Phase Change Research Articles

Phase change heat storage and enhanced heat transfer based on metal foam under unsteady rotation conditions

Phase change heat storage technology is an essential method for balancing supply and demand in solar energy heat utilization. In this study, a numerical model of the phase change heat storage process is built to explore the impact of non-constant rotation, with and without metal foam. Subsequently, an investigation into the influence of metal foam pore density and porosity on heat storage performance is conducted, with a focus on Taguchi design for statistical analysis. The research delves into the effects of foam parameters on heat storage rate, temperature response, heat storage time, and heat storage properties. Findings reveal significant resolidification in the melting process of this thermal storage structure without metal foam, due to periodic rotation speed hindrance in transferring heat to the outside. Taguchi design results underscore the greater influence of porosity on the melting time and average heat storage rate compared to pore density. Specifically, a reduction in melting time by 62.21% and 30.49%, and an increase in average heat storage rate by 237.56% and 51.19% is observed when pore density and porosity are 40 PPI and 0.97, compared with the ones with porosities of 0.99 and 0.98, demonstrating minimal impact on total heat absorption.

Processing and properties of Al–Si microcapsules with a biomimetic-corrugated structure and corundum-mullite composite shell

The encapsulation of metal-based phase change materials using ceramics can realize safe and effective storage of high-temperature thermal energy. However, the use of a low toughness ceramic shell around the microcapsules cannot ensure the provision of a high latent heat and thermal cyclic stability. Here, we provide a new and effective design strategy for preparing biomimetic Al–Si microcapsules that are based on a sea-shell corrugated structure and a nano-scale corundum-mullite composite shell. The latent heat of the microcapsules was over 400 J/g, much greater than other metal-based microcapsules reported to date. The unique biomimetic-corrugated structure microcapsules obtained by a heat treatment at 1000 °C exhibited excellent thermal stability, achieving near zero heat loss after 5000 thermal cycles, whose latent heat of absorption and release reached up to 448.3 J/g and 451.8 J/g respectively. Furthermore, the microcapsules possessed a giant heat storage density of 945.8 J/g within 300–700 °C, and the performance figure of merit was 6384.2 × 106 J2·K–1·s–1·m–4, approximately 15 times higher than that of commercial solar salt. This new approach provides a pathway the practical application of Al–Si alloys as thermal storage materials for renewable energy applications.

Diffusion-induced stress amplification in phase-transition materials for electrodes of lithium-ion batteries

This work sheds the light on the stress amplification in active material particles of electrodes caused by the localized lithium concentration inhomogeneity due to phase transitions. This is a significant issue usually neglected in the literature, as generally the ideal Fickian diffusion model is used to describe the lithium diffusion, which particularly fails when dealing with phase change materials, resulting in the underestimation of the stress. In turn, this results in the underestimation of the fracture behaviour of the electrode and the battery degradation, ultimately.To overcome these limitations, this work proposes a mechanical-transport model where the lithium transport is modelled according to the non-ideal solution theory with an equivalent diffusion coefficient depending on the potential of the host material vs Li/Li+. The results show that the proposed model correctly describes the concentration distribution within the particle of phase-change materials (graphite is chosen as a case study), in agreement with the existent experimental measurements. The differences with respect to the traditional Fickian diffusion model is substantial as the stress is up to 85% higher with the proposed model and the concentration distribution can capture the inhomogeneity caused by phase transitions.

Unlocking the power of LiOH: Key to next-generation ultra-compact thermal energy storage systems

This study explores the potential of untapped lithium hydroxide (LiOH) as a phase change material for thermal energy storage. By overcoming the challenges associated with the liquid LiOH leakage, we successfully thermal-cycled LiOH in a laboratory scale experimentation, and observed its stability (>500 thermal cycles), without chemical decomposition. This step has never been performed to date. Its solid-to-liquid reversible transitions temperatures and related solidification/melting enthalpies values have been verified. Then, the first experimental characterization of LiOH's thermal properties shows unexpected values for its heat capacity, thermal conductivity and diffusivity, in contradiction with the few ones available in literature. This opens avenues for LiOH's applications for the storage of sensible and latent heat, as shown through the increased cycle efficiency potential of a thermal energy storage system if based on its energy storage capacity; up to six times more volumetric energy density compared to traditional Solar Salt-based systems used in the solar tower plant (4.5 GJ/m3 vs. 0.76 GJ/m3 over 1000 thermal cycles). Additionally, we observed a softening phenomenon that occurs inconsistently during heating, but which may account for its excellent melting properties and the interplay with other raw chemicals. This new insight contributes certainly to the underlying mechanisms in the synthesis of another promising heat storage material in development: the peritectic compound Li4Br(OH)3. This pioneering work suggests LiOH as a promising ultra-compact thermal energy storage material for filling the intermediary gap from current to next-generation solar power plants, although its large-scale application requires further investigation to achieve economic viability.

