occurred in both regions since the beginning of this century. The current precipitation in the west part of Northwest China has far exceeded any period over the past <sc>100 a.</sc> In contrast, the east part’s recent rainfall is still currently lower than that of the 1950s and 1960s. Since 1961, Northwest China’s west region has experienced consistent humidification, which has been more pronounced since 1987. Simultaneously, the east part was drying from 1961 to 1997, and has become humid since 1997. The temperature, precipitation, and aridity index changes in the west part show the same patterns. In most periods, the west part was either cold-dry or warm-wet. In comparison, such consistency of the temperature, precipitation, and aridity changes does not exist in the east region. Before this century, warm-wet climates rarely occurred in the east region, having become more frequent. This is probably due to the different dominant temperatures and precipitation processes in the west and east regions. From a spatial point of view, the temperature increases in the whole of Northwest China, and the precipitation increases in the west region and decreases in the east region. The area with increasing rainfall has become larger during the past three climatic periods, and currently covers the whole of Northwest China. The precipitation, aridity index, and comprehensive humidity index in Northwest China have a non-linear increasing trend. The expanding humidity trend has been significant since the beginning of this century. The current warming and humidification have not changed the basic climate pattern in Northwest China. However, if the current trend continues, they would change the climate pattern in the future. Such climate change may result from the simultaneous enhancement of the westerly circulation and the East Asian summer monsoon circulations in this century. The climate warming and humidification in Northwest China significantly impacted extreme weather events, water resources, ecological environment, and agriculture during this century. This research will provide a basis for decision-making on issues such as implementing the Western development strategy in the new era, the ecological protection and high-quality development of the Yellow River Basin, environmental construction planning, and water resources management policies in Northwest China.