The Alborz Mountains are some of the highest in Iran, and they play an important role in controlling the climate of the country’s northern regions. The land surface temperature (LST) is an important variable that affects the ecosystem of this area. This study investigated the spatiotemporal changes and trends of the nighttime LST in the western region of the Central Alborz Mountains at elevations of 1500–4000 m above sea level. MODIS data were extracted for the period of 2000–2021, and the Mann–Kendall nonparametric test was applied to evaluating the changes in the LST. The results indicated a significant increasing trend for the monthly average LST in May–August along the southern aspect. Both the northern and southern aspects showed decreasing trends for the monthly average LST in October, November, and March and an increasing trend in other months. At all elevations, the average decadal change in the monthly average LST was more severe along the southern aspect (0.60°C) than along the northern aspect (0.37°C). The LST difference between the northern and southern aspects decreased in the cold months but increased in the hot months. At the same elevation, the difference in the lapse rate between the northern and southern aspects was greater in the hot months than in the cold months. With increasing elevation, the lapse rate between the northern and southern aspects disappeared. Climate change was concluded to greatly decrease the difference in LST at different elevations for April–July.