Self-healing, adaptive and shape memory polymer-based thermal interface phase change materials via boron ester cross-linking

Addressing the thermal resistance between rough interfaces without applying pressure to the interfacial sandwich has been a challenge. Herein, a thermal interface phase change material (TIPCM) is designed to realize a 3D support skeleton with a dynamic crosslinking network by introducing a boron ester crosslinking backbone into paraffin wax (PW) and ethylene-octene copolymer (EOC), thus enabling the TIPCM to ensure mechanical integrity without leakage even above the melting temperature of EOC. The chemical cross-linking between the organic solid–liquid phase change material (PCM) and the polymer realizes thermally triggered self-healing and adaptive shape memory properties. The phase transition of PW leads to a decrease in the modulus of TIPCM and activates the ester exchange of the dynamic covalent bonding of boron esters, which allows TIPCM to self-heal and self-adapt to a variety of object surfaces. These enabled the TIPCM to fill the interface gaps through small stress deformations, forming an interlocking structure that reduces contact thermal resistance and promotes heat transfer. The obtained TIPCM achieves excellent chip thermal management performance, cooling the analog CPU temperature by 67 °C at 5 V. In conclusion, this study provides a potential strategy for redesigning TIPCMs with high latent heat and special physical properties for thermal management.

Harmonic phase-sensitive detection for quartz-enhanced photoacoustic-thermoelastic spectroscopy

Quartz tuning fork (QTF)-based techniques of photoacoustic spectroscopy and thermoelastic spectroscopy play a significant role in trace gas sensing due to unique high sensitivity and compactness. However, the stability of both techniques remains plagued by the inevitable and unpredictable laser power variation and demodulation phase variation. Herein, we investigate the phase change of a QTF when integrating both techniques for enhanced gas sensing. By demonstrating harmonic phase-sensitive methane detection as an example, we achieve stable gas measurement at varying laser power (2.4–9.4mW) and varying demodulation phase (−90–90°). Besides, this method shows more tolerance to resonant frequency drift, contributing to a small signal fluctuation of ≤ 6.4% over a wide modulation range (>10 times of the QTF bandwidth). The realization of harmonic-phase detection allows strengthening the stability of QTF-based sensors in a simple manner, especially when stable parameters, such as laser power, demodulation phase, even resonant frequency, cannot always be maintained.

Analysis on Rotation Timing of Dynamic Rotating Latent-Energy-Storage Envelope

The application efficiency of the Dynamic Rotating Latent-Energy-Storage Envelope (DRLESE) system is highly contingent upon dynamic rotation timings. To gain the optimal rotation timings, six different timings were examined by employing the liquid fraction, thermal storage and release, surface temperature and heat flow. The numerical heat transfer method was employed and verified an experiment. Results indicated that the optimal initial rotation occurs in the forenoon, when the inner surface temperature aligns with the sol-air temperature. Subsequently, achieving optimal secondary rotation is possible in the afternoon when the sol-air temperature equals the liquid temperature of PCM (Phase Change Material). Under these optimized initial and secondary rotation timings, the significant enhancements in thermal performance of the DRLESE system were observed. By optimizing rotation timings, indoor effective heat release can reach up to 3182.9 kJ/Day with an effectiveness percentage exceeding 99.99%, and inner surface heat flow was increased by 5.86%∼12.26%.

