The changes in the flow field and combustion characteristics induced by the mode transition process of a turbine-based combined cycle (TBCC) engine may lead to failure of the mode transition. In this paper, the cold mixing characteristics, combustion efficiency, and cold and thermal flow losses of a TBCC multibypass combustor with a double-mixer configuration are investigated through numerical simulations, and the correlations between the thermal mixing efficiency and combustion efficiency is established. The results show that the thermal mixing efficiency of double-lobed mixer combustors is better at low ram inlet Mach numbers, but the ring-plus-lobed mixer combustor has better mixing and combustor characteristics at relatively high Mach numbers. However, the effect of the turbo core inlet Mach number on the combustion efficiency is not regular. The spacing between the double mixers that maximizes the mixing and combustion characteristics of the combustor is 75 mm. With increasing of expansion angle of the lobed mixer, the thermal mixing efficiency and combustion efficiency increase by 31.9 % and 23.3 %, respectively. In addition, the positive correlation coefficient between combustion efficiency and thermal mixing efficiency caused by changes in the inlet Mach number is greater than that caused by changes in structural parameters.