Event Abstract Back to Event Novel perspectives on the dialogue between neuronal and artificial systems Michela Chiappalone1*, Marta Bisio1, Valentina Pasquale1 and Jacopo Tessadori1 1 Istituto Italiano di Tecnologia, Neuroscience and Brain Technologies, Italy Behaviors, from simple to most complex, require a two-way interaction with the environment and the contribution of different brain areas depending on the orchestrated activation of neuronal assemblies. The environment itself can be manipulated, and the corresponding changes in dynamic behavior can provide useful information for understanding the neural systems themselves. For the above reasons, researchers have begun to explore the possibility to create new in vitro systems at the interface between neuroscience and robotics, a field known as ‘embodied electrophysiology’. At the same time, these systems can provide excellent test beds for electrical training and modulation of neuronal tissue, thus forming the basis of future adaptive, bi-directional Brain Machine Interfaces and Brain Prostheses. The first-ever in vitro closed-loop system was developed at Northwestern University: it consisted of a lamprey brain-stem bi-directionally connected to a small wheeled robot. Inspired by that pioneering study, we developed a novel bi-directional system involving a ‘reduced brain model’ (i.e. neocortical networks kept alive over Micro Electrode Arrays - MEAs) and an artificial system (e.g. a small real/virtual robot, a neuromorphic device). In vitro neuronal systems can be easily ‘engineered’ and manipulated, either chemically or electrically, in an open or closed loop fashion. The realized software architecture guarantees a bi-directional exchange of information between the natural and the artificial part by means of simple linear coding/decoding schemes. Moreover a similar closed-loop experimental paradigm can be exploited for developing novel concept Brain Prostheses, aimed at restoring lost functions in neuronal systems with different topological complexity. Acknowledgements The research leading to these results has received funding from the European Union's Seventh Framework Programme (ICT-FET FP7/2007-2013, FET Young Explorers scheme) under grant agreement n° 284772 BRAIN BOW (www.brainbowproject.eu). Keywords: closed-loop system, Micro-Electrode Arrays, in vitro, dissociated neuronal culture, Electrical Stimulation Conference: MERIDIAN 30M Workshop, Brixen, Italy, 25 Sep - 25 Sep, 2014. Presentation Type: Oral Presentation Topic: Neuroengineering Citation: Chiappalone M, Bisio M, Pasquale V and Tessadori J (2014). Novel perspectives on the dialogue between neuronal and artificial systems. Front. Neuroeng. Conference Abstract: MERIDIAN 30M Workshop. doi: 10.3389/conf.fneng.2014.11.00001 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 06 Nov 2014; Published Online: 06 Nov 2014. * Correspondence: Dr. Michela Chiappalone, Istituto Italiano di Tecnologia, Neuroscience and Brain Technologies, Genova, 16163, Italy, michela.chiappalone@iit.it Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract Supplemental Data The Authors in Frontiers Michela Chiappalone Marta Bisio Valentina Pasquale Jacopo Tessadori Google Michela Chiappalone Marta Bisio Valentina Pasquale Jacopo Tessadori Google Scholar Michela Chiappalone Marta Bisio Valentina Pasquale Jacopo Tessadori PubMed Michela Chiappalone Marta Bisio Valentina Pasquale Jacopo Tessadori Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.