Enhancing thermal comfort in buildings through the integration of phase change material on the building envelope: a simulation study

Abstract According to the report published by the International Energy Agency (IEA), active space cooling and air conditioning systems consume approximately 16% of the building sector’s final electricity consumption and contribute 3.94% of global greenhouse gas emissions. In this regard, the use of low-cost but effective passive solutions, such as organic phase change materials (PCM) on the building envelope, can provide high thermal mass and thus can lower the temperature fluctuation inside the building. In the current study, the potential of PCM-enhanced building envelopes to enhance thermal comfort has been studied. The study has been performed using the conduction finite difference (ConFD) algorithm in EnergyPlus software. A comparative study has been done for a traditional reinforced cement concrete (RCC) reference test room of size (5m x 6m x 3m) and another room of the same size with PCM-enhanced walls for the hot and humid climate zone of Guwahati (latitude 26.1, longitude 91.7), in India. A PCM thickness of 20 mm is used at the external surface of the wall between the red clay burnt brick (120 mm in thickness) and the cement plaster (25mm thick). The PCM used for the study is a biocomposite PCM, named WH-PCM, with a melting point of 31.5°C and thermal conductivity of 0.27 W/mK. The simulation results reveal that the R-value of the external wall of the room with PCM walls has been increased by 84.90% compared to the reference room with the incorporation of WH-PCM, resulting in a mean zone temperature difference of 0.3°C throughout the year. Also, the indoor thermal discomfort hours have been annually reduced by 15.82% with the use of WH-PCM when compared with the reference room. A similar temperature difference trend, which is 1.93°C, is also observed in the single PCM brick experimental result under identical testing conditions as a regular brick of the same size.

Unlocking the power of LiOH: Key to next-generation ultra-compact thermal energy storage systems

This study explores the potential of untapped lithium hydroxide (LiOH) as a phase change material for thermal energy storage. By overcoming the challenges associated with the liquid LiOH leakage, we successfully thermal-cycled LiOH in a laboratory scale experimentation, and observed its stability (>500 thermal cycles), without chemical decomposition. This step has never been performed to date. Its solid-to-liquid reversible transitions temperatures and related solidification/melting enthalpies values have been verified. Then, the first experimental characterization of LiOH's thermal properties shows unexpected values for its heat capacity, thermal conductivity and diffusivity, in contradiction with the few ones available in literature. This opens avenues for LiOH's applications for the storage of sensible and latent heat, as shown through the increased cycle efficiency potential of a thermal energy storage system if based on its energy storage capacity; up to six times more volumetric energy density compared to traditional Solar Salt-based systems used in the solar tower plant (4.5 GJ/m3 vs. 0.76 GJ/m3 over 1000 thermal cycles). Additionally, we observed a softening phenomenon that occurs inconsistently during heating, but which may account for its excellent melting properties and the interplay with other raw chemicals. This new insight contributes certainly to the underlying mechanisms in the synthesis of another promising heat storage material in development: the peritectic compound Li4Br(OH)3. This pioneering work suggests LiOH as a promising ultra-compact thermal energy storage material for filling the intermediary gap from current to next-generation solar power plants, although its large-scale application requires further investigation to achieve economic viability.

Study on Cold Start of Fuel Cell Stack Combined with Liquid Heating and Fuel Cell Self-starting

Fuel cell vehicles have been paid more and more attention, while the low temperature cold start capability has become the main reason that hinders their large-scale commercialization, especially for the fuel cell bus. Generally, liquid heating (positive temperature coefficient thermistor (PTC) as the heat source) and fuel cell self-starting heating are the common cold start methods. However, these methods can bring about low start speed and high energy consumption. Therefore, a new cold start method combined with liquid heating and fuel cell self-starting is proposed to solve the problems. Besides, phase change material (PCM) is introduced to reduce energy consumption further. The PCM can absorb the waste heat of the fuel cell stack. Then the heat can be used for stack cold start by circulating liquid. In this study, a fuel cell bus cold start system simulating model is built. Based on this model, the fuel cell temperature and energy consumption during the cold start are analyzed. The results show that the method combined with liquid heating and fuel cell self-starting is superior to the liquid heating method. The cold start time and PTC consumption of the PTC-PCM-self-starting heating mode are 19.0% and 19.2% less than that of PTC-PCM heating mode. As for the combined heating method, dropping the self-starting temperature can not only increase the cold start speed but also reduce the proportion of electric heating. For every 1 °C decrease, the start-up time is shortened by 1% on average, and the waste heat utilization rate is increased by 0.5%. Although increasing the self-starting current can increase energy consumption, it will save more cold start time and reduce the proportion of electric heating. For every 1 A increase, the start-up time is shortened by 0.3% on average, and the waste heat utilization rate is increased by 0.1%. The PTC-PCM-self-starting heating method provides a way for fuel cell stack to start quickly and energy-efficiently in low temperature environment.

Development of a novel Al-Si microcapsules with heat-resistant, high latent heat, and efficient solar heat absorption

Aluminum-silicon (Al-Si) alloys are prominent in high-temperature thermal storage due to their high thermal storage density, thermal conductivity, and low cost. Despite their potential, the corrosivity and chemical activity from their liquid phase leakage limit broader applications. The hydrothermal method, often used for encapsulating Al-Si into microencapsulated phase change materials (MEPCMs), consumes the core material, reducing latent heat values. Additionally, the inability to modify the shell material fails to meet multifunctional demands. Addressing solar thermal application needs, we developed a novel heat-resistant, high-latent-heat Al-Si MEPCMs using a “double-layer coating, sacrificial inner layer” approach. This method, originally proposed by our research group and first extended to the microencapsulation of high-temperature phase change materials (PCM), uses Al-12Si as the core, PMMA as the sacrificial layer, and SiO2 as the outer shell.The MEPCMs demonstrated an encapsulation efficiency of 90.7 % and a latent heat value of 454.9 J/g. By adjusting the core–shell ratio, the size of the internal void was optimized to enhance thermal performance and cyclic stability, with MEPCM-S3 maintaining 98.6 % of its latent heat (439.5 J/g) after 10 thermal shocks and 300 thermal cycles. Furthermore, surface loading of carbon black (CB) enhanced the spectral absorption rate to 87.72 % in the 200–2500 nm range, marking an 11 % increase. These modifiable, high-latent heat, and cycle-resistant Al-Si MEPCMs hold broad prospects for applications in high-temperature thermal storage and as next-generation efficient solar energy storage media.

Study on Phase Change Materials Integration in Concrete: Form-Stable PCM and Direct Addition

As the economy continues to develop, building energy consumption rises, necessitating sustainable solutions. Concrete, a pivotal building material, assumes a vital role in this context. To address the challenge of escalating energy consumption and environmental impact, this study studied the integration of phase change materials (PCMs) into concrete by two methods. Recycled aggregates serve as form-stable mediums for PCM absorption, while direct addition methods incorporate 7.5% and 15% free liquid PCM by volume of river sand. Six concrete mixtures underwent comprehensive evaluation encompassing workability, density, water absorption by immersion, compressive strength, flexural strength, chloride ion penetration, freeze-thaw cycling tests, and carbonation. The results reveal a decrease in concrete density and mechanical properties with increasing PCM content. Nevertheless, notable enhancements in chloride ion penetration resistance, reaching up to 18.5% with free PCM incorporation, and zero carbonation depth were observed. These results underscore the potential of PCM-concrete composites in harmonizing energy efficiency and structural integrity, offering a sustainable alternative to fossil fuel-based air conditioning systems and with great potential from the point of view of the durability of the structures.

Review of organic and inorganic waste-based phase change composites in latent thermal energy storage: Thermal properties and applications

Review of organic and inorganic waste-based phase change composites in latent thermal energy storage: Thermal properties and applications

Effect of multiple laser remelting on microstructure and corrosion resistance of Fe0.5CoCrNi1.5Nb0.68Mo0.3 high entropy alloy coatings

High entropy alloy (HEA) coatings of Fe0.5CoCrNi1.5Nb0.68Mo0.3 was prepared on 304 stainless steel using laser cladding and subsequently remelted multiple times. The effects of multiple thermal cycles on the phase composition, grain size, microstructure evolution, and corrosion resistance of the coatings are thoroughly investigated. The original coating consisted of face-centered cubic (FCC), Laves, and NbC phases, and the phase composition does not change obviously, but the distribution and microstructure of the phase change significantly after multiple remelting. As the number of remelting times increased, the bar-like eutectic structure decreased while the lamellar eutectic structure became more prominent. Laser remelting induced dynamic recrystallization in the coating, resulting in a transformation from columnar grains to equiaxed grains, and then back to columnar grains. The grain size also changes significantly with different remelting times. Potentiodynamic polarization and electrochemical impact spectroscopy measurements were conducted in a 3.5 wt% NaCl solution to evaluate the corrosion resistance of the coating. The results revealed both the original coating and the once-remelted coating exhibited lower corrosion current density and higher corrosion potential, but the latter had a higher Faraday impedance. Additionally, immersion tests were performed in 10 wt% FeCl3 solution, which demonstrated that the once-remelted coating displayed fine and uniform corrosion pits with shallow depth. This study provides theoretical support for the regulation of microstructure and the optimization of coating performance. Furthermore, the microstructure evolution law discovered in this research is also applicable to additive manufacturing.

The coupled dynamics of information-behavior-epidemic propagation considering the heterogeneity of adoption thresholds and network structures in multiplex networks

During epidemics, individual responses to prevention and control information vary significantly, affecting the execution of preventive measures. This paper introduces a novel model to analyze the co-evolution of the information-behavior-epidemic dynamic, accounting for the heterogeneity in individual behavioral adoption thresholds and network structures. The model consists of three layers: the upper layer, utilizing scale-free social networks to represent the diffusion of information; the middle and lower layers, employing community networks, to illustrate individuals’ decision-making and epidemic transmission processes, respectively. We applied the Heaviside step function to depict the effects of information and local environmental factors on individuals’ decisions. Through the microscopic Markov chain approach (MMCA), we determined the epidemic threshold. Our methodology also included extensive Monte Carlo (MC) simulations to validate our theoretical predictions. Our results reveal several key insights: (i) reducing community mobility and the threshold for adopting preventive behaviors can significantly restrain the scale of the epidemic and delay outbreaks; (ii) the level of individual activity in the physical contact network has a significant influence on epidemic transmission; (iii) integrating individuals’ behavior adoption thresholds induces a two-stage phase change, deviating from the continuous phase transition typically observed in epidemic transmission.

PENDEKATAN HISBAH KENDIRI DALAM MENANGANI KEMURUNGAN WANITA BEKERJAYA

The phase changes of the endemic Covid-19 endemic have created a new phenomenon in everyone’s lives. It is often noted in many article publications about the issue of depression, especially among working women. It is frequently associated with the emotional pressure from their partners resulting to marital breakdowns. Al-Ghazali, a figure who often talks about human soul and the process of developing the human soul. Therefore, this article examines the self-discipline (self-hisbah) approach among working women to shape a tranquil soul, in order to deal with persistent depression. This study uses a quantitative method by using a questionnaire consisting of 50 questions. A total of 48 working women from various job agencies who are married agreed to be respondents. The study found that nearly 70% of respondents experienced symptoms of depression. Indeed, the goodness of self-discipline (self-hisbah) can control women from excessive emotional pressure, provide peace of mind, and avoid worries while carrying out their responsibilities. The results show that 65% of respondents whom experiencing emotional pressure practiced the self-discipline (self-hisbah) approach when dealing with depression. The importance of this study is to assess the effectiveness of self-discipline (self-hisbah) approach as an Islamic-based self-treatment that can address symptoms of depression among working women who are married. However, they need to be consistent in applying the self-discipline approach to ensure that their career and household management are well-balanced.

Microstructure Evolution and Mechanical Properties of Extruded AlSiCuFeMnYb Alloy

This study investigates the impact of varying extrusion ratios on the microstructure and mechanical properties of AlSiCuFeMnYb alloy. Following hot extrusion, significant enhancements are observed in the microstructure of the cast rare earth aluminium alloy. Within the cross-sectional microstructure, the α-Al phase is reduced in size, and its dendritic morphology is eliminated. The morphology of the eutectic Si phase transitions from long strips to short rods, fine fibres, or granular forms. Similarly, the Fe-rich phase changes from a coarse skeletal and flat noodle shape to small strips and short skeletal forms resembling Chinese characters. The CuAl2 phase evolves from large blocks to smaller blocks and granular forms, while the Yb (Ytterbium)-rich rare earth phase shifts from large blocks to smaller, more uniformly distributed blocks. In the longitudinal section, the structure aligns into strips along the extrusion direction, with the spacing between these strips decreasing as the extrusion ratio increases. At an extrusion ratio of 22.56, the alloy demonstrates superior mechanical properties with a tensile strength of 325.50 MPa, a yield strength of 254.44 MPa, a hardness of 143.90 HV, and an elongation of 15.47%. These represent improvements of 27.8%, 36.5%, 38.9%, and 236.4%, respectively, compared with the as-cast rare earth alloy. In addition, the fracture surface of the extruded rare earth alloy exhibits obvious ductile fracture characteristics. Additionally, the alloy undergoes dynamic recrystallisation and dislocation entanglement during hot extrusion. The emergence of a twinned Si phase and a dynamically precipitated nanoscale CuAl2 phase are critical for enhancing deformation strengthening, modification strengthening, and dynamic precipitation strengthening of the extruded alloys.

Renewable and Sustainable Energy Review

The review introduced in this paper depends upon point by point survey of the Zeroed on the utilization of phase change material (PCM) for PV-Module. Thermal regulation & electrical efficiency improve the impact of high temperatures. On PV power age has been analysed and the discoveries have featured the significance of visible high temp. Guideline for PV-model. Different cooling technique utilized to keep up better PV execution are examined and the as of late arising PV-PCM framework idea for high-temperature guidelines is presented. A comprehensive paper review of best in class part of this innovation like framework improvement, execution, assessment material choice, heat remove improvement mathematical model, reproduction, and application in practice is given. The PVST-PCM system for example coordinated with a sunlight base warm (ST) system. Has subsequently been explored as the put-away intensity can be extricated for the warm application. The double PCM jobs exhibit huge application possibilities for consolidated innovation in any case. Both PV-PCM and PVST-PCM framework (system) are still mostly in the exploration and research faculty test stage, with clear extension for viable application yet with orderly difficulties. Ideas for the future work are introduced.

Flame-retardant and phase-changing microcapsules incorporating black phosphorus for efficient solar energy storage

A novel phase change microcapsule has been developed and synthesized for solar energy storage systems. The fabrication process involved the in-situ polymerization of phase change microcapsules, wherein cellulose nanocrystals (CNCs) were employed as Pickering emulsifiers and nano-fillers to enhance the properties of the melamine formaldehyde resin (MF) shells. These enhancements included improved emulsifying ability, mechanical strength, and sustainability. Subsequently, black phosphorus (BP), a two-dimensional material with high solar absorption intensity and a wide frequency range, was covalently modified by MF to enhance the photothermal capacity of the microcapsules and reduce the thermal resistance between the photothermal material and the phase change material (PCM), this functionalized BP was referred to as MF@BP. The phase change microcapsules without and with MF@BP exhibit high latent heat values of 210.79 J g−1 and 207.92 J g−1, respectively. Furthermore, the PCM core content was measured at 88.9% and 88.5%, and the encapsulation rates are 99.0% and 98.8%, respectively. The PCM microcapsules with MF@BP demonstrated excellent photothermal characteristics with an efficiency of 92.04%. Additionally, the PCM microcapsules exhibit stability below 200 °C and retain 99.4% of their latent heat even after 100 cycles of heating and cooling. Furthermore, the PCM microcapsules display self-extinguishing properties due to the flame retardancy of the MF shell, and the incorporation of black phosphorus further enhanced the flame retardancy. Overall, these PCM microcapsules exhibit significant potential for utilization in solar energy systems.

Advancements in Nanomaterial Dispersion and Stability and Thermophysical Properties of Nano-Enhanced Phase Change Materials for Biomedical Applications.

Phase change materials (PCMs) are materials that exhibit thermal response characteristics, allowing them to be utilized in the biological field for precise and controllable temperature regulation. Due to considerations of biosafety and the spatial limitations within human tissue, the amount of PCMs used in medical applications is relatively small. Therefore, researchers often augment PCMs with various materials to enhance their performance and increase their practical value. The dispersion of nanoparticles to modify the thermophysical properties of PCMs has emerged as a mature concept. This paper aims to elucidate the role of nanomaterials in addressing deficiencies and enhancing the performance of PCMs. Specifically, it discusses the dispersion methods and stabilization mechanisms of nanoparticles within PCMs, as well as their effects on thermophysical properties such as thermal conductivity, latent heat, and specific heat capacity. Furthermore, it explores how various nano-additives contribute to improved thermal conductivity and the mechanisms underlying enhanced latent heat and specific heat. Additionally, the potential applications of PCMs in biomedical fields are proposed. Finally, this paper provides a comprehensive analysis and offers suggestions for future research to maximize the utilization of nanomaterials in enhancing the thermophysical properties of PCMs for biomedical applications.